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Entry version 194 (02 Jun 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Protein hu-li tai shao

Gene

hts

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for assembling actin at ring canals in developing egg chambers. Probably interacts with other developmental proteins involved in nurse cell/oocyte transport through the ring canals. Important for normal neuromotor function (PubMed:23836506).

1 Publication

Miscellaneous

'Hu-li tai shao' means 'too little nursing' in Chinese.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Oogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-DME-5223345, Miscellaneous transport and binding events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein hu-li tai shao
Alternative name(s):
Adducin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hts
ORF Names:CG9325
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263391, hts

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002185391 – 1156Protein hu-li tai shaoAdd BLAST1156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei478Phosphoserine1 Publication1
Modified residuei480Phosphothreonine1 Publication1
Modified residuei498Phosphothreonine1 Publication1
Modified residuei603Phosphoserine1 Publication1
Modified residuei608Phosphotyrosine1 Publication1
Modified residuei609Phosphothreonine1 Publication1
Modified residuei611Phosphothreonine1 Publication1
Modified residuei614Phosphoserine1 Publication1
Modified residuei627Phosphotyrosine1 Publication1
Modified residuei630Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q02645

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform C is expressed in nurse cells. Isoform A is produced in the nurse cell but transported into the oocyte at stage 1, localizes to the oocyte cortex at stage 8 and to the anterior pole from day 9 onwards. Isoform B is expressed in the somatic follicle cells that surround the germline.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Oogenesis and early embryogenesis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263391, Expressed in central nervous system and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q02645, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02645, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62894, 23 interactors

Database of interacting proteins

More...
DIPi
DIP-23013N

Protein interaction database and analysis system

More...
IntActi
Q02645, 16 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q02645

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36
Regioni897 – 956DisorderedSequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 36Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi907 – 929Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168292

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02645

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02645

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001303, Aldolase_II/adducin_N
IPR036409, Aldolase_II/adducin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00596, Aldolase_II, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01007, Aldolase_II, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53639, SSF53639, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q02645-1) [UniParc]FASTAAdd to basket
Also known as: K, N, N4

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEVEQPPQN GIDPTAGEDD DNSKARPADI EQDMREMERR KRVEAIMGSK
60 70 80 90 100
LFREELERIV DSARDGGAGA SGILQQLSDI VGVPVSRVGS VFKSSNCMVP
110 120 130 140 150
INDIRGVESM GYAKGEKILR CKLAATFRLL DLYGWTQGLG AQITARLKVD
160 170 180 190 200
QEYFLVNPYG LLYHEITASA LNKVDMQGQI VEQGTTNFGG NKSHFVLHSV
210 220 230 240 250
VHAARPDIRC AIYIGCSPVV AISSLKTGLL PLTKDACVLG EITTHAYTGL
260 270 280 290 300
FDEEERNRLV RSLGPNSKVI LLTNHGALCC GETIEEAFFA ACHIVQACET
310 320 330 340 350
QLKLLPVGLD NLVLIPEESR KAIYEQSRRP PEDLEKKFAA VAAAEDGAAT
360 370 380 390 400
AEKDAAEAVP KVGSPPKWRV GGAEFEALMR MLDNAGYRTG YIYRHPLIKS
410 420 430 440 450
DPPKPKNDVE LPPAVSSLGY LLEEEELFRQ GIWKKGDIRK GGDRSRWLNS
460 470 480 490 500
PNVYQKVEVL ETGTPDPKKI TKWVAEGSPT HSTPVRIEDP LQFVPAGTNP
510 520 530 540 550
REFKRVQQLI KDNRRADKIS AGPQSHILEG VTWDEASRLK DATVSQAGDH
560 570 580 590 600
VVMMGAASKG IIQRGFQHNA TVYKAPYAKN PFDNVTDDEL NEYKRTVERK
610 620 630 640 650
KKSVHGEYTD TDFSESEAVL QAGTKKYPQS EPETEHQVIE IQTQQAPVPR
660 670 680 690 700
QAEVVLSDAL VSQLAQKYAF LYSPGQYMYA CMKMAPLMHK VYVIHKVEPV
710 720 730 740 750
SKHNYPPVND GNMSIHHNES GAGFMAQESS VISSTPVRNA LASVSLPEER
760 770 780 790 800
NHSILGLSST PYRTISHFGF NCPLITSPTI LLHPEHRSIW QRVAEQREKV
810 820 830 840 850
VSFIDLTTLS LDNRKLLNVV TSTHPTQCQS QSQSFISEKH IQLEVTPPKR
860 870 880 890 900
KQRVYSATIS SGLDDSLDEL DSLMSGLAIN MPRSREQDSG LYRSYTFLPS
910 920 930 940 950
NHALPKDTDA NNRDQTDRER PEAEQEESFH CAGDSGIGDS TGRRPRLATT
960 970 980 990 1000
SNDSSIQEAE AYTQGKHVKL TLSSSPTPTA TQSPATIEIL INVSLRNAEC
1010 1020 1030 1040 1050
VQTVQTHEQE FRAKLERVID EEIHYISQQL AFKQRQAELH EQQTTSRAPI
1060 1070 1080 1090 1100
ATPSFTTMHP PAPASSSSMV HRSNSAPELC HTYSYVAVGD LSTKQDQASP
1110 1120 1130 1140 1150
QLPAEGEPLN DILSSLEKEL ERLLNSVVTA HMLHNKAIIH ECRARFSQLA

DGIVSS
Length:1,156
Mass (Da):127,939
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AA90E8938A84A0A
GO
Isoform B (identifier: Q02645-2) [UniParc]FASTAAdd to basket
Also known as: I, L, M, R1

The sequence of this isoform differs from the canonical sequence as follows:
     659-718: ALVSQLAQKY...NDGNMSIHHN → GENVQNGDHS...KKKEKKKAEA
     719-1156: Missing.

Show »
Length:718
Mass (Da):79,339
Checksum:i4C0C816A0FDA5720
GO
Isoform C (identifier: Q02645-3) [UniParc]FASTAAdd to basket
Also known as: H, J, N32, R2

The sequence of this isoform differs from the canonical sequence as follows:
     473-495: WVAEGSPTHSTPVRIEDPLQFVP → VEIITFEDMKQTKTTNLKEIEGK
     496-1156: Missing.

Show »
Length:495
Mass (Da):54,552
Checksum:i876031E091AFE819
GO
Isoform D (identifier: Q02645-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     659-668: ALVSQLAQKY → GTNCCTAFIK
     669-1156: Missing.

Show »
Length:668
Mass (Da):73,692
Checksum:iF0F0B0ED4184B2D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8DYJ2A8DYJ2_DROME
Hu li tai shao, isoform P
hts 1B1, Add, add, ADD-87, Add-hts
1,833Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K849A0A0B4K849_DROME
Hu li tai shao, isoform O
hts 1B1, Add, add, ADD-87, Add-hts
716Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7A5A0A0B4K7A5_DROME
Hu li tai shao, isoform Q
hts 1B1, Add, add, ADD-87, Add-hts
739Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6M3Q7Q7A0A6M3Q7Q7_DROME
Hu li tai shao, isoform T
hts 1B1, Add, add, ADD-87, Add-hts
675Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76Missing in AAM52757 (PubMed:12537569).Curated1
Sequence conflicti351A → V in AAA28643 (PubMed:1340461).Curated1
Sequence conflicti680 – 682ACM → GCL in AAA28643 (PubMed:1340461).Curated3
Sequence conflicti689H → Q in AAA28643 (PubMed:1340461).Curated1
Sequence conflicti689H → Q in AAB59182 (PubMed:7681599).Curated1
Sequence conflicti725 – 727MAQ → LAH in AAA28643 (PubMed:1340461).Curated3
Sequence conflicti746L → F in AAA28643 (PubMed:1340461).Curated1
Sequence conflicti912N → D in AAA28643 (PubMed:1340461).Curated1
Sequence conflicti1089G → C in AAB59182 (PubMed:7681599).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009199473 – 495WVAEG…LQFVP → VEIITFEDMKQTKTTNLKEI EGK in isoform C. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_009200496 – 1156Missing in isoform C. 1 PublicationAdd BLAST661
Alternative sequenceiVSP_000191659 – 718ALVSQ…SIHHN → GENVQNGDHSEAHLSTFSQS SKEFQDVSTDGSPKKDKKKK KGLRTPSFLKKKKEKKKAEA in isoform B. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_042122659 – 668ALVSQLAQKY → GTNCCTAFIK in isoform D. Curated10
Alternative sequenceiVSP_042123669 – 1156Missing in isoform D. CuratedAdd BLAST488
Alternative sequenceiVSP_000192719 – 1156Missing in isoform B. 2 PublicationsAdd BLAST438

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05016 mRNA Translation: AAA28643.1
AF151708 mRNA Translation: AAB59182.1
AF151705 mRNA Translation: AAG01377.1
AF151706 mRNA Translation: AAG01378.1
AF151707 mRNA Translation: AAG01379.1
AE013599 Genomic DNA Translation: AAF57565.3
AE013599 Genomic DNA Translation: AAF57566.4
AE013599 Genomic DNA Translation: AAM70850.2
AE013599 Genomic DNA Translation: AAM70851.2
AE013599 Genomic DNA Translation: AAN16130.2
AE013599 Genomic DNA Translation: AAN16131.2
AE013599 Genomic DNA Translation: ACZ94475.1
AE013599 Genomic DNA Translation: ACZ94476.1
AE013599 Genomic DNA Translation: ACZ94477.1
AE013599 Genomic DNA Translation: ACZ94478.1
AY122245 mRNA Translation: AAM52757.1

Protein sequence database of the Protein Information Resource

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PIRi
A47397

NCBI Reference Sequences

More...
RefSeqi
NP_001163203.1, NM_001169732.2 [Q02645-3]
NP_001163204.1, NM_001169733.2 [Q02645-3]
NP_001163205.1, NM_001169734.2 [Q02645-1]
NP_001163206.1, NM_001169735.2 [Q02645-1]
NP_476877.1, NM_057529.4 [Q02645-1]
NP_725886.2, NM_166347.3 [Q02645-2]
NP_725887.2, NM_166348.3 [Q02645-2]
NP_725888.2, NM_166349.3 [Q02645-2]
NP_725889.1, NM_166350.2 [Q02645-4]
NP_725890.1, NM_166351.2 [Q02645-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0309102; FBpp0301110; FBgn0263391 [Q02645-4]
FBtr0309103; FBpp0301111; FBgn0263391 [Q02645-3]
FBtr0309104; FBpp0301112; FBgn0263391 [Q02645-1]
FBtr0309105; FBpp0301113; FBgn0263391 [Q02645-3]
FBtr0309106; FBpp0301114; FBgn0263391 [Q02645-2]
FBtr0309107; FBpp0301115; FBgn0263391 [Q02645-3]
FBtr0309108; FBpp0301116; FBgn0263391 [Q02645-1]
FBtr0309109; FBpp0301117; FBgn0263391 [Q02645-2]
FBtr0309110; FBpp0301118; FBgn0263391 [Q02645-2]
FBtr0309111; FBpp0301119; FBgn0263391 [Q02645-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
37230

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG43443

UCSC genome browser

More...
UCSCi
CG9325-RD, d. melanogaster
CG9325-RE, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05016 mRNA Translation: AAA28643.1
AF151708 mRNA Translation: AAB59182.1
AF151705 mRNA Translation: AAG01377.1
AF151706 mRNA Translation: AAG01378.1
AF151707 mRNA Translation: AAG01379.1
AE013599 Genomic DNA Translation: AAF57565.3
AE013599 Genomic DNA Translation: AAF57566.4
AE013599 Genomic DNA Translation: AAM70850.2
AE013599 Genomic DNA Translation: AAM70851.2
AE013599 Genomic DNA Translation: AAN16130.2
AE013599 Genomic DNA Translation: AAN16131.2
AE013599 Genomic DNA Translation: ACZ94475.1
AE013599 Genomic DNA Translation: ACZ94476.1
AE013599 Genomic DNA Translation: ACZ94477.1
AE013599 Genomic DNA Translation: ACZ94478.1
AY122245 mRNA Translation: AAM52757.1
PIRiA47397
RefSeqiNP_001163203.1, NM_001169732.2 [Q02645-3]
NP_001163204.1, NM_001169733.2 [Q02645-3]
NP_001163205.1, NM_001169734.2 [Q02645-1]
NP_001163206.1, NM_001169735.2 [Q02645-1]
NP_476877.1, NM_057529.4 [Q02645-1]
NP_725886.2, NM_166347.3 [Q02645-2]
NP_725887.2, NM_166348.3 [Q02645-2]
NP_725888.2, NM_166349.3 [Q02645-2]
NP_725889.1, NM_166350.2 [Q02645-4]
NP_725890.1, NM_166351.2 [Q02645-3]

3D structure databases

SMRiQ02645
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62894, 23 interactors
DIPiDIP-23013N
IntActiQ02645, 16 interactors

PTM databases

iPTMnetiQ02645

Proteomic databases

PRIDEiQ02645

Genome annotation databases

EnsemblMetazoaiFBtr0309102; FBpp0301110; FBgn0263391 [Q02645-4]
FBtr0309103; FBpp0301111; FBgn0263391 [Q02645-3]
FBtr0309104; FBpp0301112; FBgn0263391 [Q02645-1]
FBtr0309105; FBpp0301113; FBgn0263391 [Q02645-3]
FBtr0309106; FBpp0301114; FBgn0263391 [Q02645-2]
FBtr0309107; FBpp0301115; FBgn0263391 [Q02645-3]
FBtr0309108; FBpp0301116; FBgn0263391 [Q02645-1]
FBtr0309109; FBpp0301117; FBgn0263391 [Q02645-2]
FBtr0309110; FBpp0301118; FBgn0263391 [Q02645-2]
FBtr0309111; FBpp0301119; FBgn0263391 [Q02645-1]
GeneIDi37230
KEGGidme:Dmel_CG43443
UCSCiCG9325-RD, d. melanogaster
CG9325-RE, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116529
FlyBaseiFBgn0263391, hts

Phylogenomic databases

GeneTreeiENSGT00940000168292
InParanoidiQ02645
PhylomeDBiQ02645

Enzyme and pathway databases

ReactomeiR-DME-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-DME-5223345, Miscellaneous transport and binding events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37230, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
37230

Protein Ontology

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PROi
PR:Q02645

Gene expression databases

BgeeiFBgn0263391, Expressed in central nervous system and 36 other tissues
ExpressionAtlasiQ02645, baseline and differential
GenevisibleiQ02645, DM

Family and domain databases

InterProiView protein in InterPro
IPR001303, Aldolase_II/adducin_N
IPR036409, Aldolase_II/adducin_N_sf
PfamiView protein in Pfam
PF00596, Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007, Aldolase_II, 1 hit
SUPFAMiSSF53639, SSF53639, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02645
Secondary accession number(s): A1ZBK8
, A4UZP6, E1JGM4, E1JGM6, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: June 2, 2021
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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