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Protein

Growth hormone-releasing hormone receptor

Gene

Ghrhr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-releasing hormone receptor
Short name:
GHRH receptor
Alternative name(s):
Growth hormone-releasing factor receptor
Short name:
GRF receptor
Short name:
GRFR
Gene namesi
Name:Ghrhr
Synonyms:Grfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2688 Ghrhr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 132ExtracellularSequence analysisAdd BLAST110
Transmembranei133 – 152Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini153 – 162CytoplasmicSequence analysis10
Transmembranei163 – 181Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini182 – 204ExtracellularSequence analysisAdd BLAST23
Transmembranei205 – 227Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 262Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 304Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini305 – 370CytoplasmicSequence analysisAdd BLAST66
Transmembranei371 – 389Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini390 – 402ExtracellularSequence analysisAdd BLAST13
Transmembranei403 – 422Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini423 – 464CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3709
GuidetoPHARMACOLOGYi247

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001283123 – 464Growth hormone-releasing hormone receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 64By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi55 ↔ 96By similarity
Disulfide bondi78 ↔ 112By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02644
PRIDEiQ02644

PTM databases

PhosphoSitePlusiQ02644

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSRNOG00000011808 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ02644 baseline and differential
GenevisibleiQ02644 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016087

Chemistry databases

BindingDBiQ02644

Structurei

3D structure databases

ProteinModelPortaliQ02644
SMRiQ02644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiQ02644
KOiK04584
OMAiFLNQEVR
OrthoDBiEOG091G0NF8
PhylomeDBiQ02644
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003288 GPCR_2_GHRH_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF209 PTHR12011:SF209, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01352 GHRHRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q02644-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLLWATWV LCLLNLWGVA LGHLHLECDF ITQLRDDELA CLQAAEGTNN
60 70 80 90 100
SSMGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDPG AVKRDCTITG
110 120 130 140 150
WSDPFPPYPV ACPVPLELLT EEKSYFSTVK IIYTTGHSIS IVALCVAIAI
160 170 180 190 200
LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAVFQGD STDHCSMSTI
210 220 230 240 250
LCKVSVAVSH FATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW
260 270 280 290 300
GLPVLCTGTW VGCKLAFEDT ACWDLDDSSP YWWIIKGPIV LSVGVNFGLF
310 320 330 340 350
LNIICILLRK LGPAQGGLHT RAQYCNYLLP WSCPLPQVPR ERTDLGPSSH
360 370 380 390 400
EITVQESGTR NCQLPWRLSK STLLLIPLFG IHYIIFNFLP DSAGLGIRLP
410 420 430 440 450
LELGLGSFQG FVVAVLYCFL NQEVRTEISR KWYGHDPELL PARRTCTEWT
460
TPPRSRVKVL TSEC
Length:464
Mass (Da):51,522
Last modified:June 1, 1994 - v2
Checksum:i5FFF49A7D79A4114
GO
Isoform Short (identifier: Q02644-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-365: Missing.

Show »
Length:423
Mass (Da):46,917
Checksum:i79F335DB3E92A912
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9WU99Q9WU99_RAT
GHRH receptor beta GHRHr
Ghrhr
439Annotation score:
Q91WX4Q91WX4_RAT
Growth hormone-releasing hormone re...
Ghrhr
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233S → W in L07380 (PubMed:1334535).Curated1
Sequence conflicti305C → S in L07380 (PubMed:1334535).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002003325 – 365Missing in isoform Short. CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01407 mRNA Translation: AAA41221.1
L07380 mRNA No translation available.
PIRiS29754
RefSeqiNP_036982.1, NM_012850.1 [Q02644-2]
UniGeneiRn.10936

Genome annotation databases

EnsembliENSRNOT00000016087; ENSRNOP00000016087; ENSRNOG00000011808 [Q02644-1]
ENSRNOT00000044578; ENSRNOP00000043884; ENSRNOG00000011808 [Q02644-2]
GeneIDi25321
KEGGirno:25321
UCSCiRGD:2688 rat [Q02644-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01407 mRNA Translation: AAA41221.1
L07380 mRNA No translation available.
PIRiS29754
RefSeqiNP_036982.1, NM_012850.1 [Q02644-2]
UniGeneiRn.10936

3D structure databases

ProteinModelPortaliQ02644
SMRiQ02644
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016087

Chemistry databases

BindingDBiQ02644
ChEMBLiCHEMBL3709
GuidetoPHARMACOLOGYi247

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ02644

Proteomic databases

PaxDbiQ02644
PRIDEiQ02644

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016087; ENSRNOP00000016087; ENSRNOG00000011808 [Q02644-1]
ENSRNOT00000044578; ENSRNOP00000043884; ENSRNOG00000011808 [Q02644-2]
GeneIDi25321
KEGGirno:25321
UCSCiRGD:2688 rat [Q02644-1]

Organism-specific databases

CTDi2692
RGDi2688 Ghrhr

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiQ02644
KOiK04584
OMAiFLNQEVR
OrthoDBiEOG091G0NF8
PhylomeDBiQ02644
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-RNO-420092 Glucagon-type ligand receptors

Miscellaneous databases

PROiPR:Q02644

Gene expression databases

BgeeiENSRNOG00000011808 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ02644 baseline and differential
GenevisibleiQ02644 RN

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003288 GPCR_2_GHRH_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF209 PTHR12011:SF209, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01352 GHRHRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGHRHR_RAT
AccessioniPrimary (citable) accession number: Q02644
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: October 10, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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