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Entry version 193 (12 Aug 2020)
Sequence version 2 (01 Feb 1996)
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Protein

Nucleoporin NUP116/NSP116

Gene

NUP116

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). Plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport. By binding ATPase AFG2, promotes AFG2-mediated release of shuttling protein RLP24 from pre-60S ribosomal particles (PubMed:23185031).15 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32752-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S59.951

Transport Classification Database

More...
TCDBi
1.I.1.1.1, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin NUP116/NSP116
Alternative name(s):
Nuclear pore protein NUP116/NSP116
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP116
Synonyms:NSP116
Ordered Locus Names:YMR047C
ORF Names:YM9532.12C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YMR047C

Saccharomyces Genome Database

More...
SGDi
S000004650, NUP116

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92 – 1113Missing : Loss of interaction with AFG2. 1 PublicationAdd BLAST1022
Mutagenesisi110 – 166Missing : Prevents the release of AFG2, RLP24 and NOG1 from pre-60S ribosomal particles. Enhances growth defect in an AFG2 (drg1-18) mutant background. 1 PublicationAdd BLAST57
Mutagenesisi173 – 1113Missing : No effect on the interaction with AFG2. 1 PublicationAdd BLAST941

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048351 – 1113Nucleoporin NUP116/NSP116Add BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei886PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q02630

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02630

PRoteomics IDEntifications database

More...
PRIDEi
Q02630

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02630

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport (PubMed:10891509). NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:10891509). NUP116 interacts with the NUP82 subcomplex and GLE2 (PubMed:10801828, PubMed:9463388, PubMed:10891509). Through its FG repeats it interacts with numerous karyopherins including KAP95, PSE1 (GSP1-GDP dependent), MEX67, and to homopolymeric RNA (PubMed:9891088, PubMed:10952996, PubMed:11104765, PubMed:12372823).

Interacts with CEX1 (PubMed:17203074).

Interacts (via N-terminus) with AFG2 (via N-terminus) (PubMed:23185031).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35221, 484 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-824, Nuclear pore complex

Database of interacting proteins

More...
DIPi
DIP-2389N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q02630

Protein interaction database and analysis system

More...
IntActi
Q02630, 40 interactors

Molecular INTeraction database

More...
MINTi
Q02630

STRING: functional protein association networks

More...
STRINGi
4932.YMR047C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q02630, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02630

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q02630

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 3FG 12
Repeati17 – 18FG 22
Repeati24 – 25FG 32
Repeati40 – 41FG 42
Repeati55 – 58GLFG 1; approximate4
Repeati66 – 67FG 52
Repeati79 – 80FG 62
Repeati94 – 95FG 72
Repeati167 – 168FG 82
Repeati189 – 190FG 92
Repeati205 – 208GLFG 24
Repeati214 – 217GLFG 3; approximate4
Repeati224 – 227GLFG 4; approximate4
Repeati235 – 238GLFG 54
Repeati249 – 250FG 102
Repeati259 – 262GLFG 64
Repeati276 – 279GLFG 74
Repeati288 – 291GLFG 84
Repeati297 – 298FG 112
Repeati306 – 309GLFG 9; approximate4
Repeati327 – 330GLFG 10; approximate4
Repeati339 – 342GLFG 11; approximate4
Repeati351 – 352FG 122
Repeati359 – 362GLFG 124
Repeati370 – 371FG 132
Repeati382 – 385GLFG 134
Repeati395 – 398GLFG 144
Repeati407 – 410GLFG 154
Repeati420 – 423GLFG 164
Repeati431 – 432FG 142
Repeati439 – 442GLFG 174
Repeati448 – 451GLFG 184
Repeati470 – 471FG 152
Repeati482 – 485GLFG 194
Repeati497 – 500GLFG 204
Repeati510 – 511FG 162
Repeati525 – 526FG 172
Repeati532 – 533FG 182
Repeati572 – 575GLFG 214
Repeati585 – 588GLFG 224
Repeati604 – 607GLFG 234
Repeati616 – 617FG 192
Repeati630 – 633GLFG 24; approximate4
Repeati648 – 651GLFG 254
Repeati665 – 668GLFG 264
Repeati683 – 686GLFG 274
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1109Peptidase S59PROSITE-ProRule annotationAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 172Interaction with AFG21 PublicationAdd BLAST81
Regioni110 – 166GLE2 binding sequence (GLEBS)Add BLAST57
Regioni160 – 362Interaction with MEX67, not KAP951 PublicationAdd BLAST203
Regioni362 – 535Sufficient for interaction with MEX67 and KAP951 PublicationAdd BLAST174
Regioni536 – 732Interaction with KAP95, not MEX67Add BLAST197
Regioni967 – 1113Interaction with NUP82 NPC subcomplexAdd BLAST147
Regioni969 – 1108Nucleoporin RNA-binding motif (NRM)Add BLAST140

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 50Gln-richAdd BLAST24
Compositional biasi27 – 32Poly-Gln6
Compositional biasi164 – 712Gly-richAdd BLAST549
Compositional biasi263 – 304Asn-richAdd BLAST42
Compositional biasi280 – 567Gln-richAdd BLAST288
Compositional biasi475 – 478Poly-Gln4
Compositional biasi669 – 707Asn-richAdd BLAST39
Compositional biasi669 – 672Poly-Asn4
Compositional biasi716 – 740Gln-richAdd BLAST25
Compositional biasi729 – 735Poly-Gln7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin GLFG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0845, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011051_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02630

KEGG Orthology (KO)

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KOi
K14297

Identification of Orthologs from Complete Genome Data

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OMAi
SWANPQQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1610.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025574, Nucleoporin_FG_rpt
IPR037665, Nucleoporin_S59-like
IPR037637, NUP98-NUP96
IPR007230, Peptidase_S59
IPR036903, Peptidase_S59_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23198, PTHR23198, 3 hits
PTHR23198:SF6, PTHR23198:SF6, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF04096, Nucleoporin2, 1 hit
PF13634, Nucleoporin_FG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82215, SSF82215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51434, NUP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02630-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGVSRGAFP SATTQPFGST GSTFGGQQQQ QQPVANTSAF GLSQQTNTTQ
60 70 80 90 100
APAFGNFGNQ TSNSPFGMSG STTANGTPFG QSQLTNNNAS GSIFGGMGNN
110 120 130 140 150
TALSAGSASV VPNSTAGTSI KPFTTFEEKD PTTGVINVFQ SITCMPEYRN
160 170 180 190 200
FSFEELRFQD YQAGRKFGTS QNGTGTTFNN PQGTTNTGFG IMGNNNSTTS
210 220 230 240 250
ATTGGLFGQK PATGMFGTGT GSGGGFGSGA TNSTGLFGSS TNLSGNSAFG
260 270 280 290 300
ANKPATSGGL FGNTTNNPTN GTNNTGLFGQ QNSNTNGGLF GQQQNSFGAN
310 320 330 340 350
NVSNGGAFGQ VNRGAFPQQQ TQQGSGGIFG QSNANANGGA FGQQQGTGAL
360 370 380 390 400
FGAKPASGGL FGQSAGSKAF GMNTNPTGTT GGLFGQTNQQ QSGGGLFGQQ
410 420 430 440 450
QNSNAGGLFG QNNQSQNQSG LFGQQNSSNA FGQPQQQGGL FGSKPAGGLF
460 470 480 490 500
GQQQGASTFA SGNAQNNSIF GQNNQQQQST GGLFGQQNNQ SQSQPGGLFG
510 520 530 540 550
QTNQNNNQPF GQNGLQQPQQ NNSLFGAKPT GFGNTSLFSN STTNQSNGIS
560 570 580 590 600
GNNLQQQSGG LFQNKQQPAS GGLFGSKPSN TVGGGLFGNN QVANQNNPAS
610 620 630 640 650
TSGGLFGSKP ATGSLFGGTN STAPNASSGG IFGSNNASNT AATTNSTGLF
660 670 680 690 700
GNKPVGAGAS TSAGGLFGNN NNSSLNNSNG STGLFGSNNT SQSTNAGGLF
710 720 730 740 750
QNNTSTNTSG GGLFSQPSQS MAQSQNALQQ QQQQQRLQIQ NNNPYGTNEL
760 770 780 790 800
FSKATVTNTV SYPIQPSATK IKADERKKAS LTNAYKMIPK TLFTAKLKTN
810 820 830 840 850
NSVMDKAQIK VDPKLSISID KKNNQIAISN QQEENLDESI LKASELLFNP
860 870 880 890 900
DKRSFKNLIN NRKMLIASEE KNNGSQNNDM NFKSKSEEQE TILGKPKMDE
910 920 930 940 950
KETANGGERM VLSSKNDGED SATKHHSRNM DEENKENVAD LQKQEYSEDD
960 970 980 990 1000
KKAVFADVAE KDASFINENY YISPSLDTLS SYSLLQLRKV PHLVVGHKSY
1010 1020 1030 1040 1050
GKIEFLEPVD LAGIPLTSLG GVIITFEPKT CIIYANLPNR PKRGEGINVR
1060 1070 1080 1090 1100
ARITCFNCYP VDKSTRKPIK DPNHQLVKRH IERLKKNPNS KFESYDADSG
1110
TYVFIVNHAA EQT
Length:1,113
Mass (Da):116,234
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBAB0B9AEA958213
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26G → A in CAA78754 (PubMed:1385442).Curated1
Sequence conflicti536S → G in CAA78754 (PubMed:1385442).Curated1
Sequence conflicti720S → P in CAA78754 (PubMed:1385442).Curated1
Sequence conflicti1018S → Y in CAA78754 (PubMed:1385442).Curated1
Sequence conflicti1023I → Y in CAA78754 (PubMed:1385442).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z15036 Genomic DNA Translation: CAA78754.1
X68108 Genomic DNA Translation: CAA48228.1
Z48502 Genomic DNA Translation: CAA88413.1
BK006946 Genomic DNA Translation: DAA09946.1

Protein sequence database of the Protein Information Resource

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PIRi
S28925

NCBI Reference Sequences

More...
RefSeqi
NP_013762.1, NM_001182544.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR047C_mRNA; YMR047C; YMR047C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR047C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15036 Genomic DNA Translation: CAA78754.1
X68108 Genomic DNA Translation: CAA48228.1
Z48502 Genomic DNA Translation: CAA88413.1
BK006946 Genomic DNA Translation: DAA09946.1
PIRiS28925
RefSeqiNP_013762.1, NM_001182544.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O6PX-ray2.80C/D/E/F602-609[»]
2AIVNMR-A967-1113[»]
3PBPX-ray2.60B/E/H/K967-1113[»]
SMRiQ02630
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35221, 484 interactors
ComplexPortaliCPX-824, Nuclear pore complex
DIPiDIP-2389N
ELMiQ02630
IntActiQ02630, 40 interactors
MINTiQ02630
STRINGi4932.YMR047C

Protein family/group databases

MEROPSiS59.951
TCDBi1.I.1.1.1, the nuclear pore complex (npc) family

PTM databases

iPTMnetiQ02630

Proteomic databases

MaxQBiQ02630
PaxDbiQ02630
PRIDEiQ02630

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
855066

Genome annotation databases

EnsemblFungiiYMR047C_mRNA; YMR047C; YMR047C
GeneIDi855066
KEGGisce:YMR047C

Organism-specific databases

EuPathDBiFungiDB:YMR047C
SGDiS000004650, NUP116

Phylogenomic databases

eggNOGiKOG0845, Eukaryota
GeneTreeiENSGT00550000074799
HOGENOMiCLU_011051_0_0_1
InParanoidiQ02630
KOiK14297
OMAiSWANPQQ

Enzyme and pathway databases

BioCyciYEAST:G3O-32752-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ02630

Protein Ontology

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PROi
PR:Q02630
RNActiQ02630, protein

Family and domain databases

Gene3Di3.30.1610.10, 1 hit
InterProiView protein in InterPro
IPR025574, Nucleoporin_FG_rpt
IPR037665, Nucleoporin_S59-like
IPR037637, NUP98-NUP96
IPR007230, Peptidase_S59
IPR036903, Peptidase_S59_sf
PANTHERiPTHR23198, PTHR23198, 3 hits
PTHR23198:SF6, PTHR23198:SF6, 3 hits
PfamiView protein in Pfam
PF04096, Nucleoporin2, 1 hit
PF13634, Nucleoporin_FG, 4 hits
SUPFAMiSSF82215, SSF82215, 1 hit
PROSITEiView protein in PROSITE
PS51434, NUP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU116_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02630
Secondary accession number(s): D6VZM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: August 12, 2020
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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