UniProtKB - Q02614 (S30BP_MOUSE)
Protein
SAP30-binding protein
Gene
Sap30bp
Organism
Mus musculus (Mouse)
Status
Functioni
Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival (By similarity). May be involved in the regulation of beta-2-microglobulin genes.By similarity
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- positive regulation of cell death Source: UniProtKB
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Repressor |
Biological process | Apoptosis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: SAP30-binding proteinAlternative name(s): Transcriptional regulator protein HCNGP |
Gene namesi | Name:Sap30bp Synonyms:Hcngp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927479, Sap30bp |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- intermediate filament cytoskeleton Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083924 | 1 – 308 | SAP30-binding proteinAdd BLAST | 308 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | PhosphoserineBy similarity | 1 | |
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Modified residuei | 43 | PhosphoserineBy similarity | 1 | |
Modified residuei | 52 | PhosphoserineBy similarity | 1 | |
Cross-linki | 95 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Cross-linki | 220 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 305 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q02614 |
jPOSTi | Q02614 |
MaxQBi | Q02614 |
PaxDbi | Q02614 |
PeptideAtlasi | Q02614 |
PRIDEi | Q02614 |
PTM databases
iPTMneti | Q02614 |
PhosphoSitePlusi | Q02614 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020755, Expressed in retinal neural layer and 273 other tissues |
Genevisiblei | Q02614, MM |
Interactioni
Subunit structurei
Interacts with SAP30.
By similarityProtein-protein interaction databases
BioGRIDi | 208215, 2 interactors |
IntActi | Q02614, 3 interactors |
MINTi | Q02614 |
STRINGi | 10090.ENSMUSP00000114844 |
Miscellaneous databases
RNActi | Q02614, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 225 – 294 | Thr-richAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the HCNGP family.Curated
Phylogenomic databases
eggNOGi | KOG2959, Eukaryota |
GeneTreei | ENSGT00390000007870 |
HOGENOMi | CLU_053268_0_1_1 |
InParanoidi | Q02614 |
OMAi | WGEDSHY |
OrthoDBi | 1557444at2759 |
PhylomeDBi | Q02614 |
TreeFami | TF323387 |
Family and domain databases
InterProi | View protein in InterPro IPR012479, SAP30BP |
PANTHERi | PTHR13464, PTHR13464, 1 hit |
Pfami | View protein in Pfam PF07818, HCNGP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q02614-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKKNVLSS LAIYAEYSDP ESDGETGVDA VGGATEEKGG LVSDAYGEDD
60 70 80 90 100
FSRPGGDEDG YEEEEDENSK QSEDDDSETE KPEADDPKDN TEAEKRDPQE
110 120 130 140 150
LVASFSERVR NMSPDEIKIP PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN
160 170 180 190 200
YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN YPKDMFDPHG WSEDSYYEAL
210 220 230 240 250
AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATATST STASTAVADA
260 270 280 290 300
QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG
TIVKKAKQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | A → R in CAA48198 (PubMed:1459361).Curated | 1 | |
Sequence conflicti | 298 | A → T in CAA48198 (PubMed:1459361).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68061 mRNA Translation: CAA48198.1 AK147869 mRNA Translation: BAE28192.1 BC021757 mRNA Translation: AAH21757.1 |
CCDSi | CCDS25651.1 |
PIRi | S26660 |
RefSeqi | NP_065229.2, NM_020483.3 |
Genome annotation databases
Ensembli | ENSMUST00000140991; ENSMUSP00000114844; ENSMUSG00000020755 |
GeneIDi | 57230 |
KEGGi | mmu:57230 |
UCSCi | uc007mjd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68061 mRNA Translation: CAA48198.1 AK147869 mRNA Translation: BAE28192.1 BC021757 mRNA Translation: AAH21757.1 |
CCDSi | CCDS25651.1 |
PIRi | S26660 |
RefSeqi | NP_065229.2, NM_020483.3 |
3D structure databases
SMRi | Q02614 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208215, 2 interactors |
IntActi | Q02614, 3 interactors |
MINTi | Q02614 |
STRINGi | 10090.ENSMUSP00000114844 |
PTM databases
iPTMneti | Q02614 |
PhosphoSitePlusi | Q02614 |
Proteomic databases
EPDi | Q02614 |
jPOSTi | Q02614 |
MaxQBi | Q02614 |
PaxDbi | Q02614 |
PeptideAtlasi | Q02614 |
PRIDEi | Q02614 |
Protocols and materials databases
Antibodypediai | 19600, 264 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000140991; ENSMUSP00000114844; ENSMUSG00000020755 |
GeneIDi | 57230 |
KEGGi | mmu:57230 |
UCSCi | uc007mjd.1, mouse |
Organism-specific databases
CTDi | 29115 |
MGIi | MGI:1927479, Sap30bp |
Phylogenomic databases
eggNOGi | KOG2959, Eukaryota |
GeneTreei | ENSGT00390000007870 |
HOGENOMi | CLU_053268_0_1_1 |
InParanoidi | Q02614 |
OMAi | WGEDSHY |
OrthoDBi | 1557444at2759 |
PhylomeDBi | Q02614 |
TreeFami | TF323387 |
Miscellaneous databases
BioGRID-ORCSi | 57230, 8 hits in 17 CRISPR screens |
ChiTaRSi | Sap30bp, mouse |
PROi | PR:Q02614 |
RNActi | Q02614, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020755, Expressed in retinal neural layer and 273 other tissues |
Genevisiblei | Q02614, MM |
Family and domain databases
InterProi | View protein in InterPro IPR012479, SAP30BP |
PANTHERi | PTHR13464, PTHR13464, 1 hit |
Pfami | View protein in Pfam PF07818, HCNGP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S30BP_MOUSE | |
Accessioni | Q02614Primary (citable) accession number: Q02614 Secondary accession number(s): Q8VDJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | July 11, 2006 | |
Last modified: | August 12, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families