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UniProtKB - Q02597 (POLG_TUMVQ)

Entry version 148 (18 Sep 2019)
Sequence version 2 (01 Jun 1994)
Previous versions | rss
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Protein

Genome polyprotein

Gene
N/A
Organism
Turnip mosaic virus (strain Quebec) (TuMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Nuclear inclusion protein B: an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
Nuclear inclusion protein A: has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei270For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei279For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei313For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei706For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei779For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2161For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2196For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2266For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1313 – 1320ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...MEROPSi		C06.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
Protein P3
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Viral genome-linked protein
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTurnip mosaic virus (strain Quebec) (TuMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36396 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Potyviridae › Potyvirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAlliaria [TaxID: 126269]
Brassica [TaxID: 3705]
Calanthe [TaxID: 38206]
Capsella bursa-pastoris (Shepherd's purse) (Thlaspi bursa-pastoris) [TaxID: 3719]
Hesperis matronalis [TaxID: 264418]
Stellaria media (Common chickweed) (Alsine media) [TaxID: 13274]
Trifolium hybridum (Alsike clover) [TaxID: 74517]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008263 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Capsid protein :

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200301 – 3163Genome polyproteinAdd BLAST3163
ChainiPRO_00000404731 – 362P1 proteinaseSequence analysisAdd BLAST362
ChainiPRO_0000040474363 – 820Helper component proteinaseSequence analysisAdd BLAST458
ChainiPRO_0000040475821 – 1175Protein P3By similarityAdd BLAST355
ChainiPRO_00000404761176 – 12276 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000404771228 – 1870Cytoplasmic inclusion proteinBy similarityAdd BLAST643
ChainiPRO_00000404781871 – 19236 kDa protein 2By similarityAdd BLAST53
ChainiPRO_00000404791924 – 2115Viral genome-linked proteinBy similarityAdd BLAST192
ChainiPRO_00000404802116 – 2358Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_00000404812359 – 2875Nuclear inclusion protein BBy similarityAdd BLAST517
ChainiPRO_00000404822876 – 3163Capsid proteinBy similarityAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1986O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei362 – 363Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei820 – 821Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1175 – 1176Cleavage; by NIa-proBy similarity2
Sitei1227 – 1228Cleavage; by NIa-proBy similarity2
Sitei1870 – 1871Cleavage; by NIa-proBy similarity2
Sitei2115 – 2116Cleavage; by NIa-proBy similarity2
Sitei2358 – 2359Cleavage; by NIa-proBy similarity2
Sitei2875 – 2876Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q02597

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini219 – 362Peptidase S30PROSITE-ProRule annotationAdd BLAST144
Domaini698 – 820Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1300 – 1452Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1471 – 1630Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2116 – 2334Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini2600 – 2724RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi414 – 417Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi672 – 674Involved in virions binding and aphid transmissionBy similarity3
Motifi1402 – 1405DECH box4
Motifi1964 – 1971Nuclear localization signalSequence analysis8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potyviridae genome polyprotein family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR001456 HC-pro
IPR031159 HC_PRO_CPD_dom
IPR042308 HC_PRO_CPD_sf
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR002540 Pept_S30_P1_potyvir
IPR009003 Peptidase_S1_PA
IPR001592 Poty_coat
IPR001730 Potyv_NIa-pro_dom
IPR039560 Potyvirid-P3
IPR013648 PP_Potyviridae
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00863 Peptidase_C4, 1 hit
PF00851 Peptidase_C6, 1 hit
PF01577 Peptidase_S30, 1 hit
PF00767 Poty_coat, 1 hit
PF08440 Poty_PP, 1 hit
PF13608 Potyvirid-P3, 1 hit
PF00680 RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00966 NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51744 HC_PRO_CPD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51436 POTYVIRUS_NIA_PRO, 1 hit
PS51871 PV_P1_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: Q02597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVTFASAI TNAITNKTTS TGMVQFGSFP PMPLRSTTVT TVATPVGQPK 
        60         70         80         90        100
LYTVRFGSLD PVIVKGGAGS LAKATRQQPS VEIDVSLSEA AALEVAKPKS 
       110        120        130        140        150
SAVLRMHEEA NKERALFLDW EASLKRRSYG IAENEKVVMT TRGVSKIVPR 
       160        170        180        190        200
SSRAMKQKRA RERRRAQQPI ILKWEPKLSG FSIGGGFSAS AIEAEEVRTK 
       210        220        230        240        250
WPLHKTPSMK KRMVHKTCKM SDQGVDMLIR SLVKIFKAKS ANIEYIGKKP 
       260        270        280        290        300
IKVDFIRKER TKFARIQVAH LLGKRAQRDL LAGMEENHFI DILSEYSGNG 
       310        320        330        340        350
TTINPGVVCA GWSGIVVRNE TLTQKRSRSP SKAFVIRGEH EDKLYDARIK 
       360        370        380        390        400
ITKTMSLKIV HFSARGANFW KGFDRCFLAY RSDNREHTCY SGLDVTECGE 
       410        420        430        440        450
VAALMCLAMF PCGKITCPDC VIDSELSQGQ ASGPSMKHRL TQLRDVIKSS 
       460        470        480        490        500
YPRFKHAVQI LDRYEQSLSS ANENYQDFAE IQSISDGVEK AAFPHVNKLN 
       510        520        530        540        550
AILIKGATAT GEEFSQATKH LLEIARYLKN RTENIEKGSL KSFRNKVSQK 
       560        570        580        590        600
AHINPTLMCD NQLDKNGNFI WGERGYHAKR FFSNYFEIID PKKGYTQYET 
       610        620        630        640        650
RVVPNGSRKL AIGKLIVPTN FEVLREQMRG EPVEPYPVTV ECVSKSQGDF 
       660        670        680        690        700
VHACCCVTTE SGDPVLSEIK MPTKHHLVIG NSGDPKYIDL PEIEENKMYI 
       710        720        730        740        750
AKEGYCYINI FLAMLVNVKE SQAKEFTKVV RDKLVSELGK WPTLLDVATA 
       760        770        780        790        800
CYFLKVFYPD VANAELPRML VDHKTKIIHV VDSYGSLSTG YHVLKTNTVE 
       810        820        830        840        850
QLIKFTRCNL ESSLKHYRVG GTEWENAHGA DNIDNPQWCI KRLVKGVYRP 
       860        870        880        890        900
KQLKEDMLAN PFLPLYALLS PGVILAFYNS GSLEHLMNHY ISADSNVAVL 
       910        920        930        940        950
LVVLKSLAKK VSTSQSVLAQ LQIIERSLPE LIEAKANING PDDAATRACN 
       960        970        980        990       1000
RFMGMLLHMA EPNYELANGG YTFLRDHSIS ILEKSYLQIL DEAWNELSWS 
      1010       1020       1030       1040       1050
ERCVIRYYPS KQAIFTQKDL PMQSEADLGG RYSESVISSY EWSKQQAKGV 
      1060       1070       1080       1090       1100
KDSVVNKLRS SMSWTSSKVS NSVCRTINYL VPDVFKFMNV LVCISLLIKM 
      1110       1120       1130       1140       1150
TAEANHIITT QRRLKLDIEE TERKKIEWEL AFHHNILTHS ASQHPTLDEF 
      1160       1170       1180       1190       1200
TAYIAEKAPH LSEHIEPEEK EVVHQAKRQS EQELERVIAF VALVLMMFDA 
      1210       1220       1230       1240       1250
ERSDCVTKIL NKLKGLVATV EPTVYHQTLN EIEDDLNERN LFVDFELSSD 
      1260       1270       1280       1290       1300
SEMLQQLPAE KTFASWWSHQ LSRGFTIPHY RTEGKFMTFT RATATEVAGK 
      1310       1320       1330       1340       1350
IAHESDKDIL LMGAVGSGKS TGLPYHLSRK GNVLLLEPTR PLAENVHKQL 
      1360       1370       1380       1390       1400
SQAPFHQNTT LRMRGLTAFG SAPISVMTSG FALNYFANNR SRIEEFDFVI 
      1410       1420       1430       1440       1450
FDECHVHDAN AMAMRCLIHE CDYSGKIIKV SATPPGREVE FSTQYPVSIS 
      1460       1470       1480       1490       1500
TEDTLSFQDF VNAQGSGSNC DVISKGDNIL VYVASYNEVD TLSKLLIERD 
      1510       1520       1530       1540       1550
FKVTKVDGRT MKVGNIEITT SGTPSRKHFI VATNIIENGV TLDIDVVADF 
      1560       1570       1580       1590       1600
GTKVLPYLDT DNRMLSTTKT SINYGERIQR LGRVGRHKPG HALRIGHTER 
      1610       1620       1630       1640       1650
GLSEVPSCIA TEAALKCFTY GLPVITNNVS TSILGNVTVK QARTMSVFEI 
      1660       1670       1680       1690       1700
TPFYTSQVVR YDGSMHPQVH ALLKRFKLRD SEIVLTKLAI PNRGVNAGSQ 
      1710       1720       1730       1740       1750
PVSMHDSVQM LKIGVTLRIP FMCRDIPEKL HLDMWDVVVK FKGDAGFGRL 
      1760       1770       1780       1790       1800
SSSASKVAYT LQTDVNSIQR TVTIIDTLIA EERRKQEYFK TVTSNCVSSS 
      1810       1820       1830       1840       1850
NFSLQSITNA IKSRMMKDHP CENISVLEGA KSQLLEFRNL NSDHSFVTKT 
      1860       1870       1880       1890       1900
DGISRSFMRD YGALEAVNHQ STNEMSKFLQ LKGKWNKTLI TRDVLVICGV 
      1910       1920       1930       1940       1950
LGGGVWMVVQ HFRSKVSEPV THEAKGKKQR QKLKFRNARD NKMGREVYGD 
      1960       1970       1980       1990       2000
DDTIEHFFGD AYTKKGKSKG RTRGIGHKNR KFINMYGFDP EDFSAVRFVD 
      2010       2020       2030       2040       2050
PLTGATLDDN PFTDITLVQK HFGDIRMDLL GEDELDSNEI RMNKTIQAYY 
      2060       2070       2080       2090       2100
MNNKTGKALK VDLTPHIPLK VCDLHATIAG FPERENELRQ TGKAQPINID 
      2110       2120       2130       2140       2150
EVPRANNELV PVDHESNSMF RGLRDYNPIS NNICHLTNVS DGASNSLYGV 
      2160       2170       2180       2190       2200
GFGPLILTNR HLFERNNGEL IIKSRHGEFV IKNTTQLHLL PIPDRDLLLI 
      2210       2220       2230       2240       2250
RLPKDVPPFP QKLGFRQPEK GERICMVGSN FQTKSITSIV SETSTIMPVE 
      2260       2270       2280       2290       2300
NSQFWKHWIS TKDGQCGSPM VSTKDGKILG LHSLANFQNS INYFAAFPDD 
      2310       2320       2330       2340       2350
FTEKYLHTIE AHEWVKHWKY NTSAISWGSL NIQASQPVSL FKVSKLISDL 
      2360       2370       2380       2390       2400
DSTAVYAQTQ QNRWMFEQLT GNLKAIAHCP SQLVTKHTVK GKCQMFDLYL 
      2410       2420       2430       2440       2450
KLHDEAREYF QPMLGQYQKS KLNREAYAKD LLKYATPIEA GNIDCDLFEK 
      2460       2470       2480       2490       2500
TVEIVISDLR GYGFETCNYV TDENDIFEAL NMKSAVGALY KGKKKDYFAE 
      2510       2520       2530       2540       2550
FTPEVKEEIL KQSCERLFLG KMGVWNGSLK AELRPLEKVE ANKTRTFTAA 
      2560       2570       2580       2590       2600
PLDTLLGGKV CVDDFNNQFY DHNLRAPWDV GMTKFYCGWD RLLESLPDGW 
      2610       2620       2630       2640       2650
VYCDADGSQF DSSLSPYLIN AVLNIRLGFM EEWDVGEVML RNLYTEIVYT 
      2660       2670       2680       2690       2700
PISTPDGTLV KKFKGNNSGQ PSTVVDNTLM VILAVNYSLK KGGIPSELRD 
      2710       2720       2730       2740       2750
SIIRFFVNGD DLLLSVHPEY EYILDTMADN FRELGLKYTF DSRTREKGDL 
      2760       2770       2780       2790       2800
WFMSHQGHRR EGIWIPKLEP ERIVSILEWD RSKEPCHRLE AICAAMIESW 
      2810       2820       2830       2840       2850
GYDKLTHEIR KFYAWMIEQA PFSSLAQEGK APYIAETALR KLYLDKEPAQ 
      2860       2870       2880       2890       2900
EDLTQYLQAI FEDYEDGVEA CVYHQAGETL DADLTEEQKQ AEKEKKEREK 
      2910       2920       2930       2940       2950
AEKERERQKQ LAFKKGKDVA QEEGKRDKEV NAGTSGTFSV PRLKSLTSKM 
      2960       2970       2980       2990       3000
RVPRYEKRVA LNLDHLILYT PEQTDLSNTR STRKQFDTWF EGVMADYELT 
      3010       3020       3030       3040       3050
EDKMQIILNG LRVWCIENGT SPNINGMWVM MDGDDQVEFP IKPLIDHAKP 
      3060       3070       3080       3090       3100
TFRQIMAHFS DVAEAYIEKR NQDRPYMPRY GLQRNLTDMS LARYAFDFYE 
      3110       3120       3130       3140       3150
MTSRTPIRAR EAHIQMKAAA LRGANNNLFG LDGNVGTTVE NTERHTTEDV 
      3160 
NRNMHNLLGV QGL
Note: Produced by conventional translation.
Length:3,163
Mass (Da):357,822
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61B0F73B58DF6D59
GO
Isoform P3N-PIPO polyprotein (identifier: P0CK12-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CK12.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting in P3 ORF.
Length:1,052
Mass (Da):117,956
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2862E → G in BAA01452 (PubMed:2254757).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D10927 Genomic RNA Translation: BAA01725.1
D10601 Genomic RNA Translation: BAA01452.1

Protein sequence database of the Protein Information Resource

More...PIRi		JQ1895

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10927 Genomic RNA Translation: BAA01725.1
D10601 Genomic RNA Translation: BAA01452.1
PIRiJQ1895

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiC06.001

Proteomic databases

PRIDEiQ02597

Family and domain databases

Gene3Di3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR001456 HC-pro
IPR031159 HC_PRO_CPD_dom
IPR042308 HC_PRO_CPD_sf
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR002540 Pept_S30_P1_potyvir
IPR009003 Peptidase_S1_PA
IPR001592 Poty_coat
IPR001730 Potyv_NIa-pro_dom
IPR039560 Potyvirid-P3
IPR013648 PP_Potyviridae
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00863 Peptidase_C4, 1 hit
PF00851 Peptidase_C6, 1 hit
PF01577 Peptidase_S30, 1 hit
PF00767 Poty_coat, 1 hit
PF08440 Poty_PP, 1 hit
PF13608 Potyvirid-P3, 1 hit
PF00680 RdRP_1, 1 hit
PRINTSiPR00966 NIAPOTYPTASE
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51744 HC_PRO_CPD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51436 POTYVIRUS_NIA_PRO, 1 hit
PS51871 PV_P1_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_TUMVQ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02597
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 1994
Last modified: September 18, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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