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Protein

Helix-loop-helix protein 2

Gene

NHLH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ02577

Names & Taxonomyi

Protein namesi
Recommended name:
Helix-loop-helix protein 2
Short name:
HEN-2
Alternative name(s):
Class A basic helix-loop-helix protein 34
Short name:
bHLHa34
Nescient helix loop helix 2
Short name:
NSCL-2
Gene namesi
Name:NHLH2
Synonyms:BHLHA34, HEN2, KIAA0490
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177551.5
HGNCiHGNC:7818 NHLH2
MIMi162361 gene
neXtProtiNX_Q02577

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4808
OpenTargetsiENSG00000177551
PharmGKBiPA31620

Polymorphism and mutation databases

BioMutaiNHLH2
DMDMi399887

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271991 – 135Helix-loop-helix protein 2Add BLAST135

Proteomic databases

PaxDbiQ02577
PeptideAtlasiQ02577
PRIDEiQ02577
ProteomicsDBi58112

PTM databases

iPTMnetiQ02577
PhosphoSitePlusiQ02577

Expressioni

Gene expression databases

BgeeiENSG00000177551 Expressed in 91 organ(s), highest expression level in cerebral cortex
CleanExiHS_NHLH2
ExpressionAtlasiQ02577 baseline and differential
GenevisibleiQ02577 HS

Organism-specific databases

HPAiHPA055238

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIRT1Q96EB62EBI-5378683,EBI-1802965

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110873, 17 interactors
CORUMiQ02577
IntActiQ02577, 6 interactors
STRINGi9606.ENSP00000322087

Structurei

3D structure databases

ProteinModelPortaliQ02577
SMRiQ02577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 129bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 73Poly-Arg5

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000016617
HOVERGENiHBG016345
InParanoidiQ02577
KOiK09075
OMAiATLYPHP
OrthoDBiEOG091G0RR2
PhylomeDBiQ02577

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q02577-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLSPDQAAD SDHPSSAHSD PESLGGTDTK VLGSVSDLEP VEEAEGDGKG
60 70 80 90 100
GSRAALYPHP QQLSREEKRR RRRATAKYRS AHATRERIRV EAFNLAFAEL
110 120 130
RKLLPTLPPD KKLSKIEILR LAICYISYLN HVLDV
Length:135
Mass (Da):15,018
Last modified:July 1, 1993 - v1
Checksum:i083730499F610AAE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVY9A6PVY9_HUMAN
Helix-loop-helix protein 2
NHLH2
107Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97508 Genomic DNA Translation: AAA58635.1
AB007959 mRNA No translation available.
AL449264 Genomic DNA No translation available.
BC096359 mRNA Translation: AAH96359.1
BC096360 mRNA Translation: AAH96360.1
CCDSiCCDS885.1
PIRiB45075
RefSeqiNP_001104531.1, NM_001111061.1
NP_005590.1, NM_005599.3
UniGeneiHs.46296

Genome annotation databases

EnsembliENST00000320238; ENSP00000322087; ENSG00000177551
ENST00000369506; ENSP00000358519; ENSG00000177551
GeneIDi4808
KEGGihsa:4808
UCSCiuc001efy.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97508 Genomic DNA Translation: AAA58635.1
AB007959 mRNA No translation available.
AL449264 Genomic DNA No translation available.
BC096359 mRNA Translation: AAH96359.1
BC096360 mRNA Translation: AAH96360.1
CCDSiCCDS885.1
PIRiB45075
RefSeqiNP_001104531.1, NM_001111061.1
NP_005590.1, NM_005599.3
UniGeneiHs.46296

3D structure databases

ProteinModelPortaliQ02577
SMRiQ02577
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110873, 17 interactors
CORUMiQ02577
IntActiQ02577, 6 interactors
STRINGi9606.ENSP00000322087

PTM databases

iPTMnetiQ02577
PhosphoSitePlusiQ02577

Polymorphism and mutation databases

BioMutaiNHLH2
DMDMi399887

Proteomic databases

PaxDbiQ02577
PeptideAtlasiQ02577
PRIDEiQ02577
ProteomicsDBi58112

Protocols and materials databases

DNASUi4808
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320238; ENSP00000322087; ENSG00000177551
ENST00000369506; ENSP00000358519; ENSG00000177551
GeneIDi4808
KEGGihsa:4808
UCSCiuc001efy.4 human

Organism-specific databases

CTDi4808
DisGeNETi4808
EuPathDBiHostDB:ENSG00000177551.5
GeneCardsiNHLH2
HGNCiHGNC:7818 NHLH2
HPAiHPA055238
MIMi162361 gene
neXtProtiNX_Q02577
OpenTargetsiENSG00000177551
PharmGKBiPA31620
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000016617
HOVERGENiHBG016345
InParanoidiQ02577
KOiK09075
OMAiATLYPHP
OrthoDBiEOG091G0RR2
PhylomeDBiQ02577

Enzyme and pathway databases

SIGNORiQ02577

Miscellaneous databases

GenomeRNAii4808
PROiPR:Q02577
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177551 Expressed in 91 organ(s), highest expression level in cerebral cortex
CleanExiHS_NHLH2
ExpressionAtlasiQ02577 baseline and differential
GenevisibleiQ02577 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEN2_HUMAN
AccessioniPrimary (citable) accession number: Q02577
Secondary accession number(s): Q5T1P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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