NHLH2

Functionⁱ

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II activating transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16314316
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 1328219
mating behavior Source: Ensembl
ovulation cycle Source: Ensembl
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Traceable author statementⁱ
- 16314316
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Traceable author statementⁱ
- 16314316
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q02577

SIGNORⁱ

Q02577

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Helix-loop-helix protein 2 Short name: HEN-2 Alternative name(s): Class A basic helix-loop-helix protein 34 Short name: bHLHa34 Nescient helix loop helix 2 Short name: NSCL-2
Gene namesⁱ	Name:NHLH2 Synonyms:BHLHA34, HEN2, KIAA0490
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177551.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7818 NHLH2
MIMⁱ	162361 gene
neXtProtⁱ	NX_Q02577

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4808
Open Targets More...OpenTargetsⁱ	ENSG00000177551
PharmGKBⁱ	PA31620

Polymorphism and mutation databases

BioMutaⁱ	NHLH2
DMDMⁱ	399887

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127199	1 – 135	Helix-loop-helix protein 2Add BLAST		135

Proteomic databases

PaxDbⁱ	Q02577
PeptideAtlas More...PeptideAtlasⁱ	Q02577
PRIDEⁱ	Q02577
ProteomicsDBⁱ	58112

PTM databases

iPTMnetⁱ	Q02577
PhosphoSitePlusⁱ	Q02577

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177551 Expressed in 91 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_NHLH2
ExpressionAtlasⁱ	Q02577 baseline and differential
Genevisibleⁱ	Q02577 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055238

HPAⁱ

HPA055238

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIRT1	Q96EB6	2	EBI-5378683,EBI-1802965

With

Entry

#Exp.

IntAct

Notes

SIRT1

Q96EB6

2

EBI-5378683,EBI-1802965

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
RNA polymerase II activating transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16314316

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110873, 17 interactors
CORUMⁱ	Q02577
IntActⁱ	Q02577, 6 interactors
STRINGⁱ	9606.ENSP00000322087

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q02577
SMRⁱ	Q02577
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	77 – 129	bHLHPROSITE-ProRule annotationAdd BLAST		53

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	69 – 73	Poly-Arg		5

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000016617
HOVERGENⁱ	HBG016345
InParanoidⁱ	Q02577
KEGG Orthology (KO) More...KOⁱ	K09075
OMAⁱ	ATLYPHP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RR2
PhylomeDBⁱ	Q02577

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q02577-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMLSPDQAAD SDHPSSAHSD PESLGGTDTK VLGSVSDLEP VEEAEGDGKG 
        60         70         80         90        100
GSRAALYPHP QQLSREEKRR RRRATAKYRS AHATRERIRV EAFNLAFAEL 
       110        120        130 
RKLLPTLPPD KKLSKIEILR LAICYISYLN HVLDV

Length:135

Mass (Da):15,018

Last modified:July 1, 1993 - v1

Checksum:ⁱ083730499F610AAE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A6PVY9	A6PVY9_HUMAN		Helix-loop-helix protein 2 Helix-loop-helix protein 2	NHLH2	107	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97508 Genomic DNA Translation: AAA58635.1 AB007959 mRNA No translation available. AL449264 Genomic DNA No translation available. BC096359 mRNA Translation: AAH96359.1 BC096360 mRNA Translation: AAH96360.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS885.1
PIRⁱ	B45075
NCBI Reference Sequences More...RefSeqⁱ	NP_001104531.1, NM_001111061.1 NP_005590.1, NM_005599.3
UniGeneⁱ	Hs.46296

Genome annotation databases

Ensemblⁱ	ENST00000320238; ENSP00000322087; ENSG00000177551 ENST00000369506; ENSP00000358519; ENSG00000177551
GeneIDⁱ	4808
KEGGⁱ	hsa:4808
UCSC genome browser More...UCSCⁱ	uc001efy.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02577	Nescient helix loop helix 2, isoform CRA_a		HUMAN		135	UniRef100_Q02577
NHLH2 isoform 1		PANTR		135
NHLH2 isoform 1		PONAB		135
Uncharacterized protein		PROCO		135
Uncharacterized protein		MACMU		135
+14

Protein	Similar proteins		Species	Score	Length	Source
Q02577	Nescient helix loop helix 2, isoform CRA_a		HUMAN		135	UniRef90_Q02577
NHLH2 isoform 1		PANTR		135
NHLH2 isoform 1		PONAB		135
Uncharacterized protein		PROCO		135
Uncharacterized protein		MACMU		135
+34

Protein	Similar proteins		Species	Score	Length	Source
Q02577	Helix-loop-helix protein 1		HUMAN		133	UniRef50_Q02577
NHLH2 isoform 1		PANTR		135
NHLH2 isoform 1		PONAB		135
Uncharacterized protein		PROCO		135
Uncharacterized protein		MACMU		135
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97508 Genomic DNA Translation: AAA58635.1 AB007959 mRNA No translation available. AL449264 Genomic DNA No translation available. BC096359 mRNA Translation: AAH96359.1 BC096360 mRNA Translation: AAH96360.1
CCDSⁱ	CCDS885.1
PIRⁱ	B45075
RefSeqⁱ	NP_001104531.1, NM_001111061.1 NP_005590.1, NM_005599.3
UniGeneⁱ	Hs.46296

3D structure databases

ProteinModelPortalⁱ	Q02577
SMRⁱ	Q02577
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110873, 17 interactors
CORUMⁱ	Q02577
IntActⁱ	Q02577, 6 interactors
STRINGⁱ	9606.ENSP00000322087

PTM databases

iPTMnetⁱ	Q02577
PhosphoSitePlusⁱ	Q02577

Polymorphism and mutation databases

BioMutaⁱ	NHLH2
DMDMⁱ	399887

Proteomic databases

PaxDbⁱ	Q02577
PeptideAtlasⁱ	Q02577
PRIDEⁱ	Q02577
ProteomicsDBⁱ	58112

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4808
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000320238; ENSP00000322087; ENSG00000177551 ENST00000369506; ENSP00000358519; ENSG00000177551
GeneIDⁱ	4808
KEGGⁱ	hsa:4808
UCSCⁱ	uc001efy.4 human

Organism-specific databases

CTDⁱ	4808
DisGeNETⁱ	4808
EuPathDBⁱ	HostDB:ENSG00000177551.5
GeneCardsⁱ	NHLH2
HGNCⁱ	HGNC:7818 NHLH2
HPAⁱ	HPA055238
MIMⁱ	162361 gene
neXtProtⁱ	NX_Q02577
OpenTargetsⁱ	ENSG00000177551
PharmGKBⁱ	PA31620
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000016617
HOVERGENⁱ	HBG016345
InParanoidⁱ	Q02577
KOⁱ	K09075
OMAⁱ	ATLYPHP
OrthoDBⁱ	EOG091G0RR2
PhylomeDBⁱ	Q02577

Enzyme and pathway databases

SIGNORⁱ	Q02577

SIGNORⁱ

Q02577

Miscellaneous databases

GenomeRNAiⁱ	4808
Protein Ontology More...PROⁱ	PR:Q02577
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177551 Expressed in 91 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_NHLH2
ExpressionAtlasⁱ	Q02577 baseline and differential
Genevisibleⁱ	Q02577 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HEN2_HUMAN
Accessionⁱ	Q02577Primary (citable) accession number: Q02577 Secondary accession number(s): Q5T1P6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q02577 (HEN2_HUMAN)

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Helix-loop-helix protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ