Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Helix-loop-helix protein 1

Gene

Nhlh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Helix-loop-helix protein 1
Short name:
HEN-1
Alternative name(s):
Nescient helix loop helix 1
Short name:
NSCL-1
Gene namesi
Name:Nhlh1
Synonyms:Hen1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98481 Nhlh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271981 – 133Helix-loop-helix protein 1Add BLAST133

Proteomic databases

PaxDbiQ02576
PRIDEiQ02576

PTM databases

PhosphoSitePlusiQ02576

Expressioni

Gene expression databases

BgeeiENSMUSG00000051251 Expressed in 75 organ(s), highest expression level in head
CleanExiMM_NHLH1
GenevisibleiQ02576 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057489

Structurei

3D structure databases

ProteinModelPortaliQ02576
SMRiQ02576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 127bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 71Poly-Arg6

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000016617
HOVERGENiHBG016345
InParanoidiQ02576
KOiK09075
OMAiMMLNSDA
PhylomeDBiQ02576

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q02576-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLNSDTMEL DLPPTHSETE SGFSDCGGGP GPDGAGSGDP GVVQVRSSEL
60 70 80 90 100
GESGRKDLQH LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK
110 120 130
LLPTLPPDKK LSKIEILRLA ICYISYLNHV LDV
Length:133
Mass (Da):14,830
Last modified:July 1, 1993 - v1
Checksum:i49D4118F67ECAD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97506 Genomic DNA Translation: AAA37801.1
M82874 mRNA Translation: AAA39840.1
BC051018 mRNA Translation: AAH51018.1
CCDSiCCDS15506.1
PIRiA41788
RefSeqiNP_035046.1, NM_010916.2
UniGeneiMm.2474

Genome annotation databases

EnsembliENSMUST00000059794; ENSMUSP00000057489; ENSMUSG00000051251
GeneIDi18071
KEGGimmu:18071
UCSCiuc007dpj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97506 Genomic DNA Translation: AAA37801.1
M82874 mRNA Translation: AAA39840.1
BC051018 mRNA Translation: AAH51018.1
CCDSiCCDS15506.1
PIRiA41788
RefSeqiNP_035046.1, NM_010916.2
UniGeneiMm.2474

3D structure databases

ProteinModelPortaliQ02576
SMRiQ02576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057489

PTM databases

PhosphoSitePlusiQ02576

Proteomic databases

PaxDbiQ02576
PRIDEiQ02576

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059794; ENSMUSP00000057489; ENSMUSG00000051251
GeneIDi18071
KEGGimmu:18071
UCSCiuc007dpj.2 mouse

Organism-specific databases

CTDi4807
MGIiMGI:98481 Nhlh1

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000016617
HOVERGENiHBG016345
InParanoidiQ02576
KOiK09075
OMAiMMLNSDA
PhylomeDBiQ02576

Miscellaneous databases

PROiPR:Q02576
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051251 Expressed in 75 organ(s), highest expression level in head
CleanExiMM_NHLH1
GenevisibleiQ02576 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEN1_MOUSE
AccessioniPrimary (citable) accession number: Q02576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again