HIST1H1A

Functionⁱ

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity

GO - Molecular functionⁱ

chromatin DNA binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15911621
heparin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

nucleosome assembly Source: InterPro
positive regulation of receptor-mediated endocytosis Source: Ensembl
spermatogenesis
Source: ProtInc
Traceable author statementⁱ
- 7989039

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211227 Activation of DNA fragmentation factor R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORⁱ	Q02539

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone H1.1 Alternative name(s): Histone H1a
Gene namesⁱ	Name:HIST1H1A Synonyms:H1F1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124610.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4715 HIST1H1A
MIMⁱ	142709 gene
neXtProtⁱ	NX_Q02539

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	152	T → E: Significant destabilization of binding to chromatin. 1 Publication		1
Mutagenesisⁱ	183	S → E: Significant destabilization of binding to chromatin. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3024
Open Targets More...OpenTargetsⁱ	ENSG00000124610
PharmGKBⁱ	PA29093

Polymorphism and mutation databases

BioMutaⁱ	HIST1H1A
DMDMⁱ	18202479

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000195905	2 – 215	Histone H1.1Add BLAST		214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	2	PhosphoserineBy similarity	1
Modified residueⁱ	12	PhosphoserineBy similarity	1
Modified residueⁱ	17	N6-acetyllysineBy similarity	1
Modified residueⁱ	37	N6-(beta-hydroxybutyryl)lysineBy similarity	1
Modified residueⁱ	44	PhosphoserineBy similarity	1
Modified residueⁱ	55	N6-(beta-hydroxybutyryl)lysineBy similarity	1
Modified residueⁱ	57	CitrullineBy similarity	1
Modified residueⁱ	67	N6-(beta-hydroxybutyryl)lysineBy similarity	1
Modified residueⁱ	78	N6-acetyllysineBy similarity	1
Modified residueⁱ	88	N6-(beta-hydroxybutyryl)lysineBy similarity	1
Modified residueⁱ	93	N6-(beta-hydroxybutyryl)lysine; alternateBy similarity	1
Modified residueⁱ	93	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	107	PhosphoserineBy similarity	1
Modified residueⁱ	109	N6-(beta-hydroxybutyryl)lysineBy similarity	1
Modified residueⁱ	125	N6-acetyllysineBy similarity	1
Modified residueⁱ	204	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity

Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMⁱ

Acetylation, Citrullination, Hydroxylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q02539
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q02539
PaxDbⁱ	Q02539
PeptideAtlas More...PeptideAtlasⁱ	Q02539
PRIDEⁱ	Q02539
ProteomicsDBⁱ	58107

PTM databases

CarbonylDBⁱ	Q02539
iPTMnetⁱ	Q02539
PhosphoSitePlusⁱ	Q02539
SwissPalmⁱ	Q02539

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000124610 Expressed in 34 organ(s), highest expression level in lung
CleanExⁱ	HS_HIST1H1A
Genevisibleⁱ	Q02539 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043753

HPAⁱ

HPA043753

Interactionⁱ

Subunit structureⁱ

Interacts with DFFB.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIR2rp1	Q57V41	2	EBI-932603,EBI-7579996	From Trypanosoma brucei brucei (strain 927/4 GUTat10.1).

With

Entry

#Exp.

IntAct

Notes

SIR2rp1

Q57V41

2

EBI-932603,EBI-7579996

From Trypanosoma brucei brucei (strain 927/4 GUTat10.1).

Protein-protein interaction databases

BioGridⁱ	109275, 194 interactors
CORUMⁱ	Q02539
IntActⁱ	Q02539, 34 interactors
Molecular INTeraction database More...MINTⁱ	Q02539
STRINGⁱ	9606.ENSP00000244573

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q02539
SMRⁱ	Q02539
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 112	H15PROSITE-ProRule annotationAdd BLAST		74

Domainⁱ

The C-terminal domain is required for high-affinity binding to chromatin.1 Publication

Sequence similaritiesⁱ

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG4012 Eukaryota ENOG4112541 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000097781
HOGENOMⁱ	HOG000251627
HOVERGENⁱ	HBG009035
InParanoidⁱ	Q02539
KEGG Orthology (KO) More...KOⁱ	K11275
OMAⁱ	KDEANPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	Q02539
TreeFamⁱ	TF313664

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00073 H15, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR005818 Histone_H1/H5_H15 IPR005819 Histone_H5 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00538 Linker_histone, 1 hit
PRINTSⁱ	PR00624 HISTONEH5
SMARTⁱ	View protein in SMART SM00526 H15, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS51504 H15, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q02539-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA 
        60         70         80         90        100
ASSSKERGGV SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK 
       110        120        130        140        150
GTGASGSFKL NKKASSVETK PGASKVATKT KATGASKKLK KATGASKKSV 
       160        170        180        190        200
KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV AKSPAKAKAV KPKAAKARVT 
       210 
KPKTAKPKKA APKKK

Length:215

Mass (Da):21,842

Last modified:January 23, 2007 - v3

Checksum:ⁱ854B03622D78774A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049301	99	T → I. Corresponds to variant dbSNP:rs417751Ensembl.	1
Natural variantⁱVAR_049302	115	S → F. Corresponds to variant dbSNP:rs34541321Ensembl.	1
Natural variantⁱVAR_049303	140	K → R. Corresponds to variant dbSNP:rs16891235Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X57130 Genomic DNA Translation: CAA40409.1 AF531299 Genomic DNA Translation: AAN06699.1 U91328 Genomic DNA No translation available. BC069492 mRNA Translation: AAH69492.1 BC101593 mRNA Translation: AAI01594.1 BC112140 mRNA Translation: AAI12141.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4569.1
PIRⁱ	S26363
NCBI Reference Sequences More...RefSeqⁱ	NP_005316.1, NM_005325.3
UniGeneⁱ	Hs.150206

Genome annotation databases

Ensemblⁱ	ENST00000244573; ENSP00000244573; ENSG00000124610
GeneIDⁱ	3024
KEGGⁱ	hsa:3024
UCSC genome browser More...UCSCⁱ	uc003nfo.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02539	HIST1H1A isoform 1		PANTR		215	UniRef90_Q02539
HIST1H1A isoform 1		PONAB		215
Histone H1.1		MACMU		215
Uncharacterized protein		PANPA		215
Uncharacterized protein		CHLSB		215
+9

Protein	Similar proteins		Species	Score	Length	Source
Q02539	Histone H1.1		MOUSE		213	UniRef50_P43275
Histone H1.1		RAT		214
Histone H1.3		RABIT		213
Histone H1.1		BOVIN		218
Putative Histone H1.3		Daphnia magna		213
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X57130 Genomic DNA Translation: CAA40409.1 AF531299 Genomic DNA Translation: AAN06699.1 U91328 Genomic DNA No translation available. BC069492 mRNA Translation: AAH69492.1 BC101593 mRNA Translation: AAI01594.1 BC112140 mRNA Translation: AAI12141.1
CCDSⁱ	CCDS4569.1
PIRⁱ	S26363
RefSeqⁱ	NP_005316.1, NM_005325.3
UniGeneⁱ	Hs.150206

3D structure databases

ProteinModelPortalⁱ	Q02539
SMRⁱ	Q02539
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109275, 194 interactors
CORUMⁱ	Q02539
IntActⁱ	Q02539, 34 interactors
MINTⁱ	Q02539
STRINGⁱ	9606.ENSP00000244573

PTM databases

CarbonylDBⁱ	Q02539
iPTMnetⁱ	Q02539
PhosphoSitePlusⁱ	Q02539
SwissPalmⁱ	Q02539

Polymorphism and mutation databases

BioMutaⁱ	HIST1H1A
DMDMⁱ	18202479

Proteomic databases

EPDⁱ	Q02539
MaxQBⁱ	Q02539
PaxDbⁱ	Q02539
PeptideAtlasⁱ	Q02539
PRIDEⁱ	Q02539
ProteomicsDBⁱ	58107

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3024
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000244573; ENSP00000244573; ENSG00000124610
GeneIDⁱ	3024
KEGGⁱ	hsa:3024
UCSCⁱ	uc003nfo.4 human

Organism-specific databases

CTDⁱ	3024
DisGeNETⁱ	3024
EuPathDBⁱ	HostDB:ENSG00000124610.4
GeneCardsⁱ	HIST1H1A
HGNCⁱ	HGNC:4715 HIST1H1A
HPAⁱ	HPA043753
MIMⁱ	142709 gene
neXtProtⁱ	NX_Q02539
OpenTargetsⁱ	ENSG00000124610
PharmGKBⁱ	PA29093
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4012 Eukaryota ENOG4112541 LUCA
GeneTreeⁱ	ENSGT00670000097781
HOGENOMⁱ	HOG000251627
HOVERGENⁱ	HBG009035
InParanoidⁱ	Q02539
KOⁱ	K11275
OMAⁱ	KDEANPP
OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	Q02539
TreeFamⁱ	TF313664

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211227 Activation of DNA fragmentation factor R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORⁱ	Q02539

Miscellaneous databases

GeneWikiⁱ	HIST1H1A
GenomeRNAiⁱ	3024
Protein Ontology More...PROⁱ	PR:Q02539
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124610 Expressed in 34 organ(s), highest expression level in lung
CleanExⁱ	HS_HIST1H1A
Genevisibleⁱ	Q02539 HS

Family and domain databases

CDDⁱ	cd00073 H15, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR005818 Histone_H1/H5_H15 IPR005819 Histone_H5 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00538 Linker_histone, 1 hit
PRINTSⁱ	PR00624 HISTONEH5
SMARTⁱ	View protein in SMART SM00526 H15, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS51504 H15, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H11_HUMAN
Accessionⁱ	Q02539Primary (citable) accession number: Q02539 Secondary accession number(s): Q3MJ34
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q02539 (H11_HUMAN)

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Histone H1.1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ