UniProtKB - Q02539 (H11_HUMAN)
Protein
Histone H1.1
Gene
H1-1
Organism
Homo sapiens (Human)
Status
Functioni
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity
GO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- double-stranded DNA binding Source: GO_Central
- nucleosomal DNA binding Source: GO_Central
GO - Biological processi
- chromosome condensation Source: GO_Central
- negative regulation of chromatin silencing Source: GO_Central
- negative regulation of DNA recombination Source: GO_Central
- nucleosome assembly Source: InterPro
- nucleosome positioning Source: GO_Central
- spermatogenesis Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q02539 |
Reactomei | R-HSA-140342, Apoptosis induced DNA fragmentation R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
SIGNORi | Q02539 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H1.1Alternative name(s): Histone H1a |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4715, H1-1 |
MIMi | 142709, gene |
neXtProti | NX_Q02539 |
VEuPathDBi | HostDB:ENSG00000124610.4 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Other locations
- Chromosome PROSITE-ProRule annotation1 Publication
Note: Mainly localizes in euchromatin.
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: UniProtKB
- euchromatin Source: UniProtKB
- nucleosome Source: InterPro
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 152 | T → E: Significant destabilization of binding to chromatin. 1 Publication | 1 | |
Mutagenesisi | 183 | S → E: Significant destabilization of binding to chromatin. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3024 |
OpenTargetsi | ENSG00000124610 |
PharmGKBi | PA29093 |
Miscellaneous databases
Pharosi | Q02539, Tbio |
Genetic variation databases
BioMutai | HIST1H1A |
DMDMi | 18202479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000195905 | 2 – 215 | Histone H1.1Add BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 12 | PhosphoserineBy similarity | 1 | |
Modified residuei | 17 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 37 | N6-(beta-hydroxybutyryl)lysineBy similarity | 1 | |
Modified residuei | 44 | PhosphoserineBy similarity | 1 | |
Modified residuei | 55 | N6-(beta-hydroxybutyryl)lysineBy similarity | 1 | |
Modified residuei | 57 | CitrullineBy similarity | 1 | |
Modified residuei | 67 | N6-(beta-hydroxybutyryl)lysineBy similarity | 1 | |
Modified residuei | 78 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 88 | N6-(beta-hydroxybutyryl)lysineBy similarity | 1 | |
Modified residuei | 93 | N6-(beta-hydroxybutyryl)lysine; alternateBy similarity | 1 | |
Modified residuei | 93 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 107 | PhosphoserineBy similarity | 1 | |
Modified residuei | 109 | N6-(beta-hydroxybutyryl)lysineBy similarity | 1 | |
Modified residuei | 125 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 204 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity
Keywords - PTMi
Acetylation, Citrullination, Hydroxylation, PhosphoproteinProteomic databases
EPDi | Q02539 |
jPOSTi | Q02539 |
MassIVEi | Q02539 |
MaxQBi | Q02539 |
PaxDbi | Q02539 |
PeptideAtlasi | Q02539 |
PRIDEi | Q02539 |
ProteomicsDBi | 58107 |
PTM databases
CarbonylDBi | Q02539 |
iPTMneti | Q02539 |
PhosphoSitePlusi | Q02539 |
SwissPalmi | Q02539 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124610, Expressed in lung and 48 other tissues |
Genevisiblei | Q02539, HS |
Organism-specific databases
HPAi | ENSG00000124610, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with DFFB.
1 PublicationBinary interactionsi
Hide detailsQ02539
With | #Exp. | IntAct |
---|---|---|
H2AC21 [Q8IUE6] | 2 | EBI-932603,EBI-1642157 |
TPPP [O94811] | 2 | EBI-932603,EBI-3927802 |
SIR2rp1 [Q57V41] from Trypanosoma brucei brucei (strain 927/4 GUTat10.1). | 2 | EBI-932603,EBI-7579996 |
Protein-protein interaction databases
BioGRIDi | 109275, 317 interactors |
CORUMi | Q02539 |
IntActi | Q02539, 209 interactors |
MINTi | Q02539 |
STRINGi | 9606.ENSP00000244573 |
Miscellaneous databases
RNActi | Q02539, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 112 | H15PROSITE-ProRule annotationAdd BLAST | 74 |
Domaini
The C-terminal domain is required for high-affinity binding to chromatin.1 Publication
Sequence similaritiesi
Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
GeneTreei | ENSGT00940000163269 |
HOGENOMi | CLU_052897_7_0_1 |
InParanoidi | Q02539 |
OMAi | FVESKYH |
OrthoDBi | 1565299at2759 |
PhylomeDBi | Q02539 |
TreeFami | TF313664 |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q02539-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA
60 70 80 90 100
ASSSKERGGV SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK
110 120 130 140 150
GTGASGSFKL NKKASSVETK PGASKVATKT KATGASKKLK KATGASKKSV
160 170 180 190 200
KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV AKSPAKAKAV KPKAAKARVT
210
KPKTAKPKKA APKKK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049301 | 99 | T → I. Corresponds to variant dbSNP:rs417751Ensembl. | 1 | |
Natural variantiVAR_049302 | 115 | S → F. Corresponds to variant dbSNP:rs34541321Ensembl. | 1 | |
Natural variantiVAR_049303 | 140 | K → R. Corresponds to variant dbSNP:rs16891235Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57130 Genomic DNA Translation: CAA40409.1 AF531299 Genomic DNA Translation: AAN06699.1 U91328 Genomic DNA No translation available. BC069492 mRNA Translation: AAH69492.1 BC101593 mRNA Translation: AAI01594.1 BC112140 mRNA Translation: AAI12141.1 |
CCDSi | CCDS4569.1 |
PIRi | S26363 |
RefSeqi | NP_005316.1, NM_005325.3 |
Genome annotation databases
Ensembli | ENST00000244573; ENSP00000244573; ENSG00000124610 |
GeneIDi | 3024 |
KEGGi | hsa:3024 |
UCSCi | uc003nfo.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57130 Genomic DNA Translation: CAA40409.1 AF531299 Genomic DNA Translation: AAN06699.1 U91328 Genomic DNA No translation available. BC069492 mRNA Translation: AAH69492.1 BC101593 mRNA Translation: AAI01594.1 BC112140 mRNA Translation: AAI12141.1 |
CCDSi | CCDS4569.1 |
PIRi | S26363 |
RefSeqi | NP_005316.1, NM_005325.3 |
3D structure databases
SMRi | Q02539 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109275, 317 interactors |
CORUMi | Q02539 |
IntActi | Q02539, 209 interactors |
MINTi | Q02539 |
STRINGi | 9606.ENSP00000244573 |
PTM databases
CarbonylDBi | Q02539 |
iPTMneti | Q02539 |
PhosphoSitePlusi | Q02539 |
SwissPalmi | Q02539 |
Genetic variation databases
BioMutai | HIST1H1A |
DMDMi | 18202479 |
Proteomic databases
EPDi | Q02539 |
jPOSTi | Q02539 |
MassIVEi | Q02539 |
MaxQBi | Q02539 |
PaxDbi | Q02539 |
PeptideAtlasi | Q02539 |
PRIDEi | Q02539 |
ProteomicsDBi | 58107 |
Protocols and materials databases
Antibodypediai | 25489, 318 antibodies |
DNASUi | 3024 |
Genome annotation databases
Ensembli | ENST00000244573; ENSP00000244573; ENSG00000124610 |
GeneIDi | 3024 |
KEGGi | hsa:3024 |
UCSCi | uc003nfo.4, human |
Organism-specific databases
CTDi | 3024 |
DisGeNETi | 3024 |
GeneCardsi | H1-1 |
HGNCi | HGNC:4715, H1-1 |
HPAi | ENSG00000124610, Tissue enhanced (testis) |
MIMi | 142709, gene |
neXtProti | NX_Q02539 |
OpenTargetsi | ENSG00000124610 |
PharmGKBi | PA29093 |
VEuPathDBi | HostDB:ENSG00000124610.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
GeneTreei | ENSGT00940000163269 |
HOGENOMi | CLU_052897_7_0_1 |
InParanoidi | Q02539 |
OMAi | FVESKYH |
OrthoDBi | 1565299at2759 |
PhylomeDBi | Q02539 |
TreeFami | TF313664 |
Enzyme and pathway databases
PathwayCommonsi | Q02539 |
Reactomei | R-HSA-140342, Apoptosis induced DNA fragmentation R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
SIGNORi | Q02539 |
Miscellaneous databases
BioGRID-ORCSi | 3024, 10 hits in 987 CRISPR screens |
GeneWikii | HIST1H1A |
GenomeRNAii | 3024 |
Pharosi | Q02539, Tbio |
PROi | PR:Q02539 |
RNActi | Q02539, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124610, Expressed in lung and 48 other tissues |
Genevisiblei | Q02539, HS |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H11_HUMAN | |
Accessioni | Q02539Primary (citable) accession number: Q02539 Secondary accession number(s): Q3MJ34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families