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UniProtKB - Q02539 (H11_HUMAN)

Entry version 169 (07 Apr 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Histone H1.1

Gene

H1-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q02539

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140342, Apoptosis induced DNA fragmentation
R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF)

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q02539

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H1.1
Alternative name(s):
Histone H1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H1-1Imported
Synonyms:H1F1, HIST1H1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4715, H1-1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142709, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q02539

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124610.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi152T → E: Significant destabilization of binding to chromatin. 1 Publication1
Mutagenesisi183S → E: Significant destabilization of binding to chromatin. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3024

Open Targets

More...OpenTargetsi		ENSG00000124610

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29093

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q02539, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HIST1H1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001959052 – 215Histone H1.1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei37N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei55N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei57CitrullineBy similarity1
Modified residuei67N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei78N6-acetyllysineBy similarity1
Modified residuei88N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei93N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei93N6-acetyllysine; alternateBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei109N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei125N6-acetyllysineBy similarity1
Modified residuei204PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q02539

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q02539

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q02539

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q02539

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q02539

PeptideAtlas

More...PeptideAtlasi		Q02539

PRoteomics IDEntifications database

More...PRIDEi		Q02539

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58107

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q02539

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q02539

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q02539

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q02539

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124610, Expressed in lung and 48 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q02539, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124610, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DFFB.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109275, 317 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q02539

Protein interaction database and analysis system

More...IntActi		Q02539, 209 interactors

Molecular INTeraction database

More...MINTi		Q02539

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000244573

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q02539, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q02539

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 112H15PROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is required for high-affinity binding to chromatin.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4012, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_052897_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q02539

Identification of Orthologs from Complete Genome Data

More...OMAi		FVESKYH

Database of Orthologous Groups

More...OrthoDBi		1565299at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q02539

TreeFam database of animal gene trees

More...TreeFami		TF313664

Family and domain databases

Conserved Domains Database

More...CDDi		cd00073, H15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005819, H1/H5
IPR005818, Histone_H1/H5_H15
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00538, Linker_histone, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00624, HISTONEH5

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00526, H15, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51504, H15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q02539-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA 
        60         70         80         90        100
ASSSKERGGV SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK 
       110        120        130        140        150
GTGASGSFKL NKKASSVETK PGASKVATKT KATGASKKLK KATGASKKSV 
       160        170        180        190        200
KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV AKSPAKAKAV KPKAAKARVT 
       210 
KPKTAKPKKA APKKK
Length:215
Mass (Da):21,842
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i854B03622D78774A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04930199T → I. Corresponds to variant dbSNP:rs417751Ensembl.1
Natural variantiVAR_049302115S → F. Corresponds to variant dbSNP:rs34541321Ensembl.1
Natural variantiVAR_049303140K → R. Corresponds to variant dbSNP:rs16891235Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X57130 Genomic DNA Translation: CAA40409.1
AF531299 Genomic DNA Translation: AAN06699.1
U91328 Genomic DNA No translation available.
BC069492 mRNA Translation: AAH69492.1
BC101593 mRNA Translation: AAI01594.1
BC112140 mRNA Translation: AAI12141.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4569.1

Protein sequence database of the Protein Information Resource

More...PIRi		S26363

NCBI Reference Sequences

More...RefSeqi		NP_005316.1, NM_005325.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000244573; ENSP00000244573; ENSG00000124610

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3024

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3024

UCSC genome browser

More...UCSCi		uc003nfo.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57130 Genomic DNA Translation: CAA40409.1
AF531299 Genomic DNA Translation: AAN06699.1
U91328 Genomic DNA No translation available.
BC069492 mRNA Translation: AAH69492.1
BC101593 mRNA Translation: AAI01594.1
BC112140 mRNA Translation: AAI12141.1
CCDSiCCDS4569.1
PIRiS26363
RefSeqiNP_005316.1, NM_005325.3

3D structure databases

SMRiQ02539
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109275, 317 interactors
CORUMiQ02539
IntActiQ02539, 209 interactors
MINTiQ02539
STRINGi9606.ENSP00000244573

PTM databases

CarbonylDBiQ02539
iPTMnetiQ02539
PhosphoSitePlusiQ02539
SwissPalmiQ02539

Genetic variation databases

BioMutaiHIST1H1A
DMDMi18202479

Proteomic databases

EPDiQ02539
jPOSTiQ02539
MassIVEiQ02539
MaxQBiQ02539
PaxDbiQ02539
PeptideAtlasiQ02539
PRIDEiQ02539
ProteomicsDBi58107

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25489, 318 antibodies

The DNASU plasmid repository

More...DNASUi		3024

Genome annotation databases

EnsembliENST00000244573; ENSP00000244573; ENSG00000124610
GeneIDi3024
KEGGihsa:3024
UCSCiuc003nfo.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3024
DisGeNETi3024

GeneCards: human genes, protein and diseases

More...GeneCardsi		H1-1
HGNCiHGNC:4715, H1-1
HPAiENSG00000124610, Tissue enhanced (testis)
MIMi142709, gene
neXtProtiNX_Q02539
OpenTargetsiENSG00000124610
PharmGKBiPA29093
VEuPathDBiHostDB:ENSG00000124610.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4012, Eukaryota
GeneTreeiENSGT00940000163269
HOGENOMiCLU_052897_7_0_1
InParanoidiQ02539
OMAiFVESKYH
OrthoDBi1565299at2759
PhylomeDBiQ02539
TreeFamiTF313664

Enzyme and pathway databases

PathwayCommonsiQ02539
ReactomeiR-HSA-140342, Apoptosis induced DNA fragmentation
R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORiQ02539

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3024, 10 hits in 987 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HIST1H1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3024
PharosiQ02539, Tbio

Protein Ontology

More...PROi		PR:Q02539
RNActiQ02539, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124610, Expressed in lung and 48 other tissues
GenevisibleiQ02539, HS

Family and domain databases

CDDicd00073, H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005819, H1/H5
IPR005818, Histone_H1/H5_H15
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538, Linker_histone, 1 hit
PRINTSiPR00624, HISTONEH5
SMARTiView protein in SMART
SM00526, H15, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504, H15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02539
Secondary accession number(s): Q3MJ34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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