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Protein

Histone H1.1

Gene

HIST1H1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity

GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • heparin binding Source: Ensembl

GO - Biological processi

  • nucleosome assembly Source: InterPro
  • positive regulation of receptor-mediated endocytosis Source: Ensembl
  • spermatogenesis Source: ProtInc

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SIGNORiQ02539

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.1
Alternative name(s):
Histone H1a
Gene namesi
Name:HIST1H1A
Synonyms:H1F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124610.4
HGNCiHGNC:4715 HIST1H1A
MIMi142709 gene
neXtProtiNX_Q02539

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi152T → E: Significant destabilization of binding to chromatin. 1 Publication1
Mutagenesisi183S → E: Significant destabilization of binding to chromatin. 1 Publication1

Organism-specific databases

DisGeNETi3024
OpenTargetsiENSG00000124610
PharmGKBiPA29093

Polymorphism and mutation databases

BioMutaiHIST1H1A
DMDMi18202479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001959052 – 215Histone H1.1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei37N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei55N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei57CitrullineBy similarity1
Modified residuei67N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei78N6-acetyllysineBy similarity1
Modified residuei88N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei93N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei93N6-acetyllysine; alternateBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei109N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei125N6-acetyllysineBy similarity1
Modified residuei204PhosphothreonineBy similarity1

Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Acetylation, Citrullination, Hydroxylation, Phosphoprotein

Proteomic databases

EPDiQ02539
MaxQBiQ02539
PaxDbiQ02539
PeptideAtlasiQ02539
PRIDEiQ02539
ProteomicsDBi58107

PTM databases

CarbonylDBiQ02539
iPTMnetiQ02539
PhosphoSitePlusiQ02539
SwissPalmiQ02539

Expressioni

Gene expression databases

BgeeiENSG00000124610
CleanExiHS_HIST1H1A
GenevisibleiQ02539 HS

Organism-specific databases

HPAiHPA043753

Interactioni

Subunit structurei

Interacts with DFFB.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SIR2rp1Q57V412EBI-932603,EBI-7579996From Trypanosoma brucei brucei (strain 927/4 GUTat10.1).

Protein-protein interaction databases

BioGridi109275, 194 interactors
CORUMiQ02539
IntActiQ02539, 34 interactors
MINTiQ02539
STRINGi9606.ENSP00000244573

Structurei

3D structure databases

ProteinModelPortaliQ02539
SMRiQ02539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 112H15PROSITE-ProRule annotationAdd BLAST74

Domaini

The C-terminal domain is required for high-affinity binding to chromatin.1 Publication

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00670000097781
HOGENOMiHOG000251627
HOVERGENiHBG009035
InParanoidiQ02539
KOiK11275
OMAiKDEANPP
OrthoDBiEOG091G0XGD
PhylomeDBiQ02539
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA
60 70 80 90 100
ASSSKERGGV SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK
110 120 130 140 150
GTGASGSFKL NKKASSVETK PGASKVATKT KATGASKKLK KATGASKKSV
160 170 180 190 200
KTPKKAKKPA ATRKSSKNPK KPKTVKPKKV AKSPAKAKAV KPKAAKARVT
210
KPKTAKPKKA APKKK
Length:215
Mass (Da):21,842
Last modified:January 23, 2007 - v3
Checksum:i854B03622D78774A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04930199T → I. Corresponds to variant dbSNP:rs417751Ensembl.1
Natural variantiVAR_049302115S → F. Corresponds to variant dbSNP:rs34541321Ensembl.1
Natural variantiVAR_049303140K → R. Corresponds to variant dbSNP:rs16891235Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57130 Genomic DNA Translation: CAA40409.1
AF531299 Genomic DNA Translation: AAN06699.1
U91328 Genomic DNA No translation available.
BC069492 mRNA Translation: AAH69492.1
BC101593 mRNA Translation: AAI01594.1
BC112140 mRNA Translation: AAI12141.1
CCDSiCCDS4569.1
PIRiS26363
RefSeqiNP_005316.1, NM_005325.3
UniGeneiHs.150206

Genome annotation databases

EnsembliENST00000244573; ENSP00000244573; ENSG00000124610
GeneIDi3024
KEGGihsa:3024
UCSCiuc003nfo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiH11_HUMAN
AccessioniPrimary (citable) accession number: Q02539
Secondary accession number(s): Q3MJ34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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