UniProtKB - Q02525 (ZFP39_MOUSE)
Protein
Zinc finger protein 39
Gene
Zfp39
Organism
Mus musculus (Mouse)
Status
Functioni
A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 298 – 320 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 577 – 599 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 605 – 627 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 633 – 655 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 661 – 683 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 689 – 711 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 39Short name: Zfp-39 Alternative name(s): CtFIN33 |
Gene namesi | Name:Zfp39 Synonyms:Zfp-39 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99183, Zfp39 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047298 | 1 – 718 | Zinc finger protein 39Add BLAST | 718 |
Proteomic databases
MaxQBi | Q02525 |
PaxDbi | Q02525 |
PRIDEi | Q02525 |
PTM databases
iPTMneti | Q02525 |
PhosphoSitePlusi | Q02525 |
Expressioni
Tissue specificityi
Predominantly in the spermatocytes and spermatids of testes.
Developmental stagei
First detected between 2 and 3 weeks after birth, in parallel with the onset and progression of meiosis.
Gene expression databases
Bgeei | ENSMUSG00000037001, Expressed in spermatid and 224 other tissues |
Genevisiblei | Q02525, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000099764 |
Miscellaneous databases
RNActi | Q02525, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 130 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 298 – 320 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 577 – 599 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 605 – 627 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 633 – 655 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 661 – 683 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 689 – 711 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160177 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q02525 |
OMAi | AFHQKSY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q02525 |
TreeFami | TF339594 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
i Sequence
Sequence statusi: Complete.
Q02525-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRNLQPDSVE NSLSQLPSRC LETRKRKRSY KKRPVTYSYW RRTQRNRARK
60 70 80 90 100
HKAPVKGLVS FEDVSVDFTW DEWQDLDDSQ RKLYRDVMLE TYSSLESLGH
110 120 130 140 150
CITKPEVIFK LEQGAEPWRA EDVPKQSRAD VQKITELNET SQDNEERHLW
160 170 180 190 200
HHAITYSNKS TEEKVKLGNI VNVSSNCVSN LTVKNGNSSG MRPVALTVWQ
210 220 230 240 250
SVLPPNKPDD TRIGEELDAS LTSEPPIHAE HPGLYSRAPG TGQQFQCCMQ
260 270 280 290 300
EVTCNTKALW TKRFHIAHGS SKFGESEKVP DEVALHAQDV SWVRAETFEC
310 320 330 340 350
SICKKTFCTK CELMKHKKIH KGQQYYTCRD CEKTFIKESY HTDQRVHAGV
360 370 380 390 400
GSHRCKQCEK CFHQKNQQNV HERVPREARL WEVYQSENSF GEKPNLRRYQ
410 420 430 440 450
RTRAGYKPYG CNLCGKAFYR KSHLGRHQKI HTGEKPYGCE ECKKTFYHKS
460 470 480 490 500
SLTIHQRTHT GEKPYECKKC RKTFYCKSDL NVHHRTHTGE KPYECDECRK
510 520 530 540 550
TFYSKSHLVI HQKVHTGDKP YECEECQKAF SRKSNLTVHQ KTHTGEKPYE
560 570 580 590 600
CNVCGKTFHR QSHLNMHQGT HTGQKPYQCE ECGKAFYQKS SLRRHQRNHT
610 620 630 640 650
GSRPYACEEC RKTFLHKSSL TVHQRSHTGY KPYSCEECRK TFYSKSHLTV
660 670 680 690 700
HQRTHTGEKP YECKLCKKAF HQKSYLNRHQ VTHGSEKRFE CQECRKTFYH
710
KSSLTVHQRI HLRELLCV
Sequence cautioni
The sequence BAA01479 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | S → R in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 184 | K → E in BAC32541 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 207 | K → E in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 213 | I → T in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 265 | H → L in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 337 | K → M in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 337 | K → M in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 346 | V → A in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 346 | V → A in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 350 | V → G in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 350 | V → G in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 353 | H → Q in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 353 | H → Q in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 386 | S → P in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 386 | S → P in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 388 | N → K in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 412 | N → S in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 412 | N → S in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 472 – 473 | KT → N in BAA01479 (PubMed:1397691).Curated | 2 | |
Sequence conflicti | 496 | D → G in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 496 | D → G in BAA01479 (PubMed:1397691).Curated | 1 | |
Sequence conflicti | 544 | T → R in AAI08272 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 630 | Y → E in AAI08272 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045944 mRNA Translation: BAC32541.1 AL662903 Genomic DNA No translation available. BC108271 mRNA Translation: AAI08272.1 D10629 mRNA Translation: BAA01479.1 Frameshift. |
CCDSi | CCDS24752.1 |
PIRi | A48827 |
RefSeqi | NP_035888.2, NM_011758.2 |
Genome annotation databases
Ensembli | ENSMUST00000102703; ENSMUSP00000099764; ENSMUSG00000037001 |
GeneIDi | 22698 |
KEGGi | mmu:22698 |
UCSCi | uc007jcn.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045944 mRNA Translation: BAC32541.1 AL662903 Genomic DNA No translation available. BC108271 mRNA Translation: AAI08272.1 D10629 mRNA Translation: BAA01479.1 Frameshift. |
CCDSi | CCDS24752.1 |
PIRi | A48827 |
RefSeqi | NP_035888.2, NM_011758.2 |
3D structure databases
SMRi | Q02525 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000099764 |
PTM databases
iPTMneti | Q02525 |
PhosphoSitePlusi | Q02525 |
Proteomic databases
MaxQBi | Q02525 |
PaxDbi | Q02525 |
PRIDEi | Q02525 |
Protocols and materials databases
Antibodypediai | 16379, 100 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000102703; ENSMUSP00000099764; ENSMUSG00000037001 |
GeneIDi | 22698 |
KEGGi | mmu:22698 |
UCSCi | uc007jcn.1, mouse |
Organism-specific databases
CTDi | 22698 |
MGIi | MGI:99183, Zfp39 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160177 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q02525 |
OMAi | AFHQKSY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q02525 |
TreeFami | TF339594 |
Miscellaneous databases
BioGRID-ORCSi | 22698, 2 hits in 17 CRISPR screens |
ChiTaRSi | Zfp39, mouse |
PROi | PR:Q02525 |
RNActi | Q02525, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037001, Expressed in spermatid and 224 other tissues |
Genevisiblei | Q02525, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP39_MOUSE | |
Accessioni | Q02525Primary (citable) accession number: Q02525 Secondary accession number(s): Q2YDX7, Q5NC60, Q8BL91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | January 9, 2007 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot