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Protein

Mucin-3A

Gene

MUC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-3ACurated
Short name:
MUC-3ACurated
Alternative name(s):
Intestinal mucin-3A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC3AImported
Synonyms:MUC31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169894.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7513 MUC3A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
158371 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02505

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3227 – 3247HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4584

Open Targets

More...
OpenTargetsi
ENSG00000169894

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302571

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000015895516 – 3323Mucin-3AAdd BLAST3308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2980 ↔ 2986PROSITE-ProRule annotation
Disulfide bondi2999 ↔ 3008PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly O-glycosylated and probably also N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q02505

PeptideAtlas

More...
PeptideAtlasi
Q02505

PRoteomics IDEntifications database

More...
PRIDEi
Q02505

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58099
58100 [Q02505-2]
58101 [Q02505-3]
58102 [Q02505-4]
58103 [Q02505-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02505

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02505

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169894 Expressed in 157 organ(s), highest expression level in small intestine Peyer's patch

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q02505 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q02505 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010871

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q02505, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000324834

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02505

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02505

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1893 – 19101Add BLAST18
Repeati1911 – 19272Add BLAST17
Repeati1928 – 19443Add BLAST17
Repeati1945 – 19614Add BLAST17
Repeati1962 – 19785Add BLAST17
Repeati1979 – 19956Add BLAST17
Repeati1996 – 20127Add BLAST17
Repeati2013 – 20298Add BLAST17
Repeati2030 – 20469Add BLAST17
Repeati2047 – 206210Add BLAST16
Repeati2063 – 207911Add BLAST17
Repeati2080 – 209612Add BLAST17
Repeati2097 – 211313Add BLAST17
Repeati2114 – 213014Add BLAST17
Repeati2131 – 214715Add BLAST17
Repeati2148 – 216416Add BLAST17
Repeati2165 – 219117Add BLAST27
Repeati2192 – 220818Add BLAST17
Repeati2209 – 222519Add BLAST17
Repeati2226 – 224220Add BLAST17
Repeati2243 – 225921Add BLAST17
Repeati2260 – 227622Add BLAST17
Repeati2277 – 229323Add BLAST17
Repeati2294 – 231024Add BLAST17
Repeati2311 – 232725Add BLAST17
Repeati2328 – 234426Add BLAST17
Repeati2345 – 236127Add BLAST17
Repeati2362 – 237828Add BLAST17
Repeati2379 – 239529Add BLAST17
Repeati2396 – 241230Add BLAST17
Repeati2413 – 242931Add BLAST17
Repeati2430 – 244632Add BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2976 – 3009EGF-likePROSITE-ProRule annotationAdd BLAST34
Domaini3018 – 3143SEAPROSITE-ProRule annotationAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1893 – 244632 X approximate tandem repeats, Ser/Thr-richAdd BLAST554

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi77 – 2957Thr-richAdd BLAST2881
Compositional biasi395 – 2747Ser-richAdd BLAST2353

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVGW Eukaryota
ENOG410ZCSE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154419

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG099390

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02505

KEGG Orthology (KO)

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KOi
K22016

Identification of Orthologs from Complete Genome Data

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OMAi
NRGRFNV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02EJ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 2 hits
SM00200 SEA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82671 SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50024 SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02505-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS
60 70 80 90 100
RDLAGWPLGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT
110 120 130 140 150
STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH PTSICVTTTQ
160 170 180 190 200
VAFTSSYTST PVTQKPVTTV TSTYSMTTTE KGTSAMTSSP STTTARETPI
210 220 230 240 250
VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT SPTPVFTTLK
260 270 280 290 300
TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS
310 320 330 340 350
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYTTSP TSTVTDSTTK
360 370 380 390 400
IAYSTSMTGT LSTETSLPPT SSSLPTTETA TTPMTNLVTT TTEISSHSTP
410 420 430 440 450
SFSSSTIYST VSTSTTAISS LPPTSGTMVT STTMTPSSLS TDIPFTTPTT
460 470 480 490 500
ITHHSVGSTG FLTTATDLTS TFTVSSSSAM STSVIPSSPS IQNTETSSLV
510 520 530 540 550
SMTSATTPNV RPTFVSTLST PTSSLLTTFP ATYSFSSSMS ASSAGTTHTE
560 570 580 590 600
SISSPPASTS TLHTTAESTL APTTTTSFTT STTMEPPSTT AATTGTGQTT
610 620 630 640 650
FTSSTATFPE TTTPTPTTDM STESLTTAMT SPPITSSVTS TNTVTSMTTT
660 670 680 690 700
TSPPTTTNSF TSLTSMPLSS TPVPSTEVVT SGTINTIPPS ILVTTLPTPN
710 720 730 740 750
ASSMTTSETT YPNSPTGPGT NSTTEITYPT TMTETSSTAT SLPPTSPLVS
760 770 780 790 800
TAKTAKTPTT NLVTTTTKTT SHSTTSFTSS TVYSTASTYT TAITSVPTTL
810 820 830 840 850
GTMVTSTSMI SSTVSTGIPT SQPTTITPSS VGISGSLPMM TDLTSVYTVS
860 870 880 890 900
NMSARPTTVI PSSPTVQNTE ISISVSMTSA TTPSGGPTFT STENTPTRSL
910 920 930 940 950
LTSFPMTHSF SSSMSESSAG TTHTESISSP RGTTSTLHTT VESTPSPTTT
960 970 980 990 1000
TSFTTSTMME PPSSTVSTTG RGQTTFPSST ATFPETTTLT PTTDISTVSL
1010 1020 1030 1040 1050
TTAMTSPPPV SSSITPTNTM TSMRTTTYWP TATNTLSPLT SSILSSTPVP
1060 1070 1080 1090 1100
STEMITSHTT NTTPLSTLVT TLLTTITRST PTSETTYPTS PTSIVSDSTT
1110 1120 1130 1140 1150
EITYSTSITG TLSTATTLPP TSSSLPTTET ATMTPTTTLI TTTPNTTSLS
1160 1170 1180 1190 1200
TPSFTSSTIY STVSTSTTAI SSASPTSGTM VTSTTMTPSS LSTDTPSTTP
1210 1220 1230 1240 1250
TTITYPSVGS TGFLTTATDL TSTFTVSSSS AMSTSVIPSS PSIQNTETSS
1260 1270 1280 1290 1300
LVSMTSATTP SLRPTITSTD STLTSSLLTT FPSTYSFSSS MSASSAGTTH
1310 1320 1330 1340 1350
TETISSLPAS TNTIHTTAES ALAPTTTTSF TTSPTMEPPS TTVATTGTGQ
1360 1370 1380 1390 1400
TTFPSSTATF LETTTLTPTT DFSTESLTTA MTSTPPITSS ITPTDTMTSM
1410 1420 1430 1440 1450
RTTTSWPTAT NTLSPLTSSI LSSTPVPSTE VTTSHTTNTN PVSTLVTTLP
1460 1470 1480 1490 1500
ITITRSTLTS ETAYPSSPTS TVTESTTEIT YPTTMTETSS TATSLPPTSS
1510 1520 1530 1540 1550
LVSTAETAKT PTTNLVTTTT KTTSHSTTSF TSSTIYSTAS TPTTAITSVP
1560 1570 1580 1590 1600
TTLGTMVTST SMIPSTVSTG IPTSQPTTIT PSSVGISGSL PMMTDLTSVY
1610 1620 1630 1640 1650
TVSSMSARPT SVIPSSPTVQ NTETSIFVSM MSATTPSGGP TFTSTENTPT
1660 1670 1680 1690 1700
RSLLTSFPVT HSFSSSMSAS SVGTTHTQSI SSPPAITSTL HTTAESTPSP
1710 1720 1730 1740 1750
TTTMSFTTFT KMETPSSTVA TTGTGQTTFT SSTATSPKTT TLTPTSDIST
1760 1770 1780 1790 1800
GSFKTAVSST PPITSSITST YTVTSMTTTT PLGPTATNTL PSFTSSVSSS
1810 1820 1830 1840 1850
TPVPSTEAIT SGTTNTTPLS TLVTTFSNSD TSSTPTSETT YPTSLTSALT
1860 1870 1880 1890 1900
DSTTRTTYST NMTGTLSTVT SLRPTSSSLL TTVTATVPTT NLVTTTTKIT
1910 1920 1930 1940 1950
SHSTPSFTSS IATTETPSHS TPRFTSSITT TETPSHSTPR FTSSITNTKT
1960 1970 1980 1990 2000
TSHSSPSFTS SITTTETTSH NTPSLTSSIT TTKTTSHSTP SYTSLITTTT
2010 2020 2030 2040 2050
TTSHSTPSFT SSITTTETTS HNTPSLTSSI TTTETTSHST PSFTSSITTE
2060 2070 2080 2090 2100
TTSHSTPSFT SLITITEITS HSTLSYTTSI TTTETPSHST LSFTSSITTT
2110 2120 2130 2140 2150
ETTSHSTPSF TSSITTSEMP SHSTPSFTSS ITTTENATHS TPNFTSSITT
2160 2170 2180 2190 2200
TETTSHSTPS FTSLITTTET TSHRWGTTET TSYSTPSFTS SNTITETTSH
2210 2220 2230 2240 2250
STPSYITSIT TTETPSSSTP SFSSSITTTE TTSHSTPGFT SSITTTETTS
2260 2270 2280 2290 2300
HSTPSFTSSI TTTETTSHDT PSFTSSITTS ETPSHSTPSS TSLITTTKTT
2310 2320 2330 2340 2350
SHSTPSFTSS ITTTETTSHS AHSFTSSITT TETTSHNTRS FTSSITTTET
2360 2370 2380 2390 2400
NSHSTTSFTS SITTTETTSH STPSFSSSIT TTETPLHSTP GLTSWVTTTK
2410 2420 2430 2440 2450
TTSHITPGLT SSITTTETTS HSTPGFTSSI TTTETTSEST PSLSSSTIYS
2460 2470 2480 2490 2500
TVSTSTTAIT SHFTTSETAV TPTPVTPSSL STDIPTTSLR TLTPSSVGTS
2510 2520 2530 2540 2550
TSLTTTTDFP SIPTDISTLP TRTHIISSSP SIQSTETSSL VGTTSPTMST
2560 2570 2580 2590 2600
VRMTLRITEN TPISSFSTSI VVIPETPTQT PPVLTSATGT QTSPAPTTVT
2610 2620 2630 2640 2650
FGSTDSSTST LHTLTPSTAL STIVSTSQVP IPSTHSSTLQ TTPSTPSLQT
2660 2670 2680 2690 2700
SLTSTSEFTT ESFTRGSTST NAILTSFSTI IWSSTPTIIM SSSPSSASIT
2710 2720 2730 2740 2750
PVFSTTIHSV PSSPYIFSTE NVGSASITGF PSLSSSATTS TSSTSSSLTT
2760 2770 2780 2790 2800
ALTEITPFSY ISLPSTTPCP GTITITIVPA SPTDPCVEMD PSTEATSPPT
2810 2820 2830 2840 2850
TPLTVFPFTT EMVTCPTSIS IQTTLTTYMD TSSMMPESES SISPNASSST
2860 2870 2880 2890 2900
GTGTVPTNTV FTSTRLPTSE TWLSNSSVIP LPLPGVSTIP LTMKPSSSLP
2910 2920 2930 2940 2950
TILRTSSKST HPSPPTTRTS ETPVATTQTP TTLTSRRTTR ITSQMTTQST
2960 2970 2980 2990 3000
LTTTAGTCDN GGTWEQGQCA CLPGFSGDRC QLQTRCQNGG QWDGLKCQCP
3010 3020 3030 3040 3050
STFYGSSCEF AVEQVDLDVV ETEVGMEVSV DQQFSPDLND NTSQAYRDFN
3060 3070 3080 3090 3100
KTFWNQMQKI FADMQGFTFK GVEILSLRNG SIVVDYLVLL EMPFSPQLES
3110 3120 3130 3140 3150
EYEQVKTTLK EGLQNASQDV NSCQDSQTLC FKPDSIKVNN NSKTELTPAA
3160 3170 3180 3190 3200
ICRRAAPTGY EEFYFPLVEA TRLRCVTKCT SGVDNAIDCH QGQCVLETSG
3210 3220 3230 3240 3250
PTCRCYSTDT HWFSGPRCEV AVHWRALVGG LTAGAALLVL LLLALGVRAV
3260 3270 3280 3290 3300
RSGWWGGQRR GRSWDQDRKW FETWDEEVVG TFSNWGFEDD GTDKDTNFYV
3310 3320
ALENVDTTMK VHIKRPEMTS SSV
Length:3,323
Mass (Da):345,127
Last modified:April 13, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C6E21ADD26637EF
GO
Isoform 2 (identifier: Q02505-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3019-3063: VVETEVGMEV...WNQMQKIFAD → AEDFCRHAGL...ALQPPAGERV
     3064-3323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:3,063
Mass (Da):315,514
Checksum:i5DDF446F97DAF6C3
GO
Isoform 3 (identifier: Q02505-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3057-3080: MQKIFADMQGFTFKGVEILSLRNG → EWQHRGGLPGPAGDALQPPAGERV
     3081-3323: Missing.

Show »
Length:3,080
Mass (Da):317,703
Checksum:i8EB5575D9A5144B1
GO
Isoform 4 (identifier: Q02505-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3078-3081: RNGS → SPVF
     3082-3323: Missing.

Show »
Length:3,081
Mass (Da):318,041
Checksum:i52FA62A2517C3873
GO
Isoform 5 (identifier: Q02505-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3204-3261: Missing.

Show »
Length:3,265
Mass (Da):338,839
Checksum:i16A557A14778C0CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A182DWF7A0A182DWF7_HUMAN
Mucin-3A
MUC3A
1,002Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA63772 differs from that shown. This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.Curated
The sequence AAA63773 differs from that shown. This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.Curated
The sequence AAC02271 differs from that shown. Reason: Frameshift at positions 1535, 1542 and 1548.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti258P → S in AAQ73824 (PubMed:12853948).Curated1
Sequence conflicti337T → P in AAQ73824 (PubMed:12853948).Curated1
Sequence conflicti1149L → H in AAC02268 (PubMed:9334251).Curated1
Sequence conflicti1234T → K in AAC02268 (PubMed:9334251).Curated1
Sequence conflicti1542P → L in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1570G → D in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1587S → T in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1640P → S in AAC02271 (PubMed:9334251).Curated1
Sequence conflicti1966 – 1969ETTS → DSIV in AAC02271 (PubMed:9334251).Curated4
Sequence conflicti2099T → I in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2099T → I in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2110F → Y in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2110F → Y in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2112S → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2112S → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2117S → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2117S → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2119M → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2119M → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2127F → Y in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2127F → Y in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2129S → T in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2129S → T in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2136 – 2138NAT → TPS in AAC02272 (PubMed:9334251).Curated3
Sequence conflicti2136 – 2138NAT → TPS in AAF13032 (PubMed:10512748).Curated3
Sequence conflicti2143N → S in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2143N → S in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2164 – 2166LIT → SIR in AAC02272 (PubMed:9334251).Curated3
Sequence conflicti2164 – 2166LIT → SIR in AAF13032 (PubMed:10512748).Curated3
Sequence conflicti2169 – 2178Missing in AAC02272 (PubMed:9334251).Curated10
Sequence conflicti2169 – 2178Missing in AAF13032 (PubMed:10512748).Curated10
Sequence conflicti2322H → R in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2322H → R in AAF13032 (PubMed:10512748).Curated1
Sequence conflicti2393T → P in AAC02272 (PubMed:9334251).Curated1
Sequence conflicti2956G → GC in BAB12116 (PubMed:11289722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0307223120V → A1 PublicationCorresponds to variant dbSNP:rs6960868Ensembl.1
Natural variantiVAR_0307243299Y → H Polymorphism; may be associated with Crohn disease. 1 PublicationCorresponds to variant dbSNP:rs10258821Ensembl.1
Natural variantiVAR_0307233299Y → N2 PublicationsCorresponds to variant dbSNP:rs10258821Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0232293019 – 3063VVETE…KIFAD → AEDFCRHAGLHLQGCGDPVP EEWQHRGGLPGPAGDALQPP AGERV in isoform 2. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_0232303057 – 3080MQKIF…SLRNG → EWQHRGGLPGPAGDALQPPA GERV in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0232313064 – 3323Missing in isoform 2. 2 PublicationsAdd BLAST260
Alternative sequenceiVSP_0232323078 – 3081RNGS → SPVF in isoform 4. 1 Publication4
Alternative sequenceiVSP_0232333081 – 3323Missing in isoform 3. 1 PublicationAdd BLAST243
Alternative sequenceiVSP_0232343082 – 3323Missing in isoform 4. 1 PublicationAdd BLAST242
Alternative sequenceiVSP_0232353204 – 3261Missing in isoform 5. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC105446 Genomic DNA No translation available.
AC118759 Genomic DNA No translation available.
AC254629 Genomic DNA No translation available.
AY307930 Genomic DNA Translation: AAQ73824.1
AF007190 mRNA Translation: AAC02268.1
AF007193 mRNA Translation: AAC02271.1 Frameshift.
AF007194 mRNA Translation: AAC02272.1
AF113616 Genomic DNA Translation: AAF13032.1
AB038782 Genomic DNA Translation: BAB12116.1
AF143371 mRNA Translation: AAD45882.1
AF143372 mRNA Translation: AAD45883.1
AF143373 mRNA Translation: AAD45884.1
M55405 mRNA Translation: AAA63772.1 Sequence problems.
M55406 mRNA Translation: AAA63773.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS78262.1 [Q02505-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A35690
B35690

NCBI Reference Sequences

More...
RefSeqi
NP_005951.1, NM_005960.1 [Q02505-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.703577
Hs.723567
Hs.744422
Hs.744530

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379458; ENSP00000368771; ENSG00000169894 [Q02505-1]
ENST00000483366; ENSP00000483541; ENSG00000169894 [Q02505-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4584

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4584

UCSC genome browser

More...
UCSCi
uc033aad.2 human
uc064gjo.1 human [Q02505-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105446 Genomic DNA No translation available.
AC118759 Genomic DNA No translation available.
AC254629 Genomic DNA No translation available.
AY307930 Genomic DNA Translation: AAQ73824.1
AF007190 mRNA Translation: AAC02268.1
AF007193 mRNA Translation: AAC02271.1 Frameshift.
AF007194 mRNA Translation: AAC02272.1
AF113616 Genomic DNA Translation: AAF13032.1
AB038782 Genomic DNA Translation: BAB12116.1
AF143371 mRNA Translation: AAD45882.1
AF143372 mRNA Translation: AAD45883.1
AF143373 mRNA Translation: AAD45884.1
M55405 mRNA Translation: AAA63772.1 Sequence problems.
M55406 mRNA Translation: AAA63773.1 Sequence problems.
CCDSiCCDS78262.1 [Q02505-1]
PIRiA35690
B35690
RefSeqiNP_005951.1, NM_005960.1 [Q02505-1]
UniGeneiHs.703577
Hs.723567
Hs.744422
Hs.744530

3D structure databases

ProteinModelPortaliQ02505
SMRiQ02505
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02505, 1 interactor
STRINGi9606.ENSP00000324834

PTM databases

iPTMnetiQ02505
PhosphoSitePlusiQ02505

Polymorphism and mutation databases

DMDMi126302571

Proteomic databases

PaxDbiQ02505
PeptideAtlasiQ02505
PRIDEiQ02505
ProteomicsDBi58099
58100 [Q02505-2]
58101 [Q02505-3]
58102 [Q02505-4]
58103 [Q02505-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379458; ENSP00000368771; ENSG00000169894 [Q02505-1]
ENST00000483366; ENSP00000483541; ENSG00000169894 [Q02505-5]
GeneIDi4584
KEGGihsa:4584
UCSCiuc033aad.2 human
uc064gjo.1 human [Q02505-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4584
DisGeNETi4584
EuPathDBiHostDB:ENSG00000169894.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MUC3A
HGNCiHGNC:7513 MUC3A
HPAiHPA010871
MIMi158371 gene
neXtProtiNX_Q02505
OpenTargetsiENSG00000169894

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVGW Eukaryota
ENOG410ZCSE LUCA
GeneTreeiENSGT00940000154419
HOVERGENiHBG099390
InParanoidiQ02505
KOiK22016
OMAiNRGRFNV
OrthoDBiEOG091G02EJ

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MUC3A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4584

Protein Ontology

More...
PROi
PR:Q02505

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169894 Expressed in 157 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiQ02505 baseline and differential
GenevisibleiQ02505 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00200 SEA, 1 hit
SUPFAMiSSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50024 SEA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02505
Secondary accession number(s): A6NP22
, O14650, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 13, 2016
Last modified: December 5, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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