UniProtKB - Q02446 (SP4_HUMAN)
Protein
Transcription factor Sp4
Gene
SP4
Organism
Homo sapiens (Human)
Status
Functioni
Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 647 – 671 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 677 – 701 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 707 – 729 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q02446 |
SignaLinki | Q02446 |
SIGNORi | Q02446 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sp4Alternative name(s): SPR-1 |
Gene namesi | Name:SP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105866.13 |
HGNCi | HGNC:11209, SP4 |
MIMi | 600540, gene |
neXtProti | NX_Q02446 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6671 |
OpenTargetsi | ENSG00000105866 |
PharmGKBi | PA36046 |
Miscellaneous databases
Pharosi | Q02446, Tbio |
Polymorphism and mutation databases
BioMutai | SP4 |
DMDMi | 218511800 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047144 | 1 – 784 | Transcription factor Sp4Add BLAST | 784 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 46 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q02446 |
jPOSTi | Q02446 |
MassIVEi | Q02446 |
MaxQBi | Q02446 |
PaxDbi | Q02446 |
PeptideAtlasi | Q02446 |
PRIDEi | Q02446 |
ProteomicsDBi | 58090 |
PTM databases
GlyGeni | Q02446, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q02446 |
PhosphoSitePlusi | Q02446 |
Expressioni
Tissue specificityi
Abundant in brain.
Gene expression databases
Bgeei | ENSG00000105866, Expressed in endometrium and 225 other tissues |
ExpressionAtlasi | Q02446, baseline and differential |
Genevisiblei | Q02446, HS |
Organism-specific databases
HPAi | ENSG00000105866, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ02446
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 112554, 40 interactors |
IntActi | Q02446, 30 interactors |
STRINGi | 9606.ENSP00000222584 |
Miscellaneous databases
RNActi | Q02446, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 467 – 475 | 9aaTAD; inactive1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 11 | Poly-Glu | 5 | |
Compositional biasi | 12 – 19 | Poly-Ala | 8 | |
Compositional biasi | 122 – 130 | Poly-Ser | 9 | |
Compositional biasi | 185 – 188 | Poly-Ser | 4 |
Domaini
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP4, the motif is inactive.1 Publication
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 647 – 671 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 677 – 701 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 707 – 729 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157827 |
HOGENOMi | CLU_019688_2_0_1 |
InParanoidi | Q02446 |
OMAi | GGVQYQV |
OrthoDBi | 1085860at2759 |
PhylomeDBi | Q02446 |
TreeFami | TF350150 |
Family and domain databases
InterProi | View protein in InterPro IPR030453, SP4 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF17, PTHR23235:SF17, 2 hits |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q02446-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL
60 70 80 90 100
LAATCSKIGT PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN
110 120 130 140 150
AWQLVASTPP ASKENNVSQP ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ
160 170 180 190 200
FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ INPTSSSSLQ DLQGQIQLIS
210 220 230 240 250
AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP LQLQTLPGTQ
260 270 280 290 300
AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL
310 320 330 340 350
VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST
360 370 380 390 400
SASSSERTIE ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG
410 420 430 440 450
QPILQQIQIQ QPQQQIIQAI PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN
460 470 480 490 500
PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL SNLQVQNAGL SQQLTITPVS
510 520 530 540 550
SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN LGAAGVQVQG
560 570 580 590 600
VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ
610 620 630 640 650
VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH
660 670 680 690 700
IEGCGKVYGK TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT
710 720 730 740 750
HTGEKRFECP ECSKRFMRSD HLSKHVKTHQ NKKGGGTALA IVTSGELDSS
760 770 780
VTEVLGSPRI VTVAAISQDS NPATPNVSTN MEEF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IRW4 | A0A3B3IRW4_HUMAN | Transcription factor Sp4 | SP4 | 767 | Annotation score: | ||
C9JUS7 | C9JUS7_HUMAN | Transcription factor Sp4 | SP4 | 56 | Annotation score: | ||
F8WB93 | F8WB93_HUMAN | Transcription factor Sp4 | SP4 | 49 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 379 – 380 | QP → HA in CAA48563 (PubMed:1454515).Curated | 2 | |
Sequence conflicti | 386 | A → Q in CAA48563 (PubMed:1454515).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047975 | 197 | Q → K1 PublicationCorresponds to variant dbSNP:rs1042848Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68561 mRNA Translation: CAA48563.1 AK289728 mRNA Translation: BAF82417.1 AC004595 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93733.1 BC109300 mRNA Translation: AAI09301.1 |
CCDSi | CCDS5373.1 |
PIRi | S26638 |
RefSeqi | NP_001313472.1, NM_001326543.1 NP_003103.2, NM_003112.4 |
Genome annotation databases
Ensembli | ENST00000222584; ENSP00000222584; ENSG00000105866 |
GeneIDi | 6671 |
KEGGi | hsa:6671 |
UCSCi | uc003sva.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68561 mRNA Translation: CAA48563.1 AK289728 mRNA Translation: BAF82417.1 AC004595 Genomic DNA No translation available. CH471073 Genomic DNA Translation: EAW93733.1 BC109300 mRNA Translation: AAI09301.1 |
CCDSi | CCDS5373.1 |
PIRi | S26638 |
RefSeqi | NP_001313472.1, NM_001326543.1 NP_003103.2, NM_003112.4 |
3D structure databases
SMRi | Q02446 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112554, 40 interactors |
IntActi | Q02446, 30 interactors |
STRINGi | 9606.ENSP00000222584 |
PTM databases
GlyGeni | Q02446, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q02446 |
PhosphoSitePlusi | Q02446 |
Polymorphism and mutation databases
BioMutai | SP4 |
DMDMi | 218511800 |
Proteomic databases
EPDi | Q02446 |
jPOSTi | Q02446 |
MassIVEi | Q02446 |
MaxQBi | Q02446 |
PaxDbi | Q02446 |
PeptideAtlasi | Q02446 |
PRIDEi | Q02446 |
ProteomicsDBi | 58090 |
Protocols and materials databases
Antibodypediai | 4135, 69 antibodies |
DNASUi | 6671 |
Genome annotation databases
Ensembli | ENST00000222584; ENSP00000222584; ENSG00000105866 |
GeneIDi | 6671 |
KEGGi | hsa:6671 |
UCSCi | uc003sva.4, human |
Organism-specific databases
CTDi | 6671 |
DisGeNETi | 6671 |
EuPathDBi | HostDB:ENSG00000105866.13 |
GeneCardsi | SP4 |
HGNCi | HGNC:11209, SP4 |
HPAi | ENSG00000105866, Low tissue specificity |
MIMi | 600540, gene |
neXtProti | NX_Q02446 |
OpenTargetsi | ENSG00000105866 |
PharmGKBi | PA36046 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157827 |
HOGENOMi | CLU_019688_2_0_1 |
InParanoidi | Q02446 |
OMAi | GGVQYQV |
OrthoDBi | 1085860at2759 |
PhylomeDBi | Q02446 |
TreeFami | TF350150 |
Enzyme and pathway databases
PathwayCommonsi | Q02446 |
SignaLinki | Q02446 |
SIGNORi | Q02446 |
Miscellaneous databases
BioGRID-ORCSi | 6671, 4 hits in 867 CRISPR screens |
ChiTaRSi | SP4, human |
GeneWikii | Sp4_transcription_factor |
GenomeRNAii | 6671 |
Pharosi | Q02446, Tbio |
PROi | PR:Q02446 |
RNActi | Q02446, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105866, Expressed in endometrium and 225 other tissues |
ExpressionAtlasi | Q02446, baseline and differential |
Genevisiblei | Q02446, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030453, SP4 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF17, PTHR23235:SF17, 2 hits |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SP4_HUMAN | |
Accessioni | Q02446Primary (citable) accession number: Q02446 Secondary accession number(s): O60402, Q32M52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | December 16, 2008 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations