UniProtKB - Q02410 (APBA1_HUMAN)

BLAST

>sp|Q02410|APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 OS=Homo sapiens OX=9606 GN=APBA1 PE=1 SV=3
MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDL
RAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAV
QYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGED
EPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDE
RSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDL
ERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEV
KTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLH
PSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKN
VRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDH
PLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLI
AQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIE
KQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLS
TCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERG
GVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI

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History
Entry version 172 (07 Nov 2018)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Amyloid-beta A4 precursor protein-binding family A member 1

Gene

APBA1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.

GO - Molecular functionⁱ

amyloid-beta binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axo-dendritic transport
Source: ProtInc
Traceable author statementⁱ
- 9822620
cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 9753324
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
gamma-aminobutyric acid secretion Source: Ensembl
glutamate secretion Source: Ensembl
intracellular protein transport
Source: ProtInc
Traceable author statementⁱ
- 9614075
in utero embryonic development Source: Ensembl
locomotory behavior Source: Ensembl
multicellular organism growth Source: Ensembl
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9753324
neurotransmitter secretion Source: Reactome
protein-containing complex assembly
Source: ProtInc
Traceable author statementⁱ
- 9614075
- 9753324
regulation of gene expression Source: Ensembl
regulation of synaptic vesicle exocytosis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212676 Dopamine Neurotransmitter Release Cycle R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amyloid-beta A4 precursor protein-binding family A member 1 Alternative name(s): Adapter protein X11alpha Neuron-specific X11 protein Neuronal Munc18-1-interacting protein 1 Short name: Mint-1
Gene namesⁱ	Name:APBA1 Synonyms:MINT1, X11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107282.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:578 APBA1
MIMⁱ	602414 gene
neXtProtⁱ	NX_Q02410

Keywords - Cellular componentⁱ

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	608	F → V: Diminishes interaction with APP. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	320
Open Targets More...OpenTargetsⁱ	ENSG00000107282
PharmGKBⁱ	PA24869

Polymorphism and mutation databases

BioMutaⁱ	APBA1
DMDMⁱ	116241250

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064614	1 – 837	Amyloid-beta A4 precursor protein-binding family A member 1Add BLAST		837

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	78	PhosphoserineBy similarity	1
Modified residueⁱ	242	PhosphoserineBy similarity	1
Modified residueⁱ	246	PhosphoserineBy similarity	1
Modified residueⁱ	248	PhosphoserineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1
Modified residueⁱ	280	PhosphoserineBy similarity	1
Modified residueⁱ	285	PhosphoserineBy similarity	1
Modified residueⁱ	305	PhosphothreonineCombined sources	1
Modified residueⁱ	313	PhosphoserineBy similarity	1
Modified residueⁱ	367	PhosphoserineBy similarity	1
Modified residueⁱ	370	PhosphothreonineCombined sources	1
Modified residueⁱ	401	PhosphoserineBy similarity	1
Modified residueⁱ	403	PhosphoserineBy similarity	1
Modified residueⁱ	408	PhosphoserineBy similarity	1
Modified residueⁱ	568	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q02410
PaxDbⁱ	Q02410
PeptideAtlas More...PeptideAtlasⁱ	Q02410
PRIDEⁱ	Q02410
ProteomicsDBⁱ	58088

PTM databases

iPTMnetⁱ	Q02410
PhosphoSitePlusⁱ	Q02410

Expressionⁱ

Tissue specificityⁱ

Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107282 Expressed in 110 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_APBA1
ExpressionAtlasⁱ	Q02410 baseline and differential
Genevisibleⁱ	Q02410 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA061287

HPAⁱ

HPA061287

Interactionⁱ

Subunit structureⁱ

Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Both isoform 1 and isoform 2 bind to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB. Isoform 2, but not isoform 1, interacts (via its truncated PID domain) with active, GTP-bound RAB6A and RAB6B.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
APP	P05067	3	EBI-368690,EBI-77613
PSEN1	P49768	4	EBI-368690,EBI-297277
RAB6A	P20340-1	4	EBI-9247455,EBI-8851226
RAB6B	Q9NRW1	4	EBI-9247455,EBI-1760079

Protein-protein interaction databases

BioGridⁱ	106817, 14 interactors
CORUMⁱ	Q02410
ELMⁱ	Q02410
IntActⁱ	Q02410, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q02410
STRINGⁱ	9606.ENSP00000265381

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	455 – 457	Combined sources	3
Beta strandⁱ	459 – 472	Combined sources	14
Helixⁱ	479 – 498	Combined sources	20
Beta strandⁱ	516 – 521	Combined sources	6
Beta strandⁱ	523 – 530	Combined sources	8
Turnⁱ	531 – 533	Combined sources	3
Beta strandⁱ	536 – 541	Combined sources	6
Helixⁱ	542 – 544	Combined sources	3
Beta strandⁱ	545 – 551	Combined sources	7
Beta strandⁱ	554 – 559	Combined sources	6
Beta strandⁱ	586 – 593	Combined sources	8
Helixⁱ	597 – 616	Combined sources	20
Beta strandⁱ	655 – 660	Combined sources	6
Beta strandⁱ	669 – 672	Combined sources	4
Beta strandⁱ	676 – 679	Combined sources	4
Beta strandⁱ	684 – 688	Combined sources	5
Beta strandⁱ	690 – 692	Combined sources	3
Helixⁱ	693 – 697	Combined sources	5
Beta strandⁱ	705 – 709	Combined sources	5
Helixⁱ	719 – 727	Combined sources	9
Beta strandⁱ	730 – 740	Combined sources	11
Beta strandⁱ	746 – 756	Combined sources	11
Beta strandⁱ	760 – 764	Combined sources	5
Beta strandⁱ	767 – 771	Combined sources	5
Helixⁱ	777 – 780	Combined sources	4
Beta strandⁱ	786 – 788	Combined sources	3
Helixⁱ	796 – 798	Combined sources	3
Helixⁱ	801 – 809	Combined sources	9
Beta strandⁱ	813 – 821	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q02410
SMRⁱ	Q02410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q02410

EvolutionaryTraceⁱ

Q02410

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	457 – 643	PIDPROSITE-ProRule annotationAdd BLAST	187
Domainⁱ	656 – 742	PDZ 1PROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	747 – 822	PDZ 2PROSITE-ProRule annotationAdd BLAST	76

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	226 – 314	Munc-18-1 bindingAdd BLAST	89
Regionⁱ	373 – 436	LIN-2/CASK bindingAdd BLAST	64
Regionⁱ	626 – 641	Autoinhibitory helix linkerBy similarityAdd BLAST	16

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	67 – 70	Poly-Glu	4
Compositional biasⁱ	294 – 328	Pro-richAdd BLAST	35
Compositional biasⁱ	368 – 452	Pro-richAdd BLAST	85

Domainⁱ

Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

The autoinhibitory helix linker occludes the APP binding site.By similarity

The PID domain, truncated by 11 amino acids, as observed in isoform 2, but not full-length, mediates the interaction with RAB6A and RAB6B.1 Publication

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3605 Eukaryota ENOG410XSBD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013578
HOGENOMⁱ	HOG000033981
HOVERGENⁱ	HBG050523
InParanoidⁱ	Q02410
KEGG Orthology (KO) More...KOⁱ	K04531
OMAⁱ	EEYTENA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PDJ
PhylomeDBⁱ	Q02410
TreeFamⁱ	TF315245

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR030530 Apba1 IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom
PANTHERⁱ	PTHR12345:SF14 PTHR12345:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595 PDZ, 2 hits PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 2 hits SM00462 PTB, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 2 hits
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 2 hits PS01179 PID, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q02410-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR 
        60         70         80         90        100
HQRGRALEDL RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA 
       110        120        130        140        150
RDGYDAERAQ DPEDESAYAV QYRPEAEEYT EQAEAEHAEA THRRALPNHL 
       160        170        180        190        200
HFHSLEHEEA MNAAYSGYVY THRLFHRGED EPYSEPYADY GGLQEHVYEE 
       210        220        230        240        250
IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE RSDGESDSPE 
       260        270        280        290        300
KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 
       310        320        330        340        350
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI 
       360        370        380        390        400
KDIKEAIEEV KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD 
       410        420        430        440        450
SPSPGSSSPL GAESSSTSLH PSDPVEASTN KESRKSLASF PTYVEVPGPC 
       460        470        480        490        500
DPEDLIDGII FAANYLGSTQ LLSDKTPSKN VRMMQAQEAV SRIKMAQKLA 
       510        520        530        540        550
KSRKKAPEGE SQPMTEVDLF ISTQRIKVLN ADTQETMMDH PLRTISYIAD 
       560        570        580        590        600
IGNIVVLMAR RRMPRSNSQE NVEASHPSQD GKRQYKMICH VFESEDAQLI 
       610        620        630        640        650
AQSIGQAFSV AYQEFLRANG INPEDLSQKE YSDLLNTQDM YNDDLIHFSK 
       660        670        680        690        700
SENCKDVFIE KQKGEILGVV IVESGWGSIL PTVIIANMMH GGPAEKSGKL 
       710        720        730        740        750
NIGDQIMSIN GTSLVGLPLS TCQSIIKGLK NQSRVKLNIV RCPPVTTVLI 
       760        770        780        790        800
RRPDLRYQLG FSVQNGIICS LMRGGIAERG GVRVGHRIIE INGQSVVATP 
       810        820        830 
HEKIVHILSN AVGEIHMKTM PAAMYRLLTA QEQPVYI

Length:837

Mass (Da):92,865

Last modified:October 17, 2006 - v3

Checksum:ⁱ29C3620BBC89534B

Isoform 2 (identifier: Q02410-2) [UniParc]FASTA Add to basket

Also known as: Mint1_826

The sequence of this isoform differs from the canonical sequence as follows:
495-505: Missing.

« Hide

        10         20         30         40         50
MNHLEGSAEV EVTDEAAGGE VNESVEADLE HPEVEEEQQQ PPQQQHYVGR 
        60         70         80         90        100
HQRGRALEDL RAQLGQEEEE RGECLARSAS TESGFHNHTD TAEGDVIAAA 
       110        120        130        140        150
RDGYDAERAQ DPEDESAYAV QYRPEAEEYT EQAEAEHAEA THRRALPNHL 
       160        170        180        190        200
HFHSLEHEEA MNAAYSGYVY THRLFHRGED EPYSEPYADY GGLQEHVYEE 
       210        220        230        240        250
IGDAPELDAR DGLRLYEQER DEAAAYRQEA LGARLHHYDE RSDGESDSPE 
       260        270        280        290        300
KEAEFAPYPR MDSYEQEEDI DQIVAEVKQS MSSQSLDKAA EDMPEAEQDL 
       310        320        330        340        350
ERPPTPAGGR PDSPGLQAPA GQQRAVGPAG GGEAGQRYSK EKRDAISLAI 
       360        370        380        390        400
KDIKEAIEEV KTRTIRSPYT PDEPKEPIWV MRQDISPTRD CDDQRPMDGD 
       410        420        430        440        450
SPSPGSSSPL GAESSSTSLH PSDPVEASTN KESRKSLASF PTYVEVPGPC 
       460        470        480        490        500
DPEDLIDGII FAANYLGSTQ LLSDKTPSKN VRMMQAQEAV SRIKAPEGES 
       510        520        530        540        550
QPMTEVDLFI STQRIKVLNA DTQETMMDHP LRTISYIADI GNIVVLMARR 
       560        570        580        590        600
RMPRSNSQEN VEASHPSQDG KRQYKMICHV FESEDAQLIA QSIGQAFSVA 
       610        620        630        640        650
YQEFLRANGI NPEDLSQKEY SDLLNTQDMY NDDLIHFSKS ENCKDVFIEK 
       660        670        680        690        700
QKGEILGVVI VESGWGSILP TVIIANMMHG GPAEKSGKLN IGDQIMSING 
       710        720        730        740        750
TSLVGLPLST CQSIIKGLKN QSRVKLNIVR CPPVTTVLIR RPDLRYQLGF 
       760        770        780        790        800
SVQNGIICSL MRGGIAERGG VRVGHRIIEI NGQSVVATPH EKIVHILSNA 
       810        820 
VGEIHMKTMP AAMYRLLTAQ EQPVYI

Note: This isoform interacts with RAB6 GTPases.

Show »

Length:826

Mass (Da):91,594

Checksum:ⁱDD7B6C1C6D3D9FE7

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0D9SFA9	A0A0D9SFA9_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family A member 1	APBA1	122	Annotation score:
A0A0G2JMD7	A0A0G2JMD7_HUMAN	Amyloid-beta A4 precursor protein-b... Amyloid-beta A4 precursor protein-binding family A member 1	APBA1	437	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	164	A → V in AAA61307 (PubMed:7678331).Curated	1
Sequence conflictⁱ	208	D → H in AAC05304 (PubMed:9395480).Curated	1
Sequence conflictⁱ	427 – 429	AST → VPI in AAC05304 (PubMed:9395480).Curated	3
Sequence conflictⁱ	427 – 429	AST → VPI in AAA61307 (PubMed:7678331).Curated	3
Sequence conflictⁱ	522	S → L in AAC05304 (PubMed:9395480).Curated	1
Sequence conflictⁱ	522	S → L in AAA61307 (PubMed:7678331).Curated	1
Sequence conflictⁱ	563	M → I in AAC05304 (PubMed:9395480).Curated	1
Sequence conflictⁱ	563	M → I in AAA61307 (PubMed:7678331).Curated	1
Sequence conflictⁱ	730	K → E in AAC05304 (PubMed:9395480).Curated	1
Sequence conflictⁱ	730	K → E in AAA61307 (PubMed:7678331).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050664	184	S → A. Corresponds to variant dbSNP:rs34788368Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053518	495 – 505	Missing in isoform 2. CuratedAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029106 mRNA Translation: AAC05304.1 AF047347 mRNA Translation: AAC39766.1 AL353693 Genomic DNA No translation available. AL355140 Genomic DNA No translation available. L04953 mRNA Translation: AAA61307.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6630.1 [Q02410-1]
PIRⁱ	A47176
NCBI Reference Sequences More...RefSeqⁱ	NP_001154.2, NM_001163.3 [Q02410-1] XP_005252025.1, XM_005251968.3 [Q02410-2] XP_011516919.1, XM_011518617.2 [Q02410-1] XP_016870159.1, XM_017014670.1 [Q02410-1]
UniGeneⁱ	Hs.171939 Hs.592974

Genome annotation databases

Ensemblⁱ	ENST00000265381; ENSP00000265381; ENSG00000107282 [Q02410-1]
GeneIDⁱ	320
KEGGⁱ	hsa:320
UCSC genome browser More...UCSCⁱ	uc004ahh.3 human [Q02410-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1 (Fragment)		HUMAN		437	UniRef100_Q02410

Protein	Similar proteins		Species	Score	Length	Source
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1		MOUSE		842	UniRef90_Q02410
Amyloid-beta A4 precursor protein-binding family A member 1	)	RAT		839
Amyloid-beta A4 precursor protein-binding family A member 1 (Fragment)		HUMAN		437
Amyloid beta precursor protein binding family A member 1		CANLF		865
Amyloid beta A4 protein-binding family A member 1		HETGA		844
+145

Protein	Similar proteins		Species	Score	Length	Source
Q02410	Amyloid-beta A4 precursor protein-binding family A member 1		MOUSE		842	UniRef50_Q02410
Amyloid-beta A4 precursor protein-binding family A member 1	)	RAT		839
Amyloid-beta A4 precursor protein-binding family A member 1 (Fragment)		HUMAN		437
Amyloid beta precursor protein binding family A member 1		CANLF		865
Amyloid beta A4 protein-binding family A member 1		HETGA		844
+237

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029106 mRNA Translation: AAC05304.1 AF047347 mRNA Translation: AAC39766.1 AL353693 Genomic DNA No translation available. AL355140 Genomic DNA No translation available. L04953 mRNA Translation: AAA61307.1
CCDSⁱ	CCDS6630.1 [Q02410-1]
PIRⁱ	A47176
RefSeqⁱ	NP_001154.2, NM_001163.3 [Q02410-1] XP_005252025.1, XM_005251968.3 [Q02410-2] XP_011516919.1, XM_011518617.2 [Q02410-1] XP_016870159.1, XM_017014670.1 [Q02410-1]
UniGeneⁱ	Hs.171939 Hs.592974

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AQC	X-ray	2.30	A/B	453-623	[»]
	1U37	NMR	-	A	655-741	[»]
	1U38	NMR	-	A	655-741	[»]
	1U39	NMR	-	A	743-822	[»]
	1U3B	NMR	-	A	655-837	[»]
	1X11	X-ray	2.50	A/B	453-623	[»]
	1X45	NMR	-	A	656-740	[»]
	1Y7N	NMR	-	A	745-823	[»]
ProteinModelPortalⁱ	Q02410
SMRⁱ	Q02410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106817, 14 interactors
CORUMⁱ	Q02410
ELMⁱ	Q02410
IntActⁱ	Q02410, 11 interactors
MINTⁱ	Q02410
STRINGⁱ	9606.ENSP00000265381

PTM databases

iPTMnetⁱ	Q02410
PhosphoSitePlusⁱ	Q02410

Polymorphism and mutation databases

BioMutaⁱ	APBA1
DMDMⁱ	116241250

Proteomic databases

EPDⁱ	Q02410
PaxDbⁱ	Q02410
PeptideAtlasⁱ	Q02410
PRIDEⁱ	Q02410
ProteomicsDBⁱ	58088

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000265381; ENSP00000265381; ENSG00000107282 [Q02410-1]
GeneIDⁱ	320
KEGGⁱ	hsa:320
UCSCⁱ	uc004ahh.3 human [Q02410-1]

Organism-specific databases

CTDⁱ	320
DisGeNETⁱ	320
EuPathDBⁱ	HostDB:ENSG00000107282.7
GeneCardsⁱ	APBA1
HGNCⁱ	HGNC:578 APBA1
HPAⁱ	HPA061287
MIMⁱ	602414 gene
neXtProtⁱ	NX_Q02410
OpenTargetsⁱ	ENSG00000107282
PharmGKBⁱ	PA24869
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3605 Eukaryota ENOG410XSBD LUCA
GeneTreeⁱ	ENSGT00390000013578
HOGENOMⁱ	HOG000033981
HOVERGENⁱ	HBG050523
InParanoidⁱ	Q02410
KOⁱ	K04531
OMAⁱ	EEYTENA
OrthoDBⁱ	EOG091G0PDJ
PhylomeDBⁱ	Q02410
TreeFamⁱ	TF315245

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212676 Dopamine Neurotransmitter Release Cycle R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSⁱ	APBA1 human
EvolutionaryTraceⁱ	Q02410
GeneWikiⁱ	APBA1
GenomeRNAiⁱ	320
Protein Ontology More...PROⁱ	PR:Q02410
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107282 Expressed in 110 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_APBA1
ExpressionAtlasⁱ	Q02410 baseline and differential
Genevisibleⁱ	Q02410 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR030530 Apba1 IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom
PANTHERⁱ	PTHR12345:SF14 PTHR12345:SF14, 1 hit
Pfamⁱ	View protein in Pfam PF00595 PDZ, 2 hits PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 2 hits SM00462 PTB, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 2 hits
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 2 hits PS01179 PID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APBA1_HUMAN
Accessionⁱ	Q02410Primary (citable) accession number: Q02410 Secondary accession number(s): O14914, O60570, Q5VYR8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q02410 (APBA1_HUMAN)

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Amyloid-beta A4 precursor protein-binding family A member 1

APBA1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Gene expression databases

Organism-specific databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ