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Entry version 118 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Golgi apparatus protein 1

Gene

GLG1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils) (By similarity).

Binds fibroblast growth factor (FGF). May be involved in intracellular FGF trafficking and the regulation of cellular responses to FGFS (PubMed:1448090).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandSialic acid

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi apparatus protein 1
Alternative name(s):
Cysteine-rich fibroblast growth factor receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLG1
Synonyms:CFR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 1108ExtracellularSequence analysisAdd BLAST1079
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1109 – 1129HelicalSequence analysisAdd BLAST21
Topological domaini1130 – 1142CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1042 – 1142CAAIP…ELKDR → IVLKCGAMLQRLPQRKASLT LPCKLRPLRPRITYCL in CHO.MUTCFR mutant; unable to regulate FGF levels and is detected throughout the cell. 1 PublicationAdd BLAST101

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001112330 – 1142Golgi apparatus protein 1Add BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Fucosylation is essential for binding to E-selectin.By similarity
N-glycosylated. Contains sialic acid residues.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02391

PRoteomics IDEntifications database

More...
PRIDEi
Q02391

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
676739, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000004317

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 112Cys-rich GLG1 1Add BLAST32
Repeati113 – 175Cys-rich GLG1 2Add BLAST63
Repeati178 – 241Cys-rich GLG1 3Add BLAST64
Repeati249 – 309Cys-rich GLG1 4Add BLAST61
Repeati310 – 376Cys-rich GLG1 5Add BLAST67
Repeati377 – 436Cys-rich GLG1 6Add BLAST60
Repeati438 – 500Cys-rich GLG1 7Add BLAST63
Repeati501 – 567Cys-rich GLG1 8Add BLAST67
Repeati572 – 631Cys-rich GLG1 9Add BLAST60
Repeati633 – 691Cys-rich GLG1 10Add BLAST59
Repeati692 – 751Cys-rich GLG1 11Add BLAST60
Repeati759 – 819Cys-rich GLG1 12Add BLAST61
Repeati821 – 874Cys-rich GLG1 13Add BLAST54
Repeati875 – 942Cys-rich GLG1 14Add BLAST68
Repeati943 – 998Cys-rich GLG1 15Add BLAST56
Repeati1004 – 1064Cys-rich GLG1 16Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 69DisorderedSequence analysisAdd BLAST25

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3648, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02391

Database of Orthologous Groups

More...
OrthoDBi
189325at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02391

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001893, Cys-rich_GLG1_repeat
IPR017873, Cys-rich_GLG1_repeat_euk
IPR039728, GLG1

The PANTHER Classification System

More...
PANTHERi
PTHR11884, PTHR11884, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00839, Cys_rich_FGFR, 15 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51289, GLG1_C_RICH, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q02391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPCGRVRSR CPGPALLLLL ALAARPALAG PPAAALQAGP GLNAAGQPAQ
60 70 80 90 100
GAAPGAAGPR GARGGGGGSG GGWKLSEEAV CREDVVRLCS KHSWANNLAV
110 120 130 140 150
LECLQDVREP DNEISSDCNH LLWNYKLNLT TDPKFESVAR EVCKSTIAEI
160 170 180 190 200
KECADEPVGK GFLVSCLVDH RGNITEYQCH QYITKMTAII FSDYRLICGF
210 220 230 240 250
MDDCKADINL LKCGSIRPGE KDAHSQGEVV ACLEKGLVKE AEENDPRVQV
260 270 280 290 300
SDQCKKAILR VAELSSDDFH LDRHLYFACR DDRERFCENT QAGEGRVYKC
310 320 330 340 350
LFNHKFEESM SEKCRDALTT RQKLIAQDYK VSYSLAKSCK SDLKKYRCNV
360 370 380 390 400
ENLPRSREAR LSYLLMCLES AVHRGRQVSS ECQGEMLDYR RMLMEDFSLS
410 420 430 440 450
PEIILSCRGE IEHHCSGLHR KGRTLHCLMK VVRGEKGNVG LNCQQALQTL
460 470 480 490 500
IQETDPGADY RIDRALNEAC ESVIQTACKH IRSGDPMILS CLMEHLYTEK
510 520 530 540 550
MVEDCEHRLL ELQYFISRDW KLDVVLYRKC QGDASRLCHT HGWNETSELM
560 570 580 590 600
PPGAVFSCLY RHAYRTEEQG RRLSRECRAE VQRILHQRAM DVKLDPALQD
610 620 630 640 650
KCMIDLGKWC SEKTETGQEL ECLQDHLDDL VSDCRDIVGN LTELESEDIQ
660 670 680 690 700
IEALLMRACE PIIQTFCHEV ADNQIDSGDL MECLIQNKHQ KEMNEKCAIG
710 720 730 740 750
VTHFQLVQMK DFRFSYKFKM ACKEDVLKLC PNIKKKVDVV ICLSTTVRND
760 770 780 790 800
TLQDAKEHRV SLKCRKQLRV EELEMTEDIR LEPELYEACK SDIKNYCQNV
810 820 830 840 850
PYGNAQIIEC LKEIKKQLST RCHQKVFKLQ ETEMMDPELD YTLMRVCKQM
860 870 880 890 900
IKRFCPEADS KNMLQCLKQN KNSEVMDPKC KQMITKRQIT QNTDYRLNPV
910 920 930 940 950
LRKACKADIP KFCQNILNRA KDDTELEGQV ISCLKLKYAD QRLSPDCEDQ
960 970 980 990 1000
IRVIIQESAL DYRLDPQLQM HCSEEISSLC AEEAAAQEQT GQVEECLKVN
1010 1020 1030 1040 1050
LLKIKTEMCK KEVLNMLKES KADIFVDPVL HTACALDIKH HCAAIPPGRG
1060 1070 1080 1090 1100
RQMSCLMEAL EDKRVRLQPE CKKRLNDRIE MWSYAAKVAP AEGFSDLAMQ
1110 1120 1130 1140
VMTSPSKNYI LSVITVGICV LFLIGLMCGR ITKRVTRELK DR
Length:1,142
Mass (Da):129,711
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91CC9BE8D53CABB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M95766 mRNA Translation: AAA48769.1
U48395 mRNA Translation: AAB39211.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45031

NCBI Reference Sequences

More...
RefSeqi
NP_990827.1, NM_205496.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396492

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396492

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95766 mRNA Translation: AAA48769.1
U48395 mRNA Translation: AAB39211.1
PIRiA45031
RefSeqiNP_990827.1, NM_205496.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi676739, 1 interactor
STRINGi9031.ENSGALP00000004317

Proteomic databases

PaxDbiQ02391
PRIDEiQ02391

Genome annotation databases

GeneIDi396492
KEGGigga:396492

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2734

Phylogenomic databases

eggNOGiKOG3648, Eukaryota
InParanoidiQ02391
OrthoDBi189325at2759
PhylomeDBiQ02391

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q02391

Family and domain databases

InterProiView protein in InterPro
IPR001893, Cys-rich_GLG1_repeat
IPR017873, Cys-rich_GLG1_repeat_euk
IPR039728, GLG1
PANTHERiPTHR11884, PTHR11884, 1 hit
PfamiView protein in Pfam
PF00839, Cys_rich_FGFR, 15 hits
PROSITEiView protein in PROSITE
PS51289, GLG1_C_RICH, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSLG1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02391
Secondary accession number(s): Q91019
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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