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UniProtKB - Q02385 (SPIKE_CVMJC)

Entry version 111 (02 Dec 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Spike glycoprotein

Gene

S

Organism
Murine coronavirus (strain JHMV / variant CL-2) (MHV) (Murine hepatitis virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.UniRule annotation
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virulence, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoproteinUniRule annotation
Short name:
S glycoproteinUniRule annotation
Alternative name(s):
E2UniRule annotation
Peplomer proteinUniRule annotation
Cleaved into the following 3 chains:
Spike protein S1UniRule annotation
Spike protein S2UniRule annotation
Spike protein S2'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUniRule annotation
ORF Names:3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurine coronavirus (strain JHMV / variant CL-2) (MHV) (Murine hepatitis virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri33735 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiMus musculus (Mouse) [TaxID: 10090]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini14 – 1317ExtracellularUniRule annotationAdd BLAST1304
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1318 – 1338HelicalUniRule annotationAdd BLAST21
Topological domaini1339 – 1376CytoplasmicUniRule annotationAdd BLAST38

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 13UniRule annotationAdd BLAST13
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003721714 – 1376Spike glycoproteinAdd BLAST1363
ChainiPRO_000003721814 – 769Spike protein S1Add BLAST756
ChainiPRO_0000037219770 – 1376Spike protein S2Add BLAST607
ChainiPRO_0000444085922 – 1376Spike protein S2'UniRule annotationAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 158PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi60N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi134N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi153 ↔ 187PROSITE-ProRule annotation
Disulfide bondi165 ↔ 246PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi284 ↔ 294PROSITE-ProRule annotation
Disulfide bondi329 ↔ 354PROSITE-ProRule annotation
Glycosylationi357N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi372 ↔ 425PROSITE-ProRule annotation
Disulfide bondi384 ↔ 616PROSITE-ProRule annotation
Glycosylationi435N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi677N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi709N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi717N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi789N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi806N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi945N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi946 ↔ 957UniRule annotation
Glycosylationi1232N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1242N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1261N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1277N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1298N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. The precursor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins. Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor.UniRule annotation
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei769 – 770Cleavage; by hostBy similarity2
Sitei921 – 922CleavageUniRule annotation2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q02385

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q02385

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 296BetaCoV S1-NTDPROSITE-ProRule annotationAdd BLAST282
Domaini327 – 618BetaCoV S1-CTDPROSITE-ProRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 330Receptor binding siteAdd BLAST316
Regioni312 – 635Receptor-binding domainUniRule annotationAdd BLAST324
Regioni922 – 943Fusion peptide 1UniRule annotationAdd BLAST22
Regioni941 – 961Fusion peptide 2UniRule annotationAdd BLAST21
Regioni1022 – 1072Heptad repeat 1UniRule annotationAdd BLAST51
Regioni1266 – 1306Heptad repeat 2UniRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1051 – 1095UniRule annotationAdd BLAST45
Coiled coili1279 – 1307UniRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1372 – 1376KxHxxUniRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1339 – 1356Cys-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Fusion peptide 1 (FP1) and fusion peptide 2 (FP2) function cooperatively and have a membrane-ordering effect on lipid headgroups and shallow hydrophobic regions of target bilayers. They are considered as two domains of an extended, bipartite FP. The membrane-ordering activity is calcium-dependent and also dependent on correct folding, which is maintained by an internal disulfide bond in FP2.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the betacoronaviruses spike protein family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.790, 1 hit
2.60.120.960, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_04099, BETA_CORONA_SPIKE, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032500, bCoV_S1_N
IPR042578, BETA_CORONA_SPIKE
IPR043607, CoV_S1_C
IPR043473, S2_sf_CoV
IPR027400, S_HR2_CoV
IPR043002, Spike_N_sf
IPR018548, Spike_rcpt-bd_bCoV
IPR036326, Spike_rcpt-bd_sf_CoV
IPR002552, Spike_S2_CoV
IPR043614, Spike_S2_CoV_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16451, bCoV_S1_N, 1 hit
PF09408, bCoV_S1_RBD, 1 hit
PF19209, CoV_S1_C, 1 hit
PF01601, CoV_S2, 1 hit
PF19214, CoV_S2_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111474, SSF111474, 2 hits
SSF143587, SSF143587, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51921, BCOV_S1_CTD, 1 hit
PS51922, BCOV_S1_NTD, 1 hit
PS51923, COV_S2_HR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q02385-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFVFILFLP SCLGYIGDFR CIQTVNYNGN NASAPSISTE AVDVSKGLGT 
        60         70         80         90        100
YYVLDRVYLN ATLLLTGYYP VDGSNYRNLA LTGTNTLSLT WFKPPFLSEF 
       110        120        130        140        150
NDGIFAKVQN LKTNTPTGAT SYFPTIVIGS LFGNTSYTVV LEPYNNIIMA 
       160        170        180        190        200
SVCTYTICQL PYTPCKPNTN GNRVIGFWHT DVKPPICLLK RNFTFNVNAP 
       210        220        230        240        250
WLYFHFYQQG GTFYAYYADK PSATTFLFSV YIGDILTQYF VLPFICTPTA 
       260        270        280        290        300
GSTLLPLYWV TPLLKRQYLF NFNEKGVITS AVDCASSYIS EIKCKTQSLL 
       310        320        330        340        350
PSTGVYDLSG YTVQPVGVVY RRVPNLPDCK IEEWLTAKSV PSPLNWERRT 
       360        370        380        390        400
FQNCNFNLSS LLRYVQAESL SCNNIDASKV YGMCFGSVSV DKFAIPRSRQ 
       410        420        430        440        450
IDLQIGNSGF LQTANYKIDT AATSCQLYYS LPKNNVTINN YNPSSWNRRY 
       460        470        480        490        500
GFNDAGVFGK SKHDVAYAQQ CFIVRPSYCP CAQPDIVSAC TSQTKPMSAY 
       510        520        530        540        550
CPTGTIHREC SLWNGPHLRS ARVGSGTYTC ECTCKPNPFD TYDLRCGQIK 
       560        570        580        590        600
TIVNVGDHCE GLGVLEDKCG NSDPHKGCSC AHDSFIGWSH DTCLVNDHSQ 
       610        620        630        640        650
IFANILLNGI NSGTTCSTDL QLPNTEVATG VCVRYDLYGI TGQGVFKEVK 
       660        670        680        690        700
ADYYNSWQAL LYDVNGNLNG FRDLTTNKTY TIRSCYSGRV SAAYHKEAPE 
       710        720        730        740        750
PALLYRNINC SYVFTNNISR EENPLNYFDS YLGCVVNADN RPDEALPNCD 
       760        770        780        790        800
LRMGAGLCVD YSKSRRARRS VSTGYRLTTF EPYMPMLVND SVQSVGGLYE 
       810        820        830        840        850
MQIPTNFTIG HHEEFIQIRA PKVTIDCAAF VCGDNAACRQ QLVEYGSFCD 
       860        870        880        890        900
NVNAILNEVN NLLDNMQLQV ASALMQGVTI SSRLPDGISG PIDDINFSPL 
       910        920        930        940        950
LGCIGSTCAE DGNGPSAMRG RSAIEDLLFD KVKLSDVGFV EAYNNCTGGQ 
       960        970        980        990       1000
EVRDLLCVQS FNGIKVLPPV LSESQISGYT AGATAAAMFP PWTAAAGVPF 
      1010       1020       1030       1040       1050
SLNVQYRING LGVTMNVLSE NQKMIASAFN NALGAIQEGF DATNSALGKI 
      1060       1070       1080       1090       1100
QSVVNANAEA LNNLLNQLSN RFGAISASLQ EILTRLDRVE AKAQIDRLIN 
      1110       1120       1130       1140       1150
GRLTALNAYI SKQLSDSTLI KFSAAQAIEK VNECVKSQTT RINFCGNGNH 
      1160       1170       1180       1190       1200
ILSLVQNAPY GLCFIHFSYV PTSFKTANVS PGLCISGDRG LAPKAGYFVQ 
      1210       1220       1230       1240       1250
DNGEWKFTGS NYYYPEPITD KNSVVMISCA VNYTKAPEVF LNNSIPNLPD 
      1260       1270       1280       1290       1300
FKEELDKWFK NQTSIAPDLS LDFEKLNVTF LDLTYEMNRI QDAIKKLNES 
      1310       1320       1330       1340       1350
YINLKEVGTY EMYVKWPWYV WLLIGLAGVA VCVLLFFICC CTGCGSCCFR 
      1360       1370 
KCGSCCDEYG GHQDSIVIYN ISAHED
Length:1,376
Mass (Da):152,042
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98C30DDD979F9E75
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D10235 mRNA Translation: BAA01085.1

Protein sequence database of the Protein Information Resource

More...PIRi		JQ1534

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10235 mRNA Translation: BAA01085.1
PIRiJQ1534

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZOKX-ray2.10I/J/K/L510-518[»]
2ZOLX-ray2.70E/F510-518[»]
4PG2X-ray2.80D510-518[»]
SMRiQ02385
ModBaseiSearch...
PDBe-KBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02385

Family and domain databases

Gene3Di1.20.5.790, 1 hit
2.60.120.960, 1 hit
HAMAPiMF_04099, BETA_CORONA_SPIKE, 1 hit
InterProiView protein in InterPro
IPR032500, bCoV_S1_N
IPR042578, BETA_CORONA_SPIKE
IPR043607, CoV_S1_C
IPR043473, S2_sf_CoV
IPR027400, S_HR2_CoV
IPR043002, Spike_N_sf
IPR018548, Spike_rcpt-bd_bCoV
IPR036326, Spike_rcpt-bd_sf_CoV
IPR002552, Spike_S2_CoV
IPR043614, Spike_S2_CoV_C
PfamiView protein in Pfam
PF16451, bCoV_S1_N, 1 hit
PF09408, bCoV_S1_RBD, 1 hit
PF19209, CoV_S1_C, 1 hit
PF01601, CoV_S2, 1 hit
PF19214, CoV_S2_C, 1 hit
SUPFAMiSSF111474, SSF111474, 2 hits
SSF143587, SSF143587, 1 hit
PROSITEiView protein in PROSITE
PS51921, BCOV_S1_CTD, 1 hit
PS51922, BCOV_S1_NTD, 1 hit
PS51923, COV_S2_HR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_CVMJC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02385
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 2, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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