Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Semenogelin-2

Gene

SEMG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

GO - Molecular functioni

  • metal ion binding Source: UniProtKB
  • protease binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Semenogelin-2
Alternative name(s):
Semenogelin II
Short name:
SGII
Gene namesi
Name:SEMG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124157.6
HGNCiHGNC:10743 SEMG2
MIMi182141 gene
neXtProtiNX_Q02383

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124157
PharmGKBiPA35665

Polymorphism and mutation databases

BioMutaiSEMG2
DMDMi401079

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000003235924 – 582Semenogelin-2Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi272N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ02383
PeptideAtlasiQ02383
PRIDEiQ02383
ProteomicsDBi58084

PTM databases

iPTMnetiQ02383
PhosphoSitePlusiQ02383

Miscellaneous databases

PMAP-CutDBiQ02383

Expressioni

Tissue specificityi

Seminal vesicles, and to a much lesser extent, epididymis.

Gene expression databases

BgeeiENSG00000124157 Expressed in 26 organ(s), highest expression level in seminal vesicle
CleanExiHS_SEMG2
GenevisibleiQ02383 HS

Organism-specific databases

HPAiHPA042767
HPA042835

Interactioni

Subunit structurei

Interacts with SERPINA5.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112307, 26 interactors
IntActiQ02383, 5 interactors
MINTiQ02383
STRINGi9606.ENSP00000361855

Structurei

3D structure databases

ProteinModelPortaliQ02383
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 1293-1Add BLAST60
Repeati141 – 2002-1Add BLAST60
Repeati201 – 2602-2Add BLAST60
Repeati501 – 5593-2Add BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 559Repeat-rich regionAdd BLAST490
Regioni261 – 5004 X 60 AA tandem repeats, type IAdd BLAST240

Sequence similaritiesi

Belongs to the semenogelin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KG9B Eukaryota
ENOG4110SI0 LUCA
GeneTreeiENSGT00390000020321
HOGENOMiHOG000263413
HOVERGENiHBG054194
InParanoidiQ02383
OMAiTEEKIHG
OrthoDBiEOG091G03E6
PhylomeDBiQ02383
TreeFamiTF342360

Family and domain databases

InterProiView protein in InterPro
IPR008836 Semenogelin
PfamiView protein in Pfam
PF05474 Semenogelin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02383-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG
60 70 80 90 100
QKDQQHTKSK GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL
110 120 130 140 150
GGSQQLLNYK QEGRDHDKSK GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP
160 170 180 190 200
SGKGLSSQCS NTEKRLWVHG LSKEQASASG AQKGRTQGGS QSSYVLQTEE
210 220 230 240 250
LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP AHQDRLQHGP
260 270 280 290 300
KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH
310 320 330 340 350
GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS
360 370 380 390 400
SSTEERHLNC GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG
410 420 430 440 450
HKENKISYQS SSTEERRLNS GEKDVQKGVS KGSISIQTEE KIHGKSQNQV
460 470 480 490 500
TIPSQDQEHG HKENKMSYQS SSTEERRLNY GGKSTQKDVS QSSISFQIEK
510 520 530 540 550
LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH EQKGRYKQES
560 570 580
SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST
Length:582
Mass (Da):65,444
Last modified:July 1, 1993 - v1
Checksum:iEBF63FBF3A8EC45B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03448943Q → K. Corresponds to variant dbSNP:rs2233896Ensembl.1
Natural variantiVAR_03449057T → A. Corresponds to variant dbSNP:rs2233897Ensembl.1
Natural variantiVAR_024630274S → N1 PublicationCorresponds to variant dbSNP:rs2233901Ensembl.1
Natural variantiVAR_034491279H → Y. Corresponds to variant dbSNP:rs2233903Ensembl.1
Natural variantiVAR_024631368G → R1 PublicationCorresponds to variant dbSNP:rs2071650Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81652 mRNA Translation: AAA60562.1
M81651 Genomic DNA Translation: AAA60313.1
Z47556 Genomic DNA Translation: CAA87637.1
AY259284 Genomic DNA Translation: AAP86625.1
AY259285 Genomic DNA Translation: AAP86626.1
AY259286 Genomic DNA Translation: AAP86627.1
AL049767 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75870.1
CCDSiCCDS13346.1
PIRiA43412
RefSeqiNP_002999.1, NM_003008.2
UniGeneiHs.537218

Genome annotation databases

EnsembliENST00000372769; ENSP00000361855; ENSG00000124157
GeneIDi6407
KEGGihsa:6407
UCSCiuc002xnk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Shackled sperm - Issue 62 of September 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81652 mRNA Translation: AAA60562.1
M81651 Genomic DNA Translation: AAA60313.1
Z47556 Genomic DNA Translation: CAA87637.1
AY259284 Genomic DNA Translation: AAP86625.1
AY259285 Genomic DNA Translation: AAP86626.1
AY259286 Genomic DNA Translation: AAP86627.1
AL049767 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75870.1
CCDSiCCDS13346.1
PIRiA43412
RefSeqiNP_002999.1, NM_003008.2
UniGeneiHs.537218

3D structure databases

ProteinModelPortaliQ02383
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112307, 26 interactors
IntActiQ02383, 5 interactors
MINTiQ02383
STRINGi9606.ENSP00000361855

PTM databases

iPTMnetiQ02383
PhosphoSitePlusiQ02383

Polymorphism and mutation databases

BioMutaiSEMG2
DMDMi401079

Proteomic databases

PaxDbiQ02383
PeptideAtlasiQ02383
PRIDEiQ02383
ProteomicsDBi58084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372769; ENSP00000361855; ENSG00000124157
GeneIDi6407
KEGGihsa:6407
UCSCiuc002xnk.4 human

Organism-specific databases

CTDi6407
EuPathDBiHostDB:ENSG00000124157.6
GeneCardsiSEMG2
HGNCiHGNC:10743 SEMG2
HPAiHPA042767
HPA042835
MIMi182141 gene
neXtProtiNX_Q02383
OpenTargetsiENSG00000124157
PharmGKBiPA35665
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KG9B Eukaryota
ENOG4110SI0 LUCA
GeneTreeiENSGT00390000020321
HOGENOMiHOG000263413
HOVERGENiHBG054194
InParanoidiQ02383
OMAiTEEKIHG
OrthoDBiEOG091G03E6
PhylomeDBiQ02383
TreeFamiTF342360

Miscellaneous databases

GeneWikiiSEMG2
GenomeRNAii6407
PMAP-CutDBiQ02383
PROiPR:Q02383
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124157 Expressed in 26 organ(s), highest expression level in seminal vesicle
CleanExiHS_SEMG2
GenevisibleiQ02383 HS

Family and domain databases

InterProiView protein in InterPro
IPR008836 Semenogelin
PfamiView protein in Pfam
PF05474 Semenogelin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEMG2_HUMAN
AccessioniPrimary (citable) accession number: Q02383
Secondary accession number(s): Q53ZU2, Q6X2M5, Q6X2M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again