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UniProtKB - Q02382 (RDRP_LRVLG)
Protein
Probable RNA-directed RNA polymerase
Gene
ORF3
Organism
Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1)
Status
Functioni
RNA-dependent RNA polymerase which replicates the viral genome. Catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded from the virion into the cytoplasm where they function as mRNAs for translation of viral proteins and also as substrates for encapsidation to form new virions. Once encapsidated, the positive strand is converted to dsRNA by the RNA-directed RNA polymerase. Displays ssRNA-binding activity (By similarity).
By similarityCatalytic activityi
- EC:2.7.7.48
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
- nucleotide binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Hydrolase, Nucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Ligand | Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ORF3 |
Organismi | Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) |
Taxonomic identifieri | 58103 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Duplornaviricota › Chrymotiviricetes › Ghabrivirales › Totiviridae › Leishmaniavirus › |
Virus hosti | Leishmania major [TaxID: 5664] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404517 | 1 – 874 | Probable RNA-directed RNA polymeraseAdd BLAST | 874 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the totiviridae RNA-directed RNA polymerase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR001795, RNA-dir_pol_luteovirus |
Pfami | View protein in Pfam PF02123, RdRP_4, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
i Sequence
Sequence statusi: Complete.
Q02382-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQCPNQNHML VNRAMVVAAL DSFEDARRII SGVLDLSRLT NTSVKGQHTN
60 70 80 90 100
DTNYFSRYSN FFSQMPAIIL NQLKCCIKAQ VDDAVKMVLQ KAKKVEVSKP
110 120 130 140 150
VEKMLTFTTL NTYLGYPEST GCVMEYTEEQ SGPIAAKLLI TLLSSTLNAM
160 170 180 190 200
VRPKSDPNIS QNKIPRHYYQ LKVHVGAQKK VNLTAIEVIR GCQHECSVVY
210 220 230 240 250
CEFVRYSAYF AGLYDDQVAA ILLYAVAAHN VQGFGARFCV LWALMCVRIA
260 270 280 290 300
GFADDINIYI KHRGMSGLLP QLVEMKCLLG RGVNEIDVET EARRRLDVGS
310 320 330 340 350
LSMQRLDENE LRAAVRLIYS EELRRPVTYP LICDFWSSRW LWAANGSHSR
360 370 380 390 400
ALEHAHPELA TRKEGQAYRK AVMEQWQHNP MDRWDGTVYV TPSAKLEHGK
410 420 430 440 450
TRLLLACDTL SYMWFEYALR PVERIWENSN VILDPGSMGN CGIATRINGW
460 470 480 490 500
RNGMPGQSFF AVDYDDFNSQ HTLMSQKIVF EELFHHIGYN ASWVKTLVDS
510 520 530 540 550
FDSMELWIKG KCAGIMAGTL MSGHRATSFI NSVLNRAYII CAGGHVPTSM
560 570 580 590 600
HVGDDILMSC TLGHADNLIA NLNRKGVRLN ASKQVFSKTS GEFLRVAHRE
610 620 630 640 650
HTSHGYLARV ISSAVSGNWV SDHTLNQQEA LMNAIVCCRG ILNRSLPGEK
660 670 680 690 700
NPVVRVISRS VSKRTKIEEK TIRLLLSGRA CLKGGVVYGE QTNYIQVYRI
710 720 730 740 750
NCRVERSEEK LPPYRHATED YLNNHLADIE VMAVRQYGSD IADIMAQASW
760 770 780 790 800
KKSMSTEGAE DVSRLSLQRD KTLPCLHCIT EKETSLLPVR YGLFSSYPIL
810 820 830 840 850
MMLKDRIPIK EALKLAVTIG YRPQPNSDLE LDLWGESNNS CAIEGVLPYN
860 870
EATSLAQKLP CGGVVIQVIH NVYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92355 Genomic RNA Translation: AAB50024.1 |
PIRi | C46171 |
RefSeqi | NP_041191.1, NC_002063.1 |
Genome annotation databases
GeneIDi | 1446405 |
KEGGi | vg:1446405 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92355 Genomic RNA Translation: AAB50024.1 |
PIRi | C46171 |
RefSeqi | NP_041191.1, NC_002063.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 1446405 |
KEGGi | vg:1446405 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR001795, RNA-dir_pol_luteovirus |
Pfami | View protein in Pfam PF02123, RdRP_4, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_LRVLG | |
Accessioni | Q02382Primary (citable) accession number: Q02382 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | November 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families