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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

NDUFC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:NDUFC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:31968 NDUFC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 59HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionAdd BLAST27
ChainiPRO_000002004828 – 76NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialAdd BLAST49

Proteomic databases

PaxDbiQ02376

Expressioni

Gene expression databases

BgeeiENSBTAG00000039582

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.3 Publications

Protein-protein interaction databases

CORUMiQ02376
DIPiDIP-38817N
IntActiQ02376, 1 interactor
STRINGi9913.ENSBTAP00000051891

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35c1-76[»]
5LDWelectron microscopy4.27c28-76[»]
5LDXelectron microscopy5.60c28-76[»]
5LNKelectron microscopy3.90x28-76[»]
5O31electron microscopy4.13c28-76[»]
SMRiQ02376
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MG Eukaryota
ENOG410XUGS LUCA
GeneTreeiENSGT00390000002565
HOGENOMiHOG000013086
HOVERGENiHBG006500
InParanoidiQ02376
KOiK03967
OMAiNAKPDWL
OrthoDBiEOG091G14QE
TreeFamiTF338333

Family and domain databases

InterProiView protein in InterPro
IPR026192 NDUFC1
PANTHERiPTHR17097 PTHR17097, 1 hit
PfamiView protein in Pfam
PF15088 NADH_dh_m_C1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSALLRPF WKLLAPARFP SVSSSRSKFY IQEPPHGSPN WLKVGLTLGT
60 70
SVFLWIYLIK QHNEDVLEYK RRNGLE
Length:76
Mass (Da):8,784
Last modified:July 1, 1993 - v1
Checksum:i326286716C4394F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63214 mRNA Translation: CAA44899.1
BC102392 mRNA Translation: AAI02393.1
PIRiS28250
RefSeqiNP_776989.1, NM_174564.2
XP_005217593.1, XM_005217536.2
UniGeneiBt.98783

Genome annotation databases

EnsembliENSBTAT00000055713; ENSBTAP00000051891; ENSBTAG00000039582
GeneIDi282289
KEGGibta:282289

Similar proteinsi

Entry informationi

Entry nameiNDUC1_BOVIN
AccessioniPrimary (citable) accession number: Q02376
Secondary accession number(s): Q3T0H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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