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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

NDUFS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
Complex I-AQDQ
Short name:
CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesi
Name:NDUFS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:50229 NDUFS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionAdd BLAST42
ChainiPRO_000002003743 – 175NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST133

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02375
PeptideAtlasiQ02375
PRIDEiQ02375

PTM databases

iPTMnetiQ02375

Expressioni

Gene expression databases

BgeeiENSBTAG00000003728

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.2 Publications

Protein-protein interaction databases

CORUMiQ02375
DIPiDIP-38808N
IntActiQ02375, 3 interactors
STRINGi9913.ENSBTAP00000044670

Structurei

3D structure databases

ProteinModelPortaliQ02375
SMRiQ02375
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3389 Eukaryota
ENOG4111TR4 LUCA
GeneTreeiENSGT00390000013835
HOGENOMiHOG000140414
HOVERGENiHBG003007
InParanoidiQ02375
KOiK03937
OMAiNDLMGYQ
OrthoDBiEOG091G0LT1
TreeFamiTF105619

Family and domain databases

Gene3Di3.30.160.190, 1 hit
InterProiView protein in InterPro
IPR006885 NADH_UbQ_FeS_4_mit
IPR038532 NDUFS4-like_sf
PANTHERiPTHR12219 PTHR12219, 1 hit
PfamiView protein in Pfam
PF04800 ETC_C1_NDUFA4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSMSVAL RQALWGRRVA TVAAVSVSKV STRSLSTSTW RLAQDQTRDT
60 70 80 90 100
QLITVDEKLD ITTITGVPEE HIKTRKARIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNLVLTFST KEDAVAFAEK NGWSYDVEER
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):19,812
Last modified:July 1, 1993 - v1
Checksum:iC77BE67FE6E5A407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63215 mRNA Translation: CAA44900.1
PIRiS28240
RefSeqiNP_786994.1, NM_175800.2
UniGeneiBt.58

Genome annotation databases

EnsembliENSBTAT00000047463; ENSBTAP00000044670; ENSBTAG00000003728
GeneIDi327680
KEGGibta:327680

Similar proteinsi

Entry informationi

Entry nameiNDUS4_BOVIN
AccessioniPrimary (citable) accession number: Q02375
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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