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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

NDUFA6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB-KW
  • response to oxidative stress Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6By similarity
Alternative name(s):
Complex I-B14
Short name:
CI-B14
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:NDUFA6By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:31950 NDUFA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001743012 – 128NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ02366
PRIDEiQ02366

PTM databases

iPTMnetiQ02366

Expressioni

Gene expression databases

BgeeiENSBTAG00000009509

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

CORUMiQ02366
DIPiDIP-38828N
IntActiQ02366, 3 interactors
STRINGi9913.ENSBTAP00000012512

Structurei

3D structure databases

SMRiQ02366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3426 Eukaryota
ENOG4111S2F LUCA
GeneTreeiENSGT00390000018898
HOGENOMiHOG000200993
HOVERGENiHBG002032
InParanoidiQ02366
KOiK03950
OMAiEWIRAAP
OrthoDBiEOG091G0UGT
TreeFamiTF105625

Family and domain databases

InterProiView protein in InterPro
IPR008011 Complex1_LYR
IPR016488 NADH_Ub_cplx-1_asu_su-6
PANTHERiPTHR12964 PTHR12964, 1 hit
PfamiView protein in Pfam
PF05347 Complex1_LYR, 1 hit
PIRSFiPIRSF006643 NDUA6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGLRQAA VAASTSVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHLF
60 70 80 90 100
QLDISVKQGR DKVREMFKKN AHITDPRVVD LLVIKGKMEL EETIKVWKQR
110 120
THVMRFFHET EAPRPKDFLS KFYVGHDP
Length:128
Mass (Da):15,053
Last modified:January 23, 2007 - v2
Checksum:i4DB92284502488BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63211 mRNA Translation: CAA44896.1
BC102430 mRNA Translation: AAI02431.1
PIRiS28245
RefSeqiNP_786985.1, NM_175791.2
UniGeneiBt.63

Genome annotation databases

EnsembliENSBTAT00000012512; ENSBTAP00000012512; ENSBTAG00000009509
GeneIDi327670
KEGGibta:327670

Similar proteinsi

Entry informationi

Entry nameiNDUA6_BOVIN
AccessioniPrimary (citable) accession number: Q02366
Secondary accession number(s): Q3T0E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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