UniProtKB - Q02365 (NDUB3_BOVIN)
Protein
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Gene
NDUFB3
Organism
Bos taurus (Bovine)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity
GO - Biological processi
- electron transport chain Source: InterPro
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-BTA-611105, Respiratory electron transport R-BTA-6799198, Complex I biogenesis |
Protein family/group databases
TCDBi | 3.D.1.6.1, the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3Alternative name(s): Complex I-B12 Short name: CI-B12 NADH-ubiquinone oxidoreductase B12 subunit |
Gene namesi | Name:NDUFB3 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:31963, NDUFB3 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Single-pass membrane protein Curated; Matrix side Curated
Mitochondrion
- mitochondrial respiratory chain complex I Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 61 – 83 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000118796 | 2 – 98 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3Add BLAST | 97 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine; partial1 Publication | 1 | |
Modified residuei | 5 | Methylhistidine; partial1 Publication | 1 | |
Modified residuei | 7 | Methylhistidine; partial1 Publication | 1 | |
Modified residuei | 9 | Methylhistidine; partial1 Publication | 1 | |
Modified residuei | 23 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 23 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
Acetylation, MethylationProteomic databases
PaxDbi | Q02365 |
PRIDEi | Q02365 |
PTM databases
iPTMneti | Q02365 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012760, Expressed in longissimus thoracis muscle and 19 other tissues |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
1 PublicationProtein-protein interaction databases
CORUMi | Q02365 |
DIPi | DIP-38800N |
IntActi | Q02365, 3 interactors |
STRINGi | 9913.ENSBTAP00000016957 |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFB3 subunit family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4631, Eukaryota |
GeneTreei | ENSGT00390000010316 |
HOGENOMi | CLU_160226_1_0_1 |
InParanoidi | Q02365 |
OMAi | EAWRYEP |
OrthoDBi | 1568057at2759 |
TreeFami | TF319656 |
Family and domain databases
InterProi | View protein in InterPro IPR012576, NDUFB3 |
PANTHERi | PTHR15082, PTHR15082, 1 hit |
Pfami | View protein in Pfam PF08122, NDUF_B12, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q02365-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHGHGHEHG PSKMELPDYK QWKIEGTPLE TVQEKLAARG LRDPWGRNEA
60 70 80 90
WRYMGGFANN VSFVGALLKG FKWGFAAFVV AIGAEYYLES QKKDKKHH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63213 mRNA Translation: CAA44898.1 BC105433 mRNA Translation: AAI05434.1 |
PIRi | S28243 |
RefSeqi | NP_788840.1, NM_176667.2 |
Genome annotation databases
Ensembli | ENSBTAT00000016957; ENSBTAP00000016957; ENSBTAG00000012760 |
GeneIDi | 338073 |
KEGGi | bta:338073 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63213 mRNA Translation: CAA44898.1 BC105433 mRNA Translation: AAI05434.1 |
PIRi | S28243 |
RefSeqi | NP_788840.1, NM_176667.2 |
3D structure databases
SMRi | Q02365 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | Q02365 |
DIPi | DIP-38800N |
IntActi | Q02365, 3 interactors |
STRINGi | 9913.ENSBTAP00000016957 |
Protein family/group databases
TCDBi | 3.D.1.6.1, the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family |
PTM databases
iPTMneti | Q02365 |
Proteomic databases
PaxDbi | Q02365 |
PRIDEi | Q02365 |
Genome annotation databases
Ensembli | ENSBTAT00000016957; ENSBTAP00000016957; ENSBTAG00000012760 |
GeneIDi | 338073 |
KEGGi | bta:338073 |
Organism-specific databases
CTDi | 4709 |
VGNCi | VGNC:31963, NDUFB3 |
Phylogenomic databases
eggNOGi | KOG4631, Eukaryota |
GeneTreei | ENSGT00390000010316 |
HOGENOMi | CLU_160226_1_0_1 |
InParanoidi | Q02365 |
OMAi | EAWRYEP |
OrthoDBi | 1568057at2759 |
TreeFami | TF319656 |
Enzyme and pathway databases
Reactomei | R-BTA-611105, Respiratory electron transport R-BTA-6799198, Complex I biogenesis |
Gene expression databases
Bgeei | ENSBTAG00000012760, Expressed in longissimus thoracis muscle and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR012576, NDUFB3 |
PANTHERi | PTHR15082, PTHR15082, 1 hit |
Pfami | View protein in Pfam PF08122, NDUF_B12, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUB3_BOVIN | |
Accessioni | Q02365Primary (citable) accession number: Q02365 Secondary accession number(s): Q2KJB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families