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Entry version 128 (02 Dec 2020)
Sequence version 1 (01 Jul 1993)
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Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene

CACNA1E

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei309Calcium ion selectivity and permeabilityBy similarity1
Sitei657Calcium ion selectivity and permeabilityBy similarity1
Sitei1362Calcium ion selectivity and permeabilityBy similarity1
Sitei1653Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi426 – 437PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1742 – 1753PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
Brain calcium channel II
Short name:
BII
Calcium channel, L type, alpha-1 polypeptide, isoform 6
Voltage-gated calcium channel subunit alpha Cav2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1E
Synonyms:CACH6, CACNL1A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 89CytoplasmicSequence analysisAdd BLAST89
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei90 – 108Helical; Name=S1 of repeat IAdd BLAST19
Topological domaini109 – 126ExtracellularSequence analysisAdd BLAST18
Transmembranei127 – 146Helical; Name=S2 of repeat IAdd BLAST20
Topological domaini147 – 158CytoplasmicSequence analysisAdd BLAST12
Transmembranei159 – 176Helical; Name=S3 of repeat IAdd BLAST18
Topological domaini177 – 185ExtracellularSequence analysis9
Transmembranei186 – 204Helical; Name=S4 of repeat IAdd BLAST19
Topological domaini205 – 223CytoplasmicSequence analysisAdd BLAST19
Transmembranei224 – 243Helical; Name=S5 of repeat IAdd BLAST20
Topological domaini244 – 326ExtracellularSequence analysisAdd BLAST83
Transmembranei327 – 351Helical; Name=S6 of repeat IAdd BLAST25
Topological domaini352 – 476CytoplasmicSequence analysisAdd BLAST125
Transmembranei477 – 495Helical; Name=S1 of repeat IIAdd BLAST19
Topological domaini496 – 510ExtracellularSequence analysisAdd BLAST15
Transmembranei511 – 530Helical; Name=S2 of repeat IIAdd BLAST20
Topological domaini531 – 538CytoplasmicSequence analysis8
Transmembranei539 – 557Helical; Name=S3 of repeat IIAdd BLAST19
Topological domaini558 – 567ExtracellularSequence analysis10
Transmembranei568 – 586Helical; Name=S4 of repeat IIAdd BLAST19
Topological domaini587 – 605CytoplasmicSequence analysisAdd BLAST19
Transmembranei606 – 625Helical; Name=S5 of repeat IIAdd BLAST20
Topological domaini626 – 678ExtracellularSequence analysisAdd BLAST53
Transmembranei679 – 703Helical; Name=S6 of repeat IIAdd BLAST25
Topological domaini704 – 1143CytoplasmicSequence analysisAdd BLAST440
Transmembranei1144 – 1162Helical; Name=S1 of repeat IIIAdd BLAST19
Topological domaini1163 – 1178ExtracellularSequence analysisAdd BLAST16
Transmembranei1179 – 1198Helical; Name=S2 of repeat IIIAdd BLAST20
Topological domaini1199 – 1210CytoplasmicSequence analysisAdd BLAST12
Transmembranei1211 – 1229Helical; Name=S3 of repeat IIIAdd BLAST19
Topological domaini1230 – 1243ExtracellularSequence analysisAdd BLAST14
Transmembranei1244 – 1262Helical; Name=S4 of repeat IIIAdd BLAST19
Topological domaini1263 – 1281CytoplasmicSequence analysisAdd BLAST19
Transmembranei1282 – 1301Helical; Name=S5 of repeat IIIAdd BLAST20
Topological domaini1302 – 1388ExtracellularSequence analysisAdd BLAST87
Transmembranei1389 – 1413Helical; Name=S6 of repeat IIIAdd BLAST25
Topological domaini1414 – 1468CytoplasmicSequence analysisAdd BLAST55
Transmembranei1469 – 1487Helical; Name=S1 of repeat IVAdd BLAST19
Topological domaini1488 – 1502ExtracellularSequence analysisAdd BLAST15
Transmembranei1503 – 1522Helical; Name=S2 of repeat IVAdd BLAST20
Topological domaini1523 – 1530CytoplasmicSequence analysis8
Transmembranei1531 – 1549Helical; Name=S3 of repeat IVAdd BLAST19
Topological domaini1550 – 1561ExtracellularSequence analysisAdd BLAST12
Transmembranei1562 – 1580Helical; Name=S4 of repeat IVAdd BLAST19
Topological domaini1581 – 1599CytoplasmicSequence analysisAdd BLAST19
Transmembranei1600 – 1619Helical; Name=S5 of repeat IVAdd BLAST20
Topological domaini1620 – 1688ExtracellularSequence analysisAdd BLAST69
Transmembranei1689 – 1712Helical; Name=S6 of repeat IVAdd BLAST24
Topological domaini1713 – 2259CytoplasmicSequence analysisAdd BLAST547

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539401 – 2259Voltage-dependent R-type calcium channel subunit alpha-1EAdd BLAST2259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei427PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei745PhosphoserineBy similarity1
Modified residuei793PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1
Modified residuei853PhosphoserineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei1088PhosphoserineBy similarity1
Glycosylationi1556N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1561N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2041PhosphoserineBy similarity1
Modified residuei2060PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q02343

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in the cerebral cortex, hippocampus, and corpus striatum.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9986.ENSOCUP00000015082

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati76 – 354IAdd BLAST279
Repeati464 – 706IIAdd BLAST243
Repeati1130 – 1414IIIAdd BLAST285
Repeati1453 – 1716IVAdd BLAST264
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1729 – 1764EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni374 – 391Binding to the beta subunitBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi716 – 721Poly-Glu6
Compositional biasi748 – 753Poly-Arg6
Compositional biasi767 – 772Poly-Arg6
Compositional biasi1218 – 1221Poly-Val4
Compositional biasi1976 – 1979Poly-Ser4
Compositional biasi2231 – 2235Poly-Arg5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02343

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005449, VDCC_R_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45628:SF5, PTHR45628:SF5, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01633, RVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform BII-1 (identifier: Q02343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARFGEAAAG RPASGEGDSD QGRNLPGTPV PASGSAAAYK QSKAQRARTM
60 70 80 90 100
ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII
110 120 130 140 150
ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF
160 170 180 190 200
HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL
210 220 230 240 250
VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA
260 270 280 290 300
CFVNNSGVLE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL
310 320 330 340 350
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL
360 370 380 390 400
SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK
410 420 430 440 450
NSGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA
460 470 480 490 500
KVDGASYFRH KERLLRISVR HAVKSQVFYW IVLSLVALNT ACVAIVHHNQ
510 520 530 540 550
PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG
560 570 580 590 600
SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
610 620 630 640 650
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV
660 670 680 690 700
FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA VYFIVLTLFG NYTLLNVFLA
710 720 730 740 750
IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNVPSIERDR
760 770 780 790 800
RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRRHMQ MSSQEALNKE
810 820 830 840 850
EAPPMNPLNP LNPLSPLNPL NAHPSLYRRP RPMEGLALGL EKCEEEHVSR
860 870 880 890 900
GGSLKGALDC QRSPLSLGRR EPPWLARPCH GNCEPALQET AGGETVVTFE
910 920 930 940 950
DRARHRQSQR RSRHRRVRTE AKESSSASRS RSVSQERSLD EGASTEGERD
960 970 980 990 1000
HEARGSHGGK EPTIHEEERA QDLRRTDSLM VPKGSGLAGG LDEAGTPLVL
1010 1020 1030 1040 1050
SSPEGVGKEA APTEQHADGS GEPALLGHVQ LDVGRAISQS EPDLSCVTAT
1060 1070 1080 1090 1100
TDKVTTESTD VTVAIPDAEP LVDSTVVHIG NKTDGEASPF QEAEMKEAEQ
1110 1120 1130 1140 1150
ETEKQKKKER PASGKAMVPH SSMFIFSTSN PIRRACHYVV NLRYFEMCIL
1160 1170 1180 1190 1200
LVIAASSIAL AAEDPVLTNS ERNRVLRYFD YVFTGVFTFE MVIKMIDQGL
1210 1220 1230 1240 1250
ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD IKTIKSLRVL
1260 1270 1280 1290 1300
RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM FIFAVIAVQL
1310 1320 1330 1340 1350
FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR HEFHYDNIIW
1360 1370 1380 1390 1400
ALLTLFTVST GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS IFYVVYFVVF
1410 1420 1430 1440 1450
PFFFVNIFVA LIIITFQEQG DKMMEECSLE KNERACIDFA ISAKPLTRYM
1460 1470 1480 1490 1500
PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY SAPCTYELAL
1510 1520 1530 1540 1550
KYLNIAFTMV FSLECVLKVI AFGFVNYFRD TWNIFDFITV IGSITEIVLT
1560 1570 1580 1590 1600
DSKLVNTTGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF VQSFKALPYV
1610 1620 1630 1640 1650
CLLIAMLFFI YAIIGMQVFG NIRLDEESHI NRHNNFRSFF GSLMLLFRSA
1660 1670 1680 1690 1700
TGEAWQEIML SCLGEKGCEP DTTAPSGQQE SERCGTDLAY VYFVSFIFFC
1710 1720 1730 1740 1750
SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFVRVWAE YDRAACGRIH
1760 1770 1780 1790 1800
YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED MTVHFTSTLM
1810 1820 1830 1840 1850
ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM LDLLVPMPKA
1860 1870 1880 1890 1900
SDLTVGKIYA AMMIMDYYKQ SKVKKQRRQL EEQKNAPMFQ RMEPSSLPQE
1910 1920 1930 1940 1950
IIANAKALPC LPQGPPAGLG GRSGCPAMSP LSPQIFQLTC MDPADDDGQF
1960 1970 1980 1990 2000
QEQRSLVVTD PGSMRRSFST IRDKRSSSSW LEEFSMERSS DNTYKSRRRS
2010 2020 2030 2040 2050
YHSSLRLSAH RLNSDSGHKS DTHRSGGRER GRSKEREHLL SADVSRCSSE
2060 2070 2080 2090 2100
ERGAQADWDS PERHPSRSPS EGRSQSPSRQ GTGSLSESSI PSVSDTSTPR
2110 2120 2130 2140 2150
HSRRQLPPVP PKPRPLLSYS SLKQQPSNFS PPADGSQGGS LLASPALESA
2160 2170 2180 2190 2200
QVGLPESSDS PRRAQGSHAS PQRYISEPYL ALHEDSHASD CGEEETLTFE
2210 2220 2230 2240 2250
AAVATSLGRS NTIGSAPPLR HSWQMPNGHY RRRRRGGPGA GALCGAVGDL

LSDTEEDKC
Length:2,259
Mass (Da):254,252
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4A757076E38779E
GO
Isoform BII-2 (identifier: Q02343-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2101-2259: HSRRQLPPVP...LLSDTEEDKC → QQWGPQEEGV...AGGTCDSLSP

Show »
Length:2,178
Mass (Da):245,599
Checksum:iB3DC01D072AD7C15
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0009382101 – 2259HSRRQ…EEDKC → QQWGPQEEGVLLHPHQGCGW PCRDRRWMPGRRGWSGEKSH SPLPHCGRDSTGGAGQGPPR YCGSGAGDAGGTCDSLSP in isoform BII-2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67855 mRNA Translation: CAA48040.1
X67856 mRNA Translation: CAA48041.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S29236
S29237

NCBI Reference Sequences

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RefSeqi
NP_001095186.1, NM_001101716.1 [Q02343-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100009403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ocu:100009403

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67855 mRNA Translation: CAA48040.1
X67856 mRNA Translation: CAA48041.1
PIRiS29236
S29237
RefSeqiNP_001095186.1, NM_001101716.1 [Q02343-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015082

Proteomic databases

PRIDEiQ02343

Genome annotation databases

GeneIDi100009403
KEGGiocu:100009403

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
777

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
InParanoidiQ02343
OrthoDBi172471at2759

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005449, VDCC_R_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR45628:SF5, PTHR45628:SF5, 2 hits
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01633, RVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1E_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02343
Secondary accession number(s): Q02344
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: December 2, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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