UniProtKB - Q02326 (RL6A_YEAST)
60S ribosomal protein L6-A
RPL6A
Functioni
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
1 PublicationMiscellaneous
GO - Molecular functioni
- RNA binding Source: SGD
- structural constituent of ribosome Source: SGD
GO - Biological processi
- cytoplasmic translation Source: SGD
- ribosomal large subunit assembly Source: SGD
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L6-A1 PublicationAlternative name(s): L17 Large ribosomal subunit protein eL6-A1 Publication RP18 YL16 |
Gene namesi | Ordered Locus Names:YML073C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004538, RPL6A |
VEuPathDBi | FungiDB:YML073C |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000171017 | 2 – 176 | 60S ribosomal protein L6-AAdd BLAST | 175 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 | |
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Cross-linki | 128 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q02326 |
PaxDbi | Q02326 |
PRIDEi | Q02326 |
PTM databases
CarbonylDBi | Q02326 |
iPTMneti | Q02326 |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).
1 Publication1 PublicationProtein-protein interaction databases
BioGRIDi | 35068, 193 interactors |
IntActi | Q02326, 39 interactors |
MINTi | Q02326 |
STRINGi | 4932.YML073C |
Miscellaneous databases
RNActi | Q02326, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q02326 |
SMRi | Q02326 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1694, Eukaryota |
GeneTreei | ENSGT00390000003682 |
HOGENOMi | CLU_066767_2_1_1 |
InParanoidi | Q02326 |
OMAi | GPYEVNG |
Family and domain databases
CDDi | cd13156, KOW_RPL6, 1 hit |
Gene3Di | 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR000915, 60S_ribosomal_L6E IPR041997, KOW_RPL6 IPR014722, Rib_L2_dom2 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR10715, PTHR10715, 1 hit |
Pfami | View protein in Pfam PF01159, Ribosomal_L6e, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
PROSITEi | View protein in PROSITE PS01170, RIBOSOMAL_L6E, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK
60 70 80 90 100
RVVYLKHLED NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK
110 120 130 140 150
FNVEYFAKEK LTKKEKKEAN LFPEQQNKEI KAERVEDQKV VDKALIAEIK
160 170
KTPLLKQYLS ASFSLKNGDK PHMLKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10225 Genomic DNA Translation: BAA01077.1 Z46373 Genomic DNA Translation: CAA86505.1 BK006946 Genomic DNA Translation: DAA09824.1 |
PIRi | S28944 |
RefSeqi | NP_013638.1, NM_001182432.1 |
Genome annotation databases
EnsemblFungii | YML073C_mRNA; YML073C; YML073C |
GeneIDi | 854902 |
KEGGi | sce:YML073C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10225 Genomic DNA Translation: BAA01077.1 Z46373 Genomic DNA Translation: CAA86505.1 BK006946 Genomic DNA Translation: DAA09824.1 |
PIRi | S28944 |
RefSeqi | NP_013638.1, NM_001182432.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J6X | electron microscopy | 6.10 | L6 | 1-176 | [»] | |
3J6Y | electron microscopy | 6.10 | L6 | 1-176 | [»] | |
3J77 | electron microscopy | 6.20 | L6 | 1-176 | [»] | |
3J78 | electron microscopy | 6.30 | L6 | 1-176 | [»] | |
3JBS | electron microscopy | 2.90 | A | 1-176 | [»] | |
3JCT | electron microscopy | 3.08 | E | 1-176 | [»] | |
4U3M | X-ray | 3.00 | L6/l6 | 2-176 | [»] | |
4U3N | X-ray | 3.20 | L6/l6 | 2-176 | [»] | |
4U3U | X-ray | 2.90 | L6/l6 | 2-176 | [»] | |
4U4N | X-ray | 3.10 | L6/l6 | 2-176 | [»] | |
4U4O | X-ray | 3.60 | L6/l6 | 2-176 | [»] | |
4U4Q | X-ray | 3.00 | L6/l6 | 2-176 | [»] | |
4U4R | X-ray | 2.80 | L6/l6 | 2-176 | [»] | |
4U4U | X-ray | 3.00 | L6/l6 | 2-176 | [»] | |
4U4Y | X-ray | 3.20 | L6/l6 | 2-176 | [»] | |
4U4Z | X-ray | 3.10 | L6/l6 | 2-176 | [»] | |
4U50 | X-ray | 3.20 | L6/l6 | 2-176 | [»] | |
4U51 | X-ray | 3.20 | L6/l6 | 2-176 | [»] | |
4U52 | X-ray | 3.00 | L6/l6 | 2-176 | [»] | |
4U53 | X-ray | 3.30 | L6/l6 | 2-176 | [»] | |
4U55 | X-ray | 3.20 | L6/l6 | 2-176 | [»] | |
4U56 | X-ray | 3.45 | L6/l6 | 2-176 | [»] | |
4U6F | X-ray | 3.10 | L6/l6 | 2-176 | [»] | |
4V6I | electron microscopy | 8.80 | BG | 1-176 | [»] | |
4V7F | electron microscopy | 8.70 | G | 1-176 | [»] | |
4V7R | X-ray | 4.00 | BF/DF | 1-176 | [»] | |
4V88 | X-ray | 3.00 | BE/DE | 1-176 | [»] | |
4V8T | electron microscopy | 8.10 | E | 1-176 | [»] | |
4V8Y | electron microscopy | 4.30 | BE | 2-176 | [»] | |
4V8Z | electron microscopy | 6.60 | BE | 2-176 | [»] | |
4V91 | electron microscopy | 3.70 | E | 1-176 | [»] | |
5APN | electron microscopy | 3.91 | E | 1-176 | [»] | |
5DAT | X-ray | 3.15 | L6/l6 | 2-176 | [»] | |
5DC3 | X-ray | 3.25 | L6/l6 | 2-176 | [»] | |
5DGE | X-ray | 3.45 | L6/l6 | 2-176 | [»] | |
5DGF | X-ray | 3.30 | L6/l6 | 2-176 | [»] | |
5DGV | X-ray | 3.10 | L6/l6 | 2-176 | [»] | |
5FCI | X-ray | 3.40 | L6/l6 | 2-176 | [»] | |
5FCJ | X-ray | 3.10 | L6/l6 | 2-176 | [»] | |
5FL8 | electron microscopy | 9.50 | E | 1-176 | [»] | |
5GAK | electron microscopy | 3.88 | I | 1-176 | [»] | |
5H4P | electron microscopy | 3.07 | E | 1-176 | [»] | |
5I4L | X-ray | 3.10 | L6/l6 | 1-176 | [»] | |
5JCS | electron microscopy | 9.50 | E | 1-176 | [»] | |
5JUO | electron microscopy | 4.00 | J | 1-176 | [»] | |
5JUP | electron microscopy | 3.50 | J | 1-176 | [»] | |
5JUS | electron microscopy | 4.20 | J | 1-176 | [»] | |
5JUT | electron microscopy | 4.00 | J | 1-176 | [»] | |
5JUU | electron microscopy | 4.00 | J | 1-176 | [»] | |
5LYB | X-ray | 3.25 | L6/l6 | 2-176 | [»] | |
5M1J | electron microscopy | 3.30 | E5 | 2-176 | [»] | |
5MC6 | electron microscopy | 3.80 | BM | 1-176 | [»] | |
5MEI | X-ray | 3.50 | CH/n | 2-176 | [»] | |
5NDG | X-ray | 3.70 | L6/l6 | 1-176 | [»] | |
5NDV | X-ray | 3.30 | L6/l6 | 1-176 | [»] | |
5NDW | X-ray | 3.70 | L6/l6 | 1-176 | [»] | |
5OBM | X-ray | 3.40 | L6/l6 | 1-176 | [»] | |
5ON6 | X-ray | 3.10 | CH/n | 2-176 | [»] | |
5T62 | electron microscopy | 3.30 | H | 1-176 | [»] | |
5T6R | electron microscopy | 4.50 | H | 1-176 | [»] | |
5TBW | X-ray | 3.00 | CH/n | 2-176 | [»] | |
5TGA | X-ray | 3.30 | L6/l6 | 2-176 | [»] | |
5TGM | X-ray | 3.50 | L6/l6 | 2-176 | [»] | |
5Z3G | electron microscopy | 3.65 | I | 1-176 | [»] | |
6C0F | electron microscopy | 3.70 | E | 1-176 | [»] | |
6CB1 | electron microscopy | 4.60 | E | 1-176 | [»] | |
6ELZ | electron microscopy | 3.30 | E | 1-176 | [»] | |
6EM1 | electron microscopy | 3.60 | E | 1-176 | [»] | |
6EM3 | electron microscopy | 3.20 | E | 1-176 | [»] | |
6EM4 | electron microscopy | 4.10 | E | 1-176 | [»] | |
6EM5 | electron microscopy | 4.30 | E | 1-176 | [»] | |
6FT6 | electron microscopy | 3.90 | E | 1-176 | [»] | |
6GQ1 | electron microscopy | 4.40 | E | 2-176 | [»] | |
6GQB | electron microscopy | 3.90 | E | 2-176 | [»] | |
6GQV | electron microscopy | 4.00 | E | 2-176 | [»] | |
6HD7 | electron microscopy | 3.40 | I | 1-176 | [»] | |
6HHQ | X-ray | 3.10 | CH/n | 1-176 | [»] | |
6I7O | electron microscopy | 5.30 | BM/YM | 1-176 | [»] | |
6M62 | electron microscopy | 3.20 | E | 1-176 | [»] | |
6N8J | electron microscopy | 3.50 | E | 1-176 | [»] | |
6N8K | electron microscopy | 3.60 | E | 1-176 | [»] | |
6N8L | electron microscopy | 3.60 | E | 1-176 | [»] | |
6N8M | electron microscopy | 3.50 | H | 1-176 | [»] | |
6N8N | electron microscopy | 3.80 | H | 1-176 | [»] | |
6N8O | electron microscopy | 3.50 | H | 1-176 | [»] | |
6OIG | electron microscopy | 3.80 | E | 2-176 | [»] | |
6Q8Y | electron microscopy | 3.10 | BM | 2-176 | [»] | |
6QIK | electron microscopy | 3.10 | G | 1-176 | [»] | |
6QT0 | electron microscopy | 3.40 | G | 1-176 | [»] | |
6QTZ | electron microscopy | 3.50 | G | 1-176 | [»] | |
6R84 | electron microscopy | 3.60 | I | 2-176 | [»] | |
6R86 | electron microscopy | 3.40 | I | 2-176 | [»] | |
6R87 | electron microscopy | 3.40 | I | 2-176 | [»] | |
6RI5 | electron microscopy | 3.30 | G | 1-176 | [»] | |
6RZZ | electron microscopy | 3.20 | G | 1-176 | [»] | |
6S05 | electron microscopy | 3.90 | G | 1-176 | [»] | |
6S47 | electron microscopy | 3.28 | AH | 2-176 | [»] | |
6SV4 | electron microscopy | 3.30 | BM/YM/ZM | 1-176 | [»] | |
6T83 | electron microscopy | 4.00 | Ey/Ha | 1-176 | [»] | |
6WOO | electron microscopy | 2.90 | E | 2-176 | [»] | |
6XIQ | electron microscopy | 4.20 | E | 1-176 | [»] | |
6XIR | electron microscopy | 3.20 | E | 1-176 | [»] | |
6YLG | electron microscopy | 3.00 | E | 1-176 | [»] | |
6YLH | electron microscopy | 3.10 | E | 1-176 | [»] | |
6YLX | electron microscopy | 3.90 | E | 1-176 | [»] | |
6YLY | electron microscopy | 3.80 | E | 1-176 | [»] | |
6Z6J | electron microscopy | 3.40 | LE | 1-176 | [»] | |
6Z6K | electron microscopy | 3.40 | LE | 1-176 | [»] | |
7AZY | electron microscopy | 2.88 | A | 1-176 | [»] | |
7BT6 | electron microscopy | 3.12 | E | 1-176 | [»] | |
7BTB | electron microscopy | 3.22 | E | 1-176 | [»] | |
7OF1 | electron microscopy | 3.10 | E | 1-176 | [»] | |
7OH3 | electron microscopy | 3.40 | E | 1-176 | [»] | |
7OHP | electron microscopy | 3.90 | E | 1-176 | [»] | |
7OHQ | electron microscopy | 3.10 | E | 1-176 | [»] | |
7OHR | electron microscopy | 4.72 | E | 1-176 | [»] | |
7OHS | electron microscopy | 4.38 | E | 1-176 | [»] | |
7OHT | electron microscopy | 4.70 | E | 1-176 | [»] | |
7OHU | electron microscopy | 3.70 | E | 1-176 | [»] | |
7OHV | electron microscopy | 3.90 | E | 1-176 | [»] | |
7OHW | electron microscopy | 3.50 | E | 1-176 | [»] | |
7OHX | electron microscopy | 3.30 | E | 1-176 | [»] | |
7OHY | electron microscopy | 3.90 | E | 1-176 | [»] | |
AlphaFoldDBi | Q02326 | |||||
SMRi | Q02326 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35068, 193 interactors |
IntActi | Q02326, 39 interactors |
MINTi | Q02326 |
STRINGi | 4932.YML073C |
PTM databases
CarbonylDBi | Q02326 |
iPTMneti | Q02326 |
Proteomic databases
MaxQBi | Q02326 |
PaxDbi | Q02326 |
PRIDEi | Q02326 |
Genome annotation databases
EnsemblFungii | YML073C_mRNA; YML073C; YML073C |
GeneIDi | 854902 |
KEGGi | sce:YML073C |
Organism-specific databases
SGDi | S000004538, RPL6A |
VEuPathDBi | FungiDB:YML073C |
Phylogenomic databases
eggNOGi | KOG1694, Eukaryota |
GeneTreei | ENSGT00390000003682 |
HOGENOMi | CLU_066767_2_1_1 |
InParanoidi | Q02326 |
OMAi | GPYEVNG |
Miscellaneous databases
PROi | PR:Q02326 |
RNActi | Q02326, protein |
Family and domain databases
CDDi | cd13156, KOW_RPL6, 1 hit |
Gene3Di | 2.30.30.30, 1 hit |
InterProi | View protein in InterPro IPR000915, 60S_ribosomal_L6E IPR041997, KOW_RPL6 IPR014722, Rib_L2_dom2 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR10715, PTHR10715, 1 hit |
Pfami | View protein in Pfam PF01159, Ribosomal_L6e, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
PROSITEi | View protein in PROSITE PS01170, RIBOSOMAL_L6E, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL6A_YEAST | |
Accessioni | Q02326Primary (citable) accession number: Q02326 Secondary accession number(s): D6VZA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families