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Protein

Plasminogen-like protein B

Gene

PLGLB1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasminogen-like protein B
Alternative name(s):
Plasminogen-related protein B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLGLB1
Synonyms:PLGL, PRGB
AND
Name:PLGLB2
Synonyms:PLGP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125551.18
HostDB:ENSG00000183281.14

Human Gene Nomenclature Database

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HGNCi
HGNC:9072 PLGLB1
HGNC:9073 PLGLB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173340 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02325

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5342
5343

Open Targets

More...
OpenTargetsi
ENSG00000125551
ENSG00000183281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33406

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLGLB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
548594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002210520 – 96Plasminogen-like protein BAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 73PROSITE-ProRule annotation
Disulfide bondi53 ↔ 61PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q02325

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02325

PeptideAtlas

More...
PeptideAtlasi
Q02325

PRoteomics IDEntifications database

More...
PRIDEi
Q02325

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58081

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02325

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02325

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125551 Expressed in 86 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLGLB1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q02325 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02325 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053770

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02325

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q02325

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 96PANPROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115578

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003051

Identification of Orthologs from Complete Genome Data

More...
OMAi
IEDCASR

Database of Orthologous Groups

More...
OrthoDBi
1872575at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02325

TreeFam database of animal gene trees

More...
TreeFami
TF344093

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003609 Pan_app
IPR016351 Plasminogen-rel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00024 PAN_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002483 Plasminogen-related, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00473 PAN_AP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50948 PAN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q02325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA
60 70 80 90
AKCEEDKEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK
Length:96
Mass (Da):10,971
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D8073F529F2716D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCD6F8WCD6_HUMAN
Plasminogen-like protein B
PLGLB1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M93143 mRNA Translation: AAB06491.1
M86876, M86874, M86875 Genomic DNA Translation: AAA60169.1
AC093616 Genomic DNA Translation: AAX82025.1
BC005379 mRNA Translation: AAH05379.1
BC022294 mRNA Translation: AAH22294.1
BC109248 mRNA Translation: AAI09249.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1999.1
CCDS33238.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC1195

NCBI Reference Sequences

More...
RefSeqi
NP_001027564.1, NM_001032392.2
NP_002656.1, NM_002665.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.652169
Hs.652174

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355705; ENSP00000347933; ENSG00000183281
ENST00000359481; ENSP00000352458; ENSG00000125551
ENST00000409310; ENSP00000386505; ENSG00000183281
ENST00000409801; ENSP00000386975; ENSG00000183281
ENST00000410086; ENSP00000386317; ENSG00000125551

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5342
5343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5342
hsa:5343

UCSC genome browser

More...
UCSCi
uc002ssd.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93143 mRNA Translation: AAB06491.1
M86876, M86874, M86875 Genomic DNA Translation: AAA60169.1
AC093616 Genomic DNA Translation: AAX82025.1
BC005379 mRNA Translation: AAH05379.1
BC022294 mRNA Translation: AAH22294.1
BC109248 mRNA Translation: AAI09249.1
CCDSiCCDS1999.1
CCDS33238.1
PIRiJC1195
RefSeqiNP_001027564.1, NM_001032392.2
NP_002656.1, NM_002665.4
UniGeneiHs.652169
Hs.652174

3D structure databases

ProteinModelPortaliQ02325
SMRiQ02325
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ02325
PhosphoSitePlusiQ02325

Polymorphism and mutation databases

BioMutaiPLGLB1
DMDMi548594

Proteomic databases

jPOSTiQ02325
PaxDbiQ02325
PeptideAtlasiQ02325
PRIDEiQ02325
ProteomicsDBi58081

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355705; ENSP00000347933; ENSG00000183281
ENST00000359481; ENSP00000352458; ENSG00000125551
ENST00000409310; ENSP00000386505; ENSG00000183281
ENST00000409801; ENSP00000386975; ENSG00000183281
ENST00000410086; ENSP00000386317; ENSG00000125551
GeneIDi5342
5343
KEGGihsa:5342
hsa:5343
UCSCiuc002ssd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5342
5343
DisGeNETi5342
5343
EuPathDBiHostDB:ENSG00000125551.18
HostDB:ENSG00000183281.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLGLB1
PLGLB2
HGNCiHGNC:9072 PLGLB1
HGNC:9073 PLGLB2
HPAiHPA053770
MIMi173340 gene
neXtProtiNX_Q02325
OpenTargetsiENSG00000125551
ENSG00000183281
PharmGKBiPA33406

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155208
HOGENOMiHOG000115578
HOVERGENiHBG003051
OMAiIEDCASR
OrthoDBi1872575at2759
PhylomeDBiQ02325
TreeFamiTF344093

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PLGLB2

Protein Ontology

More...
PROi
PR:Q02325

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125551 Expressed in 86 organ(s), highest expression level in liver
CleanExiHS_PLGLB1
ExpressionAtlasiQ02325 baseline and differential
GenevisibleiQ02325 HS

Family and domain databases

InterProiView protein in InterPro
IPR003609 Pan_app
IPR016351 Plasminogen-rel
PfamiView protein in Pfam
PF00024 PAN_1, 1 hit
PIRSFiPIRSF002483 Plasminogen-related, 1 hit
SMARTiView protein in SMART
SM00473 PAN_AP, 1 hit
PROSITEiView protein in PROSITE
PS50948 PAN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLGB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02325
Secondary accession number(s): Q580R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 16, 2019
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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