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Protein

Plasminogen-like protein B

Gene

PLGLB1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen-like protein B
Alternative name(s):
Plasminogen-related protein B
Gene namesi
Name:PLGLB1
Synonyms:PLGL, PRGB
AND
Name:PLGLB2
Synonyms:PLGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000125551.18
HostDB:ENSG00000183281.14
HGNCiHGNC:9072 PLGLB1
HGNC:9073 PLGLB2
MIMi173340 gene
neXtProtiNX_Q02325

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5342
5343
OpenTargetsiENSG00000125551
ENSG00000183281
PharmGKBiPA33406

Polymorphism and mutation databases

BioMutaiPLGLB1
DMDMi548594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002210520 – 96Plasminogen-like protein BAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 73PROSITE-ProRule annotation
Disulfide bondi53 ↔ 61PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ02325
PeptideAtlasiQ02325
PRIDEiQ02325
ProteomicsDBi58081

PTM databases

iPTMnetiQ02325
PhosphoSitePlusiQ02325

Expressioni

Gene expression databases

BgeeiENSG00000125551 Expressed in 86 organ(s), highest expression level in liver
CleanExiHS_PLGLB1
ExpressionAtlasiQ02325 baseline and differential
GenevisibleiQ02325 HS

Organism-specific databases

HPAiHPA053770

Structurei

3D structure databases

ProteinModelPortaliQ02325
SMRiQ02325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 96PANPROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000014844
HOGENOMiHOG000115578
HOVERGENiHBG003051
PhylomeDBiQ02325
TreeFamiTF344093

Family and domain databases

InterProiView protein in InterPro
IPR003609 Pan_app
IPR016351 Plasminogen-rel
PfamiView protein in Pfam
PF00024 PAN_1, 1 hit
PIRSFiPIRSF002483 Plasminogen-related, 1 hit
SMARTiView protein in SMART
SM00473 PAN_AP, 1 hit
PROSITEiView protein in PROSITE
PS50948 PAN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q02325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA
60 70 80 90
AKCEEDKEFT CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK
Length:96
Mass (Da):10,971
Last modified:June 1, 1994 - v1
Checksum:i8D8073F529F2716D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCD6F8WCD6_HUMAN
Plasminogen-like protein B
PLGLB1
89Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93143 mRNA Translation: AAB06491.1
M86876, M86874, M86875 Genomic DNA Translation: AAA60169.1
AC093616 Genomic DNA Translation: AAX82025.1
BC005379 mRNA Translation: AAH05379.1
BC022294 mRNA Translation: AAH22294.1
BC109248 mRNA Translation: AAI09249.1
CCDSiCCDS1999.1
CCDS33238.1
PIRiJC1195
RefSeqiNP_001027564.1, NM_001032392.2
NP_002656.1, NM_002665.4
UniGeneiHs.652169
Hs.652174

Genome annotation databases

EnsembliENST00000355705; ENSP00000347933; ENSG00000183281
ENST00000359481; ENSP00000352458; ENSG00000125551
ENST00000409310; ENSP00000386505; ENSG00000183281
ENST00000409801; ENSP00000386975; ENSG00000183281
ENST00000410086; ENSP00000386317; ENSG00000125551
GeneIDi5342
5343
KEGGihsa:5342
hsa:5343
UCSCiuc002ssd.4 human

Similar proteinsi

Entry informationi

Entry nameiPLGB_HUMAN
AccessioniPrimary (citable) accession number: Q02325
Secondary accession number(s): Q580R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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