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UniProtKB - Q02297 (NRG1_HUMAN)

Entry version 231 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Pro-neuregulin-1, membrane-bound isoform

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q02297

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1227986, Signaling by ERBB2 [Q02297-10]
R-HSA-1236394, Signaling by ERBB4 [Q02297-10]
R-HSA-1250196, SHC1 events in ERBB2 signaling [Q02297-10]
R-HSA-1250342, PI3K events in ERBB4 signaling
R-HSA-1250347, SHC1 events in ERBB4 signaling
R-HSA-1251985, Nuclear signaling by ERBB4
R-HSA-1257604, PIP3 activates AKT signaling [Q02297-10]
R-HSA-1306955, GRB7 events in ERBB2 signaling [Q02297-10]
R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling [Q02297-10]
R-HSA-1963640, GRB2 events in ERBB2 signaling
R-HSA-1963642, PI3K events in ERBB2 signaling [Q02297-10]
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [Q02297-10]
R-HSA-5673001, RAF/MAP kinase cascade [Q02297-10]
R-HSA-6785631, ERBB2 Regulates Cell Motility [Q02297-10]
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Q02297-10]
R-HSA-8847993, ERBB2 Activates PTK6 Signaling [Q02297-10]
R-HSA-8863795, Downregulation of ERBB2 signaling [Q02297-10]
R-HSA-9620244, Long-term potentiation
R-HSA-9664565, Signaling by ERBB2 KD Mutants [Q02297-10]
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [Q02297-10]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q02297

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q02297

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-neuregulin-1, membrane-bound isoform
Short name:
Pro-NRG1
Cleaved into the following chain:
Neuregulin-1
Alternative name(s):
Acetylcholine receptor-inducing activity
Short name:
ARIA
Breast cancer cell differentiation factor p45
Glial growth factor
Heregulin
Short name:
HRG
Neu differentiation factor
Sensory and motor neuron-derived factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRG1
Synonyms:GGF, HGL, HRGA, NDF, SMDF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000157168.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:7997, NRG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142445, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q02297

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 242ExtracellularSequence analysisAdd BLAST223
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei243 – 265Helical; Note=Internal signal sequenceSequence analysisAdd BLAST23
Topological domaini266 – 640CytoplasmicSequence analysisAdd BLAST375

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi181K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-185 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-185 and E-187. 1 Publication1
Mutagenesisi185K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-187. 1 Publication1
Mutagenesisi187K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-185. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-185. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei34Breakpoint for translocation to form gamma-heregulin1

Organism-specific databases

DisGeNET

More...DisGeNETi		3084

MalaCards human disease database

More...MalaCardsi		NRG1

Open Targets

More...OpenTargetsi		ENSG00000157168

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31776

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q02297, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NRG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		9297018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000194621 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001946320 – 640Pro-neuregulin-1, membrane-bound isoformAdd BLAST621
ChainiPRO_000001946420 – 241Neuregulin-1Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 112By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi182 ↔ 1961 Publication
Disulfide bondi190 ↔ 2101 Publication
Disulfide bondi212 ↔ 2211 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q02297

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q02297

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q02297

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q02297

PeptideAtlas

More...PeptideAtlasi		Q02297

PRoteomics IDEntifications database

More...PRIDEi		Q02297

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20533
58070 [Q02297-1]
58071 [Q02297-10]
58072 [Q02297-11]
58073 [Q02297-2]
58074 [Q02297-3]
58075 [Q02297-4]
58076 [Q02297-6]
58077 [Q02297-7]
58078 [Q02297-8]
58079 [Q02297-9]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q02297, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q02297

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q02297

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157168, Expressed in ventricular zone and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q02297, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q02297, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157168, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity).

Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109332, 84 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q02297

Database of interacting proteins

More...DIPi		DIP-355N

Protein interaction database and analysis system

More...IntActi		Q02297, 55 interactors

Molecular INTeraction database

More...MINTi		Q02297

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384620

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q02297, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1640
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q02297

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q02297

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 128Ig-like C2-typeAdd BLAST92
Domaini178 – 222EGF-likePROSITE-ProRule annotationAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi165 – 177Ser/Thr-richAdd BLAST13

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).By similarity
ERBB receptor binding is elicited entirely by the EGF-like domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuregulin family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRUM, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157326

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023628_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q02297

Database of Orthologous Groups

More...OrthoDBi		313400at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q02297

TreeFam database of animal gene trees

More...TreeFami		TF332469

Family and domain databases

Database of protein disorder

More...DisProti		DP01520 [Q02297-10]

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR040180, Neuregulin
IPR002154, Neuregulin_C
IPR018250, NRG1

The PANTHER Classification System

More...PANTHERi		PTHR11100, PTHR11100, 1 hit
PTHR11100:SF7, PTHR11100:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 1 hit
PF07679, I-set, 1 hit
PF02158, Neuregulin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01089, NEUREGULIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9), type III NRGs (isoforms with a Cys-rich domain, isoform 10) and type IV NRGs (isoforms with additional 5' exons, isoform 11). All these isoforms perform distinct tissue-specific functions.

This entry has 11 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02297-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ KRVLTITGIC 
       260        270        280        290        300
IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
       310        320        330        340        350
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
       360        370        380        390        400
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE 
       410        420        430        440        450
CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS 
       460        470        480        490        500
EMSPPVSSMT VSMPSMAVSP FMEEERPLLL VTPPRLREKK FDHHPQQFSS 
       510        520        530        540        550
FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK LANSRRAKRT 
       560        570        580        590        600
KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV
Length:640
Mass (Da):70,392
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC30D3F614AADFF62
GO
Isoform 2 (identifier: Q02297-2) [UniParc]FASTAAdd to basket
Also known as: Alpha1A

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: K → KHLGIEFIE

Show »
Length:648
Mass (Da):71,331
Checksum:i775329E1F5FED358
GO
Isoform 3 (identifier: Q02297-3) [UniParc]FASTAAdd to basket
Also known as: Alpha2B

The sequence of this isoform differs from the canonical sequence as follows:
     424-462: YVSAMTTPAR...SPPVSSMTVS → HNLIAELRRN...SSIPHLGFIL
     463-640: Missing.

Show »
Length:462
Mass (Da):50,879
Checksum:i00F513509DED3269
GO
Isoform 4 (identifier: Q02297-4) [UniParc]FASTAAdd to basket
Also known as: Alpha3

The sequence of this isoform differs from the canonical sequence as follows:
     234-247: KAEELYQKRVLTIT → SAQMSLLVIAAKTT
     248-640: Missing.

Show »
Length:247
Mass (Da):26,590
Checksum:i8D44247649C60C67
GO
Isoform 6 (identifier: Q02297-6) [UniParc]FASTAAdd to basket
Also known as: Beta1, Beta1A

The sequence of this isoform differs from the canonical sequence as follows:
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

Show »
Length:645
Mass (Da):71,157
Checksum:iD61555DF50325386
GO
Isoform 7 (identifier: Q02297-7) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY

Show »
Length:637
Mass (Da):70,200
Checksum:iD92B25445628869D
GO
Isoform 8 (identifier: Q02297-8) [UniParc]FASTAAdd to basket
Also known as: Beta3, GGFHFB1

The sequence of this isoform differs from the canonical sequence as follows:
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Show »
Length:241
Mass (Da):26,143
Checksum:iD2450DB340E6B64D
GO
Isoform 9 (identifier: Q02297-9) [UniParc]FASTAAdd to basket
Also known as: GGF2, GGFHPP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP → MRWRRAPRRS...EVSRVLCKRC
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Show »
Length:422
Mass (Da):45,141
Checksum:i3535A1E4AB8EEA8E
GO
Isoform 10 (identifier: Q02297-10) [UniParc]FASTAAdd to basket
Also known as: SMDF

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-167: S → MEIYSPDMSE...ETNLQTAPKL
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Note: Potential internal signal sequence at positions 76-100.Curated
Show »
Length:296
Mass (Da):31,686
Checksum:i8D41743217F7EB02
GO
Isoform 11 (identifier: Q02297-11) [UniParc]FASTAAdd to basket
Also known as: Type IV-beta1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-33: KKPESAAGSQSP → MGKGRAGRVGTT
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

Show »
Length:590
Mass (Da):65,460
Checksum:iB4DCA7D49EE8117B
GO
Isoform 12 (identifier: Q02297-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY
     424-640: Missing.

Show »
Length:420
Mass (Da):46,226
Checksum:iBE6F4EBA41F043A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBA3H0YBA3_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
713Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0K4A0A494C0K4_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
459Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1F5A0A494C1F5_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
624Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1F8A0A494C1F8_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
607Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C043A0A494C043_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
461Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RJN6F6RJN6_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
308Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0L9A0A494C0L9_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
522Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0Q4A0A494C0Q4_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
700Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1B5A0A494C1B5_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
483Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHA5A0A5F9ZHA5_HUMAN
Pro-neuregulin-1, membrane-bound is...
NRG1
168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA19955 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAC51756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94K → A in AAA19953 (PubMed:7509448).Curated1
Sequence conflicti107S → P in ABQ53539 (PubMed:17565985).Curated1
Sequence conflicti261V → L in ABQ53540 (PubMed:17565985).Curated1
Sequence conflicti414S → F in AAA19953 (PubMed:7509448).Curated1
Sequence conflicti535Q → R in AAA19951 (PubMed:7509448).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00930738R → Q1 PublicationCorresponds to variant dbSNP:rs3924999Ensembl.1
Natural variantiVAR_053531289M → T2 PublicationsCorresponds to variant dbSNP:rs10503929Ensembl.1
Natural variantiVAR_009308463M → K. 1
Isoform 10 (identifier: Q02297-10)
Natural variantiVAR_08286646G → RCuratedCorresponds to variant dbSNP:rs3735774Ensembl.1
Natural variantiVAR_082867127A → PCuratedCorresponds to variant dbSNP:rs34822181Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0375621 – 166Missing in isoform 10. 3 PublicationsAdd BLAST166
Alternative sequenceiVSP_0034251 – 33MSERK…GSQSP → MRWRRAPRRSGRPGPRAQRP GSAARSSPPLPLLPLLLLLG TAALAPGAAAGNEAAPAGAS VCYSSPPSVGSVQELAQRAA VVIEGKVHPQRRQQGALDRK AAAAAGEAGAWGGDREPPAA GPRALGPPAEEPLLAANGTV PSWPTAPVPSAGEPGEEAPY LVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLK EDSRYIFFMEPDANSTSRAP AAFRASFPPLETGRNLKKEV SRVLCKRC in isoform 9. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0375631 – 21Missing in isoform 11. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_03756422 – 33KKPES…GSQSP → MGKGRAGRVGTT in isoform 11. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_003426134 – 168EIITG…NTSSS → A in isoform 9 and isoform 11. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_037565167S → MEIYSPDMSEVAAERSSSPS TQLSADPSLDGLPAAEDMPE PQTEDGRTPGLVGLAVPCCA CLEAERLRGCLNSEKICIVP ILACLVSLCLCIAGLKWVFV DKIFEYDSPTHLDPGGLGQD PIISLDATAASAVWVSSEAY TSPVSRAQSESEVQVTVQGD KAVVSFEPSAAPTPKNRIFA FSFLPSTAPSFPSPTRNPEV RTPKSATQPQTTETNLQTAP KL in isoform 10. 3 Publications1
Alternative sequenceiVSP_003429213 – 241QPGFT…ELYQK → PNEFTGDRCQNYVMASFYST STPFLSLPE in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST29
Alternative sequenceiVSP_003428213 – 234QPGFT…QNQEK → PNEFTGDRCQNYVMASFYKH LGIEFME in isoform 6 and isoform 11. 3 PublicationsAdd BLAST22
Alternative sequenceiVSP_003427213 – 233QPGFT…VQNQE → PNEFTGDRCQNYVMASFY in isoform 7 and isoform 12. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_003432234 – 247KAEEL…VLTIT → SAQMSLLVIAAKTT in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_003431234K → KHLGIEFIE in isoform 2. 1 Publication1
Alternative sequenceiVSP_003430242 – 640Missing in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST399
Alternative sequenceiVSP_003433248 – 640Missing in isoform 4. 1 PublicationAdd BLAST393
Alternative sequenceiVSP_046417424 – 640Missing in isoform 12. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_003434424 – 462YVSAM…SMTVS → HNLIAELRRNKAHRSKCMQI QLSATHLRSSSIPHLGFIL in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_003435463 – 640Missing in isoform 3. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M94165 mRNA Translation: AAA58638.1
M94166 mRNA Translation: AAA58639.1
M94167 mRNA Translation: AAA58640.1
M94168 mRNA Translation: AAA58641.1
U02325 mRNA Translation: AAA19950.1
U02326 mRNA Translation: AAA19951.1
U02327 mRNA Translation: AAA19952.1
U02328 mRNA Translation: AAA19953.1
U02329 mRNA Translation: AAA19954.1
U02330 mRNA Translation: AAA19955.1 Sequence problems.
L12260 mRNA Translation: AAB59622.1
L12261 mRNA Translation: AAB59358.1
L41827 mRNA Translation: AAC41764.1
AK289927 mRNA Translation: BAF82616.1
AK298132 mRNA Translation: BAH12729.1
AC021909 Genomic DNA No translation available.
AC022833 Genomic DNA No translation available.
AC022850 Genomic DNA No translation available.
AC023948 Genomic DNA No translation available.
AC068359 Genomic DNA No translation available.
AC068931 Genomic DNA No translation available.
AC083977 Genomic DNA No translation available.
AC103675 Genomic DNA No translation available.
AC104000 Genomic DNA No translation available.
AC104029 Genomic DNA No translation available.
AC113209 Genomic DNA No translation available.
AF009227 mRNA Translation: AAC51756.1 Different initiation.
AF491780 Genomic DNA Translation: AAM71137.1
AF491780 Genomic DNA Translation: AAM71139.1
AF491780 Genomic DNA Translation: AAM71140.1
EF372273 mRNA Translation: ABQ53539.1
EF372274 mRNA Translation: ABQ53540.1
CH471080 Genomic DNA Translation: EAW63411.1
BC064587 mRNA Translation: AAH64587.1
BC073871 mRNA Translation: AAH73871.1
AF026146 mRNA Translation: AAD01795.1
BK000383 Genomic DNA Translation: DAA00044.1
BK000383 Genomic DNA Translation: DAA00045.1
BK000383 Genomic DNA Translation: DAA00046.1
BK000383 Genomic DNA Translation: DAA00047.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47836.1 [Q02297-9]
CCDS55218.1 [Q02297-11]
CCDS55219.1 [Q02297-12]
CCDS6083.1 [Q02297-6]
CCDS6084.1 [Q02297-7]
CCDS6085.1 [Q02297-1]
CCDS6086.1 [Q02297-3]
CCDS6087.1 [Q02297-10]

Protein sequence database of the Protein Information Resource

More...PIRi		A43273
A56943
B43273
C43273
D43273
I38403
I38404
I38408
S32357

NCBI Reference Sequences

More...RefSeqi		NP_001153467.1, NM_001159995.2
NP_001153471.1, NM_001159999.2
NP_001153473.1, NM_001160001.2 [Q02297-11]
NP_001153477.1, NM_001160005.1
NP_001153480.1, NM_001160008.1 [Q02297-12]
NP_001309134.1, NM_001322205.1
NP_001309135.1, NM_001322206.1
NP_001309136.1, NM_001322207.1
NP_039250.2, NM_013956.4 [Q02297-6]
NP_039251.2, NM_013957.4 [Q02297-7]
NP_039252.2, NM_013958.3 [Q02297-8]
NP_039253.1, NM_013959.3 [Q02297-10]
NP_039254.1, NM_013960.4 [Q02297-3]
NP_039256.2, NM_013962.2 [Q02297-9]
NP_039258.1, NM_013964.4 [Q02297-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000287842; ENSP00000287842; ENSG00000157168 [Q02297-6]
ENST00000356819; ENSP00000349275; ENSG00000157168 [Q02297-7]
ENST00000405005; ENSP00000384620; ENSG00000157168 [Q02297-1]
ENST00000519301; ENSP00000429582; ENSG00000157168 [Q02297-11]
ENST00000520407; ENSP00000434640; ENSG00000157168 [Q02297-9]
ENST00000520502; ENSP00000433289; ENSG00000157168 [Q02297-10]
ENST00000521670; ENSP00000428828; ENSG00000157168 [Q02297-3]
ENST00000523079; ENSP00000430120; ENSG00000157168 [Q02297-12]
ENST00000650919; ENSP00000498811; ENSG00000157168 [Q02297-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3084

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3084

UCSC genome browser

More...UCSCi		uc003xip.4, human [Q02297-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Tipping the mind - Issue 129 of June 2011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94165 mRNA Translation: AAA58638.1
M94166 mRNA Translation: AAA58639.1
M94167 mRNA Translation: AAA58640.1
M94168 mRNA Translation: AAA58641.1
U02325 mRNA Translation: AAA19950.1
U02326 mRNA Translation: AAA19951.1
U02327 mRNA Translation: AAA19952.1
U02328 mRNA Translation: AAA19953.1
U02329 mRNA Translation: AAA19954.1
U02330 mRNA Translation: AAA19955.1 Sequence problems.
L12260 mRNA Translation: AAB59622.1
L12261 mRNA Translation: AAB59358.1
L41827 mRNA Translation: AAC41764.1
AK289927 mRNA Translation: BAF82616.1
AK298132 mRNA Translation: BAH12729.1
AC021909 Genomic DNA No translation available.
AC022833 Genomic DNA No translation available.
AC022850 Genomic DNA No translation available.
AC023948 Genomic DNA No translation available.
AC068359 Genomic DNA No translation available.
AC068931 Genomic DNA No translation available.
AC083977 Genomic DNA No translation available.
AC103675 Genomic DNA No translation available.
AC104000 Genomic DNA No translation available.
AC104029 Genomic DNA No translation available.
AC113209 Genomic DNA No translation available.
AF009227 mRNA Translation: AAC51756.1 Different initiation.
AF491780 Genomic DNA Translation: AAM71137.1
AF491780 Genomic DNA Translation: AAM71139.1
AF491780 Genomic DNA Translation: AAM71140.1
EF372273 mRNA Translation: ABQ53539.1
EF372274 mRNA Translation: ABQ53540.1
CH471080 Genomic DNA Translation: EAW63411.1
BC064587 mRNA Translation: AAH64587.1
BC073871 mRNA Translation: AAH73871.1
AF026146 mRNA Translation: AAD01795.1
BK000383 Genomic DNA Translation: DAA00044.1
BK000383 Genomic DNA Translation: DAA00045.1
BK000383 Genomic DNA Translation: DAA00046.1
BK000383 Genomic DNA Translation: DAA00047.1
CCDSiCCDS47836.1 [Q02297-9]
CCDS55218.1 [Q02297-11]
CCDS55219.1 [Q02297-12]
CCDS6083.1 [Q02297-6]
CCDS6084.1 [Q02297-7]
CCDS6085.1 [Q02297-1]
CCDS6086.1 [Q02297-3]
CCDS6087.1 [Q02297-10]
PIRiA43273
A56943
B43273
C43273
D43273
I38403
I38404
I38408
S32357
RefSeqiNP_001153467.1, NM_001159995.2
NP_001153471.1, NM_001159999.2
NP_001153473.1, NM_001160001.2 [Q02297-11]
NP_001153477.1, NM_001160005.1
NP_001153480.1, NM_001160008.1 [Q02297-12]
NP_001309134.1, NM_001322205.1
NP_001309135.1, NM_001322206.1
NP_001309136.1, NM_001322207.1
NP_039250.2, NM_013956.4 [Q02297-6]
NP_039251.2, NM_013957.4 [Q02297-7]
NP_039252.2, NM_013958.3 [Q02297-8]
NP_039253.1, NM_013959.3 [Q02297-10]
NP_039254.1, NM_013960.4 [Q02297-3]
NP_039256.2, NM_013962.2 [Q02297-9]
NP_039258.1, NM_013964.4 [Q02297-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HAENMR-A177-239[»]
1HAFNMR-A177-239[»]
1HRENMR-A175-241[»]
1HRFNMR-A175-241[»]
3U7UX-ray3.03G/H/I/J/K/L175-212[»]
SMRiQ02297
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109332, 84 interactors
CORUMiQ02297
DIPiDIP-355N
IntActiQ02297, 55 interactors
MINTiQ02297
STRINGi9606.ENSP00000384620

PTM databases

GlyGeniQ02297, 3 sites
iPTMnetiQ02297
PhosphoSitePlusiQ02297

Polymorphism and mutation databases

BioMutaiNRG1
DMDMi9297018

Proteomic databases

jPOSTiQ02297
MassIVEiQ02297
MaxQBiQ02297
PaxDbiQ02297
PeptideAtlasiQ02297
PRIDEiQ02297
ProteomicsDBi20533
58070 [Q02297-1]
58071 [Q02297-10]
58072 [Q02297-11]
58073 [Q02297-2]
58074 [Q02297-3]
58075 [Q02297-4]
58076 [Q02297-6]
58077 [Q02297-7]
58078 [Q02297-8]
58079 [Q02297-9]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q02297, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3706, 925 antibodies

The DNASU plasmid repository

More...DNASUi		3084

Genome annotation databases

EnsembliENST00000287842; ENSP00000287842; ENSG00000157168 [Q02297-6]
ENST00000356819; ENSP00000349275; ENSG00000157168 [Q02297-7]
ENST00000405005; ENSP00000384620; ENSG00000157168 [Q02297-1]
ENST00000519301; ENSP00000429582; ENSG00000157168 [Q02297-11]
ENST00000520407; ENSP00000434640; ENSG00000157168 [Q02297-9]
ENST00000520502; ENSP00000433289; ENSG00000157168 [Q02297-10]
ENST00000521670; ENSP00000428828; ENSG00000157168 [Q02297-3]
ENST00000523079; ENSP00000430120; ENSG00000157168 [Q02297-12]
ENST00000650919; ENSP00000498811; ENSG00000157168 [Q02297-8]
GeneIDi3084
KEGGihsa:3084
UCSCiuc003xip.4, human [Q02297-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3084
DisGeNETi3084
EuPathDBiHostDB:ENSG00000157168.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		NRG1
HGNCiHGNC:7997, NRG1
HPAiENSG00000157168, Tissue enhanced (brain)
MalaCardsiNRG1
MIMi142445, gene
neXtProtiNX_Q02297
OpenTargetsiENSG00000157168
PharmGKBiPA31776

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRUM, Eukaryota
GeneTreeiENSGT00940000157326
HOGENOMiCLU_023628_1_0_1
InParanoidiQ02297
OrthoDBi313400at2759
PhylomeDBiQ02297
TreeFamiTF332469

Enzyme and pathway databases

PathwayCommonsiQ02297
ReactomeiR-HSA-1227986, Signaling by ERBB2 [Q02297-10]
R-HSA-1236394, Signaling by ERBB4 [Q02297-10]
R-HSA-1250196, SHC1 events in ERBB2 signaling [Q02297-10]
R-HSA-1250342, PI3K events in ERBB4 signaling
R-HSA-1250347, SHC1 events in ERBB4 signaling
R-HSA-1251985, Nuclear signaling by ERBB4
R-HSA-1257604, PIP3 activates AKT signaling [Q02297-10]
R-HSA-1306955, GRB7 events in ERBB2 signaling [Q02297-10]
R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling [Q02297-10]
R-HSA-1963640, GRB2 events in ERBB2 signaling
R-HSA-1963642, PI3K events in ERBB2 signaling [Q02297-10]
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [Q02297-10]
R-HSA-5673001, RAF/MAP kinase cascade [Q02297-10]
R-HSA-6785631, ERBB2 Regulates Cell Motility [Q02297-10]
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Q02297-10]
R-HSA-8847993, ERBB2 Activates PTK6 Signaling [Q02297-10]
R-HSA-8863795, Downregulation of ERBB2 signaling [Q02297-10]
R-HSA-9620244, Long-term potentiation
R-HSA-9664565, Signaling by ERBB2 KD Mutants [Q02297-10]
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [Q02297-10]
SignaLinkiQ02297
SIGNORiQ02297

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3084, 3 hits in 855 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NRG1, human
EvolutionaryTraceiQ02297

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Neuregulin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3084
PharosiQ02297, Tbio

Protein Ontology

More...PROi		PR:Q02297
RNActiQ02297, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157168, Expressed in ventricular zone and 174 other tissues
ExpressionAtlasiQ02297, baseline and differential
GenevisibleiQ02297, HS

Family and domain databases

DisProtiDP01520 [Q02297-10]
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR040180, Neuregulin
IPR002154, Neuregulin_C
IPR018250, NRG1
PANTHERiPTHR11100, PTHR11100, 1 hit
PTHR11100:SF7, PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF07679, I-set, 1 hit
PF02158, Neuregulin, 1 hit
PRINTSiPR01089, NEUREGULIN
SMARTiView protein in SMART
SM00181, EGF, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50835, IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02297
Secondary accession number(s): A5YAK4
, A5YAK5, A8K1L2, B7Z4Z3, E9PHH4, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q15491, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 231 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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