NRG1

Functionⁱ

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537).

Binds to ERBB3 (PubMed:20682778).

Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778).

Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

By similarity4 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor

Molecular function

Growth factor

Enzyme and pathway databases

PathwayCommonsⁱ	Q02297
Reactomeⁱ	R-HSA-1227986, Signaling by ERBB2 [Q02297-10] R-HSA-1236394, Signaling by ERBB4 [Q02297-10] R-HSA-1250196, SHC1 events in ERBB2 signaling [Q02297-10] R-HSA-1250342, PI3K events in ERBB4 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1257604, PIP3 activates AKT signaling [Q02297-10] R-HSA-1306955, GRB7 events in ERBB2 signaling [Q02297-10] R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling [Q02297-10] R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-1963642, PI3K events in ERBB2 signaling [Q02297-10] R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [Q02297-10] R-HSA-5673001, RAF/MAP kinase cascade [Q02297-10] R-HSA-6785631, ERBB2 Regulates Cell Motility [Q02297-10] R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Q02297-10] R-HSA-8847993, ERBB2 Activates PTK6 Signaling [Q02297-10] R-HSA-8863795, Downregulation of ERBB2 signaling [Q02297-10] R-HSA-9620244, Long-term potentiation R-HSA-9664565, Signaling by ERBB2 KD Mutants [Q02297-10] R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [Q02297-10]
SignaLinkⁱ	Q02297
SIGNORⁱ	Q02297

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pro-neuregulin-1, membrane-bound isoform Short name: Pro-NRG1 Cleaved into the following chain: Neuregulin-1 Alternative name(s): Acetylcholine receptor-inducing activity Short name: ARIA Breast cancer cell differentiation factor p45 Glial growth factor Heregulin Short name: HRG Neu differentiation factor Sensory and motor neuron-derived factor
Gene namesⁱ	Name:NRG1 Synonyms:GGF, HGL, HRGA, NDF, SMDF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7997, NRG1
MIMⁱ	142445, gene
neXtProtⁱ	NX_Q02297
VEuPathDBⁱ	HostDB:ENSG00000157168.18

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 242	ExtracellularSequence analysisAdd BLAST	223
Transmembraneⁱ	243 – 265	Helical; Note=Internal signal sequenceSequence analysisAdd BLAST	23
Topological domainⁱ	266 – 640	CytoplasmicSequence analysisAdd BLAST	375

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	181	K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-185 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-185 and E-187. 1 Publication	1
Mutagenesisⁱ	185	K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-187. 1 Publication	1
Mutagenesisⁱ	187	K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-185. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-185. 1 Publication	1

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	34	Breakpoint for translocation to form gamma-heregulin		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3084
MalaCards human disease database More...MalaCardsⁱ	NRG1
Open Targets More...OpenTargetsⁱ	ENSG00000157168
PharmGKBⁱ	PA31776

Miscellaneous databases

Pharosⁱ	Q02297, Tbio

Pharosⁱ

Q02297, Tbio

Genetic variation databases

BioMutaⁱ	NRG1
DMDMⁱ	9297018

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
PropeptideⁱPRO_0000019462	1 – 19	1 PublicationAdd BLAST	19
ChainⁱPRO_0000019463	20 – 640	Pro-neuregulin-1, membrane-bound isoformAdd BLAST	621
ChainⁱPRO_0000019464	20 – 241	Neuregulin-1Add BLAST	222

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	57 ↔ 112	By similarity
Glycosylationⁱ	120	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	126	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	164	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	182 ↔ 196	1 Publication
Disulfide bondⁱ	190 ↔ 210	1 Publication
Disulfide bondⁱ	212 ↔ 221	1 Publication

Post-translational modificationⁱ

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.

N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

jPOSTⁱ	Q02297
MassIVEⁱ	Q02297
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q02297
PaxDbⁱ	Q02297
PeptideAtlas More...PeptideAtlasⁱ	Q02297
PRIDEⁱ	Q02297
ProteomicsDBⁱ	20533 58070 [Q02297-1] 58071 [Q02297-10] 58072 [Q02297-11] 58073 [Q02297-2] 58074 [Q02297-3] 58075 [Q02297-4] 58076 [Q02297-6] 58077 [Q02297-7] 58078 [Q02297-8] 58079 [Q02297-9]

PTM databases

GlyGenⁱ	Q02297, 3 sites
iPTMnetⁱ	Q02297
PhosphoSitePlusⁱ	Q02297

Expressionⁱ

Tissue specificityⁱ

Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.1 Publication

Developmental stageⁱ

Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000157168, Expressed in ventricular zone and 175 other tissues
ExpressionAtlasⁱ	Q02297, baseline and differential
Genevisibleⁱ	Q02297, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000157168, Tissue enhanced (brain)

HPAⁱ

ENSG00000157168, Tissue enhanced (brain)

Interactionⁱ

Subunit structureⁱ

The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity).

Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).

By similarity1 Publication

Binary interactionsⁱ

Hide details

Isoform 6 [Q02297-6]

With	#Exp.	IntAct
ERBB3 [P21860]	2	EBI-15651799,EBI-720706
ERBB4 [Q15303]	3	EBI-15651799,EBI-80371

Isoform 7 [Q02297-7]

With	#Exp.	IntAct
ERBB2 [P04626]	2	EBI-2460927,EBI-641062
ERBB3 [P21860]	3	EBI-2460927,EBI-720706

Isoform 10 [Q02297-10]

With	#Exp.	IntAct
ASGR2 - isoform 3 [P07307-3]	3	EBI-12842334,EBI-12808270
CD72 [P21854]	3	EBI-12842334,EBI-307924
JAGN1 [Q8N5M9]	3	EBI-12842334,EBI-10266796
LAPTM4B [Q86VI4]	3	EBI-12842334,EBI-3267258
MS4A4A [Q96JQ5]	3	EBI-12842334,EBI-12820341
PLP1 - isoform DM-20 [P60201-2]	3	EBI-12842334,EBI-12188331
TMEM54 [Q969K7]	3	EBI-12842334,EBI-3922833

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	109332, 85 interactors
CORUMⁱ	Q02297
Database of interacting proteins More...DIPⁱ	DIP-355N
IntActⁱ	Q02297, 55 interactors
Molecular INTeraction database More...MINTⁱ	Q02297
STRINGⁱ	9606.ENSP00000384620

Miscellaneous databases

RNActⁱ	Q02297, protein

RNActⁱ

Q02297, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	179 – 181	Combined sources	3
Turnⁱ	185 – 189	Combined sources	5
Beta strandⁱ	190 – 193	Combined sources	4
Beta strandⁱ	195 – 199	Combined sources	5
Beta strandⁱ	200 – 204	Combined sources	5
Beta strandⁱ	208 – 212	Combined sources	5
Beta strandⁱ	216 – 218	Combined sources	3
Beta strandⁱ	233 – 235	Combined sources	3

Show more details

3D structure databases

SMRⁱ	Q02297
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q02297

EvolutionaryTraceⁱ

Q02297

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	37 – 128	Ig-like C2-typeAdd BLAST		92
Domainⁱ	178 – 222	EGF-likePROSITE-ProRule annotationAdd BLAST		45

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 53	DisorderedSequence analysisAdd BLAST	53
Regionⁱ	334 – 360	DisorderedSequence analysisAdd BLAST	27
Regionⁱ	375 – 399	DisorderedSequence analysisAdd BLAST	25
Regionⁱ	433 – 461	DisorderedSequence analysisAdd BLAST	29
Regionⁱ	524 – 588	DisorderedSequence analysisAdd BLAST	65

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	375 – 389	Polar residuesSequence analysisAdd BLAST		15
Compositional biasⁱ	559 – 573	Polar residuesSequence analysisAdd BLAST		15

Domainⁱ

The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).By similarity

ERBB receptor binding is elicited entirely by the EGF-like domain.

Sequence similaritiesⁱ

Belongs to the neuregulin family.Curated

Keywords - Domainⁱ

EGF-like domain, Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502QRUM, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157326
HOGENOMⁱ	CLU_023628_1_0_1
InParanoidⁱ	Q02297
Database of Orthologous Groups More...OrthoDBⁱ	313400at2759
PhylomeDBⁱ	Q02297
TreeFamⁱ	TF332469

Family and domain databases

Database of protein disorder More...DisProtⁱ	DP01520 [Q02297-10]
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C IPR018250, NRG1
PANTHERⁱ	PTHR11100, PTHR11100, 1 hit PTHR11100:SF25, PTHR11100:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008, EGF, 1 hit PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit
PRINTSⁱ	PR01089, NEUREGULIN
SMARTⁱ	View protein in SMART SM00181, EGF, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit

Sequences (11+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9), type III NRGs (isoforms with a Cys-rich domain, isoform 10) and type IV NRGs (isoforms with additional 5' exons, isoform 11). All these isoforms perform distinct tissue-specific functions.

This entry has 11 described isoforms and 21 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q02297-1) [UniParc]FASTA Add to basket

Also known as: Alpha

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ KRVLTITGIC 
       260        270        280        290        300
IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
       310        320        330        340        350
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
       360        370        380        390        400
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE 
       410        420        430        440        450
CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS 
       460        470        480        490        500
EMSPPVSSMT VSMPSMAVSP FMEEERPLLL VTPPRLREKK FDHHPQQFSS 
       510        520        530        540        550
FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK LANSRRAKRT 
       560        570        580        590        600
KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV

Length:640

Mass (Da):70,392

Last modified:January 23, 2007 - v3

Checksum:ⁱC30D3F614AADFF62

GO

Isoform 2 (identifier: Q02297-2) [UniParc]FASTA Add to basket

Also known as: Alpha1A

The sequence of this isoform differs from the canonical sequence as follows:
234-234: K → KHLGIEFIE

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKHLGIEF IEAEELYQKR 
       260        270        280        290        300
VLTITGICIA LLVVGIMCVV AYCKTKKQRK KLHDRLRQSL RSERNNMMNI 
       310        320        330        340        350
ANGPHHPNPP PENVQLVNQY VSKNVISSEH IVEREAETSF STSHYTSTAH 
       360        370        380        390        400
HSTTVTQTPS HSWSNGHTES ILSESHSVIV MSSVENSRHS SPTGGPRGRL 
       410        420        430        440        450
NGTGGPRECN SFLRHARETP DSYRDSPHSE RYVSAMTTPA RMSPVDFHTP 
       460        470        480        490        500
SSPKSPPSEM SPPVSSMTVS MPSMAVSPFM EEERPLLLVT PPRLREKKFD 
       510        520        530        540        550
HHPQQFSSFH HNPAHDSNSL PASPLRIVED EEYETTQEYE PAQEPVKKLA 
       560        570        580        590        600
NSRRAKRTKP NGHIANRLEV DSNTSSQSSN SESETEDERV GEDTPFLGIQ 
       610        620        630        640 
NPLAASLEAT PAFRLADSRT NPAGRFSTQE EIQARLSSVI ANQDPIAV

Show »

Length:648

Mass (Da):71,331

Checksum:ⁱ775329E1F5FED358

GO

Isoform 3 (identifier: Q02297-3) [UniParc]FASTA Add to basket

Also known as: Alpha2B

The sequence of this isoform differs from the canonical sequence as follows:
424-462: YVSAMTTPAR...SPPVSSMTVS → HNLIAELRRN...SSIPHLGFIL
463-640: Missing.

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ KRVLTITGIC 
       260        270        280        290        300
IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
       310        320        330        340        350
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
       360        370        380        390        400
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE 
       410        420        430        440        450
CNSFLRHARE TPDSYRDSPH SERHNLIAEL RRNKAHRSKC MQIQLSATHL 
       460 
RSSSIPHLGF IL

Show »

Length:462

Mass (Da):50,879

Checksum:ⁱ00F513509DED3269

GO

Isoform 4 (identifier: Q02297-4) [UniParc]FASTA Add to basket

Also known as: Alpha3

The sequence of this isoform differs from the canonical sequence as follows:
234-247: KAEELYQKRVLTIT → SAQMSLLVIAAKTT
248-640: Missing.

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240 
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQESAQMSLL VIAAKTT

Show »

Length:247

Mass (Da):26,590

Checksum:ⁱ8D44247649C60C67

GO

Isoform 6 (identifier: Q02297-6) [UniParc]FASTA Add to basket

Also known as: Beta1, Beta1A

The sequence of this isoform differs from the canonical sequence as follows:
213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQKRVLT 
       260        270        280        290        300
ITGICIALLV VGIMCVVAYC KTKKQRKKLH DRLRQSLRSE RNNMMNIANG 
       310        320        330        340        350
PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REAETSFSTS HYTSTAHHST 
       360        370        380        390        400
TVTQTPSHSW SNGHTESILS ESHSVIVMSS VENSRHSSPT GGPRGRLNGT 
       410        420        430        440        450
GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP 
       460        470        480        490        500
KSPPSEMSPP VSSMTVSMPS MAVSPFMEEE RPLLLVTPPR LREKKFDHHP 
       510        520        530        540        550
QQFSSFHHNP AHDSNSLPAS PLRIVEDEEY ETTQEYEPAQ EPVKKLANSR 
       560        570        580        590        600
RAKRTKPNGH IANRLEVDSN TSSQSSNSES ETEDERVGED TPFLGIQNPL 
       610        620        630        640 
AASLEATPAF RLADSRTNPA GRFSTQEEIQ ARLSSVIANQ DPIAV

Show »

Length:645

Mass (Da):71,157

Checksum:ⁱD61555DF50325386

GO

Isoform 7 (identifier: Q02297-7) [UniParc]FASTA Add to basket

Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV LTITGICIAL 
       260        270        280        290        300
LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNMMNIA NGPHHPNPPP 
       310        320        330        340        350
ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH 
       360        370        380        390        400
SWSNGHTESI LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS 
       410        420        430        440        450
FLRHARETPD SYRDSPHSER YVSAMTTPAR MSPVDFHTPS SPKSPPSEMS 
       460        470        480        490        500
PPVSSMTVSM PSMAVSPFME EERPLLLVTP PRLREKKFDH HPQQFSSFHH 
       510        520        530        540        550
NPAHDSNSLP ASPLRIVEDE EYETTQEYEP AQEPVKKLAN SRRAKRTKPN 
       560        570        580        590        600
GHIANRLEVD SNTSSQSSNS ESETEDERVG EDTPFLGIQN PLAASLEATP 
       610        620        630 
AFRLADSRTN PAGRFSTQEE IQARLSSVIA NQDPIAV

Show »

Length:637

Mass (Da):70,200

Checksum:ⁱD92B25445628869D

GO

Isoform 8 (identifier: Q02297-8) [UniParc]FASTA Add to basket

Also known as: Beta3, GGFHFB1

The sequence of this isoform differs from the canonical sequence as follows:
213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
242-640: Missing.

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240 
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY STSTPFLSLP E

Show »

Length:241

Mass (Da):26,143

Checksum:ⁱD2450DB340E6B64D

GO

Isoform 9 (identifier: Q02297-9) [UniParc]FASTA Add to basket

Also known as: GGF2, GGFHPP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP → MRWRRAPRRS...EVSRVLCKRC
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

« Hide

        10         20         30         40         50
MRWRRAPRRS GRPGPRAQRP GSAARSSPPL PLLPLLLLLG TAALAPGAAA 
        60         70         80         90        100
GNEAAPAGAS VCYSSPPSVG SVQELAQRAA VVIEGKVHPQ RRQQGALDRK 
       110        120        130        140        150
AAAAAGEAGA WGGDREPPAA GPRALGPPAE EPLLAANGTV PSWPTAPVPS 
       160        170        180        190        200
AGEPGEEAPY LVKVHQVWAV KAGGLKKDSL LTVRLGTWGH PAFPSCGRLK 
       210        220        230        240        250
EDSRYIFFME PDANSTSRAP AAFRASFPPL ETGRNLKKEV SRVLCKRCAL 
       260        270        280        290        300
PPRLKEMKSQ ESAAGSKLVL RCETSSEYSS LRFKWFKNGN ELNRKNKPQN 
       310        320        330        340        350
IKIQKKPGKS ELRINKASLA DSGEYMCKVI SKLGNDSASA NITIVESNAT 
       360        370        380        390        400
STSTTGTSHL VKCAEKEKTF CVNGGECFMV KDLSNPSRYL CKCPNEFTGD 
       410        420 
RCQNYVMASF YSTSTPFLSL PE

Show »

Length:422

Mass (Da):45,141

Checksum:ⁱ3535A1E4AB8EEA8E

GO

Isoform 10 (identifier: Q02297-10) [UniParc]FASTA Add to basket

Also known as: SMDF

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-167: S → MEIYSPDMSE...ETNLQTAPKL
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

« Hide

        10         20         30         40         50
MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG 
        60         70         80         90        100
LVGLAVPCCA CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV 
       110        120        130        140        150
DKIFEYDSPT HLDPGGLGQD PIISLDATAA SAVWVSSEAY TSPVSRAQSE 
       160        170        180        190        200
SEVQVTVQGD KAVVSFEPSA APTPKNRIFA FSFLPSTAPS FPSPTRNPEV 
       210        220        230        240        250
RTPKSATQPQ TTETNLQTAP KLSTSTSTTG TSHLVKCAEK EKTFCVNGGE 
       260        270        280        290 
CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYSTSTP FLSLPE

Note: Potential internal signal sequence at positions 76-100.Curated

Show »

Length:296

Mass (Da):31,686

Checksum:ⁱ8D41743217F7EB02

GO

Isoform 11 (identifier: Q02297-11) [UniParc]FASTA Add to basket

Also known as: Type IV-beta1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-33: KKPESAAGSQSP → MGKGRAGRVGTT
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

« Hide

        10         20         30         40         50
MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF 
        60         70         80         90        100
KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND 
       110        120        130        140        150
SASANITIVE SNATSTSTTG TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP 
       160        170        180        190        200
SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ KRVLTITGIC 
       210        220        230        240        250
IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
       260        270        280        290        300
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
       310        320        330        340        350
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE 
       360        370        380        390        400
CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS 
       410        420        430        440        450
EMSPPVSSMT VSMPSMAVSP FMEEERPLLL VTPPRLREKK FDHHPQQFSS 
       460        470        480        490        500
FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK LANSRRAKRT 
       510        520        530        540        550
KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 
       560        570        580        590
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV

Show »

Length:590

Mass (Da):65,460

Checksum:ⁱB4DCA7D49EE8117B

GO

Isoform 12 (identifier: Q02297-12) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY
424-640: Missing.

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV LTITGICIAL 
       260        270        280        290        300
LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNMMNIA NGPHHPNPPP 
       310        320        330        340        350
ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH 
       360        370        380        390        400
SWSNGHTESI LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS 
       410        420
FLRHARETPD SYRDSPHSER

Show »

Length:420

Mass (Da):46,226

Checksum:ⁱBE6F4EBA41F043A9

GO

Computationally mapped potential isoform sequencesⁱ

There are 21 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	H0YBA3	H0YBA3_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	713	Annotation score:
	A0A494C0K4	A0A494C0K4_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	459	Annotation score:
	A0A494C1F5	A0A494C1F5_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	624	Annotation score:
	A0A494C1F8	A0A494C1F8_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	607	Annotation score:
	A0A494C043	A0A494C043_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	461	Annotation score:
	F6RJN6	F6RJN6_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	308	Annotation score:
	A0A494C0L9	A0A494C0L9_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	522	Annotation score:
	A0A494C0Q4	A0A494C0Q4_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	700	Annotation score:
	A0A494C1B5	A0A494C1B5_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	483	Annotation score:
	A0A5F9ZHA5	A0A5F9ZHA5_HUMAN	Pro-neuregulin-1, membrane-bound is... Pro-neuregulin-1, membrane-bound isoform	NRG1	168	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAA19955 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence AAC51756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	94	K → A in AAA19953 (PubMed:7509448).Curated	1
Sequence conflictⁱ	107	S → P in ABQ53539 (PubMed:17565985).Curated	1
Sequence conflictⁱ	261	V → L in ABQ53540 (PubMed:17565985).Curated	1
Sequence conflictⁱ	414	S → F in AAA19953 (PubMed:7509448).Curated	1
Sequence conflictⁱ	535	Q → R in AAA19951 (PubMed:7509448).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_009307	38	R → Q1 PublicationCorresponds to variant dbSNP:rs3924999Ensembl.	1
Natural variantⁱVAR_053531	289	M → T2 PublicationsCorresponds to variant dbSNP:rs10503929Ensembl.	1
Natural variantⁱVAR_009308	463	M → K.	1
Isoform 10 (identifier: Q02297-10)
Natural variantⁱVAR_082866	46	G → RCuratedCorresponds to variant dbSNP:rs3735774Ensembl.	1
Natural variantⁱVAR_082867	127	A → PCuratedCorresponds to variant dbSNP:rs34822181Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_037562	1 – 166	Missing in isoform 10. 3 PublicationsAdd BLAST	166
Alternative sequenceⁱVSP_003425	1 – 33	MSERK…GSQSP → MRWRRAPRRSGRPGPRAQRP GSAARSSPPLPLLPLLLLLG TAALAPGAAAGNEAAPAGAS VCYSSPPSVGSVQELAQRAA VVIEGKVHPQRRQQGALDRK AAAAAGEAGAWGGDREPPAA GPRALGPPAEEPLLAANGTV PSWPTAPVPSAGEPGEEAPY LVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLK EDSRYIFFMEPDANSTSRAP AAFRASFPPLETGRNLKKEV SRVLCKRC in isoform 9. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_037563	1 – 21	Missing in isoform 11. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_037564	22 – 33	KKPES…GSQSP → MGKGRAGRVGTT in isoform 11. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_003426	134 – 168	EIITG…NTSSS → A in isoform 9 and isoform 11. 2 PublicationsAdd BLAST	35
Alternative sequenceⁱVSP_037565	167	S → MEIYSPDMSEVAAERSSSPS TQLSADPSLDGLPAAEDMPE PQTEDGRTPGLVGLAVPCCA CLEAERLRGCLNSEKICIVP ILACLVSLCLCIAGLKWVFV DKIFEYDSPTHLDPGGLGQD PIISLDATAASAVWVSSEAY TSPVSRAQSESEVQVTVQGD KAVVSFEPSAAPTPKNRIFA FSFLPSTAPSFPSPTRNPEV RTPKSATQPQTTETNLQTAP KL in isoform 10. 3 Publications	1
Alternative sequenceⁱVSP_003429	213 – 241	QPGFT…ELYQK → PNEFTGDRCQNYVMASFYST STPFLSLPE in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST	29
Alternative sequenceⁱVSP_003428	213 – 234	QPGFT…QNQEK → PNEFTGDRCQNYVMASFYKH LGIEFME in isoform 6 and isoform 11. 3 PublicationsAdd BLAST	22
Alternative sequenceⁱVSP_003427	213 – 233	QPGFT…VQNQE → PNEFTGDRCQNYVMASFY in isoform 7 and isoform 12. 3 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_003432	234 – 247	KAEEL…VLTIT → SAQMSLLVIAAKTT in isoform 4. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_003431	234	K → KHLGIEFIE in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_003430	242 – 640	Missing in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST	399
Alternative sequenceⁱVSP_003433	248 – 640	Missing in isoform 4. 1 PublicationAdd BLAST	393
Alternative sequenceⁱVSP_046417	424 – 640	Missing in isoform 12. 1 PublicationAdd BLAST	217
Alternative sequenceⁱVSP_003434	424 – 462	YVSAM…SMTVS → HNLIAELRRNKAHRSKCMQI QLSATHLRSSSIPHLGFIL in isoform 3. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_003435	463 – 640	Missing in isoform 3. 1 PublicationAdd BLAST	178

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M94165 mRNA Translation: AAA58638.1 M94166 mRNA Translation: AAA58639.1 M94167 mRNA Translation: AAA58640.1 M94168 mRNA Translation: AAA58641.1 U02325 mRNA Translation: AAA19950.1 U02326 mRNA Translation: AAA19951.1 U02327 mRNA Translation: AAA19952.1 U02328 mRNA Translation: AAA19953.1 U02329 mRNA Translation: AAA19954.1 U02330 mRNA Translation: AAA19955.1 Sequence problems. L12260 mRNA Translation: AAB59622.1 L12261 mRNA Translation: AAB59358.1 L41827 mRNA Translation: AAC41764.1 AK289927 mRNA Translation: BAF82616.1 AK298132 mRNA Translation: BAH12729.1 AC021909 Genomic DNA No translation available. AC022833 Genomic DNA No translation available. AC022850 Genomic DNA No translation available. AC023948 Genomic DNA No translation available. AC068359 Genomic DNA No translation available. AC068931 Genomic DNA No translation available. AC083977 Genomic DNA No translation available. AC103675 Genomic DNA No translation available. AC104000 Genomic DNA No translation available. AC104029 Genomic DNA No translation available. AC113209 Genomic DNA No translation available. AF009227 mRNA Translation: AAC51756.1 Different initiation. AF491780 Genomic DNA Translation: AAM71137.1 AF491780 Genomic DNA Translation: AAM71139.1 AF491780 Genomic DNA Translation: AAM71140.1 EF372273 mRNA Translation: ABQ53539.1 EF372274 mRNA Translation: ABQ53540.1 CH471080 Genomic DNA Translation: EAW63411.1 BC064587 mRNA Translation: AAH64587.1 BC073871 mRNA Translation: AAH73871.1 AF026146 mRNA Translation: AAD01795.1 BK000383 Genomic DNA Translation: DAA00044.1 BK000383 Genomic DNA Translation: DAA00045.1 BK000383 Genomic DNA Translation: DAA00046.1 BK000383 Genomic DNA Translation: DAA00047.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47836.1 [Q02297-9] CCDS55218.1 [Q02297-11] CCDS55219.1 [Q02297-12] CCDS6083.1 [Q02297-6] CCDS6084.1 [Q02297-7] CCDS6085.1 [Q02297-1] CCDS6086.1 [Q02297-3] CCDS6087.1 [Q02297-10]
PIRⁱ	A43273 A56943 B43273 C43273 D43273 I38403 I38404 I38408 S32357
NCBI Reference Sequences More...RefSeqⁱ	NP_001153467.1, NM_001159995.2 NP_001153471.1, NM_001159999.2 NP_001153473.1, NM_001160001.2 [Q02297-11] NP_001153477.1, NM_001160005.1 NP_001153480.1, NM_001160008.1 [Q02297-12] NP_001309134.1, NM_001322205.1 NP_001309135.1, NM_001322206.1 NP_001309136.1, NM_001322207.1 NP_039250.2, NM_013956.4 [Q02297-6] NP_039251.2, NM_013957.4 [Q02297-7] NP_039252.2, NM_013958.3 [Q02297-8] NP_039253.1, NM_013959.3 [Q02297-10] NP_039254.1, NM_013960.4 [Q02297-3] NP_039256.2, NM_013962.2 [Q02297-9] NP_039258.1, NM_013964.4 [Q02297-1]

Genome annotation databases

Ensemblⁱ	ENST00000287842; ENSP00000287842; ENSG00000157168 [Q02297-6] ENST00000356819; ENSP00000349275; ENSG00000157168 [Q02297-7] ENST00000405005; ENSP00000384620; ENSG00000157168 [Q02297-1] ENST00000519301; ENSP00000429582; ENSG00000157168 [Q02297-11] ENST00000520407; ENSP00000434640; ENSG00000157168 [Q02297-9] ENST00000520502; ENSP00000433289; ENSG00000157168 [Q02297-10] ENST00000521670; ENSP00000428828; ENSG00000157168 [Q02297-3] ENST00000523079; ENSP00000430120; ENSG00000157168 [Q02297-12] ENST00000650919; ENSP00000498811; ENSG00000157168 [Q02297-8]
GeneIDⁱ	3084
KEGGⁱ	hsa:3084
UCSC genome browser More...UCSCⁱ	uc003xip.4, human [Q02297-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02297-2	Neuregulin 1 isoform HRG-gamma		HUMAN		211	UniRef100_Q7RTW5
Neuregulin 1 isoform HRG-alpha (Fragment)		HUMAN		167
Q02297-3	Neuregulin 1		PANTR		462	UniRef100_K7CGP9
NRG1 isoform 11		PONAB		462
Neuregulin 1		PANPA		462
Neuregulin 1		GORGO		462
NRG1 isoform 8		PANTR		462
Q02297-4	NRG1 isoform 14		PONAB		206	UniRef100_A0A2J8X5N1
NRG1 isoform 16		PANTR		206
Neuregulin 1 isoform 4 (Fragment)		HUMAN		58
Q02297-8	Neuregulin 1 isoform HRG-beta3		HUMAN		241	UniRef100_A0A024QY88
Neuregulin 1		PANTR		241
Q02297-9	NRG1 isoform 15		PANTR		422	UniRef100_A0A2J8N843
Q02297-12	NRG1 isoform 10		PONAB		637	UniRef100_A0A2J8X5M1
Neuregulin 1		PANTR		637
Neuregulin 1		PANPA		637
Neuregulin 1		GORGO		637
NRG1 isoform 9		PONAB		420
+1

Protein	Similar proteins		Species	Score	Length	Source
Q02297-2	Neuregulin 1 isoform HRG-gamma		HUMAN		211	UniRef90_Q7RTW5
Neuregulin 1 isoform HRG-alpha (Fragment)		HUMAN		167
Q02297-3	Pro-neuregulin-1, membrane-bound isoform		HUMAN		461	UniRef90_A0A494C043
Neuregulin 1		PANTR		462
NRG1 isoform 11		PONAB		462
Neuregulin 1		PANPA		462
Neuregulin 1		GORGO		462
+1
Q02297-4	Neuregulin 1		HUMAN		241	UniRef90_Q6PK61
Neuregulin 1		PANTR		241
NRG1 isoform 14		PONAB		206
Neuregulin 1 isoform HRG-beta3		HUMAN		241
Isoform 8 of Pro-neuregulin-1, membrane-bound isoform		HUMAN		241
+2
Q02297-9	pro-neuregulin-1, membrane-bound isoform isoform X5		CALUR		418	UniRef90_A0A3Q7RMJ5
NRG1 isoform 15		PANTR		422
Neuregulin 1		MACFA		420
pro-neuregulin-1, membrane-bound isoform isoform X8		ZALCA		418
Uncharacterized protein		RHIFE		417
+12
Q02297-10	EGF-like domain-containing protein		ROUAE		324	UniRef90_Q02297-10
Pro-neuregulin-1, membrane-bound isoform isoform SMDF		CALJA		296
Neuregulin 1 isoform SMDF variant (Fragment)		HUMAN		296
Neuregulin 1		SAIBB		296
Neuregulin 1		MOLMO		296
+25
Q02297-11	Neuregulin 1 type IV beta 1a		HUMAN		590	UniRef90_Q02297-11
NRG1 isoform 1 (Fragment)		PONAB		481
Pro-neuregulin-1, membrane-bound isoform (Fragment)		HUMAN		155
Q02297-12	NRG1 isoform 10		PONAB		637	UniRef90_A0A2J8X5M1
Neuregulin 1		PANTR		637
Neuregulin 1		PANPA		637
Neuregulin 1		GORGO		637
NRG1 isoform 9		PONAB		420
+1

Protein	Similar proteins		Species	Score	Length	Source
Q02297	Pro-neuregulin-1, membrane-bound isoform		RAT		662	UniRef50_Q02297
pro-neuregulin-1, membrane-bound isoform isoform X2		VULVU		694
Pro-neuregulin-1, membrane-bound isoform (Fragment)		HETGA		620
EGF-like domain-containing protein		CALJA		692
pro-neuregulin-1, membrane-bound isoform isoform X7		TURTR		609
+853
Q02297-2	Neuregulin 1		PANTR		640	UniRef50_K7B8C7
NRG1 isoform 13		PONAB		640
Neuregulin 1		PANPA		640
Neuregulin 1		GORGO		640
Neuregulin 1 isoform HRG-gamma		HUMAN		211
+40
Q02297-3	Neuregulin 1		MOUSE		462	UniRef50_A0A140LIK5
pro-neuregulin-1, membrane-bound isoform isoform X11		MUSCR		460
NRG1 protein (Fragment)		amazonian umbrellabird		409
Neuregulin 1		PIG		456
pro-neuregulin-3, membrane-bound isoform-like isoform X4		LIPVE		459
+239
Q02297-4	Neuregulin 1		MOUSE		241	UniRef50_A0A5F8MPN0
NRG1 isoform 14		PONAB		206
NRG1 isoform 16		PANTR		206
Neuregulin 1 isoform 4 (Fragment)		HUMAN		58
Neuregulin 1		RABIT		252
+19
Q02297-6	pro-neuregulin-1, membrane-bound isoform isoform X4		Florida manatee		501	UniRef50_Q02297-6
EGF-like domain-containing protein		ONCMY		477
Neuregulin 1		SALTR		587
Uncharacterized protein		NOMLE		590
NRG1 isoform 6		PANTR		590
+121
Q02297-7	Neuregulin 1		MOLMO		641	UniRef50_Q02297-7
pro-neuregulin-3, membrane-bound isoform-like isoform X3		CHRAS		637
pro-neuregulin-1, membrane-bound isoform isoform X4		pale spear-nosed bat		646
pro-neuregulin-1, membrane-bound isoform isoform X4		NEOSC		635
pro-neuregulin-1, membrane-bound isoform isoform X6		CARSF		570
+137
Q02297-9	Neuregulin 1		MOUSE		420	UniRef50_A0A5F8MPS5
Uncharacterized protein		ROUAE		418
Neuregulin 1		MOLMO		417
Neuregulin 1		PIPKU		439
NRG1 isoform 15		PANTR		422
+22
Q02297-10	EGF-like domain-containing protein		ROUAE		324	UniRef50_Q02297-10
pro-neuregulin-3, membrane-bound isoform-like isoform X6		LIPVE		296
pro-neuregulin-1, membrane-bound isoform isoform X7		URSMA		296
Neuregulin 1		GORGO		296
Neuregulin 1		COLAP		296
+44

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Tipping the mind - Issue 129 of June 2011

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M94165 mRNA Translation: AAA58638.1 M94166 mRNA Translation: AAA58639.1 M94167 mRNA Translation: AAA58640.1 M94168 mRNA Translation: AAA58641.1 U02325 mRNA Translation: AAA19950.1 U02326 mRNA Translation: AAA19951.1 U02327 mRNA Translation: AAA19952.1 U02328 mRNA Translation: AAA19953.1 U02329 mRNA Translation: AAA19954.1 U02330 mRNA Translation: AAA19955.1 Sequence problems. L12260 mRNA Translation: AAB59622.1 L12261 mRNA Translation: AAB59358.1 L41827 mRNA Translation: AAC41764.1 AK289927 mRNA Translation: BAF82616.1 AK298132 mRNA Translation: BAH12729.1 AC021909 Genomic DNA No translation available. AC022833 Genomic DNA No translation available. AC022850 Genomic DNA No translation available. AC023948 Genomic DNA No translation available. AC068359 Genomic DNA No translation available. AC068931 Genomic DNA No translation available. AC083977 Genomic DNA No translation available. AC103675 Genomic DNA No translation available. AC104000 Genomic DNA No translation available. AC104029 Genomic DNA No translation available. AC113209 Genomic DNA No translation available. AF009227 mRNA Translation: AAC51756.1 Different initiation. AF491780 Genomic DNA Translation: AAM71137.1 AF491780 Genomic DNA Translation: AAM71139.1 AF491780 Genomic DNA Translation: AAM71140.1 EF372273 mRNA Translation: ABQ53539.1 EF372274 mRNA Translation: ABQ53540.1 CH471080 Genomic DNA Translation: EAW63411.1 BC064587 mRNA Translation: AAH64587.1 BC073871 mRNA Translation: AAH73871.1 AF026146 mRNA Translation: AAD01795.1 BK000383 Genomic DNA Translation: DAA00044.1 BK000383 Genomic DNA Translation: DAA00045.1 BK000383 Genomic DNA Translation: DAA00046.1 BK000383 Genomic DNA Translation: DAA00047.1
CCDSⁱ	CCDS47836.1 [Q02297-9] CCDS55218.1 [Q02297-11] CCDS55219.1 [Q02297-12] CCDS6083.1 [Q02297-6] CCDS6084.1 [Q02297-7] CCDS6085.1 [Q02297-1] CCDS6086.1 [Q02297-3] CCDS6087.1 [Q02297-10]
PIRⁱ	A43273 A56943 B43273 C43273 D43273 I38403 I38404 I38408 S32357
RefSeqⁱ	NP_001153467.1, NM_001159995.2 NP_001153471.1, NM_001159999.2 NP_001153473.1, NM_001160001.2 [Q02297-11] NP_001153477.1, NM_001160005.1 NP_001153480.1, NM_001160008.1 [Q02297-12] NP_001309134.1, NM_001322205.1 NP_001309135.1, NM_001322206.1 NP_001309136.1, NM_001322207.1 NP_039250.2, NM_013956.4 [Q02297-6] NP_039251.2, NM_013957.4 [Q02297-7] NP_039252.2, NM_013958.3 [Q02297-8] NP_039253.1, NM_013959.3 [Q02297-10] NP_039254.1, NM_013960.4 [Q02297-3] NP_039256.2, NM_013962.2 [Q02297-9] NP_039258.1, NM_013964.4 [Q02297-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HAE	NMR	-	A	177-239	[»]
	1HAF	NMR	-	A	177-239	[»]
	1HRE	NMR	-	A	175-241	[»]
	1HRF	NMR	-	A	175-241	[»]
	3U7U	X-ray	3.03	G/H/I/J/K/L	175-212	[»]
SMRⁱ	Q02297
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109332, 85 interactors
CORUMⁱ	Q02297
DIPⁱ	DIP-355N
IntActⁱ	Q02297, 55 interactors
MINTⁱ	Q02297
STRINGⁱ	9606.ENSP00000384620

PTM databases

GlyGenⁱ	Q02297, 3 sites
iPTMnetⁱ	Q02297
PhosphoSitePlusⁱ	Q02297

Genetic variation databases

BioMutaⁱ	NRG1
DMDMⁱ	9297018

Proteomic databases

jPOSTⁱ	Q02297
MassIVEⁱ	Q02297
MaxQBⁱ	Q02297
PaxDbⁱ	Q02297
PeptideAtlasⁱ	Q02297
PRIDEⁱ	Q02297
ProteomicsDBⁱ	20533 58070 [Q02297-1] 58071 [Q02297-10] 58072 [Q02297-11] 58073 [Q02297-2] 58074 [Q02297-3] 58075 [Q02297-4] 58076 [Q02297-6] 58077 [Q02297-7] 58078 [Q02297-8] 58079 [Q02297-9]

Protocols and materials databases

ABCDⁱ	Q02297, 1 sequenced antibody
Antibodypediaⁱ	3706, 960 antibodies
The DNASU plasmid repository More...DNASUⁱ	3084

Genome annotation databases

Organism-specific databases

CTDⁱ	3084
DisGeNETⁱ	3084
GeneCardsⁱ	NRG1
HGNCⁱ	HGNC:7997, NRG1
HPAⁱ	ENSG00000157168, Tissue enhanced (brain)
MalaCardsⁱ	NRG1
MIMⁱ	142445, gene
neXtProtⁱ	NX_Q02297
OpenTargetsⁱ	ENSG00000157168
PharmGKBⁱ	PA31776
VEuPathDBⁱ	HostDB:ENSG00000157168.18
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QRUM, Eukaryota
GeneTreeⁱ	ENSGT00940000157326
HOGENOMⁱ	CLU_023628_1_0_1
InParanoidⁱ	Q02297
OrthoDBⁱ	313400at2759
PhylomeDBⁱ	Q02297
TreeFamⁱ	TF332469

Enzyme and pathway databases

PathwayCommonsⁱ	Q02297
Reactomeⁱ	R-HSA-1227986, Signaling by ERBB2 [Q02297-10] R-HSA-1236394, Signaling by ERBB4 [Q02297-10] R-HSA-1250196, SHC1 events in ERBB2 signaling [Q02297-10] R-HSA-1250342, PI3K events in ERBB4 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1257604, PIP3 activates AKT signaling [Q02297-10] R-HSA-1306955, GRB7 events in ERBB2 signaling [Q02297-10] R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling [Q02297-10] R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-1963642, PI3K events in ERBB2 signaling [Q02297-10] R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [Q02297-10] R-HSA-5673001, RAF/MAP kinase cascade [Q02297-10] R-HSA-6785631, ERBB2 Regulates Cell Motility [Q02297-10] R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Q02297-10] R-HSA-8847993, ERBB2 Activates PTK6 Signaling [Q02297-10] R-HSA-8863795, Downregulation of ERBB2 signaling [Q02297-10] R-HSA-9620244, Long-term potentiation R-HSA-9664565, Signaling by ERBB2 KD Mutants [Q02297-10] R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [Q02297-10]
SignaLinkⁱ	Q02297
SIGNORⁱ	Q02297

Miscellaneous databases

BioGRID-ORCSⁱ	3084, 3 hits in 999 CRISPR screens
ChiTaRSⁱ	NRG1, human
EvolutionaryTraceⁱ	Q02297
GeneWikiⁱ	Neuregulin_1
GenomeRNAiⁱ	3084
Pharosⁱ	Q02297, Tbio
Protein Ontology More...PROⁱ	PR:Q02297
RNActⁱ	Q02297, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157168, Expressed in ventricular zone and 175 other tissues
ExpressionAtlasⁱ	Q02297, baseline and differential
Genevisibleⁱ	Q02297, HS

Family and domain databases

DisProtⁱ	DP01520 [Q02297-10]
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C IPR018250, NRG1
PANTHERⁱ	PTHR11100, PTHR11100, 1 hit PTHR11100:SF25, PTHR11100:SF25, 1 hit
Pfamⁱ	View protein in Pfam PF00008, EGF, 1 hit PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit
PRINTSⁱ	PR01089, NEUREGULIN
SMARTⁱ	View protein in SMART SM00181, EGF, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRG1_HUMAN
Accessionⁱ	Q02297Primary (citable) accession number: Q02297 Secondary accession number(s): A5YAK4 Q9UPE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	January 23, 2007
	Last modified:	June 2, 2021
	This is version 234 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Annotation systems

Supporting data

UniProtKB - Q02297 (NRG1_HUMAN)

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Pro-neuregulin-1, membrane-bound isoform

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Nucleus

Extracellular region or secreted

Other locations

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Sites

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ