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UniProtKB - Q02297 (NRG1_HUMAN)

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Protein

Pro-neuregulin-1, membrane-bound isoform

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).By similarity4 Publications

GO - Molecular functioni

  • chemorepellent activity Source: Ensembl
  • cytokine activity Source: BHF-UCL
  • ErbB-2 class receptor binding Source: Ensembl
  • ErbB-3 class receptor binding Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • integrin binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • protein tyrosine kinase activator activity Source: BHF-UCL
  • protein tyrosine kinase activity Source: Reactome
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • receptor tyrosine kinase binding Source: UniProtKB
  • signaling receptor binding Source: BHF-UCL
  • transcription coregulator activity Source: MGI
  • transmembrane receptor protein tyrosine kinase activator activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • activation of protein kinase B activity Source: UniProtKB
  • activation of transmembrane receptor protein tyrosine kinase activity Source: BHF-UCL
  • axon ensheathment Source: Ensembl
  • cardiac conduction system development Source: Ensembl
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle cell myoblast differentiation Source: BHF-UCL
  • cell communication Source: BHF-UCL
  • cell morphogenesis Source: Ensembl
  • cell proliferation Source: BHF-UCL
  • cellular protein complex disassembly Source: MGI
  • chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: Ensembl
  • embryo development Source: InterPro
  • endocardial cell differentiation Source: BHF-UCL
  • ERBB2 signaling pathway Source: Reactome
  • ERBB3 signaling pathway Source: CAFA
  • ERBB4 signaling pathway Source: UniProtKB
  • ERBB signaling pathway Source: BHF-UCL
  • glial cell fate commitment Source: Ensembl
  • locomotory behavior Source: Ensembl
  • mammary gland development Source: BHF-UCL
  • MAPK cascade Source: Reactome
  • negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  • negative regulation of neuron migration Source: Ensembl
  • negative regulation of protein catabolic process Source: Ensembl
  • negative regulation of secretion Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: BHF-UCL
  • neural crest cell development Source: BHF-UCL
  • neuron fate commitment Source: Ensembl
  • neurotransmitter receptor metabolic process Source: Ensembl
  • oligodendrocyte differentiation Source: Ensembl
  • peripheral nervous system development Source: Ensembl
  • positive regulation of axon extension Source: Ensembl
  • positive regulation of calcineurin-NFAT signaling cascade Source: Ensembl
  • positive regulation of cardiac muscle cell differentiation Source: Ensembl
  • positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of cell adhesion Source: BHF-UCL
  • positive regulation of cell growth Source: BHF-UCL
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of dendritic spine development Source: Ensembl
  • positive regulation of myelination Source: Ensembl
  • positive regulation of peptidyl-tyrosine autophosphorylation Source: UniProtKB
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  • positive regulation of protein kinase B signaling Source: Reactome
  • positive regulation of protein localization to cell surface Source: Ensembl
  • positive regulation of Ras protein signal transduction Source: Ensembl
  • positive regulation of striated muscle cell differentiation Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • regulation of cell motility Source: Reactome
  • regulation of protein heterodimerization activity Source: BHF-UCL
  • regulation of protein homodimerization activity Source: BHF-UCL
  • startle response Source: Ensembl
  • synapse assembly Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
  • ventricular cardiac muscle cell differentiation Source: BHF-UCL
  • ventricular trabecula myocardium morphogenesis Source: BHF-UCL
  • wound healing Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-1227986 Signaling by ERBB2
R-HSA-1236394 Signaling by ERBB4
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250342 PI3K events in ERBB4 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1306955 GRB7 events in ERBB2 signaling
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6785631 ERBB2 Regulates Cell Motility
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847993 ERBB2 Activates PTK6 Signaling
R-HSA-8863795 Downregulation of ERBB2 signaling
SignaLinkiQ02297
SIGNORiQ02297

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuregulin-1, membrane-bound isoform
Short name:
Pro-NRG1
Cleaved into the following chain:
Neuregulin-1
Alternative name(s):
Acetylcholine receptor-inducing activity
Short name:
ARIA
Breast cancer cell differentiation factor p45
Glial growth factor
Heregulin
Short name:
HRG
Neu differentiation factor
Sensory and motor neuron-derived factor
Gene namesi
Name:NRG1
Synonyms:GGF, HGL, HRGA, NDF, SMDF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000157168.18
HGNCiHGNC:7997 NRG1
MIMi142445 gene
neXtProtiNX_Q02297

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 242ExtracellularSequence analysisAdd BLAST223
Transmembranei243 – 265Helical; Note=Internal signal sequenceSequence analysisAdd BLAST23
Topological domaini266 – 640CytoplasmicSequence analysisAdd BLAST375

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi181K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-185 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-185 and E-187. 1 Publication1
Mutagenesisi185K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-187. 1 Publication1
Mutagenesisi187K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-185. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-185. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Breakpoint for translocation to form gamma-heregulin1

Organism-specific databases

DisGeNETi3084
MalaCardsiNRG1
OpenTargetsiENSG00000157168
PharmGKBiPA31776

Polymorphism and mutation databases

BioMutaiNRG1
DMDMi9297018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000194621 – 191 PublicationAdd BLAST19
ChainiPRO_000001946320 – 640Pro-neuregulin-1, membrane-bound isoformAdd BLAST621
ChainiPRO_000001946420 – 241Neuregulin-1Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 112By similarity
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi182 ↔ 1961 Publication
Disulfide bondi190 ↔ 2101 Publication
Disulfide bondi212 ↔ 2211 Publication

Post-translational modificationi

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ02297
PaxDbiQ02297
PeptideAtlasiQ02297
PRIDEiQ02297
ProteomicsDBi58070
58071 [Q02297-10]
58072 [Q02297-11]
58073 [Q02297-2]
58074 [Q02297-3]
58075 [Q02297-4]
58076 [Q02297-6]
58077 [Q02297-7]
58078 [Q02297-8]
58079 [Q02297-9]

PTM databases

iPTMnetiQ02297
PhosphoSitePlusiQ02297

Miscellaneous databases

PMAP-CutDBiQ02297

Expressioni

Tissue specificityi

Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.1 Publication

Developmental stagei

Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000157168
CleanExiHS_NRG1
ExpressionAtlasiQ02297 baseline and differential
GenevisibleiQ02297 HS

Organism-specific databases

HPAiHPA010964

Interactioni

Subunit structurei

The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemorepellent activity Source: Ensembl
  • cytokine activity Source: BHF-UCL
  • ErbB-2 class receptor binding Source: Ensembl
  • ErbB-3 class receptor binding Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • integrin binding Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • receptor tyrosine kinase binding Source: UniProtKB
  • signaling receptor binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi109332, 71 interactors
CORUMiQ02297
DIPiDIP-355N
IntActiQ02297, 13 interactors
MINTiQ02297
STRINGi9606.ENSP00000349275

Structurei

Secondary structure

1640
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi179 – 181Combined sources3
Turni185 – 189Combined sources5
Beta strandi190 – 193Combined sources4
Beta strandi195 – 199Combined sources5
Beta strandi200 – 204Combined sources5
Beta strandi208 – 212Combined sources5
Beta strandi216 – 218Combined sources3
Beta strandi233 – 235Combined sources3

3D structure databases

ProteinModelPortaliQ02297
SMRiQ02297
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02297

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 128Ig-like C2-typeAdd BLAST92
Domaini178 – 222EGF-likePROSITE-ProRule annotationAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 177Ser/Thr-richAdd BLAST13

Domaini

The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).By similarity
ERBB receptor binding is elicited entirely by the EGF-like domain.

Sequence similaritiesi

Belongs to the neuregulin family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEU9 Eukaryota
ENOG4110ST7 LUCA
GeneTreeiENSGT00900000140940
HOGENOMiHOG000273863
HOVERGENiHBG006531
InParanoidiQ02297
KOiK05455
PhylomeDBiQ02297
TreeFamiTF332469

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002154 Neuregulin_C
IPR018250 NRG1
PANTHERiPTHR11100:SF7 PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07679 I-set, 1 hit
PF02158 Neuregulin, 1 hit
PRINTSiPR01089 NEUREGULIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9), type III NRGs (isoforms with a Cys-rich domain, isoform 10) and type IV NRGs (isoforms with additional 5' exons, isoform 11). All these isoforms perform distinct tissue-specific functions.
Isoform 1 (identifier: Q02297-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG 
        60         70         80         90        100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN 
       110        120        130        140        150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS 
       160        170        180        190        200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK 
       210        220        230        240        250
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ KRVLTITGIC 
       260        270        280        290        300
IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN 
       310        320        330        340        350
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT 
       360        370        380        390        400
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE 
       410        420        430        440        450
CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS 
       460        470        480        490        500
EMSPPVSSMT VSMPSMAVSP FMEEERPLLL VTPPRLREKK FDHHPQQFSS 
       510        520        530        540        550
FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK LANSRRAKRT 
       560        570        580        590        600
KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE 
       610        620        630        640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV
Length:640
Mass (Da):70,392
Last modified:January 23, 2007 - v3
Checksum:iC30D3F614AADFF62
GO
Isoform 2 (identifier: Q02297-2) [UniParc]FASTAAdd to basket
Also known as: Alpha1A

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: K → KHLGIEFIE

Show »
Length:648
Mass (Da):71,331
Checksum:i775329E1F5FED358
GO
Isoform 3 (identifier: Q02297-3) [UniParc]FASTAAdd to basket
Also known as: Alpha2B

The sequence of this isoform differs from the canonical sequence as follows:
     424-462: YVSAMTTPAR...SPPVSSMTVS → HNLIAELRRN...SSIPHLGFIL
     463-640: Missing.

Show »
Length:462
Mass (Da):50,879
Checksum:i00F513509DED3269
GO
Isoform 4 (identifier: Q02297-4) [UniParc]FASTAAdd to basket
Also known as: Alpha3

The sequence of this isoform differs from the canonical sequence as follows:
     234-247: KAEELYQKRVLTIT → SAQMSLLVIAAKTT
     248-640: Missing.

Show »
Length:247
Mass (Da):26,590
Checksum:i8D44247649C60C67
GO
Isoform 6 (identifier: Q02297-6) [UniParc]FASTAAdd to basket
Also known as: Beta1, Beta1A

The sequence of this isoform differs from the canonical sequence as follows:
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

Show »
Length:645
Mass (Da):71,157
Checksum:iD61555DF50325386
GO
Isoform 7 (identifier: Q02297-7) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY

Show »
Length:637
Mass (Da):70,200
Checksum:iD92B25445628869D
GO
Isoform 8 (identifier: Q02297-8) [UniParc]FASTAAdd to basket
Also known as: Beta3, GGFHFB1

The sequence of this isoform differs from the canonical sequence as follows:
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Show »
Length:241
Mass (Da):26,143
Checksum:iD2450DB340E6B64D
GO
Isoform 9 (identifier: Q02297-9) [UniParc]FASTAAdd to basket
Also known as: GGF2, GGFHPP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP → MRWRRAPRRS...EVSRVLCKRC
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Show »
Length:422
Mass (Da):45,141
Checksum:i3535A1E4AB8EEA8E
GO
Isoform 10 (identifier: Q02297-10) [UniParc]FASTAAdd to basket
Also known as: SMDF

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.
     167-167: S → MEIYSPDMSE...ETNLQTAPKL
     213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
     242-640: Missing.

Note: Potential internal signal sequence at positions 76-100.
Show »
Length:296
Mass (Da):31,686
Checksum:i8D41743217F7EB02
GO
Isoform 11 (identifier: Q02297-11) [UniParc]FASTAAdd to basket
Also known as: Type IV-beta1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     22-33: KKPESAAGSQSP → MGKGRAGRVGTT
     134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
     213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME

Show »
Length:590
Mass (Da):65,460
Checksum:iB4DCA7D49EE8117B
GO
Isoform 12 (identifier: Q02297-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY
     424-640: Missing.

Note: No experimental confirmation available.
Show »
Length:420
Mass (Da):46,226
Checksum:iBE6F4EBA41F043A9
GO

Sequence cautioni

The sequence AAA19955 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAC51756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94K → A in AAA19953 (PubMed:7509448).Curated1
Sequence conflicti107S → P in ABQ53539 (PubMed:17565985).Curated1
Sequence conflicti261V → L in ABQ53540 (PubMed:17565985).Curated1
Sequence conflicti414S → F in AAA19953 (PubMed:7509448).Curated1
Sequence conflicti535Q → R in AAA19951 (PubMed:7509448).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00930738R → Q1 PublicationCorresponds to variant dbSNP:rs3924999Ensembl.1
Natural variantiVAR_053531289M → T2 PublicationsCorresponds to variant dbSNP:rs10503929Ensembl.1
Natural variantiVAR_009308463M → K. 1
Isoform 10 (identifier: Q02297-10)
Natural varianti46G → R. Corresponds to variant dbSNP:rs3735774Ensembl.1
Natural varianti127A → P. Corresponds to variant dbSNP:rs34822181Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0375621 – 166Missing in isoform 10. 3 PublicationsAdd BLAST166
Alternative sequenceiVSP_0034251 – 33MSERK…GSQSP → MRWRRAPRRSGRPGPRAQRP GSAARSSPPLPLLPLLLLLG TAALAPGAAAGNEAAPAGAS VCYSSPPSVGSVQELAQRAA VVIEGKVHPQRRQQGALDRK AAAAAGEAGAWGGDREPPAA GPRALGPPAEEPLLAANGTV PSWPTAPVPSAGEPGEEAPY LVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLK EDSRYIFFMEPDANSTSRAP AAFRASFPPLETGRNLKKEV SRVLCKRC in isoform 9. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0375631 – 21Missing in isoform 11. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_03756422 – 33KKPES…GSQSP → MGKGRAGRVGTT in isoform 11. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_003426134 – 168EIITG…NTSSS → A in isoform 9 and isoform 11. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_037565167S → MEIYSPDMSEVAAERSSSPS TQLSADPSLDGLPAAEDMPE PQTEDGRTPGLVGLAVPCCA CLEAERLRGCLNSEKICIVP ILACLVSLCLCIAGLKWVFV DKIFEYDSPTHLDPGGLGQD PIISLDATAASAVWVSSEAY TSPVSRAQSESEVQVTVQGD KAVVSFEPSAAPTPKNRIFA FSFLPSTAPSFPSPTRNPEV RTPKSATQPQTTETNLQTAP KL in isoform 10. 3 Publications1
Alternative sequenceiVSP_003429213 – 241QPGFT…ELYQK → PNEFTGDRCQNYVMASFYST STPFLSLPE in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST29
Alternative sequenceiVSP_003428213 – 234QPGFT…QNQEK → PNEFTGDRCQNYVMASFYKH LGIEFME in isoform 6 and isoform 11. 3 PublicationsAdd BLAST22
Alternative sequenceiVSP_003427213 – 233QPGFT…VQNQE → PNEFTGDRCQNYVMASFY in isoform 7 and isoform 12. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_003432234 – 247KAEEL…VLTIT → SAQMSLLVIAAKTT in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_003431234K → KHLGIEFIE in isoform 2. 1 Publication1
Alternative sequenceiVSP_003430242 – 640Missing in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST399
Alternative sequenceiVSP_003433248 – 640Missing in isoform 4. 1 PublicationAdd BLAST393
Alternative sequenceiVSP_046417424 – 640Missing in isoform 12. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_003434424 – 462YVSAM…SMTVS → HNLIAELRRNKAHRSKCMQI QLSATHLRSSSIPHLGFIL in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_003435463 – 640Missing in isoform 3. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94165 mRNA Translation: AAA58638.1
M94166 mRNA Translation: AAA58639.1
M94167 mRNA Translation: AAA58640.1
M94168 mRNA Translation: AAA58641.1
U02325 mRNA Translation: AAA19950.1
U02326 mRNA Translation: AAA19951.1
U02327 mRNA Translation: AAA19952.1
U02328 mRNA Translation: AAA19953.1
U02329 mRNA Translation: AAA19954.1
U02330 mRNA Translation: AAA19955.1 Sequence problems.
L12260 mRNA Translation: AAB59622.1
L12261 mRNA Translation: AAB59358.1
L41827 mRNA Translation: AAC41764.1
AK289927 mRNA Translation: BAF82616.1
AK298132 mRNA Translation: BAH12729.1
AC021909 Genomic DNA No translation available.
AC022833 Genomic DNA No translation available.
AC022850 Genomic DNA No translation available.
AC023948 Genomic DNA No translation available.
AC068359 Genomic DNA No translation available.
AC068931 Genomic DNA No translation available.
AC083977 Genomic DNA No translation available.
AC103675 Genomic DNA No translation available.
AC104000 Genomic DNA No translation available.
AC104029 Genomic DNA No translation available.
AC113209 Genomic DNA No translation available.
AF009227 mRNA Translation: AAC51756.1 Different initiation.
AF491780 Genomic DNA Translation: AAM71137.1
AF491780 Genomic DNA Translation: AAM71139.1
AF491780 Genomic DNA Translation: AAM71140.1
EF372273 mRNA Translation: ABQ53539.1
EF372274 mRNA Translation: ABQ53540.1
CH471080 Genomic DNA Translation: EAW63411.1
BC064587 mRNA Translation: AAH64587.1
BC073871 mRNA Translation: AAH73871.1
AF026146 mRNA Translation: AAD01795.1
BK000383 Genomic DNA Translation: DAA00044.1
BK000383 Genomic DNA Translation: DAA00045.1
BK000383 Genomic DNA Translation: DAA00046.1
BK000383 Genomic DNA Translation: DAA00047.1
CCDSiCCDS47836.1 [Q02297-9]
CCDS55218.1 [Q02297-11]
CCDS55219.1 [Q02297-12]
CCDS6083.1 [Q02297-6]
CCDS6084.1 [Q02297-7]
CCDS6085.1 [Q02297-1]
CCDS6086.1 [Q02297-3]
CCDS6087.1 [Q02297-10]
PIRiA43273
A56943
B43273
C43273
D43273
I38403
I38404
I38408
S32357
RefSeqiNP_001153467.1, NM_001159995.2
NP_001153471.1, NM_001159999.2
NP_001153473.1, NM_001160001.2 [Q02297-11]
NP_001153477.1, NM_001160005.1
NP_001153480.1, NM_001160008.1 [Q02297-12]
NP_001309134.1, NM_001322205.1
NP_001309135.1, NM_001322206.1
NP_001309136.1, NM_001322207.1
NP_039250.2, NM_013956.4 [Q02297-6]
NP_039251.2, NM_013957.4 [Q02297-7]
NP_039252.2, NM_013958.3 [Q02297-8]
NP_039253.1, NM_013959.3 [Q02297-10]
NP_039254.1, NM_013960.4 [Q02297-3]
NP_039256.2, NM_013962.2 [Q02297-9]
NP_039258.1, NM_013964.4 [Q02297-1]
UniGeneiHs.453951
Hs.668810

Genome annotation databases

EnsembliENST00000287842; ENSP00000287842; ENSG00000157168 [Q02297-6]
ENST00000356819; ENSP00000349275; ENSG00000157168 [Q02297-7]
ENST00000405005; ENSP00000384620; ENSG00000157168 [Q02297-1]
ENST00000519301; ENSP00000429582; ENSG00000157168 [Q02297-11]
ENST00000520407; ENSP00000434640; ENSG00000157168 [Q02297-9]
ENST00000520502; ENSP00000433289; ENSG00000157168 [Q02297-10]
ENST00000521670; ENSP00000428828; ENSG00000157168 [Q02297-3]
ENST00000523079; ENSP00000430120; ENSG00000157168 [Q02297-12]
GeneIDi3084
KEGGihsa:3084
UCSCiuc003xip.4 human [Q02297-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNRG1_HUMAN
AccessioniPrimary (citable) accession number: Q02297
Secondary accession number(s): A5YAK4
, A5YAK5, A8K1L2, B7Z4Z3, E9PHH4, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q15491, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 212 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

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