UniProtKB - Q02297 (NRG1_HUMAN)
Pro-neuregulin-1, membrane-bound isoform
NRG1
Functioni
GO - Molecular functioni
- chemorepellent activity Source: GO_Central
- cytokine activity Source: BHF-UCL
- ErbB-2 class receptor binding Source: Ensembl
- ErbB-3 class receptor binding Source: BHF-UCL
- growth factor activity Source: BHF-UCL
- integrin binding Source: UniProtKB
- protein tyrosine kinase activator activity Source: BHF-UCL
- receptor tyrosine kinase binding Source: UniProtKB
- signaling receptor binding Source: BHF-UCL
- transcription coregulator activity Source: MGI
- transmembrane receptor protein tyrosine kinase activator activity Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- activation of protein kinase B activity Source: UniProtKB
- activation of transmembrane receptor protein tyrosine kinase activity Source: BHF-UCL
- animal organ development Source: GO_Central
- cardiac conduction system development Source: Ensembl
- cardiac muscle cell differentiation Source: BHF-UCL
- cardiac muscle cell myoblast differentiation Source: BHF-UCL
- cell communication Source: BHF-UCL
- cell differentiation Source: GO_Central
- cell morphogenesis Source: Ensembl
- cell population proliferation Source: BHF-UCL
- cellular protein complex disassembly Source: MGI
- chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: Ensembl
- endocardial cell differentiation Source: BHF-UCL
- ERBB2 signaling pathway Source: Reactome
- ERBB3 signaling pathway Source: CAFA
- ERBB4 signaling pathway Source: UniProtKB
- ERBB signaling pathway Source: BHF-UCL
- glial cell fate commitment Source: Ensembl
- intracellular signal transduction Source: GO_Central
- locomotory behavior Source: Ensembl
- mammary gland development Source: BHF-UCL
- MAPK cascade Source: Reactome
- myelination in peripheral nervous system Source: Ensembl
- negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
- negative regulation of neuron migration Source: Ensembl
- negative regulation of protein catabolic process Source: Ensembl
- negative regulation of secretion Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: MGI
- nervous system development Source: GO_Central
- neural crest cell development Source: BHF-UCL
- neuron fate commitment Source: Ensembl
- neurotransmitter receptor metabolic process Source: Ensembl
- oligodendrocyte differentiation Source: Ensembl
- positive regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- positive regulation of cardiac muscle cell differentiation Source: Ensembl
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cell adhesion Source: BHF-UCL
- positive regulation of cell growth Source: BHF-UCL
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: Ensembl
- positive regulation of peptidyl-tyrosine autophosphorylation Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of Ras protein signal transduction Source: Ensembl
- positive regulation of striated muscle cell differentiation Source: BHF-UCL
- regulation of cell motility Source: Reactome
- regulation of postsynaptic neurotransmitter receptor internalization Source: SynGO
- synapse assembly Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
- ventricular cardiac muscle cell differentiation Source: BHF-UCL
- ventricular trabecula myocardium morphogenesis Source: BHF-UCL
- wound healing Source: BHF-UCL
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
PathwayCommonsi | Q02297 |
Reactomei | R-HSA-1227986, Signaling by ERBB2 [Q02297-10] R-HSA-1236394, Signaling by ERBB4 [Q02297-10] R-HSA-1250196, SHC1 events in ERBB2 signaling [Q02297-10] R-HSA-1250342, PI3K events in ERBB4 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1257604, PIP3 activates AKT signaling [Q02297-10] R-HSA-1306955, GRB7 events in ERBB2 signaling [Q02297-10] R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling [Q02297-10] R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-1963642, PI3K events in ERBB2 signaling [Q02297-10] R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [Q02297-10] R-HSA-5673001, RAF/MAP kinase cascade [Q02297-10] R-HSA-6785631, ERBB2 Regulates Cell Motility [Q02297-10] R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Q02297-10] R-HSA-8847993, ERBB2 Activates PTK6 Signaling [Q02297-10] R-HSA-8863795, Downregulation of ERBB2 signaling [Q02297-10] R-HSA-9620244, Long-term potentiation R-HSA-9664565, Signaling by ERBB2 KD Mutants [Q02297-10] R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [Q02297-10] |
SignaLinki | Q02297 |
SIGNORi | Q02297 |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-neuregulin-1, membrane-bound isoformShort name: Pro-NRG1 Cleaved into the following chain: Alternative name(s): Acetylcholine receptor-inducing activity Short name: ARIA Breast cancer cell differentiation factor p45 Glial growth factor Heregulin Short name: HRG Neu differentiation factor Sensory and motor neuron-derived factor |
Gene namesi | Name:NRG1 Synonyms:GGF, HGL, HRGA, NDF, SMDF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000157168.18 |
HGNCi | HGNC:7997, NRG1 |
MIMi | 142445, gene |
neXtProti | NX_Q02297 |
Subcellular locationi
Plasma membrane
Note: Does not seem to be active.
Extracellular region or secreted
Nucleus
Note: May be nuclear.
Extracellular region or secreted
Note: Has a signal peptide.
Other locations
Note: May possess an internal uncleaved signal sequence.
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: Ensembl
- integral component of postsynaptic density membrane Source: SynGO
- integral component of presynaptic active zone membrane Source: SynGO
Other locations
- axon Source: Ensembl
- cytoplasm Source: Ensembl
- glutamatergic synapse Source: SynGO
- membrane Source: UniProtKB
- neuromuscular junction Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 242 | ExtracellularSequence analysisAdd BLAST | 223 | |
Transmembranei | 243 – 265 | Helical; Note=Internal signal sequenceSequence analysisAdd BLAST | 23 | |
Topological domaini | 266 – 640 | CytoplasmicSequence analysisAdd BLAST | 375 |
Keywords - Cellular componenti
Cell membrane, Membrane, Nucleus, SecretedPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 181 | K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-185 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-185 and E-187. 1 Publication | 1 | |
Mutagenesisi | 185 | K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-187. 1 Publication | 1 | |
Mutagenesisi | 187 | K → E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-185. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-185. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 34 | Breakpoint for translocation to form gamma-heregulin | 1 |
Organism-specific databases
DisGeNETi | 3084 |
MalaCardsi | NRG1 |
OpenTargetsi | ENSG00000157168 |
PharmGKBi | PA31776 |
Miscellaneous databases
Pharosi | Q02297, Tbio |
Polymorphism and mutation databases
BioMutai | NRG1 |
DMDMi | 9297018 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000019462 | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000019463 | 20 – 640 | Pro-neuregulin-1, membrane-bound isoformAdd BLAST | 621 | |
ChainiPRO_0000019464 | 20 – 241 | Neuregulin-1Add BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 112 | By similarity | ||
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 164 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 182 ↔ 196 | 1 Publication | ||
Disulfide bondi | 190 ↔ 210 | 1 Publication | ||
Disulfide bondi | 212 ↔ 221 | 1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q02297 |
MassIVEi | Q02297 |
MaxQBi | Q02297 |
PaxDbi | Q02297 |
PeptideAtlasi | Q02297 |
PRIDEi | Q02297 |
ProteomicsDBi | 20533 58070 [Q02297-1] 58071 [Q02297-10] 58072 [Q02297-11] 58073 [Q02297-2] 58074 [Q02297-3] 58075 [Q02297-4] 58076 [Q02297-6] 58077 [Q02297-7] 58078 [Q02297-8] 58079 [Q02297-9] |
PTM databases
GlyGeni | Q02297, 3 sites |
iPTMneti | Q02297 |
PhosphoSitePlusi | Q02297 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000157168, Expressed in ventricular zone and 174 other tissues |
ExpressionAtlasi | Q02297, baseline and differential |
Genevisiblei | Q02297, HS |
Organism-specific databases
HPAi | ENSG00000157168, Tissue enhanced (brain) |
Interactioni
Subunit structurei
The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity).
Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).
By similarity1 PublicationBinary interactionsi
Hide detailsIsoform 6 [Q02297-6]
With | #Exp. | IntAct |
---|---|---|
ERBB3 [P21860] | 2 | EBI-15651799,EBI-720706 |
ERBB4 [Q15303] | 3 | EBI-15651799,EBI-80371 |
Isoform 7 [Q02297-7]
With | #Exp. | IntAct |
---|---|---|
ERBB2 [P04626] | 2 | EBI-2460927,EBI-641062 |
ERBB3 [P21860] | 3 | EBI-2460927,EBI-720706 |
Isoform 10 [Q02297-10]
GO - Molecular functioni
- chemorepellent activity Source: GO_Central
- cytokine activity Source: BHF-UCL
- ErbB-2 class receptor binding Source: Ensembl
- ErbB-3 class receptor binding Source: BHF-UCL
- growth factor activity Source: BHF-UCL
- integrin binding Source: UniProtKB
- receptor tyrosine kinase binding Source: UniProtKB
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109332, 84 interactors |
CORUMi | Q02297 |
DIPi | DIP-355N |
IntActi | Q02297, 55 interactors |
MINTi | Q02297 |
STRINGi | 9606.ENSP00000384620 |
Miscellaneous databases
RNActi | Q02297, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q02297 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q02297 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 128 | Ig-like C2-typeAdd BLAST | 92 | |
Domaini | 178 – 222 | EGF-likePROSITE-ProRule annotationAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 165 – 177 | Ser/Thr-richAdd BLAST | 13 |
Domaini
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Immunoglobulin domain, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRUM, Eukaryota |
GeneTreei | ENSGT00940000157326 |
HOGENOMi | CLU_023628_1_0_1 |
InParanoidi | Q02297 |
OrthoDBi | 313400at2759 |
PhylomeDBi | Q02297 |
TreeFami | TF332469 |
Family and domain databases
DisProti | DP01520 [Q02297-10] |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C IPR018250, NRG1 |
PANTHERi | PTHR11100, PTHR11100, 1 hit PTHR11100:SF7, PTHR11100:SF7, 1 hit |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit |
PRINTSi | PR01089, NEUREGULIN |
SMARTi | View protein in SMART SM00181, EGF, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit |
s (11+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 11 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 11 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG
60 70 80 90 100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN
110 120 130 140 150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS
160 170 180 190 200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK
210 220 230 240 250
DLSNPSRYLC KCQPGFTGAR CTENVPMKVQ NQEKAEELYQ KRVLTITGIC
260 270 280 290 300
IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM NIANGPHHPN
310 320 330 340 350
PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST AHHSTTVTQT
360 370 380 390 400
PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG RLNGTGGPRE
410 420 430 440 450
CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH TPSSPKSPPS
460 470 480 490 500
EMSPPVSSMT VSMPSMAVSP FMEEERPLLL VTPPRLREKK FDHHPQQFSS
510 520 530 540 550
FHHNPAHDSN SLPASPLRIV EDEEYETTQE YEPAQEPVKK LANSRRAKRT
560 570 580 590 600
KPNGHIANRL EVDSNTSSQS SNSESETEDE RVGEDTPFLG IQNPLAASLE
610 620 630 640
ATPAFRLADS RTNPAGRFST QEEIQARLSS VIANQDPIAV
The sequence of this isoform differs from the canonical sequence as follows:
1-33: MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP → MRWRRAPRRS...EVSRVLCKRC
134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
242-640: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-166: Missing.
167-167: S → MEIYSPDMSE...ETNLQTAPKL
213-241: QPGFTGARCTENVPMKVQNQEKAEELYQK → PNEFTGDRCQNYVMASFYSTSTPFLSLPE
242-640: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-21: Missing.
22-33: KKPESAAGSQSP → MGKGRAGRVGTT
134-168: EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS → A
213-234: QPGFTGARCTENVPMKVQNQEK → PNEFTGDRCQNYVMASFYKHLGIEFME
The sequence of this isoform differs from the canonical sequence as follows:
213-233: QPGFTGARCTENVPMKVQNQE → PNEFTGDRCQNYVMASFY
424-640: Missing.
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBA3 | H0YBA3_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 713 | Annotation score: | ||
A0A494C0K4 | A0A494C0K4_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 459 | Annotation score: | ||
A0A494C1F5 | A0A494C1F5_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 624 | Annotation score: | ||
A0A494C1F8 | A0A494C1F8_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 607 | Annotation score: | ||
A0A494C043 | A0A494C043_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 461 | Annotation score: | ||
F6RJN6 | F6RJN6_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 308 | Annotation score: | ||
A0A494C0L9 | A0A494C0L9_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 522 | Annotation score: | ||
A0A494C0Q4 | A0A494C0Q4_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 700 | Annotation score: | ||
A0A494C1B5 | A0A494C1B5_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 483 | Annotation score: | ||
A0A5F9ZHA5 | A0A5F9ZHA5_HUMAN | Pro-neuregulin-1, membrane-bound is... | NRG1 | 168 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 94 | K → A in AAA19953 (PubMed:7509448).Curated | 1 | |
Sequence conflicti | 107 | S → P in ABQ53539 (PubMed:17565985).Curated | 1 | |
Sequence conflicti | 261 | V → L in ABQ53540 (PubMed:17565985).Curated | 1 | |
Sequence conflicti | 414 | S → F in AAA19953 (PubMed:7509448).Curated | 1 | |
Sequence conflicti | 535 | Q → R in AAA19951 (PubMed:7509448).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_009307 | 38 | R → Q1 PublicationCorresponds to variant dbSNP:rs3924999Ensembl. | 1 | ||
Natural variantiVAR_053531 | 289 | M → T2 PublicationsCorresponds to variant dbSNP:rs10503929Ensembl. | 1 | ||
Natural variantiVAR_009308 | 463 | M → K. | 1 | ||
Isoform 10 (identifier: Q02297-10) | |||||
Natural variantiVAR_082866 | 46 | G → RCuratedCorresponds to variant dbSNP:rs3735774Ensembl. | 1 | ||
Natural variantiVAR_082867 | 127 | A → PCuratedCorresponds to variant dbSNP:rs34822181Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037562 | 1 – 166 | Missing in isoform 10. 3 PublicationsAdd BLAST | 166 | |
Alternative sequenceiVSP_003425 | 1 – 33 | MSERK…GSQSP → MRWRRAPRRSGRPGPRAQRP GSAARSSPPLPLLPLLLLLG TAALAPGAAAGNEAAPAGAS VCYSSPPSVGSVQELAQRAA VVIEGKVHPQRRQQGALDRK AAAAAGEAGAWGGDREPPAA GPRALGPPAEEPLLAANGTV PSWPTAPVPSAGEPGEEAPY LVKVHQVWAVKAGGLKKDSL LTVRLGTWGHPAFPSCGRLK EDSRYIFFMEPDANSTSRAP AAFRASFPPLETGRNLKKEV SRVLCKRC in isoform 9. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_037563 | 1 – 21 | Missing in isoform 11. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_037564 | 22 – 33 | KKPES…GSQSP → MGKGRAGRVGTT in isoform 11. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_003426 | 134 – 168 | EIITG…NTSSS → A in isoform 9 and isoform 11. 2 PublicationsAdd BLAST | 35 | |
Alternative sequenceiVSP_037565 | 167 | S → MEIYSPDMSEVAAERSSSPS TQLSADPSLDGLPAAEDMPE PQTEDGRTPGLVGLAVPCCA CLEAERLRGCLNSEKICIVP ILACLVSLCLCIAGLKWVFV DKIFEYDSPTHLDPGGLGQD PIISLDATAASAVWVSSEAY TSPVSRAQSESEVQVTVQGD KAVVSFEPSAAPTPKNRIFA FSFLPSTAPSFPSPTRNPEV RTPKSATQPQTTETNLQTAP KL in isoform 10. 3 Publications | 1 | |
Alternative sequenceiVSP_003429 | 213 – 241 | QPGFT…ELYQK → PNEFTGDRCQNYVMASFYST STPFLSLPE in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_003428 | 213 – 234 | QPGFT…QNQEK → PNEFTGDRCQNYVMASFYKH LGIEFME in isoform 6 and isoform 11. 3 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_003427 | 213 – 233 | QPGFT…VQNQE → PNEFTGDRCQNYVMASFY in isoform 7 and isoform 12. 3 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_003432 | 234 – 247 | KAEEL…VLTIT → SAQMSLLVIAAKTT in isoform 4. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_003431 | 234 | K → KHLGIEFIE in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_003430 | 242 – 640 | Missing in isoform 8, isoform 9 and isoform 10. 6 PublicationsAdd BLAST | 399 | |
Alternative sequenceiVSP_003433 | 248 – 640 | Missing in isoform 4. 1 PublicationAdd BLAST | 393 | |
Alternative sequenceiVSP_046417 | 424 – 640 | Missing in isoform 12. 1 PublicationAdd BLAST | 217 | |
Alternative sequenceiVSP_003434 | 424 – 462 | YVSAM…SMTVS → HNLIAELRRNKAHRSKCMQI QLSATHLRSSSIPHLGFIL in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_003435 | 463 – 640 | Missing in isoform 3. 1 PublicationAdd BLAST | 178 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94165 mRNA Translation: AAA58638.1 M94166 mRNA Translation: AAA58639.1 M94167 mRNA Translation: AAA58640.1 M94168 mRNA Translation: AAA58641.1 U02325 mRNA Translation: AAA19950.1 U02326 mRNA Translation: AAA19951.1 U02327 mRNA Translation: AAA19952.1 U02328 mRNA Translation: AAA19953.1 U02329 mRNA Translation: AAA19954.1 U02330 mRNA Translation: AAA19955.1 Sequence problems. L12260 mRNA Translation: AAB59622.1 L12261 mRNA Translation: AAB59358.1 L41827 mRNA Translation: AAC41764.1 AK289927 mRNA Translation: BAF82616.1 AK298132 mRNA Translation: BAH12729.1 AC021909 Genomic DNA No translation available. AC022833 Genomic DNA No translation available. AC022850 Genomic DNA No translation available. AC023948 Genomic DNA No translation available. AC068359 Genomic DNA No translation available. AC068931 Genomic DNA No translation available. AC083977 Genomic DNA No translation available. AC103675 Genomic DNA No translation available. AC104000 Genomic DNA No translation available. AC104029 Genomic DNA No translation available. AC113209 Genomic DNA No translation available. AF009227 mRNA Translation: AAC51756.1 Different initiation. AF491780 Genomic DNA Translation: AAM71137.1 AF491780 Genomic DNA Translation: AAM71139.1 AF491780 Genomic DNA Translation: AAM71140.1 EF372273 mRNA Translation: ABQ53539.1 EF372274 mRNA Translation: ABQ53540.1 CH471080 Genomic DNA Translation: EAW63411.1 BC064587 mRNA Translation: AAH64587.1 BC073871 mRNA Translation: AAH73871.1 AF026146 mRNA Translation: AAD01795.1 BK000383 Genomic DNA Translation: DAA00044.1 BK000383 Genomic DNA Translation: DAA00045.1 BK000383 Genomic DNA Translation: DAA00046.1 BK000383 Genomic DNA Translation: DAA00047.1 |
CCDSi | CCDS47836.1 [Q02297-9] CCDS55218.1 [Q02297-11] CCDS55219.1 [Q02297-12] CCDS6083.1 [Q02297-6] CCDS6084.1 [Q02297-7] CCDS6085.1 [Q02297-1] CCDS6086.1 [Q02297-3] CCDS6087.1 [Q02297-10] |
PIRi | A43273 A56943 B43273 C43273 D43273 I38403 I38404 I38408 S32357 |
RefSeqi | NP_001153467.1, NM_001159995.2 NP_001153471.1, NM_001159999.2 NP_001153473.1, NM_001160001.2 [Q02297-11] NP_001153477.1, NM_001160005.1 NP_001153480.1, NM_001160008.1 [Q02297-12] NP_001309134.1, NM_001322205.1 NP_001309135.1, NM_001322206.1 NP_001309136.1, NM_001322207.1 NP_039250.2, NM_013956.4 [Q02297-6] NP_039251.2, NM_013957.4 [Q02297-7] NP_039252.2, NM_013958.3 [Q02297-8] NP_039253.1, NM_013959.3 [Q02297-10] NP_039254.1, NM_013960.4 [Q02297-3] NP_039256.2, NM_013962.2 [Q02297-9] NP_039258.1, NM_013964.4 [Q02297-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Tipping the mind - Issue 129 of June 2011 |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HAE | NMR | - | A | 177-239 | [»] | |
1HAF | NMR | - | A | 177-239 | [»] | |
1HRE | NMR | - | A | 175-241 | [»] | |
1HRF | NMR | - | A | 175-241 | [»] | |
3U7U | X-ray | 3.03 | G/H/I/J/K/L | 175-212 | [»] | |
SMRi | Q02297 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109332, 84 interactors |
CORUMi | Q02297 |
DIPi | DIP-355N |
IntActi | Q02297, 55 interactors |
MINTi | Q02297 |
STRINGi | 9606.ENSP00000384620 |
PTM databases
GlyGeni | Q02297, 3 sites |
iPTMneti | Q02297 |
PhosphoSitePlusi | Q02297 |
Polymorphism and mutation databases
BioMutai | NRG1 |
DMDMi | 9297018 |
Proteomic databases
jPOSTi | Q02297 |
MassIVEi | Q02297 |
MaxQBi | Q02297 |
PaxDbi | Q02297 |
PeptideAtlasi | Q02297 |
PRIDEi | Q02297 |
ProteomicsDBi | 20533 58070 [Q02297-1] 58071 [Q02297-10] 58072 [Q02297-11] 58073 [Q02297-2] 58074 [Q02297-3] 58075 [Q02297-4] 58076 [Q02297-6] 58077 [Q02297-7] 58078 [Q02297-8] 58079 [Q02297-9] |
Protocols and materials databases
ABCDi | Q02297, 1 sequenced antibody |
Antibodypediai | 3706, 925 antibodies |
DNASUi | 3084 |
Genome annotation databases
Organism-specific databases
CTDi | 3084 |
DisGeNETi | 3084 |
EuPathDBi | HostDB:ENSG00000157168.18 |
GeneCardsi | NRG1 |
HGNCi | HGNC:7997, NRG1 |
HPAi | ENSG00000157168, Tissue enhanced (brain) |
MalaCardsi | NRG1 |
MIMi | 142445, gene |
neXtProti | NX_Q02297 |
OpenTargetsi | ENSG00000157168 |
PharmGKBi | PA31776 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRUM, Eukaryota |
GeneTreei | ENSGT00940000157326 |
HOGENOMi | CLU_023628_1_0_1 |
InParanoidi | Q02297 |
OrthoDBi | 313400at2759 |
PhylomeDBi | Q02297 |
TreeFami | TF332469 |
Enzyme and pathway databases
PathwayCommonsi | Q02297 |
Reactomei | R-HSA-1227986, Signaling by ERBB2 [Q02297-10] R-HSA-1236394, Signaling by ERBB4 [Q02297-10] R-HSA-1250196, SHC1 events in ERBB2 signaling [Q02297-10] R-HSA-1250342, PI3K events in ERBB4 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1257604, PIP3 activates AKT signaling [Q02297-10] R-HSA-1306955, GRB7 events in ERBB2 signaling [Q02297-10] R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling [Q02297-10] R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-1963642, PI3K events in ERBB2 signaling [Q02297-10] R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [Q02297-10] R-HSA-5673001, RAF/MAP kinase cascade [Q02297-10] R-HSA-6785631, ERBB2 Regulates Cell Motility [Q02297-10] R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Q02297-10] R-HSA-8847993, ERBB2 Activates PTK6 Signaling [Q02297-10] R-HSA-8863795, Downregulation of ERBB2 signaling [Q02297-10] R-HSA-9620244, Long-term potentiation R-HSA-9664565, Signaling by ERBB2 KD Mutants [Q02297-10] R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [Q02297-10] |
SignaLinki | Q02297 |
SIGNORi | Q02297 |
Miscellaneous databases
BioGRID-ORCSi | 3084, 3 hits in 855 CRISPR screens |
ChiTaRSi | NRG1, human |
EvolutionaryTracei | Q02297 |
GeneWikii | Neuregulin_1 |
GenomeRNAii | 3084 |
Pharosi | Q02297, Tbio |
PROi | PR:Q02297 |
RNActi | Q02297, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157168, Expressed in ventricular zone and 174 other tissues |
ExpressionAtlasi | Q02297, baseline and differential |
Genevisiblei | Q02297, HS |
Family and domain databases
DisProti | DP01520 [Q02297-10] |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C IPR018250, NRG1 |
PANTHERi | PTHR11100, PTHR11100, 1 hit PTHR11100:SF7, PTHR11100:SF7, 1 hit |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit |
PRINTSi | PR01089, NEUREGULIN |
SMARTi | View protein in SMART SM00181, EGF, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NRG1_HUMAN | |
Accessioni | Q02297Primary (citable) accession number: Q02297 Secondary accession number(s): A5YAK4 Q9UPE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 231 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations