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Entry version 115 (17 Jun 2020)
Sequence version 1 (01 Apr 1993)
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Protein

T-protein

Gene

tyrA

Organism
Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA), T-protein (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional chorismate mutase/prephenate dehydratase (pheA), T-protein (tyrA), Monofunctional chorismate mutase (aroQ), T-protein (tyrA), Chorismate mutase (E5821_21460)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Oxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00120;UER00203
UPA00122;UER00961

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tyrA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri549 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaePantoeaPantoea agglomerans group

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001191961 – 373T-proteinAdd BLAST373

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q02287

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
549.BW31_02110

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02287

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 90Chorismate mutasePROSITE-ProRule annotationAdd BLAST90
Domaini99 – 361Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST263

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the prephenate/arogenate dehydrogenase family.Curated

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
533829at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.59.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR008244 Chor_mut/prephenate_DH_T
IPR036263 Chorismate_II_sf
IPR036979 CM_dom_sf
IPR002701 CM_II_prokaryot
IPR011277 CM_T
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01817 CM_2, 1 hit
PF02153 PDH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001499 Chor_mut_pdh_Tpr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00830 CM_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48179 SSF48179, 1 hit
SSF48600 SSF48600, 1 hit
SSF51735 SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01799 CM_T, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51168 CHORISMATE_MUT_2, 1 hit
PS51176 PDH_ADH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02287-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAELTALRD QIDSVDKALL DLLAKRLELV AEVGEVKSRY GLPIYVPERE
60 70 80 90 100
ASMLASRRKE AEALGVPPDL IEDVLRRVMR ESYTSENDKG FKTLCPELRP
110 120 130 140 150
VVIVGGKGQM GRLFEKMLGL SGYTVKTLDK EDWPQAETLL SDAGMVIISV
160 170 180 190 200
PIHLTEQVIA QLPPLPEDCI LVDLASVKNR PLQAMLAAHN GPVLGLHPMF
210 220 230 240 250
GPDSGSLAKQ VVVWCDGRQP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA
260 270 280 290 300
FIQALRHFAT FAYGLHLAEE NVNLDQLLAL SSPIYRLELA MVGRLFAQDP
310 320 330 340 350
QLYADIIMSS ESNLALIKRY YQRFGEAIAL LEQGDKQAFI ASFNRVEQWF
360 370
GDHAKRFLVE SRSLLRSAND SRP
Length:373
Mass (Da):41,847
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6E3C3B877A0628C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60420 Genomic DNA Translation: CAA42950.1
M74135 Genomic DNA Translation: AAA24868.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S29934

NCBI Reference Sequences

More...
RefSeqi
WP_010248465.1, NZ_WHOZ01000001.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31703945

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60420 Genomic DNA Translation: CAA42950.1
M74135 Genomic DNA Translation: AAA24868.1
PIRiS29934
RefSeqiWP_010248465.1, NZ_WHOZ01000001.1

3D structure databases

SMRiQ02287
ModBaseiSearch...

Protein-protein interaction databases

STRINGi549.BW31_02110

Proteomic databases

PRIDEiQ02287

Genome annotation databases

GeneIDi31703945

Phylogenomic databases

OrthoDBi533829at2

Enzyme and pathway databases

UniPathwayiUPA00120;UER00203
UPA00122;UER00961

Family and domain databases

Gene3Di1.20.59.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR008244 Chor_mut/prephenate_DH_T
IPR036263 Chorismate_II_sf
IPR036979 CM_dom_sf
IPR002701 CM_II_prokaryot
IPR011277 CM_T
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH
PfamiView protein in Pfam
PF01817 CM_2, 1 hit
PF02153 PDH, 1 hit
PIRSFiPIRSF001499 Chor_mut_pdh_Tpr, 1 hit
SMARTiView protein in SMART
SM00830 CM_2, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF48600 SSF48600, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01799 CM_T, 1 hit
PROSITEiView protein in PROSITE
PS51168 CHORISMATE_MUT_2, 1 hit
PS51176 PDH_ADH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYRA_ENTAG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02287
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 17, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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