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Entry version 196 (12 Aug 2020)
Sequence version 1 (01 Jul 1993)
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Protein

Contactin-2

Gene

CNTN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q02246

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373760, L1CAM interactions
R-HSA-419037, NCAM1 interactions
R-HSA-447038, NrCAM interactions

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.23.1.3, the basigin (basigin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-2
Alternative name(s):
Axonal glycoprotein TAG-1
Axonin-1
Transient axonal glycoprotein 1
Short name:
TAX-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTN2
Synonyms:AXT, TAG1, TAX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184144.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2172, CNTN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190197, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02246

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy, familial adult myoclonic, 5 (FAME5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME5 is characterized by onset of seizures in adolescence, followed by the development of cortical myoclonic tremor later in life. Inheritance is autosomal recessive.
Related information in OMIM

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
6900

MalaCards human disease database

More...
MalaCardsi
CNTN2
MIMi615400, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000184144

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
86814, Benign adult familial myoclonic epilepsy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26686

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q02246, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNTN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
399092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 301 PublicationAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001469531 – 1012Contactin-2Add BLAST982
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000146961013 – 1040Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi61 ↔ 111PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 207PROSITE-ProRule annotation1 Publication
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 306PROSITE-ProRule annotation1 Publication
Disulfide bondi348 ↔ 395PROSITE-ProRule annotation1 Publication
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi830N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi904N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi918N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi940N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1012GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q02246

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02246

PeptideAtlas

More...
PeptideAtlasi
Q02246

PRoteomics IDEntifications database

More...
PRIDEi
Q02246

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58068

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q02246, 11 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02246

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02246

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184144, Expressed in corpus callosum and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q02246, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02246, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184144, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112763, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q02246, 2 interactors

Molecular INTeraction database

More...
MINTi
Q02246

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330633

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q02246, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11040
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02246

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q02246

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 128Ig-like C2-type 1Add BLAST86
Domaini133 – 222Ig-like C2-type 2Add BLAST90
Domaini239 – 322Ig-like C2-type 3Add BLAST84
Domaini327 – 411Ig-like C2-type 4Add BLAST85
Domaini417 – 504Ig-like C2-type 5Add BLAST88
Domaini509 – 603Ig-like C2-type 6Add BLAST95
Domaini610 – 708Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini713 – 810Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini815 – 910Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini915 – 1006Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi794 – 796Cell attachment siteBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi606 – 612Gly/Pro-rich7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3513, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159193

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005756_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02246

KEGG Orthology (KO)

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KOi
K06760

Identification of Orthologs from Complete Genome Data

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OMAi
HYVYRNE

Database of Orthologous Groups

More...
OrthoDBi
655902at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02246

TreeFam database of animal gene trees

More...
TreeFami
TF351103

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043204, Basigin-like
IPR032991, Contactin-2
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

The PANTHER Classification System

More...
PANTHERi
PTHR10075, PTHR10075, 1 hit
PTHR10075:SF55, PTHR10075:SF55, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 3 hits
PF07679, I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 4 hits
SM00409, IG, 6 hits
SM00408, IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 4 hits
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q02246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTATRRKPH LLLVAAVALV SSSAWSSALG SQTTFGPVFE DQPLSVLFPE
60 70 80 90 100
ESTEEQVLLA CRARASPPAT YRWKMNGTEM KLEPGSRHQL VGGNLVIMNP
110 120 130 140 150
TKAQDAGVYQ CLASNPVGTV VSREAILRFG FLQEFSKEER DPVKAHEGWG
160 170 180 190 200
VMLPCNPPAH YPGLSYRWLL NEFPNFIPTD GRHFVSQTTG NLYIARTNAS
210 220 230 240 250
DLGNYSCLAT SHMDFSTKSV FSKFAQLNLA AEDTRLFAPS IKARFPAETY
260 270 280 290 300
ALVGQQVTLE CFAFGNPVPR IKWRKVDGSL SPQWTTAEPT LQIPSVSFED
310 320 330 340 350
EGTYECEAEN SKGRDTVQGR IIVQAQPEWL KVISDTEADI GSNLRWGCAA
360 370 380 390 400
AGKPRPTVRW LRNGEPLASQ NRVEVLAGDL RFSKLSLEDS GMYQCVAENK
410 420 430 440 450
HGTIYASAEL AVQALAPDFR LNPVRRLIPA ARGGEILIPC QPRAAPKAVV
460 470 480 490 500
LWSKGTEILV NSSRVTVTPD GTLIIRNISR SDEGKYTCFA ENFMGKANST
510 520 530 540 550
GILSVRDATK ITLAPSSADI NLGDNLTLQC HASHDPTMDL TFTWTLDDFP
560 570 580 590 600
IDFDKPGGHY RRTNVKETIG DLTILNAQLR HGGKYTCMAQ TVVDSASKEA
610 620 630 640 650
TVLVRGPPGP PGGVVVRDIG DTTIQLSWSR GFDNHSPIAK YTLQARTPPA
660 670 680 690 700
GKWKQVRTNP ANIEGNAETA QVLGLTPWMD YEFRVIASNI LGTGEPSGPS
710 720 730 740 750
SKIRTREAAP SVAPSGLSGG GGAPGELIVN WTPMSREYQN GDGFGYLLSF
760 770 780 790 800
RRQGSTHWQT ARVPGADAQY FVYSNESVRP YTPFEVKIRS YNRRGDGPES
810 820 830 840 850
LTALVYSAEE EPRVAPTKVW AKGVSSSEMN VTWEPVQQDM NGILLGYEIR
860 870 880 890 900
YWKAGDKEAA ADRVRTAGLD TSARVSGLHP NTKYHVTVRA YNRAGTGPAS
910 920 930 940 950
PSANATTMKP PPRRPPGNIS WTFSSSSLSI KWDPVVPFRN ESAVTGYKML
960 970 980 990 1000
YQNDLHLTPT LHLTGKNWIE IPVPEDIGHA LVQIRTTGPG GDGIPAEVHI
1010 1020 1030 1040
VRNGGTSMMV ENMAVRPAPH PGTVISHSVA MLILIGSLEL
Length:1,040
Mass (Da):113,393
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i254E78DD3C28EFB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQ11A0A1W2PQ11_HUMAN
Contactin-2
CNTN2
1,085Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTL7A0A1B0GTL7_HUMAN
Contactin-2
CNTN2
1,011Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PR60A0A1W2PR60_HUMAN
Contactin-2
CNTN2
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPY1A0A1W2PPY1_HUMAN
Contactin-2
CNTN2
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQJ4A0A1W2PQJ4_HUMAN
Contactin-2
CNTN2
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ86A0A1W2PQ86_HUMAN
Contactin-2
CNTN2
764Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPQ9A0A1W2PPQ9_HUMAN
Contactin-2
CNTN2
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021918145A → T. Corresponds to variant dbSNP:rs2275697Ensembl.1
Natural variantiVAR_029129366P → L. Corresponds to variant dbSNP:rs2229866Ensembl.1
Natural variantiVAR_021919657R → W. Corresponds to variant dbSNP:rs2305276EnsemblClinVar.1
Natural variantiVAR_0498671024V → I. Corresponds to variant dbSNP:rs17416074Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68274 mRNA Translation: CAA48335.1
X67734 mRNA Translation: CAA47963.1
X84420 Genomic DNA Translation: CAA59137.1
AL583832 Genomic DNA No translation available.
X92681 Genomic DNA Translation: CAA63365.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1449.1

Protein sequence database of the Protein Information Resource

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PIRi
S35508, A49356

NCBI Reference Sequences

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RefSeqi
NP_001333012.1, NM_001346083.1
NP_005067.1, NM_005076.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331830; ENSP00000330633; ENSG00000184144
ENST00000638378; ENSP00000492617; ENSG00000184144
ENST00000639302; ENSP00000491671; ENSG00000184144
ENST00000640326; ENSP00000492495; ENSG00000184144

Database of genes from NCBI RefSeq genomes

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GeneIDi
6900

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6900

UCSC genome browser

More...
UCSCi
uc001hbr.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68274 mRNA Translation: CAA48335.1
X67734 mRNA Translation: CAA47963.1
X84420 Genomic DNA Translation: CAA59137.1
AL583832 Genomic DNA No translation available.
X92681 Genomic DNA Translation: CAA63365.1
CCDSiCCDS1449.1
PIRiS35508, A49356
RefSeqiNP_001333012.1, NM_001346083.1
NP_005067.1, NM_005076.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OM5X-ray3.07A34-414[»]
SMRiQ02246
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112763, 11 interactors
IntActiQ02246, 2 interactors
MINTiQ02246
STRINGi9606.ENSP00000330633

Protein family/group databases

TCDBi8.A.23.1.3, the basigin (basigin) family

PTM databases

GlyGeniQ02246, 11 sites
iPTMnetiQ02246
PhosphoSitePlusiQ02246

Polymorphism and mutation databases

BioMutaiCNTN2
DMDMi399092

Proteomic databases

MassIVEiQ02246
PaxDbiQ02246
PeptideAtlasiQ02246
PRIDEiQ02246
ProteomicsDBi58068

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
670, 261 antibodies

Genome annotation databases

EnsembliENST00000331830; ENSP00000330633; ENSG00000184144
ENST00000638378; ENSP00000492617; ENSG00000184144
ENST00000639302; ENSP00000491671; ENSG00000184144
ENST00000640326; ENSP00000492495; ENSG00000184144
GeneIDi6900
KEGGihsa:6900
UCSCiuc001hbr.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6900
DisGeNETi6900
EuPathDBiHostDB:ENSG00000184144.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CNTN2
HGNCiHGNC:2172, CNTN2
HPAiENSG00000184144, Tissue enriched (brain)
MalaCardsiCNTN2
MIMi190197, gene
615400, phenotype
neXtProtiNX_Q02246
OpenTargetsiENSG00000184144
Orphaneti86814, Benign adult familial myoclonic epilepsy
PharmGKBiPA26686

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3513, Eukaryota
GeneTreeiENSGT00940000159193
HOGENOMiCLU_005756_0_0_1
InParanoidiQ02246
KOiK06760
OMAiHYVYRNE
OrthoDBi655902at2759
PhylomeDBiQ02246
TreeFamiTF351103

Enzyme and pathway databases

PathwayCommonsiQ02246
ReactomeiR-HSA-373760, L1CAM interactions
R-HSA-419037, NCAM1 interactions
R-HSA-447038, NrCAM interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6900, 9 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CNTN2, human
EvolutionaryTraceiQ02246

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CNTN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6900
PharosiQ02246, Tbio

Protein Ontology

More...
PROi
PR:Q02246
RNActiQ02246, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184144, Expressed in corpus callosum and 141 other tissues
ExpressionAtlasiQ02246, baseline and differential
GenevisibleiQ02246, HS

Family and domain databases

CDDicd00063, FN3, 3 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR043204, Basigin-like
IPR032991, Contactin-2
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PANTHERiPTHR10075, PTHR10075, 1 hit
PTHR10075:SF55, PTHR10075:SF55, 1 hit
PfamiView protein in Pfam
PF00041, fn3, 3 hits
PF07679, I-set, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 4 hits
SM00409, IG, 6 hits
SM00408, IGc2, 5 hits
SUPFAMiSSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 4 hits
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02246
Secondary accession number(s): P78432, Q5T054
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: August 12, 2020
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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