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Protein

Programmed cell death protein 1

Gene

Pdcd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 1
Short name:
Protein PD-1
Short name:
mPD-1
Alternative name(s):
CD_antigen: CD279
Gene namesi
Name:Pdcd1
Synonyms:Pd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104879 Pdcd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 169ExtracellularSequence analysisAdd BLAST149
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 288CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001489321 – 288Programmed cell death protein 1Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 123PROSITE-ProRule annotation3 Publications
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02242
PRIDEiQ02242

PTM databases

iPTMnetiQ02242
PhosphoSitePlusiQ02242
SwissPalmiQ02242

Expressioni

Tissue specificityi

Thymus.

Developmental stagei

Induced at programmed cell death.

Gene expression databases

BgeeiENSMUSG00000026285 Expressed in 26 organ(s), highest expression level in cumulus cell
CleanExiMM_PDCD1
ExpressionAtlasiQ02242 baseline and differential
GenevisibleiQ02242 MM

Interactioni

Subunit structurei

Monomer.3 Publications

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-29730N
IntActiQ02242, 4 interactors
STRINGi10090.ENSMUSP00000027507

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ02242
SMRiQ02242
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02242

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 139Ig-like V-typeAdd BLAST109

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J26W Eukaryota
ENOG41116U6 LUCA
GeneTreeiENSGT00390000013662
HOGENOMiHOG000253959
HOVERGENiHBG053534
InParanoidiQ02242
KOiK06744
OMAiSFVLNWY
OrthoDBiEOG091G0EE8
PhylomeDBiQ02242
TreeFamiTF336181

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02242-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVRQVPWSF TWAVLQLSWQ SGWLLEVPNG PWRSLTFYPA WLTVSEGANA
60 70 80 90 100
TFTCSLSNWS EDLMLNWNRL SPSNQTEKQA AFCNGLSQPV QDARFQIIQL
110 120 130 140 150
PNRHDFHMNI LDTRRNDSGI YLCGAISLHP KAKIEESPGA ELVVTERILE
160 170 180 190 200
TSTRYPSPSP KPEGRFQGMV IGIMSALVGI PVLLLLAWAL AVFCSTSMSE
210 220 230 240 250
ARGAGSKDDT LKEEPSAAPV PSVAYEELDF QGREKTPELP TACVHTEYAT
260 270 280
IVFTEGLGAS AMGRRGSADG LQGPRPPRHE DGHCSWPL
Length:288
Mass (Da):31,842
Last modified:July 1, 1993 - v1
Checksum:i4AD3C5F0F9D4200A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67914 mRNA Translation: CAA48113.1
CCDSiCCDS15200.1
PIRiS28029
RefSeqiNP_032824.1, NM_008798.2
UniGeneiMm.5024

Genome annotation databases

EnsembliENSMUST00000027507; ENSMUSP00000027507; ENSMUSG00000026285
GeneIDi18566
KEGGimmu:18566
UCSCiuc007cev.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67914 mRNA Translation: CAA48113.1
CCDSiCCDS15200.1
PIRiS28029
RefSeqiNP_032824.1, NM_008798.2
UniGeneiMm.5024

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NPUX-ray2.00A34-150[»]
3BIKX-ray2.65B/C25-157[»]
3BP5X-ray1.80A34-150[»]
3BP6X-ray1.60A34-150[»]
3RNKX-ray1.74A34-150[»]
3RNQX-ray1.60A34-150[»]
3SBWX-ray2.28A/B34-150[»]
ProteinModelPortaliQ02242
SMRiQ02242
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29730N
IntActiQ02242, 4 interactors
STRINGi10090.ENSMUSP00000027507

PTM databases

iPTMnetiQ02242
PhosphoSitePlusiQ02242
SwissPalmiQ02242

Proteomic databases

PaxDbiQ02242
PRIDEiQ02242

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027507; ENSMUSP00000027507; ENSMUSG00000026285
GeneIDi18566
KEGGimmu:18566
UCSCiuc007cev.1 mouse

Organism-specific databases

CTDi5133
MGIiMGI:104879 Pdcd1

Phylogenomic databases

eggNOGiENOG410J26W Eukaryota
ENOG41116U6 LUCA
GeneTreeiENSGT00390000013662
HOGENOMiHOG000253959
HOVERGENiHBG053534
InParanoidiQ02242
KOiK06744
OMAiSFVLNWY
OrthoDBiEOG091G0EE8
PhylomeDBiQ02242
TreeFamiTF336181

Enzyme and pathway databases

ReactomeiR-MMU-389948 PD-1 signaling

Miscellaneous databases

EvolutionaryTraceiQ02242
PROiPR:Q02242
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026285 Expressed in 26 organ(s), highest expression level in cumulus cell
CleanExiMM_PDCD1
ExpressionAtlasiQ02242 baseline and differential
GenevisibleiQ02242 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD1_MOUSE
AccessioniPrimary (citable) accession number: Q02242
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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