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Entry version 193 (13 Feb 2019)
Sequence version 3 (28 Nov 2006)
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Protein

Kinesin-like protein KIF23

Gene

KIF23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi112 – 119ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: UniProtKB
  • microtubule motor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-68884 Mitotic Telophase/Cytokinesis
R-HSA-983189 Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF23
Alternative name(s):
Kinesin-like protein 5
Mitotic kinesin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF23
Synonyms:KNSL5, MKLP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137807.13

Human Gene Nomenclature Database

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HGNCi
HGNC:6392 KIF23

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605064 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9493

MalaCards human disease database

More...
MalaCardsi
KIF23

Open Targets

More...
OpenTargetsi
ENSG00000137807

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
98870 Congenital dyserythropoietic anemia type III

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30181

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5899

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIF23

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572664

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254341 – 960Kinesin-like protein KIF23Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei155PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki571Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei605PhosphoserineCombined sources1
Cross-linki624Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki662Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki665Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei682PhosphoserineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei738PhosphothreonineCombined sources1
Cross-linki741Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei814PhosphoserineCombined sources1
Cross-linki823Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki854Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei867PhosphoserineCombined sources1
Cross-linki874Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki877Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki899Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei902PhosphoserineCombined sources1
Modified residuei911PhosphoserineCombined sources1
Modified residuei927PhosphothreonineCombined sources1
Cross-linki956Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP8/UBPY.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q02241

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q02241

MaxQB - The MaxQuant DataBase

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MaxQBi
Q02241

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q02241

PeptideAtlas

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PeptideAtlasi
Q02241

PRoteomics IDEntifications database

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PRIDEi
Q02241

ProteomicsDB human proteome resource

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ProteomicsDBi
58066
58067 [Q02241-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q02241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q02241

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q02241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137807 Expressed in 139 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q02241 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q02241 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010414
HPA045208
HPA068831

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114873, 72 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q02241

Database of interacting proteins

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DIPi
DIP-40359N

Protein interaction database and analysis system

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IntActi
Q02241, 41 interactors

Molecular INTeraction database

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MINTi
Q02241

STRING: functional protein association networks

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STRINGi
9606.ENSP00000260363

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q02241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VHXX-ray2.81B/D/F/H794-911[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q02241

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02241

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 436Kinesin motorPROSITE-ProRule annotationAdd BLAST412

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni794 – 911Interaction with ARF61 PublicationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili535 – 620Sequence analysisAdd BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi7 – 11Nuclear localization signalSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0247 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000273893

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052253

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02241

KEGG Orthology (KO)

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KOi
K17387

Database of Orthologous Groups

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OrthoDBi
314538at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q02241

TreeFam database of animal gene trees

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TreeFami
TF105232

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.12000, 1 hit
3.40.850.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032924 KIF23
IPR032384 Kif23_Arf-bd
IPR038105 Kif23_Arf-bd_sf
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24115 PTHR24115, 1 hit
PTHR24115:SF467 PTHR24115:SF467, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit
PF16540 MKLP1_Arf_bdg, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSARAKTPR KPTVKKGSQT NLKDPVGVYC RVRPLGFPDQ ECCIEVINNT
60 70 80 90 100
TVQLHTPEGY RLNRNGDYKE TQYSFKQVFG THTTQKELFD VVANPLVNDL
110 120 130 140 150
IHGKNGLLFT YGVTGSGKTH TMTGSPGEGG LLPRCLDMIF NSIGSFQAKR
160 170 180 190 200
YVFKSNDRNS MDIQCEVDAL LERQKREAMP NPKTSSSKRQ VDPEFADMIT
210 220 230 240 250
VQEFCKAEEV DEDSVYGVFV SYIEIYNNYI YDLLEEVPFD PIKPKPPQSK
260 270 280 290 300
LLREDKNHNM YVAGCTEVEV KSTEEAFEVF WRGQKKRRIA NTHLNRESSR
310 320 330 340 350
SHSVFNIKLV QAPLDADGDN VLQEKEQITI SQLSLVDLAG SERTNRTRAE
360 370 380 390 400
GNRLREAGNI NQSLMTLRTC MDVLRENQMY GTNKMVPYRD SKLTHLFKNY
410 420 430 440 450
FDGEGKVRMI VCVNPKAEDY EENLQVMRFA EVTQEVEVAR PVDKAICGLT
460 470 480 490 500
PGRRYRNQPR GPVGNEPLVT DVVLQSFPPL PSCEILDIND EQTLPRLIEA
510 520 530 540 550
LEKRHNLRQM MIDEFNKQSN AFKALLQEFD NAVLSKENHM QGKLNEKEKM
560 570 580 590 600
ISGQKLEIER LEKKNKTLEY KIEILEKTTT IYEEDKRNLQ QELETQNQKL
610 620 630 640 650
QRQFSDKRRL EARLQGMVTE TTMKWEKECE RRVAAKQLEM QNKLWVKDEK
660 670 680 690 700
LKQLKAIVTE PKTEKPERPS RERDREKVTQ RSVSPSPVPL SSNYIAQISN
710 720 730 740 750
GQQLMSQPQL HRRSNSCSSI SVASCISEWE QKIPTYNTPL KVTSIARRRQ
760 770 780 790 800
QEPGQSKTCI VSDRRRGMYW TEGREVVPTF RNEIEIEEDH CGRLLFQPDQ
810 820 830 840 850
NAPPIRLRHR RSRSAGDRWV DHKPASNMQT ETVMQPHVPH AITVSVANEK
860 870 880 890 900
ALAKCEKYML THQELASDGE IETKLIKGDI YKTRGGGQSV QFTDIETLKQ
910 920 930 940 950
ESPNGSRKRR SSTVAPAQPD GAESEWTDVE TRCSVAVEMR AGSQLGPGYQ
960
HHAQPKRKKP
Length:960
Mass (Da):110,059
Last modified:November 28, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2AA784D2D236A90
GO
Isoform 2 (identifier: Q02241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-793: Missing.

Show »
Length:856
Mass (Da):98,105
Checksum:iDDE7CEB480ABE58A
GO
Isoform 3 (identifier: Q02241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: Missing.
     245-245: K → KWNSCSTPMRNTDFV
     690-793: Missing.

Note: No experimental confirmation available.
Show »
Length:673
Mass (Da):77,699
Checksum:iF231A82604D60888
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYN4H7BYN4_HUMAN
Kinesin-like protein
KIF23
952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZL8A0A2U3TZL8_HUMAN
Kinesin-like protein
KIF23
810Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YME6H0YME6_HUMAN
Kinesin-like protein KIF23
KIF23
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMJ4H0YMJ4_HUMAN
Kinesin-like protein KIF23
KIF23
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y531A0A2R8Y531_HUMAN
Kinesin-like protein KIF23
KIF23
283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049686515F → L. Corresponds to variant dbSNP:rs17310879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0573481 – 197Missing in isoform 3. 1 PublicationAdd BLAST197
Alternative sequenceiVSP_057349245K → KWNSCSTPMRNTDFV in isoform 3. 1 Publication1
Alternative sequenceiVSP_021801690 – 793Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67155 mRNA Translation: CAA47628.2
AK303874 mRNA Translation: BAG64812.1
AC027237 Genomic DNA No translation available.
BC017705 mRNA Translation: AAH17705.2
BC051826 mRNA Translation: AAH51826.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32278.1 [Q02241-1]
CCDS32279.1 [Q02241-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S28262

NCBI Reference Sequences

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RefSeqi
NP_004847.2, NM_004856.6 [Q02241-2]
NP_612565.1, NM_138555.3 [Q02241-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.270845

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260363; ENSP00000260363; ENSG00000137807 [Q02241-1]
ENST00000352331; ENSP00000304978; ENSG00000137807 [Q02241-2]
ENST00000647715; ENSP00000497065; ENSG00000137807 [Q02241-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9493

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9493

UCSC genome browser

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UCSCi
uc002asb.5 human [Q02241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67155 mRNA Translation: CAA47628.2
AK303874 mRNA Translation: BAG64812.1
AC027237 Genomic DNA No translation available.
BC017705 mRNA Translation: AAH17705.2
BC051826 mRNA Translation: AAH51826.1
CCDSiCCDS32278.1 [Q02241-1]
CCDS32279.1 [Q02241-2]
PIRiS28262
RefSeqiNP_004847.2, NM_004856.6 [Q02241-2]
NP_612565.1, NM_138555.3 [Q02241-1]
UniGeneiHs.270845

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VHXX-ray2.81B/D/F/H794-911[»]
ProteinModelPortaliQ02241
SMRiQ02241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114873, 72 interactors
CORUMiQ02241
DIPiDIP-40359N
IntActiQ02241, 41 interactors
MINTiQ02241
STRINGi9606.ENSP00000260363

Chemistry databases

BindingDBiQ02241
ChEMBLiCHEMBL5899

PTM databases

iPTMnetiQ02241
PhosphoSitePlusiQ02241
SwissPalmiQ02241

Polymorphism and mutation databases

BioMutaiKIF23
DMDMi118572664

Proteomic databases

EPDiQ02241
jPOSTiQ02241
MaxQBiQ02241
PaxDbiQ02241
PeptideAtlasiQ02241
PRIDEiQ02241
ProteomicsDBi58066
58067 [Q02241-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9493
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260363; ENSP00000260363; ENSG00000137807 [Q02241-1]
ENST00000352331; ENSP00000304978; ENSG00000137807 [Q02241-2]
ENST00000647715; ENSP00000497065; ENSG00000137807 [Q02241-1]
GeneIDi9493
KEGGihsa:9493
UCSCiuc002asb.5 human [Q02241-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9493
DisGeNETi9493
EuPathDBiHostDB:ENSG00000137807.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIF23
HGNCiHGNC:6392 KIF23
HPAiCAB010414
HPA045208
HPA068831
MalaCardsiKIF23
MIMi605064 gene
neXtProtiNX_Q02241
OpenTargetsiENSG00000137807
Orphaneti98870 Congenital dyserythropoietic anemia type III
PharmGKBiPA30181

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0247 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000155837
HOGENOMiHOG000273893
HOVERGENiHBG052253
InParanoidiQ02241
KOiK17387
OrthoDBi314538at2759
PhylomeDBiQ02241
TreeFamiTF105232

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-68884 Mitotic Telophase/Cytokinesis
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIF23 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KIF23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9493

Protein Ontology

More...
PROi
PR:Q02241

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137807 Expressed in 139 organ(s), highest expression level in lung
ExpressionAtlasiQ02241 baseline and differential
GenevisibleiQ02241 HS

Family and domain databases

Gene3Di3.40.50.12000, 1 hit
3.40.850.10, 2 hits
InterProiView protein in InterPro
IPR032924 KIF23
IPR032384 Kif23_Arf-bd
IPR038105 Kif23_Arf-bd_sf
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF467 PTHR24115:SF467, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PF16540 MKLP1_Arf_bdg, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF23_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02241
Secondary accession number(s): B4E1K0, Q8WVP0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 28, 2006
Last modified: February 13, 2019
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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