UniProtKB - Q02223 (TNR17_HUMAN)
Protein
Tumor necrosis factor receptor superfamily member 17
Gene
TNFRSF17
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.3 Publications
GO - Molecular functioni
- signaling receptor activity Source: ProtInc
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- lymphocyte homeostasis Source: Ensembl
- multicellular organism development Source: ProtInc
- signal transduction Source: ProtInc
- tumor necrosis factor-mediated signaling pathway Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q02223 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SIGNORi | Q02223 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 17Alternative name(s): B-cell maturation protein CD_antigen: CD269 |
Gene namesi | Name:TNFRSF17 Synonyms:BCM, BCMA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11913, TNFRSF17 |
MIMi | 109545, gene |
neXtProti | NX_Q02223 |
VEuPathDBi | HostDB:ENSG00000048462.10 |
Subcellular locationi
Plasma membrane
Other locations
Note: Perinuclear Golgi-like structures.
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- endomembrane system Source: UniProtKB-SubCell
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 54 | ExtracellularSequence analysisAdd BLAST | 54 | |
Transmembranei | 55 – 77 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 78 – 184 | CytoplasmicSequence analysisAdd BLAST | 107 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 3 – 4 | Breakpoint for translocation to form IL2/TNFRSF17 oncogene | 2 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 608 |
OpenTargetsi | ENSG00000048462 |
PharmGKBi | PA36606 |
Miscellaneous databases
Pharosi | Q02223, Tbio |
Chemistry databases
DrugBanki | DB15719, Belantamab mafodotin |
GuidetoPHARMACOLOGYi | 1889 |
Genetic variation databases
BioMutai | TNFRSF17 |
DMDMi | 313104029 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058935 | 1 – 184 | Tumor necrosis factor receptor superfamily member 17Add BLAST | 184 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 8 ↔ 21 | 2 Publications | ||
Disulfide bondi | 24 ↔ 37 | 2 Publications | ||
Disulfide bondi | 28 ↔ 41 | 2 Publications |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | Q02223 |
MassIVEi | Q02223 |
PaxDbi | Q02223 |
PeptideAtlasi | Q02223 |
PRIDEi | Q02223 |
ProteomicsDBi | 58062 [Q02223-1] 61498 |
PTM databases
GlyGeni | Q02223, 1 site |
iPTMneti | Q02223 |
PhosphoSitePlusi | Q02223 |
Expressioni
Tissue specificityi
Expressed in mature B-cells, but not in T-cells or monocytes.
Gene expression databases
Bgeei | ENSG00000048462, Expressed in tonsil and 123 other tissues |
ExpressionAtlasi | Q02223, baseline and differential |
Genevisiblei | Q02223, HS |
Organism-specific databases
HPAi | ENSG00000048462, Tissue enhanced (blood, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.
2 PublicationsBinary interactionsi
Hide detailsQ02223
With | #Exp. | IntAct |
---|---|---|
CMTM7 [Q96FZ5] | 3 | EBI-519945,EBI-2807956 |
PEX16 [Q9Y5Y5] | 3 | EBI-519945,EBI-981985 |
TMBIM6 [P55061] | 3 | EBI-519945,EBI-1045825 |
Protein-protein interaction databases
BioGRIDi | 107080, 23 interactors |
IntActi | Q02223, 18 interactors |
STRINGi | 9606.ENSP00000053243 |
Miscellaneous databases
RNActi | Q02223, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q02223 |
SMRi | Q02223 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q02223 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 41 | TNFR-CysAdd BLAST | 35 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SF2N, Eukaryota |
GeneTreei | ENSGT00940000154485 |
HOGENOMi | CLU_131588_0_0_1 |
InParanoidi | Q02223 |
OMAi | CHLRCSN |
OrthoDBi | 1334921at2759 |
PhylomeDBi | Q02223 |
TreeFami | TF337842 |
Family and domain databases
CDDi | cd13414, TNFRSF17, 1 hit |
InterProi | View protein in InterPro IPR015337, BCMA_Tall-1-bd IPR043521, TNFR_13C/17 IPR022320, TNFR_17 |
PANTHERi | PTHR20437, PTHR20437, 1 hit |
Pfami | View protein in Pfam PF09257, BCMA-Tall_bind, 1 hit |
PIRSFi | PIRSF011859, BCMA_Tall-1_bd, 1 hit |
PRINTSi | PR01967, TNFACTORR17 |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q02223-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK
60 70 80 90 100
GTNAILWTCL GLSLIISLAV FVLMFLLRKI NSEPLKDEFK NTGSGLLGMA
110 120 130 140 150
NIDLEKSRTG DEIILPRGLE YTVEECTCED CIKSKPKVDS DHCFPLPAME
160 170 180
EGATILVTTK TNDYCKSLPA ALSATEIEKS ISAR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BMB5 | H3BMB5_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF17 | 133 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018755 | 54 | A → V1 PublicationCorresponds to variant dbSNP:rs11570146Ensembl. | 1 | |
Natural variantiVAR_018756 | 65 | I → V1 PublicationCorresponds to variant dbSNP:rs11570147Ensembl. | 1 | |
Natural variantiVAR_018757 | 75 | F → V1 PublicationCorresponds to variant dbSNP:rs11570148EnsemblClinVar. | 1 | |
Natural variantiVAR_018758 | 81 | N → S5 PublicationsCorresponds to variant dbSNP:rs373496Ensembl. | 1 | |
Natural variantiVAR_012234 | 153 | A → T1 PublicationCorresponds to variant dbSNP:rs150352299Ensembl. | 1 | |
Natural variantiVAR_018759 | 165 | C → S1 PublicationCorresponds to variant dbSNP:rs11570159Ensembl. | 1 | |
Natural variantiVAR_061855 | 176 | E → D. Corresponds to variant dbSNP:rs34546237EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047678 | 44 – 93 | SVTNS…FKNTG → R in isoform 2. 2 PublicationsAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z14954 mRNA Translation: CAA78679.1 Z29574 Genomic DNA Translation: CAA82690.1 Z29575 mRNA Translation: CAA82691.1 AB052772 Genomic DNA Translation: BAB60895.1 EF152355 mRNA Translation: ABN42510.1 AY684975 mRNA Translation: AAV92616.1 AY509112 Genomic DNA Translation: AAR84240.1 U95742 Genomic DNA Translation: AAB67251.1 AC007216 Genomic DNA No translation available. |
CCDSi | CCDS10552.1 [Q02223-1] |
PIRi | S43486 |
RefSeqi | NP_001183.2, NM_001192.2 [Q02223-1] |
Genome annotation databases
Ensembli | ENST00000053243; ENSP00000053243; ENSG00000048462 [Q02223-1] ENST00000396495; ENSP00000379753; ENSG00000048462 [Q02223-2] |
GeneIDi | 608 |
KEGGi | hsa:608 |
UCSCi | uc002dbv.3, human [Q02223-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z14954 mRNA Translation: CAA78679.1 Z29574 Genomic DNA Translation: CAA82690.1 Z29575 mRNA Translation: CAA82691.1 AB052772 Genomic DNA Translation: BAB60895.1 EF152355 mRNA Translation: ABN42510.1 AY684975 mRNA Translation: AAV92616.1 AY509112 Genomic DNA Translation: AAR84240.1 U95742 Genomic DNA Translation: AAB67251.1 AC007216 Genomic DNA No translation available. |
CCDSi | CCDS10552.1 [Q02223-1] |
PIRi | S43486 |
RefSeqi | NP_001183.2, NM_001192.2 [Q02223-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OQD | X-ray | 2.60 | K/L/M/N/O/P/Q/R | 8-46 | [»] | |
1XU2 | X-ray | 2.35 | R/S/T | 5-51 | [»] | |
2KN1 | NMR | - | A | 2-50 | [»] | |
4ZFO | X-ray | 1.90 | F/K | 1-54 | [»] | |
6J7W | X-ray | 2.60 | C/D | 6-44 | [»] | |
BMRBi | Q02223 | |||||
SMRi | Q02223 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107080, 23 interactors |
IntActi | Q02223, 18 interactors |
STRINGi | 9606.ENSP00000053243 |
Chemistry databases
DrugBanki | DB15719, Belantamab mafodotin |
GuidetoPHARMACOLOGYi | 1889 |
PTM databases
GlyGeni | Q02223, 1 site |
iPTMneti | Q02223 |
PhosphoSitePlusi | Q02223 |
Genetic variation databases
BioMutai | TNFRSF17 |
DMDMi | 313104029 |
Proteomic databases
jPOSTi | Q02223 |
MassIVEi | Q02223 |
PaxDbi | Q02223 |
PeptideAtlasi | Q02223 |
PRIDEi | Q02223 |
ProteomicsDBi | 58062 [Q02223-1] 61498 |
Protocols and materials databases
ABCDi | Q02223, 224 sequenced antibodies |
Antibodypediai | 11568, 670 antibodies |
CPTCi | Q02223, 1 antibody |
DNASUi | 608 |
Genome annotation databases
Ensembli | ENST00000053243; ENSP00000053243; ENSG00000048462 [Q02223-1] ENST00000396495; ENSP00000379753; ENSG00000048462 [Q02223-2] |
GeneIDi | 608 |
KEGGi | hsa:608 |
UCSCi | uc002dbv.3, human [Q02223-1] |
Organism-specific databases
CTDi | 608 |
DisGeNETi | 608 |
GeneCardsi | TNFRSF17 |
HGNCi | HGNC:11913, TNFRSF17 |
HPAi | ENSG00000048462, Tissue enhanced (blood, intestine, lymphoid tissue) |
MIMi | 109545, gene |
neXtProti | NX_Q02223 |
OpenTargetsi | ENSG00000048462 |
PharmGKBi | PA36606 |
VEuPathDBi | HostDB:ENSG00000048462.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SF2N, Eukaryota |
GeneTreei | ENSGT00940000154485 |
HOGENOMi | CLU_131588_0_0_1 |
InParanoidi | Q02223 |
OMAi | CHLRCSN |
OrthoDBi | 1334921at2759 |
PhylomeDBi | Q02223 |
TreeFami | TF337842 |
Enzyme and pathway databases
PathwayCommonsi | Q02223 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SIGNORi | Q02223 |
Miscellaneous databases
BioGRID-ORCSi | 608, 10 hits in 989 CRISPR screens |
ChiTaRSi | TNFRSF17, human |
EvolutionaryTracei | Q02223 |
GeneWikii | TNFRSF17 |
GenomeRNAii | 608 |
Pharosi | Q02223, Tbio |
PROi | PR:Q02223 |
RNActi | Q02223, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000048462, Expressed in tonsil and 123 other tissues |
ExpressionAtlasi | Q02223, baseline and differential |
Genevisiblei | Q02223, HS |
Family and domain databases
CDDi | cd13414, TNFRSF17, 1 hit |
InterProi | View protein in InterPro IPR015337, BCMA_Tall-1-bd IPR043521, TNFR_13C/17 IPR022320, TNFR_17 |
PANTHERi | PTHR20437, PTHR20437, 1 hit |
Pfami | View protein in Pfam PF09257, BCMA-Tall_bind, 1 hit |
PIRSFi | PIRSF011859, BCMA_Tall-1_bd, 1 hit |
PRINTSi | PR01967, TNFACTORR17 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR17_HUMAN | |
Accessioni | Q02223Primary (citable) accession number: Q02223 Secondary accession number(s): Q2TQ40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references