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UniProtKB - Q02197 (NAA35_YEAST)
Protein
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Gene
MAK10
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK10 has a role in the propagation of L-A and M viruses, perhaps in the viral assembly. It is apparently directly needed for optimum respiration.
1 PublicationMiscellaneous
Present with 1970 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- macroautophagy Source: SGD
- N-terminal peptidyl-methionine acetylation Source: InterPro
- N-terminal protein amino acid acetylation Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: N-alpha-acetyltransferase 35, NatC auxiliary subunitAlternative name(s): Glucose repressible protein MAK10 L-A virus GAG protein N-acetyltransferase subunit MAK10 Maintenance of killer protein 10 N-terminal acetyltransferase C complex subunit MAK10 Short name: NatC complex subunit MAK10 |
Gene namesi | Name:MAK10 Synonyms:NAA35 Ordered Locus Names:YEL053C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000779, MAK10 |
VEuPathDBi | FungiDB:YEL053C |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Reactome
Other locations
- cytoplasm Source: SGD
- NatC complex Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084553 | 1 – 733 | N-alpha-acetyltransferase 35, NatC auxiliary subunitAdd BLAST | 733 |
Proteomic databases
MaxQBi | Q02197 |
PaxDbi | Q02197 |
PRIDEi | Q02197 |
Expressioni
Inductioni
Glucose-repressed.
Interactioni
Subunit structurei
Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of MAK3, MAK10 and MAK31.
1 PublicationBinary interactionsi
Q02197
With | #Exp. | IntAct |
---|---|---|
MAK3 [Q03503] | 3 | EBI-10924,EBI-10388 |
Protein-protein interaction databases
BioGRIDi | 36676, 75 interactors |
ComplexPortali | CPX-781, NatC N-alpha-acetyltransferase complex |
DIPi | DIP-1428N |
IntActi | Q02197, 4 interactors |
MINTi | Q02197 |
STRINGi | 4932.YEL053C |
Miscellaneous databases
RNActi | Q02197, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q02197 |
SMRi | Q02197 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the MAK10 family.Curated
Phylogenomic databases
eggNOGi | KOG2343, Eukaryota |
GeneTreei | ENSGT00390000002445 |
HOGENOMi | CLU_022669_1_0_1 |
InParanoidi | Q02197 |
OMAi | NTCRYRQ |
Family and domain databases
InterProi | View protein in InterPro IPR007244, Naa35/Mak10 |
PANTHERi | PTHR21373, PTHR21373, 1 hit |
Pfami | View protein in Pfam PF04112, Mak10, 1 hit |
i Sequence
Sequence statusi: Complete.
Q02197-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVDSILGSL SITDDFDQLV DVTSLFDELC SKLKPEAIVK DPRFDLFEGT
60 70 80 90 100
HSLEVNNSKL DSSLIELTAE EIEFDVNVAY DPPLASVAAI ADRLLRCVIS
110 120 130 140 150
WLNDYQTLPT TVLSCRYTES LLSSLVKGTT AGSSWCTGNI LYDKVLGSCI
160 170 180 190 200
LGVCYLTKFV QKLLSAGIVF EEEDLNFNNM GFNTFDNLPG QDVVINSLTE
210 220 230 240 250
SLQILEAYSD DSLHLTMLKH ILKIIICLVH LEDHLTDYST KTSHLDELIE
260 270 280 290 300
NANSVNGIFP QLQLSPPKGA FSTYIQKHRS NQFPPRKITK LPTDYSGFIT
310 320 330 340 350
LANDVKTILL VDKAESALET YQFAKFFNKL EQRHVIARIL FPLFFIRDDR
360 370 380 390 400
TVLGKFSYTQ FYLLHVKEFS AQTPSEFESS IGNELIQESS NMLLEWYQNC
410 420 430 440 450
SQNTCRYRQG FNRQLILWDS LQAQFESVNS QVYCSWTYFM KLSSMIEFSL
460 470 480 490 500
KGFDLDIYKP FEAYSMFWYV YYLSHHLETF LKDSQNDIES NINAIHSMNK
510 520 530 540 550
KLKKLKAGEK KDQLRLKYRF AMDNEMEQLQ ATKQFLNYLL KEINITKSLC
560 570 580 590 600
LIEVFQFAIL KSFGLIDNKN STPSKFSNER LIHNLRFKPF NSIGVPELPE
610 620 630 640 650
YEVFQQTLKD FVIEEKGAAF DIKLERATNF IETEVRNVVS SIDEIMQGIK
660 670 680 690 700
GGDNNGVLVT GTRLVQELSL EYYCKLKHTS KALSVNSKVI VNTLKKNIKN
710 720 730
KDSHEYKVEL VHTTEGWNYF PIQTLRIKQD RYK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94533 Genomic RNA Translation: AAA34749.1 U18779 Genomic DNA Translation: AAB64989.1 BK006939 Genomic DNA Translation: DAA07601.1 |
PIRi | S31288 |
RefSeqi | NP_010861.3, NM_001178868.3 |
Genome annotation databases
EnsemblFungii | YEL053C_mRNA; YEL053C; YEL053C |
GeneIDi | 856657 |
KEGGi | sce:YEL053C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94533 Genomic RNA Translation: AAA34749.1 U18779 Genomic DNA Translation: AAB64989.1 BK006939 Genomic DNA Translation: DAA07601.1 |
PIRi | S31288 |
RefSeqi | NP_010861.3, NM_001178868.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6YGA | X-ray | 2.40 | B | 1-733 | [»] | |
6YGB | X-ray | 2.45 | B | 1-733 | [»] | |
6YGC | X-ray | 2.99 | B | 1-733 | [»] | |
6YGD | X-ray | 2.75 | B | 1-733 | [»] | |
AlphaFoldDBi | Q02197 | |||||
SMRi | Q02197 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36676, 75 interactors |
ComplexPortali | CPX-781, NatC N-alpha-acetyltransferase complex |
DIPi | DIP-1428N |
IntActi | Q02197, 4 interactors |
MINTi | Q02197 |
STRINGi | 4932.YEL053C |
Proteomic databases
MaxQBi | Q02197 |
PaxDbi | Q02197 |
PRIDEi | Q02197 |
Genome annotation databases
EnsemblFungii | YEL053C_mRNA; YEL053C; YEL053C |
GeneIDi | 856657 |
KEGGi | sce:YEL053C |
Organism-specific databases
SGDi | S000000779, MAK10 |
VEuPathDBi | FungiDB:YEL053C |
Phylogenomic databases
eggNOGi | KOG2343, Eukaryota |
GeneTreei | ENSGT00390000002445 |
HOGENOMi | CLU_022669_1_0_1 |
InParanoidi | Q02197 |
OMAi | NTCRYRQ |
Miscellaneous databases
PROi | PR:Q02197 |
RNActi | Q02197, protein |
Family and domain databases
InterProi | View protein in InterPro IPR007244, Naa35/Mak10 |
PANTHERi | PTHR21373, PTHR21373, 1 hit |
Pfami | View protein in Pfam PF04112, Mak10, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NAA35_YEAST | |
Accessioni | Q02197Primary (citable) accession number: Q02197 Secondary accession number(s): D3DLJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families