Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q02197 (NAA35_YEAST)

Entry version 156 (25 May 2022)
Sequence version 1 (01 Jul 1993)
Previous versions | rss
Add a publicationFeedback
Protein

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Gene

MAK10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK10 has a role in the propagation of L-A and M viruses, perhaps in the viral assembly. It is apparently directly needed for optimum respiration.

1 Publication

Miscellaneous

Present with 1970 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Alternative name(s):
Glucose repressible protein MAK10
L-A virus GAG protein N-acetyltransferase subunit MAK10
Maintenance of killer protein 10
N-terminal acetyltransferase C complex subunit MAK10
Short name:
NatC complex subunit MAK10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAK10
Synonyms:NAA35
Ordered Locus Names:YEL053C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000000779, MAK10

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YEL053C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845531 – 733N-alpha-acetyltransferase 35, NatC auxiliary subunitAdd BLAST733

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q02197

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q02197

PRoteomics IDEntifications database

More...PRIDEi		Q02197

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Glucose-repressed.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of MAK3, MAK10 and MAK31.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		36676, 75 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-781, NatC N-alpha-acetyltransferase complex

Database of interacting proteins

More...DIPi		DIP-1428N

Protein interaction database and analysis system

More...IntActi		Q02197, 4 interactors

Molecular INTeraction database

More...MINTi		Q02197

STRING: functional protein association networks

More...STRINGi		4932.YEL053C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q02197, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1733
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q02197

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q02197

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAK10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2343, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022669_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q02197

Identification of Orthologs from Complete Genome Data

More...OMAi		NTCRYRQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007244, Naa35/Mak10

The PANTHER Classification System

More...PANTHERi		PTHR21373, PTHR21373, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04112, Mak10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02197-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVDSILGSL SITDDFDQLV DVTSLFDELC SKLKPEAIVK DPRFDLFEGT 
        60         70         80         90        100
HSLEVNNSKL DSSLIELTAE EIEFDVNVAY DPPLASVAAI ADRLLRCVIS 
       110        120        130        140        150
WLNDYQTLPT TVLSCRYTES LLSSLVKGTT AGSSWCTGNI LYDKVLGSCI 
       160        170        180        190        200
LGVCYLTKFV QKLLSAGIVF EEEDLNFNNM GFNTFDNLPG QDVVINSLTE 
       210        220        230        240        250
SLQILEAYSD DSLHLTMLKH ILKIIICLVH LEDHLTDYST KTSHLDELIE 
       260        270        280        290        300
NANSVNGIFP QLQLSPPKGA FSTYIQKHRS NQFPPRKITK LPTDYSGFIT 
       310        320        330        340        350
LANDVKTILL VDKAESALET YQFAKFFNKL EQRHVIARIL FPLFFIRDDR 
       360        370        380        390        400
TVLGKFSYTQ FYLLHVKEFS AQTPSEFESS IGNELIQESS NMLLEWYQNC 
       410        420        430        440        450
SQNTCRYRQG FNRQLILWDS LQAQFESVNS QVYCSWTYFM KLSSMIEFSL 
       460        470        480        490        500
KGFDLDIYKP FEAYSMFWYV YYLSHHLETF LKDSQNDIES NINAIHSMNK 
       510        520        530        540        550
KLKKLKAGEK KDQLRLKYRF AMDNEMEQLQ ATKQFLNYLL KEINITKSLC 
       560        570        580        590        600
LIEVFQFAIL KSFGLIDNKN STPSKFSNER LIHNLRFKPF NSIGVPELPE 
       610        620        630        640        650
YEVFQQTLKD FVIEEKGAAF DIKLERATNF IETEVRNVVS SIDEIMQGIK 
       660        670        680        690        700
GGDNNGVLVT GTRLVQELSL EYYCKLKHTS KALSVNSKVI VNTLKKNIKN 
       710        720        730 
KDSHEYKVEL VHTTEGWNYF PIQTLRIKQD RYK
Length:733
Mass (Da):84,302
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11148C1FC6BB0931
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M94533 Genomic RNA Translation: AAA34749.1
U18779 Genomic DNA Translation: AAB64989.1
BK006939 Genomic DNA Translation: DAA07601.1

Protein sequence database of the Protein Information Resource

More...PIRi		S31288

NCBI Reference Sequences

More...RefSeqi		NP_010861.3, NM_001178868.3

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YEL053C_mRNA; YEL053C; YEL053C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		856657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YEL053C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94533 Genomic RNA Translation: AAA34749.1
U18779 Genomic DNA Translation: AAB64989.1
BK006939 Genomic DNA Translation: DAA07601.1
PIRiS31288
RefSeqiNP_010861.3, NM_001178868.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6YGAX-ray2.40B1-733[»]
6YGBX-ray2.45B1-733[»]
6YGCX-ray2.99B1-733[»]
6YGDX-ray2.75B1-733[»]
AlphaFoldDBiQ02197
SMRiQ02197
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36676, 75 interactors
ComplexPortaliCPX-781, NatC N-alpha-acetyltransferase complex
DIPiDIP-1428N
IntActiQ02197, 4 interactors
MINTiQ02197
STRINGi4932.YEL053C

Proteomic databases

MaxQBiQ02197
PaxDbiQ02197
PRIDEiQ02197

Genome annotation databases

EnsemblFungiiYEL053C_mRNA; YEL053C; YEL053C
GeneIDi856657
KEGGisce:YEL053C

Organism-specific databases

SGDiS000000779, MAK10
VEuPathDBiFungiDB:YEL053C

Phylogenomic databases

eggNOGiKOG2343, Eukaryota
GeneTreeiENSGT00390000002445
HOGENOMiCLU_022669_1_0_1
InParanoidiQ02197
OMAiNTCRYRQ

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q02197
RNActiQ02197, protein

Family and domain databases

InterProiView protein in InterPro
IPR007244, Naa35/Mak10
PANTHERiPTHR21373, PTHR21373, 1 hit
PfamiView protein in Pfam
PF04112, Mak10, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAA35_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02197
Secondary accession number(s): D3DLJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 25, 2022
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again