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Protein

M-protein, striated muscle

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is a structural constituent of myofibrillar M-band in striated muscle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • muscle alpha-actinin binding Source: GO_Central
  • structural constituent of muscle Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
M-protein, striated muscle
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726831 – 1450M-protein, striated muscleAdd BLAST1450

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02173

PRoteomics IDEntifications database

More...
PRIDEi
Q02173

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pectoralis and cardiac muscle.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Can be detected by day 10-13 in ovo, the content is gradually increased throughout the ovo development and reached its peak after hatching.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000026310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02173

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02173

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 233Ig-like C2-type 1Add BLAST92
Domaini254 – 359Ig-like C2-type 2Add BLAST106
Domaini373 – 468Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini501 – 596Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini602 – 695Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini698 – 800Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST103
Domaini803 – 900Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini899 – 995Ig-like C2-type 3Add BLAST97
Domaini1002 – 1115Ig-like C2-type 4Add BLAST114
Domaini1118 – 1204Ig-like C2-type 5Add BLAST87
Domaini1225 – 1322Ig-like C2-type 6Add BLAST98
Domaini1333 – 1422Ig-like C2-type 7Add BLAST90

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293283

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004977

Database of Orthologous Groups

More...
OrthoDBi
57219at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02173

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVAVPFYQ RRHKHFDQSY RNIQTRYVLE EYAARKAASR QAAHYESTGL
60 70 80 90 100
GKTTCRLCAR RARSLAHEAM QESRKRTHEQ KSHASDEKRI KFASELSSLE
110 120 130 140 150
REIHMARHHA REQLDRLAIQ RMVEENMALE RHVVEEKISR APEILVRLRS
160 170 180 190 200
HTVWEKMSVR LCFTVQGFPS PVVQWYKNEE LITPASDPAK YSVENKYGVH
210 220 230 240 250
VLHINRADFD DSATYSAVAT NIHGQASTNC AVVVRRFRES EEPHPAGIMP
260 270 280 290 300
FHLPLSYDVC FTHFDVQFLE KFGVTFATEG ETLTLKCSVL VTPELKRLRP
310 320 330 340 350
RAEWYRDDVL IKDSKWTKLY FGEGQAALSF THLNKDDEGL YTLRMVTKGG
360 370 380 390 400
VNECSAFLFV RDADALIAGA PGAPMDVKCH DANRDYVIVT WKPPNTTSQN
410 420 430 440 450
PVIGYFVDKC EVGLENWVQC NDAPVKICKY PVTGLYEGRS YIFRVRAVNS
460 470 480 490 500
AGISRPSRVS EPVAALDPVD LERTQTVHVD EGRKIVISKD DLEGDIQIPG
510 520 530 540 550
PPTNVHASEI SKTYVVLSWD PPVPRGREPL TYFIEKSMVG SGSWQRVNAQ
560 570 580 590 600
VAVKSPRYAV FDLAEGKPYV FRVLSANKHG ISDPSEITEP IQPQDIVVVP
610 620 630 640 650
SAPGRVVATR NTKTSVVVQW DKPKHEENLY GYYIDYSVVG SNQWEPANHK
660 670 680 690 700
PINYNRFVVH GLETGEQYIF RVKAVNAVGF SENSQESEAI KVQAALTCPS
710 720 730 740 750
YPHGITLLNC DGHSMTLGWK APKYSGGSPI LGYYIDKREA NHKNWHEVNS
760 770 780 790 800
SVISRTIYTV EDLTEDAFYE FKIAAANVVG IGHPSDPSEH FKCKAWTMPE
810 820 830 840 850
PGPAYDLTVC EVRNTSLVLL WKAPVYEGKS PITGYLVDYK EVDTEDWITA
860 870 880 890 900
NEKPTSHRYF KVTDLHQGHT YVFKVRAVND AGVGKSSEIS EPVFVEASPG
910 920 930 940 950
TKEIFSGVDE EGNIYLGFEC KEATDASHFL WGKSYEEIED SDKFKIETKG
960 970 980 990 1000
DHSKLYFKHP DKSDLGTYCI SVSDTDGVSS SFVLDEEELE RLMTLSNEIK
1010 1020 1030 1040 1050
NPTIPLKSEL AYEVLDKGEV RFWIQAESLS PNSTYRFVIN DKEVENGDRH
1060 1070 1080 1090 1100
KISCDHSNGI IEMVMDKFTI DNEGTYTVQI QDGKAKNQSS LVLIGDAFKA
1110 1120 1130 1140 1150
ILAESELQRK EFLRKQGPHF SEFLYWEVTE ECEVLLACKI ANTKKETVFK
1160 1170 1180 1190 1200
WYRNGSGIDV DEAPDLQKGE CHLTVPKLSR KDEGVYKATL SDDRGHDVST
1210 1220 1230 1240 1250
LELSGKVYND IILALSRVSG KTASPLKILC TEEGIRLQCF LKYYNEEMKV
1260 1270 1280 1290 1300
TWSHRESKIS SGEKMKIGGG EDVAWLQITE PTEKDKGNYT FEIFSDKESF
1310 1320 1330 1340 1350
KRTLDLSGQA FDDALTEFQR LKAAAFAEKN RGKVIGGLPD VVTIMDGKTL
1360 1370 1380 1390 1400
NLTCTVFGNP DPEVVWFKND KALELNEHYL VSLEQGKYAS LTIKGVTSED
1410 1420 1430 1440 1450
SGKYSIYVKN KYGGETVDVT VSVYRHGEKI PEVNQGQLAK PRLIPPSSST
Length:1,450
Mass (Da):163,401
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE313C7D39FE6CAC7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D11474 mRNA Translation: BAA02033.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A44027

NCBI Reference Sequences

More...
RefSeqi
NP_990466.1, NM_205135.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.4216

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396034

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11474 mRNA Translation: BAA02033.1
PIRiA44027
RefSeqiNP_990466.1, NM_205135.1
UniGeneiGga.4216

3D structure databases

ProteinModelPortaliQ02173
SMRiQ02173
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026310

Proteomic databases

PaxDbiQ02173
PRIDEiQ02173

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396034
KEGGigga:396034

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9172

Phylogenomic databases

eggNOGiENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA
HOGENOMiHOG000293283
HOVERGENiHBG004977
OrthoDBi57219at2759
PhylomeDBiQ02173

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q02173

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPSF_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02173
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 16, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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