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Protein

Blood group Rh(D) polypeptide

Gene

RHD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.11.4.3 the ammonium transporter channel (amt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Blood group Rh(D) polypeptide
Alternative name(s):
RHXIII
Rh polypeptide 2
Short name:
RhPII
Rhesus D antigen
CD_antigen: CD240D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RHD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187010.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10009 RHD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
111680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02161

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6007

MalaCards human disease database

More...
MalaCardsi
RHD

Open Targets

More...
OpenTargetsi
ENSG00000187010

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
71275 Rh deficiency syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34387

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712996

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RHD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved3 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001681902 – 417Blood group Rh(D) polypeptideAdd BLAST416

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q02161

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02161

PeptideAtlas

More...
PeptideAtlasi
Q02161

PRoteomics IDEntifications database

More...
PRIDEi
Q02161

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58055
58056 [Q02161-2]
58057 [Q02161-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02161

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02161

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to tissues or cell lines expressing erythroid characters.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187010 Expressed in 102 organ(s), highest expression level in trabecular bone tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q02161 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02161 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111939, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q02161, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331871

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02161

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3796 Eukaryota
ENOG410XTF8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154945

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004374

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02161

KEGG Orthology (KO)

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KOi
K06579

Identification of Orthologs from Complete Genome Data

More...
OMAi
SLFAMLX

Database of Orthologous Groups

More...
OrthoDBi
910733at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02161

TreeFam database of animal gene trees

More...
TreeFami
TF314450

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3430.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00909 Ammonium_transp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00342 RHESUSRHD

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02161-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV
60 70 80 90 100
GQDLTVMAAI GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ
110 120 130 140 150
FPSGKVVITL FSIRLATMSA LSVLISVDAV LGKVNLAQLV VMVLVEVTAL
160 170 180 190 200
GNLRMVISNI FNTDYHMNMM HIYVFAAYFG LSVAWCLPKP LPEGTEDKDQ
210 220 230 240 250
TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN TYYAVAVSVV
260 270 280 290 300
TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
310 320 330 340 350
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD
360 370 380 390 400
TVGAGNGMIG FQVLLSIGEL SLAIVIALMS GLLTGLLLNL KIWKAPHEAK
410
YFDDQVFWKF PHLAVGF
Length:417
Mass (Da):45,211
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38721BFA664AE199
GO
Isoform 2 (identifier: Q02161-2) [UniParc]FASTAAdd to basket
Also known as: Short 1

The sequence of this isoform differs from the canonical sequence as follows:
     314-409: Missing.

Show »
Length:321
Mass (Da):34,837
Checksum:i79E9FB671F8F84E8
GO
Isoform 3 (identifier: Q02161-3) [UniParc]FASTAAdd to basket
Also known as: Short 2

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: C → S
     317-417: Missing.

Show »
Length:316
Mass (Da):34,215
Checksum:i4BCD39AC4813587F
GO
Isoform 4 (identifier: Q02161-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-417: IGFQVLLSIG...WKFPHLAVGF → SLGWNLAVKM...PFIMHCRIQQ

Show »
Length:493
Mass (Da):53,641
Checksum:iA1122BAAF7764F2F
GO
Isoform 5 (identifier: Q02161-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-417: MIGFQVLLSI...WKFPHLAVGF → IFLIWLLDFK...LPAFVREKRS

Show »
Length:396
Mass (Da):43,290
Checksum:i39E89394C36B903F
GO
Isoform 6 (identifier: Q02161-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-378: GCCNRVLGIP...ELSLAIVIAL → DWLPGPPQHW...LPAFVREKRS
     379-417: Missing.

Show »
Length:378
Mass (Da):41,694
Checksum:i21ACB09A3D7A5DD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVW1E7EVW1_HUMAN
Blood group Rh(D) polypeptide
RHD
431Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT10H3BT10_HUMAN
Blood group Rh(D) polypeptide
RHD
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU43A0A3B3IU43_HUMAN
Blood group Rh(D) polypeptide
RHD
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39E → G in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti103S → P in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti127V → A in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti174V → M in AAB34852 (PubMed:7606008).Curated1
Sequence conflicti182S → T in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti314G → V in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti314G → V in AAB31911 (PubMed:8080999).Curated1
Sequence conflicti323P → H in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti379M → T in CAA44811 (PubMed:1438298).Curated1
Sequence conflicti379M → T in CAA44808 (PubMed:1438298).Curated1
Sequence conflicti379M → T in AAA02679 (PubMed:8329718).Curated1
Sequence conflicti379M → T in AAB26081 (PubMed:7916743).Curated1
Sequence conflicti379M → T in AAB34852 (PubMed:7606008).Curated1
Sequence conflicti379M → T in BAA81899 (PubMed:16510313).Curated1
Sequence conflicti379M → T in BAA81900 (PubMed:16510313).Curated1
Sequence conflicti379M → T in BAA81901 (PubMed:16510313).Curated1
Sequence conflicti379M → T in BAA82159 (PubMed:16510313).Curated1
Sequence conflicti398E → V in AAB34852 (PubMed:7606008).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a polymorphism in position 110.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03445516W → C1 PublicationCorresponds to variant dbSNP:rs772865539Ensembl.1
Natural variantiVAR_035615103S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_006919110L → P in Tar antigen. 1 PublicationCorresponds to variant dbSNP:rs121912762EnsemblClinVar.1
Natural variantiVAR_034456193E → K. Corresponds to variant dbSNP:rs1053352Ensembl.1
Natural variantiVAR_034457201T → R. Corresponds to variant dbSNP:rs1053355EnsemblClinVar.1
Natural variantiVAR_006920218M → I1 PublicationCorresponds to variant dbSNP:rs141540728Ensembl.1
Natural variantiVAR_013304223F → V Found in RhDVa(FK) and RhDVa(TT). 1 PublicationCorresponds to variant dbSNP:rs1053356EnsemblClinVar.1
Natural variantiVAR_013305233E → Q Found in RhDVa(FK), RhDVa(TO), RhDVa(TT) and RhDYo. 1 PublicationCorresponds to variant dbSNP:rs1053359EnsemblClinVar.1
Natural variantiVAR_013306238V → M Found in RhDVa(TO) and RhDVa(TT). 1 PublicationCorresponds to variant dbSNP:rs1053360Ensembl.1
Natural variantiVAR_013307245V → L Found in RhDVa(TT). 1 PublicationCorresponds to variant dbSNP:rs150073306EnsemblClinVar.1
Natural variantiVAR_047996263G → R. Corresponds to variant dbSNP:rs3118454Ensembl.1
Natural variantiVAR_047997306V → I. Corresponds to variant dbSNP:rs590813Ensembl.1
Natural variantiVAR_047998311Y → C. Corresponds to variant dbSNP:rs590787Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005706314 – 409Missing in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_047795314 – 378GCCNR…IVIAL → DWLPGPPQHWGTQLGHRDSS HVWSPDSFLIWLLDFKQKHP RKTRPVQKQDNFLSLLPAFV REKRS in isoform 6. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_005707316C → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_005708317 – 417Missing in isoform 3. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_047796358 – 417MIGFQ…LAVGF → IFLIWLLDFKQKHPRKTRPV QKQDNFLSLLPAFVREKRS in isoform 5. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_047797359 – 417IGFQV…LAVGF → SLGWNLAVKMAEAGDEELMR LDVSQRNHGGAAVPTGSWMP STETTIAPNYRDHISVVSSF GCWILSKSIQEKQGLFKNKT TSSHCCLHLYVRNAHDSKVS NVRAGTGVRENGVESFLCHS LRRISPFIMHCRIQQ in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_047798379 – 417Missing in isoform 6. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63097 mRNA Translation: CAA44811.1
X63094 mRNA Translation: CAA44808.1
L08429 mRNA Translation: AAA02679.1
S57971 mRNA Translation: AAB26081.1
S70174 mRNA Translation: AAB30756.1
S78509 mRNA Translation: AAB34852.1
S73913 mRNA Translation: AAB31911.1
AY751492 mRNA Translation: AAU93636.1
AY751493 mRNA Translation: AAU93637.1
AY751495 mRNA Translation: AAU93639.1
AB018966 mRNA Translation: BAA81899.1
AB018967 mRNA Translation: BAA81900.1
AB018968 mRNA Translation: BAA81901.1
AB018969 mRNA Translation: BAA82159.1
AL928711 Genomic DNA Translation: CAH72602.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS262.1 [Q02161-1]
CCDS53285.1 [Q02161-2]
CCDS60028.1 [Q02161-4]
CCDS60030.1 [Q02161-5]
CCDS60031.1 [Q02161-6]

Protein sequence database of the Protein Information Resource

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PIRi
A46368
I52615

NCBI Reference Sequences

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RefSeqi
NP_001121163.1, NM_001127691.2 [Q02161-2]
NP_001269797.1, NM_001282868.1 [Q02161-6]
NP_001269798.1, NM_001282869.1 [Q02161-5]
NP_001269800.1, NM_001282871.1 [Q02161-4]
NP_057208.2, NM_016124.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.449968

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000328664; ENSP00000331871; ENSG00000187010 [Q02161-1]
ENST00000342055; ENSP00000339577; ENSG00000187010 [Q02161-4]
ENST00000357542; ENSP00000350150; ENSG00000187010 [Q02161-5]
ENST00000417538; ENSP00000396420; ENSG00000187010 [Q02161-6]
ENST00000454452; ENSP00000413849; ENSG00000187010 [Q02161-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6007

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6007

UCSC genome browser

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UCSCi
uc001bjz.5 human [Q02161-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63097 mRNA Translation: CAA44811.1
X63094 mRNA Translation: CAA44808.1
L08429 mRNA Translation: AAA02679.1
S57971 mRNA Translation: AAB26081.1
S70174 mRNA Translation: AAB30756.1
S78509 mRNA Translation: AAB34852.1
S73913 mRNA Translation: AAB31911.1
AY751492 mRNA Translation: AAU93636.1
AY751493 mRNA Translation: AAU93637.1
AY751495 mRNA Translation: AAU93639.1
AB018966 mRNA Translation: BAA81899.1
AB018967 mRNA Translation: BAA81900.1
AB018968 mRNA Translation: BAA81901.1
AB018969 mRNA Translation: BAA82159.1
AL928711 Genomic DNA Translation: CAH72602.1
CCDSiCCDS262.1 [Q02161-1]
CCDS53285.1 [Q02161-2]
CCDS60028.1 [Q02161-4]
CCDS60030.1 [Q02161-5]
CCDS60031.1 [Q02161-6]
PIRiA46368
I52615
RefSeqiNP_001121163.1, NM_001127691.2 [Q02161-2]
NP_001269797.1, NM_001282868.1 [Q02161-6]
NP_001269798.1, NM_001282869.1 [Q02161-5]
NP_001269800.1, NM_001282871.1 [Q02161-4]
NP_057208.2, NM_016124.4
UniGeneiHs.449968

3D structure databases

ProteinModelPortaliQ02161
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111939, 1 interactor
IntActiQ02161, 7 interactors
STRINGi9606.ENSP00000331871

Chemistry databases

ChEMBLiCHEMBL3712996

Protein family/group databases

TCDBi1.A.11.4.3 the ammonium transporter channel (amt) family

PTM databases

iPTMnetiQ02161
PhosphoSitePlusiQ02161

Polymorphism and mutation databases

BioMutaiRHD
DMDMi296452980

Proteomic databases

jPOSTiQ02161
PaxDbiQ02161
PeptideAtlasiQ02161
PRIDEiQ02161
ProteomicsDBi58055
58056 [Q02161-2]
58057 [Q02161-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6007
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328664; ENSP00000331871; ENSG00000187010 [Q02161-1]
ENST00000342055; ENSP00000339577; ENSG00000187010 [Q02161-4]
ENST00000357542; ENSP00000350150; ENSG00000187010 [Q02161-5]
ENST00000417538; ENSP00000396420; ENSG00000187010 [Q02161-6]
ENST00000454452; ENSP00000413849; ENSG00000187010 [Q02161-2]
GeneIDi6007
KEGGihsa:6007
UCSCiuc001bjz.5 human [Q02161-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6007
DisGeNETi6007
EuPathDBiHostDB:ENSG00000187010.18

GeneCards: human genes, protein and diseases

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GeneCardsi
RHD
HGNCiHGNC:10009 RHD
MalaCardsiRHD
MIMi111680 gene
neXtProtiNX_Q02161
OpenTargetsiENSG00000187010
Orphaneti71275 Rh deficiency syndrome
PharmGKBiPA34387

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3796 Eukaryota
ENOG410XTF8 LUCA
GeneTreeiENSGT00940000154945
HOVERGENiHBG004374
InParanoidiQ02161
KOiK06579
OMAiSLFAMLX
OrthoDBi910733at2759
PhylomeDBiQ02161
TreeFamiTF314450

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RHD_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6007

Protein Ontology

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PROi
PR:Q02161

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187010 Expressed in 102 organ(s), highest expression level in trabecular bone tissue
ExpressionAtlasiQ02161 baseline and differential
GenevisibleiQ02161 HS

Family and domain databases

Gene3Di1.10.3430.10, 1 hit
InterProiView protein in InterPro
IPR029020 Ammonium/urea_transptr
IPR024041 NH4_transpt_AmtB-like_dom
IPR002229 RhesusRHD
PfamiView protein in Pfam
PF00909 Ammonium_transp, 1 hit
PRINTSiPR00342 RHESUSRHD

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02161
Secondary accession number(s): Q02162
, Q07618, Q16147, Q16235, Q16355, Q5VSK0, Q5XLS9, Q5XLT1, Q5XLT2, Q9NPK0, Q9UQ20, Q9UQ21, Q9UQ22, Q9UQ23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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