Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 62 (18 Sep 2019)
Sequence version 1 (01 Jul 1993)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

RNA-directed RNA polymerase P1

Gene
N/A
Organism
Rice dwarf virus (isolate Akita) (RDV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that is involved in both transcription and genome replication. Together with the capping enzyme P5 and protein P7, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core (By similarity).PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase P1 (EC:2.7.7.48)
Alternative name(s):
Replicase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRice dwarf virus (isolate Akita) (RDV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri142803 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaReoviridaeSedoreovirinaePhytoreovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAlopecurus aequalis [TaxID: 114194]
Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli) [TaxID: 90397]
Nephotettix cincticeps (Green rice leafhopper) (Selenocephalus cincticeps) [TaxID: 94400]
Oryza sativa (Rice) [TaxID: 4530]
Paspalum [TaxID: 147271]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Virion By similarity
  • Host cytoplasm By similarity
  • Note: Located inside the inner capsid. Found in the interior of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002227771 – 1444RNA-directed RNA polymerase P1Add BLAST1444

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q02119

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini690 – 897RdRp catalyticPROSITE-ProRule annotationAdd BLAST208

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007097 RNA-dir_pol_reovirus
IPR014383 RNA-dir_poll_phytoreovirus

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000822 RdRPol_RDV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50523 RDRP_DSRNA_REO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLARSDIIP HLLCLFQEII QANIQKVSEA YDLELKIMNI LTLWRNGSDN
60 70 80 90 100
LISDNDDYMK KGLFFSRSND PLALQARYAQ MYDDLFKLNN YKVPDDVVRK
110 120 130 140 150
HDTKILDIIL KESSVPFWYD ISDDEAHESM LPEFRLQDIH EFRLNLKRVA
160 170 180 190 200
VVPDESEEIQ MDESQSDKRR RKKRMEKSRP VWLSGSENDR RIELNDSLKP
210 220 230 240 250
SQKFETKLSS YLLNRLMNEM NPHYCGHPLP ALFVTLIMLK AYSLKNKFFS
260 270 280 290 300
YGIRYMELVC NEIGGPDLNT RTFPVLFGSD GSFVGTRVYS HYPIKLRMIL
310 320 330 340 350
NDLTYLLTYS DLHKFQEFEL DVNDEVLLHM LHSPNDGRQL KKAVTRLNLY
360 370 380 390 400
YGLKFNPKTT DCGVVNGMDF THKHPITKTA DFTSPVLPMT NSFNKAEICY
410 420 430 440 450
GHSSKILNRA VFTDTVRGYI REDLKNVADL DLPKLHEHVS KLVDMRVNYT
460 470 480 490 500
IIYDLMFLRV MLNLGGYSRS NQITDFRKTI DEITKMNEDF LSGADPEKNI
510 520 530 540 550
DILNAWMAPT MEDCGYRLTK SILFGKFRKA KYPSDLEAKS NIDYYVTARS
560 570 580 590 600
AGIGNLRISI ETDKRKYKVR TTSKSAFVNA MGSGILDVNP VSNEPMMLTD
610 620 630 640 650
YLLTQTPETR ANLEAAIDSG SISDSELMRI LGQNSIGSRS TTAWRPVRPI
660 670 680 690 700
YINVLQAHLA QAFIIGPHIN ATVNQHESQP TSLWFTGDDL GVGFATLYQN
710 720 730 740 750
GTADIIAPAI EASSTGKALS VLADCSSWDQ TFLTATIIPY YNGIKKALLE
760 770 780 790 800
YQQADMRNFY MIDSSRTGVP GMKLSEIVDW FNSFQTKRIF NASYLKERHS
810 820 830 840 850
FVVKYMWSGR LDTFFMNSVQ NALITRRIAE EVSLKVSNTG LSWFQVAGDD
860 870 880 890 900
AIMVYDGSSI STTEQVTRVN EITVRNYEES NHIINPQKTV ISHISGEYAK
910 920 930 940 950
IYYYAGMHFR DPSIQLHESE KDSGASDVTE SLRGFGQVIY EYNKRAIGTL
960 970 980 990 1000
RVNALYGRLI AGLAYSVNVR RYDASKRTYA NMKYYPPPTS VIAPAAFKGG
1010 1020 1030 1040 1050
LGLSFTGLSL NEVLFIKMHL HEAVSQGLHV ISMISFEANE VVSNSLSAYY
1060 1070 1080 1090 1100
LKDQKDLLRD MKLGKHLEKV KGISFKSSDL AFSGSDFSQG LNLKRESIDK
1110 1120 1130 1140 1150
VKLEVSRKSI RDLRSSGISV PSTHAYENLP YASLHQSFKS LKVDRDTSKF
1160 1170 1180 1190 1200
TNERLLVSLL EYKSDIPRVS VTSQYPVYDL INISKVDELN VRSGGPVRFI
1210 1220 1230 1240 1250
STPIEGKLLE ENIGTRQGVQ FKNRGYGGSQ EVLHFIRSNG LVITEQALID
1260 1270 1280 1290 1300
LIIKSGVLLM INPQRGLIDL FQSLSGDTAS SMHLANFFMA EKPHWEDNAI
1310 1320 1330 1340 1350
SLTIAGSLLE NCDSRIENVK NFVSVLATGM QKDLQRMFYY VGFVYYAQRL
1360 1370 1380 1390 1400
IWSGGHSSKI FVSIDEDKLA DFLRGSKPIT RRRKAMAGTK REPINLSANF
1410 1420 1430 1440
SYEISEPDRE ISEYDPLVLC HPLSMPFFGN WQEKYSVMQS DEQM
Length:1,444
Mass (Da):164,144
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i900F7EB7C3EBEAF7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti9I → V in strain: Isolate H. 1
Natural varianti92K → E in strain: Isolate H. 1
Natural varianti100K → R in strain: Isolate H. 1
Natural varianti152V → A in strain: Isolate H. 1
Natural varianti225C → V in strain: Isolate H. 1
Natural varianti244L → I in strain: Isolate H. 1
Natural varianti279S → R in strain: Isolate H. 1
Natural varianti323N → S in strain: Isolate H. 1
Natural varianti426N → S in strain: Isolate H. 1
Natural varianti445M → T in strain: Isolate H. 1
Natural varianti502I → T in strain: Isolate H. 1
Natural varianti726S → T in strain: Isolate H. 1
Natural varianti746K → R in strain: Isolate H. 1
Natural varianti773K → R in strain: Isolate H. 1
Natural varianti1332K → R in strain: Isolate H. 1
Natural varianti1369L → F in strain: Isolate H. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D90198 Genomic RNA Translation: BAA14222.1
D10222 mRNA Translation: BAA01074.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A43377

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90198 Genomic RNA Translation: BAA14222.1
D10222 mRNA Translation: BAA01074.1
PIRiA43377

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ02119

Family and domain databases

InterProiView protein in InterPro
IPR007097 RNA-dir_pol_reovirus
IPR014383 RNA-dir_poll_phytoreovirus
PIRSFiPIRSF000822 RdRPol_RDV, 1 hit
PROSITEiView protein in PROSITE
PS50523 RDRP_DSRNA_REO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_RDVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02119
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 18, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again