UniProtKB - Q02110 (HPPD_PIG)
Protein
4-hydroxyphenylpyruvate dioxygenase
Gene
HPD
Organism
Sus scrofa (Pig)
Status
Functioni
Key enzyme in the degradation of tyrosine.By similarity
Catalytic activityi
- EC:1.13.11.27
Cofactori
Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
: L-phenylalanine degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.Proteins known to be involved in the 6 steps of the subpathway in this organism are:
- Phe-4-monooxygenase, Phe-4-monooxygenase (PAH), Phe-4-monooxygenase, Phe-4-monooxygenase, Phe-4-monooxygenase (PAH)
- Tyrosine aminotransferase (TAT), Tyrosine aminotransferase (TAT)
- 4-hydroxyphenylpyruvate dioxygenase (HPD)
- Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase, Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD)
- Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1)
- Fumarylacetoacetase (FAH), Fumarylacetoacetase (FAH), Fumarylacetoacetase, Fumarylacetoacetase, Fumarylacetoacetase (FAH), Fumarylacetoacetase
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 183 | IronBy similarity | 1 | |
Metal bindingi | 266 | IronBy similarity | 1 | |
Metal bindingi | 349 | IronBy similarity | 1 |
GO - Molecular functioni
- 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- L-phenylalanine catabolic process Source: UniProtKB-UniPathway
- tyrosine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Phenylalanine catabolism, Tyrosine catabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)Alternative name(s): 4-hydroxyphenylpyruvic acid oxidase Short name: 4HPPD Short name: HPD Short name: HPPDase |
Gene namesi | Name:HPD |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000088390 | 2 – 393 | 4-hydroxyphenylpyruvate dioxygenaseAdd BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonine1 Publication | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 | |
Modified residuei | 226 | PhosphoserineBy similarity | 1 | |
Modified residuei | 250 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PeptideAtlasi | Q02110 |
PRIDEi | Q02110 |
PTM databases
iPTMneti | Q02110 |
Expressioni
Tissue specificityi
Liver and kidney.
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000010467 |
Chemistry databases
BindingDBi | Q02110 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 152 | VOC 1PROSITE-ProRule annotationAdd BLAST | 135 | |
Domaini | 180 – 338 | VOC 2PROSITE-ProRule annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the 4HPPD family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0638, Eukaryota |
InParanoidi | Q02110 |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 1 hit |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q02110-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSYSDKGEK PERGRFLHFH SVTFWVGNAK QAASYYCSKI GFEPLAYKGL
60 70 80 90 100
ETGSREVVSH VVKQDKIVFV FSSALNPWNK EMGDHLVKHG DGVKDIAFEV
110 120 130 140 150
EDCDYIVQKA RERGAIIVRE EVCCAADVRG HHTPLDRARQ VWEGTLVEKM
160 170 180 190 200
TFCLDSRPQP SQTLLHRLLL SKLPKCGLEI IDHIVGNQPD QEMESASQWY
210 220 230 240 250
MRNLQFHRFW SVDDTQIHTE YSALRSVVMA NYEESIKMPI NEPAPGKKKS
260 270 280 290 300
QIQEYVDYNG GAGVQHIALK TEDIITAIRS LRERGVEFLA VPFTYYKQLQ
310 320 330 340 350
EKLKSAKIRV KESIDVLEEL KILVDYDEKG YLLQIFTKPM QDRPTVFLEV
360 370 380 390
IQRNNHQGFG AGNFNSLFKA FEEEQELRGN LTDTDPNGVP FRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13390 mRNA Translation: BAA02660.1 |
PIRi | S32821 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13390 mRNA Translation: BAA02660.1 |
PIRi | S32821 |
3D structure databases
SMRi | Q02110 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000010467 |
Chemistry databases
BindingDBi | Q02110 |
ChEMBLi | CHEMBL3203 |
DrugCentrali | Q02110 |
PTM databases
iPTMneti | Q02110 |
Proteomic databases
PeptideAtlasi | Q02110 |
PRIDEi | Q02110 |
Phylogenomic databases
eggNOGi | KOG0638, Eukaryota |
InParanoidi | Q02110 |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Miscellaneous databases
PROi | PR:Q02110 |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 1 hit |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HPPD_PIG | |
Accessioni | Q02110Primary (citable) accession number: Q02110 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families