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Protein

Complement C1q subcomponent subunit C

Gene

C1qc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Biological processi

Keywordsi

Biological processComplement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166663 Initial triggering of complement
R-MMU-173623 Classical antibody-mediated complement activation
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit C
Gene namesi
Name:C1qc
Synonyms:C1qg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88225 C1qc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000000352530 – 246Complement C1q subcomponent subunit CAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33InterchainBy similarity
Modified residuei374-hydroxyprolineBy similarity1
Modified residuei404-hydroxyprolineBy similarity1
Modified residuei434-hydroxyprolineBy similarity1
Modified residuei464-hydroxyprolineBy similarity1
Modified residuei644-hydroxyprolineBy similarity1
Modified residuei765-hydroxylysineBy similarity1
Modified residuei824-hydroxyprolineBy similarity1
Modified residuei974-hydroxyprolineBy similarity1
Modified residuei1004-hydroxyprolineBy similarity1
Modified residuei1064-hydroxyprolineBy similarity1

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDbiQ02105
PeptideAtlasiQ02105
PRIDEiQ02105

PTM databases

iPTMnetiQ02105
PhosphoSitePlusiQ02105

Expressioni

Gene expression databases

BgeeiENSMUSG00000036896 Expressed in 183 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_C1QC
GenevisibleiQ02105 MM

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Protein-protein interaction databases

BioGridi198415, 1 interactor
IntActiQ02105, 1 interactor
STRINGi10090.ENSMUSP00000036747

Structurei

3D structure databases

ProteinModelPortaliQ02105
SMRiQ02105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 113Collagen-likeAdd BLAST82
Domaini116 – 246C1qPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWVM Eukaryota
ENOG4111MQB LUCA
GeneTreeiENSGT00760000118830
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiQ02105
KOiK03988
OMAiYKQKHQS
OrthoDBiEOG091G0L3Y
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 2 hits
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVGPSCQPP CGLCLLLLFL LALPLRSQAS AGCYGIPGMP GMPGAPGKDG
60 70 80 90 100
HDGLQGPKGE PGIPAVPGTR GPKGQKGEPG MPGHRGKNGP RGTSGLPGDP
110 120 130 140 150
GPRGPPGEPG VEGRYKQKHQ SVFTVTRQTT QYPEANALVR FNSVVTNPQG
160 170 180 190 200
HYNPSTGKFT CEVPGLYYFV YYTSHTANLC VHLNLNLARV ASFCDHMFNS
210 220 230 240
KQVSSGGVLL RLQRGDEVWL SVNDYNGMVG IEGSNSVFSG FLLFPD
Length:246
Mass (Da):25,992
Last modified:October 3, 2012 - v2
Checksum:iD3D2EB5851359791
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10P → Q in CAA46993 (PubMed:1396691).Curated1
Sequence conflicti10P → Q in CAA63535 (PubMed:8606057).Curated1
Sequence conflicti10P → Q in AAH43945 (PubMed:15489334).Curated1
Sequence conflicti10P → Q in AAH54443 (PubMed:15489334).Curated1
Sequence conflicti70R → Q in CAA46993 (PubMed:1396691).Curated1
Sequence conflicti70R → Q in AAH43945 (PubMed:15489334).Curated1
Sequence conflicti70R → Q in AAH54443 (PubMed:15489334).Curated1
Sequence conflicti208V → A in CAA46993 (PubMed:1396691).Curated1
Sequence conflicti208V → A in AAH43945 (PubMed:15489334).Curated1
Sequence conflicti208V → A in AAH54443 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66295 mRNA Translation: CAA46993.1
X92960 Genomic DNA Translation: CAA63535.1
AL627214 Genomic DNA Translation: CAM46145.1
BC043945 mRNA Translation: AAH43945.1
BC054443 mRNA Translation: AAH54443.1
BC075724 mRNA Translation: AAH75724.1
CCDSiCCDS18811.1
PIRiS29328
RefSeqiNP_031600.2, NM_007574.2
XP_017175416.1, XM_017319927.1
UniGeneiMm.439732

Genome annotation databases

EnsembliENSMUST00000046332; ENSMUSP00000036747; ENSMUSG00000036896
GeneIDi12262
KEGGimmu:12262
UCSCiuc008viq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66295 mRNA Translation: CAA46993.1
X92960 Genomic DNA Translation: CAA63535.1
AL627214 Genomic DNA Translation: CAM46145.1
BC043945 mRNA Translation: AAH43945.1
BC054443 mRNA Translation: AAH54443.1
BC075724 mRNA Translation: AAH75724.1
CCDSiCCDS18811.1
PIRiS29328
RefSeqiNP_031600.2, NM_007574.2
XP_017175416.1, XM_017319927.1
UniGeneiMm.439732

3D structure databases

ProteinModelPortaliQ02105
SMRiQ02105
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198415, 1 interactor
IntActiQ02105, 1 interactor
STRINGi10090.ENSMUSP00000036747

PTM databases

iPTMnetiQ02105
PhosphoSitePlusiQ02105

Proteomic databases

PaxDbiQ02105
PeptideAtlasiQ02105
PRIDEiQ02105

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046332; ENSMUSP00000036747; ENSMUSG00000036896
GeneIDi12262
KEGGimmu:12262
UCSCiuc008viq.1 mouse

Organism-specific databases

CTDi714
MGIiMGI:88225 C1qc

Phylogenomic databases

eggNOGiENOG410IWVM Eukaryota
ENOG4111MQB LUCA
GeneTreeiENSGT00760000118830
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiQ02105
KOiK03988
OMAiYKQKHQS
OrthoDBiEOG091G0L3Y
TreeFamiTF329591

Enzyme and pathway databases

ReactomeiR-MMU-166663 Initial triggering of complement
R-MMU-173623 Classical antibody-mediated complement activation
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

PROiPR:Q02105
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036896 Expressed in 183 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_C1QC
GenevisibleiQ02105 MM

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 2 hits
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC1QC_MOUSE
AccessioniPrimary (citable) accession number: Q02105
Secondary accession number(s): Q6DI63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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