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Entry version 170 (17 Jun 2020)
Sequence version 1 (01 Jul 1993)
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Protein

CRE-binding bZIP protein SKO1

Gene

SKO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes.

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33183-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-3214847 HATs acetylate histones
R-SCE-450341 Activation of the AP-1 family of transcription factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CRE-binding bZIP protein SKO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKO1
Synonyms:ACR1
Ordered Locus Names:YNL167C
ORF Names:N1702
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YNL167C

Saccharomyces Genome Database

More...
SGDi
S000005111 SKO1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000765171 – 647CRE-binding bZIP protein SKO1Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94PhosphoserineCombined sources1
Modified residuei113PhosphothreonineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q02100

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02100

PRoteomics IDEntifications database

More...
PRIDEi
Q02100

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02100

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35661, 70 interactors

Database of interacting proteins

More...
DIPi
DIP-700N

Protein interaction database and analysis system

More...
IntActi
Q02100, 3 interactors

Molecular INTeraction database

More...
MINTi
Q02100

STRING: functional protein association networks

More...
STRINGi
4932.YNL167C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q02100 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q02100

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini429 – 492bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni430 – 451Basic motifPROSITE-ProRule annotationAdd BLAST22
Regioni454 – 461Leucine-zipperPROSITE-ProRule annotation8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027901_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02100

KEGG Orthology (KO)

More...
KOi
K09051

Identification of Orthologs from Complete Genome Data

More...
OMAi
NATPFNW

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827 bZIP
IPR020956 TF_Aft1_OSM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11785 Aft1_OSA, 1 hit
PF00170 bZIP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEERSRQP STVSTFDLEP NPFEQSFASS KKALSLPGTI SHPSLPKELS
60 70 80 90 100
RNNSTSTITQ HSQRSTHSLN SIPEENGNST VTDNSNHNDV KKDSPSFLPG
110 120 130 140 150
QQRPTIISPP ILTPGGSKRL PPLLLSPSIL YQANSTTNPS QNSHSVSVSN
160 170 180 190 200
SNPSAIGVSS TSGSLYPNSS SPSGTSLIRQ PRNSNVTTSN SGNGFPTNDS
210 220 230 240 250
QMPGFLLNLS KSGLTPNESN IRTGLTPGIL TQSYNYPVLP SINKNTITGS
260 270 280 290 300
KNVNKSVTVN GSIENHPHVN IMHPTVNGTP LTPGLSSLLN LPSTGVLANP
310 320 330 340 350
VFKSTPTTNT TDGTVNNSIS NSNFSPNTST KAAVKMDNPA EFNAIEHSAH
360 370 380 390 400
NHKENENLTT QIENNDQFNN KTRKRKRRMS STSSTSKASR KNSISRKNSA
410 420 430 440 450
VTTAPAQKDD VENNKISNNV TLDENEEQER KRKEFLERNR VAASKFRKRK
460 470 480 490 500
KEYIKKIEND LQFYESEYDD LTQVIGKLCG IIPSSSSNSQ FNVNVSTPSS
510 520 530 540 550
SSPPSTSLIA LLESSISRSD YSSAMSVLSN MKQLICETNF YRRGGKNPRD
560 570 580 590 600
DMDGQEDSFN KDTNVVKSEN AGYPSVNSRP IILDKKYSLN SGANISKSNT
610 620 630 640
TTNNVGNSAQ NIINSCYSVT NPLVINANSD THDTNKHDVL STLPHNN
Length:647
Mass (Da):70,192
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E0B8C72A6CE14AB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67875 Genomic DNA Translation: CAA48074.1
S49588 Genomic DNA Translation: AAB24288.1
X92517 Genomic DNA Translation: CAA63272.1
Z71443 Genomic DNA Translation: CAA96054.1
BK006947 Genomic DNA Translation: DAA10381.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S26386

NCBI Reference Sequences

More...
RefSeqi
NP_014232.1, NM_001183005.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL167C_mRNA; YNL167C; YNL167C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL167C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67875 Genomic DNA Translation: CAA48074.1
S49588 Genomic DNA Translation: AAB24288.1
X92517 Genomic DNA Translation: CAA63272.1
Z71443 Genomic DNA Translation: CAA96054.1
BK006947 Genomic DNA Translation: DAA10381.1
PIRiS26386
RefSeqiNP_014232.1, NM_001183005.1

3D structure databases

SMRiQ02100
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35661, 70 interactors
DIPiDIP-700N
IntActiQ02100, 3 interactors
MINTiQ02100
STRINGi4932.YNL167C

PTM databases

iPTMnetiQ02100

Proteomic databases

MaxQBiQ02100
PaxDbiQ02100
PRIDEiQ02100

Genome annotation databases

EnsemblFungiiYNL167C_mRNA; YNL167C; YNL167C
GeneIDi855554
KEGGisce:YNL167C

Organism-specific databases

EuPathDBiFungiDB:YNL167C
SGDiS000005111 SKO1

Phylogenomic databases

GeneTreeiENSGT00940000176028
HOGENOMiCLU_027901_0_0_1
InParanoidiQ02100
KOiK09051
OMAiNATPFNW

Enzyme and pathway databases

BioCyciYEAST:G3O-33183-MONOMER
ReactomeiR-SCE-3214847 HATs acetylate histones
R-SCE-450341 Activation of the AP-1 family of transcription factors

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q02100
RNActiQ02100 protein

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR020956 TF_Aft1_OSM
PfamiView protein in Pfam
PF11785 Aft1_OSA, 1 hit
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKO1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02100
Secondary accession number(s): D6W115
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 17, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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