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Protein

Transcription factor Sp2

Gene

SP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri525 – 549C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri555 – 579C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri585 – 607C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ02086
SIGNORiQ02086

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp2
Gene namesi
Name:SP2
Synonyms:KIAA0048
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167182.12
HGNCiHGNC:11207 SP2
MIMi601801 gene
neXtProtiNX_Q02086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6668
OpenTargetsiENSG00000167182
PharmGKBiPA36044

Polymorphism and mutation databases

BioMutaiSP2
DMDMi119370531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471401 – 613Transcription factor Sp2Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ02086
MaxQBiQ02086
PaxDbiQ02086
PeptideAtlasiQ02086
PRIDEiQ02086
ProteomicsDBi58047
58048 [Q02086-2]

PTM databases

iPTMnetiQ02086
PhosphoSitePlusiQ02086

Expressioni

Gene expression databases

BgeeiENSG00000167182 Expressed in 217 organ(s), highest expression level in heart left ventricle
CleanExiHS_SP2
ExpressionAtlasiQ02086 baseline and differential
GenevisibleiQ02086 HS

Organism-specific databases

HPAiCAB010245
HPA003357

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112551, 14 interactors
IntActiQ02086, 8 interactors
MINTiQ02086
STRINGi9606.ENSP00000365931

Structurei

3D structure databases

ProteinModelPortaliQ02086
SMRiQ02086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri525 – 549C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri555 – 579C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri585 – 607C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiQ02086
KOiK09192
OMAiKRRMACT
OrthoDBiEOG091G0HX6
PhylomeDBiQ02086
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR030451 SP2_TF
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF1 PTHR23235:SF1, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02086-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ
110 120 130 140 150
LSASYPGGQL VFAIQNPTMI NKGTRSNANI QYQAVPQIQA SNSQTIQVQP
160 170 180 190 200
NLTNQIQIIP GTNQAIITPS PSSHKPVPIK PAPIQKSSTT TTPVQSGANV
210 220 230 240 250
VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL SKTNKKARKK
260 270 280 290 300
SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ
310 320 330 340 350
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT
360 370 380 390 400
PTQVYIRTPS GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK
410 420 430 440 450
HSAAILRKER PLPKIAPAGS IISLNAAQLA AAAQAMQTIN INGVQVQGVP
460 470 480 490 500
VTITNTGGQQ QLTVQNVSGN NLTISGLSPT QIQLQMEQAL AGETQPGEKR
510 520 530 540 550
RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS LLRAHVRLHT
560 570 580 590 600
GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL
610
TKHYKTHLVT KNL
Length:613
Mass (Da):64,900
Last modified:December 12, 2006 - v3
Checksum:iDEE6BFCAE3405793
GO
Isoform 2 (identifier: Q02086-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:606
Mass (Da):64,153
Checksum:iA27C6D460D36E186
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BRW5Q9BRW5_HUMAN
SP2 protein
SP2
249Annotation score:
A0A1B0GVH1A0A1B0GVH1_HUMAN
Transcription factor Sp2
SP2
97Annotation score:
A0A1B0GV29A0A1B0GV29_HUMAN
Transcription factor Sp2
SP2
53Annotation score:
A0A1B0GTK3A0A1B0GTK3_HUMAN
Transcription factor Sp2
SP2
43Annotation score:
A0A286YFJ7A0A286YFJ7_HUMAN
Transcription factor Sp2
SP2
88Annotation score:

Sequence cautioni

The sequence AAH16680 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA05923 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0220211 – 7Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28588 mRNA Translation: BAA05923.2 Different initiation.
AC018521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94785.1
BC016680 mRNA Translation: AAH16680.1 Different initiation.
BC033814 mRNA Translation: AAH33814.1 Different initiation.
M97190 mRNA Translation: AAA36629.1
CCDSiCCDS11521.2 [Q02086-1]
PIRiA44489
RefSeqiNP_003101.3, NM_003110.5 [Q02086-1]
UniGeneiHs.514276

Genome annotation databases

EnsembliENST00000376741; ENSP00000365931; ENSG00000167182 [Q02086-1]
GeneIDi6668
KEGGihsa:6668
UCSCiuc002imk.3 human [Q02086-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28588 mRNA Translation: BAA05923.2 Different initiation.
AC018521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94785.1
BC016680 mRNA Translation: AAH16680.1 Different initiation.
BC033814 mRNA Translation: AAH33814.1 Different initiation.
M97190 mRNA Translation: AAA36629.1
CCDSiCCDS11521.2 [Q02086-1]
PIRiA44489
RefSeqiNP_003101.3, NM_003110.5 [Q02086-1]
UniGeneiHs.514276

3D structure databases

ProteinModelPortaliQ02086
SMRiQ02086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112551, 14 interactors
IntActiQ02086, 8 interactors
MINTiQ02086
STRINGi9606.ENSP00000365931

PTM databases

iPTMnetiQ02086
PhosphoSitePlusiQ02086

Polymorphism and mutation databases

BioMutaiSP2
DMDMi119370531

Proteomic databases

EPDiQ02086
MaxQBiQ02086
PaxDbiQ02086
PeptideAtlasiQ02086
PRIDEiQ02086
ProteomicsDBi58047
58048 [Q02086-2]

Protocols and materials databases

DNASUi6668
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376741; ENSP00000365931; ENSG00000167182 [Q02086-1]
GeneIDi6668
KEGGihsa:6668
UCSCiuc002imk.3 human [Q02086-1]

Organism-specific databases

CTDi6668
DisGeNETi6668
EuPathDBiHostDB:ENSG00000167182.12
GeneCardsiSP2
HGNCiHGNC:11207 SP2
HPAiCAB010245
HPA003357
MIMi601801 gene
neXtProtiNX_Q02086
OpenTargetsiENSG00000167182
PharmGKBiPA36044
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiQ02086
KOiK09192
OMAiKRRMACT
OrthoDBiEOG091G0HX6
PhylomeDBiQ02086
TreeFamiTF350150

Enzyme and pathway databases

SignaLinkiQ02086
SIGNORiQ02086

Miscellaneous databases

ChiTaRSiSP2 human
GeneWikiiSp2_transcription_factor
GenomeRNAii6668
PROiPR:Q02086
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167182 Expressed in 217 organ(s), highest expression level in heart left ventricle
CleanExiHS_SP2
ExpressionAtlasiQ02086 baseline and differential
GenevisibleiQ02086 HS

Family and domain databases

InterProiView protein in InterPro
IPR030451 SP2_TF
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF1 PTHR23235:SF1, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP2_HUMAN
AccessioniPrimary (citable) accession number: Q02086
Secondary accession number(s): A6NK74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 12, 2006
Last modified: October 10, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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