UniProtKB - Q02086 (SP2_HUMAN)
Protein
Transcription factor Sp2
Gene
SP2
Organism
Homo sapiens (Human)
Status
Functioni
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 525 – 549 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 555 – 579 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 585 – 607 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- histone deacetylase binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- immune response Source: ProtInc
- multicellular organism growth Source: InterPro
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q02086 |
SignaLinki | Q02086 |
SIGNORi | Q02086 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sp2 |
Gene namesi | Name:SP2 Synonyms:KIAA0048 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167182.12 |
HGNCi | HGNC:11207, SP2 |
MIMi | 601801, gene |
neXtProti | NX_Q02086 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6668 |
OpenTargetsi | ENSG00000167182 |
PharmGKBi | PA36044 |
Miscellaneous databases
Pharosi | Q02086, Tbio |
Polymorphism and mutation databases
BioMutai | SP2 |
DMDMi | 119370531 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047140 | 1 – 613 | Transcription factor Sp2Add BLAST | 613 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q02086 |
jPOSTi | Q02086 |
MassIVEi | Q02086 |
MaxQBi | Q02086 |
PaxDbi | Q02086 |
PeptideAtlasi | Q02086 |
PRIDEi | Q02086 |
ProteomicsDBi | 58047 [Q02086-1] 58048 [Q02086-2] |
PTM databases
iPTMneti | Q02086 |
PhosphoSitePlusi | Q02086 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167182, Expressed in heart left ventricle and 231 other tissues |
ExpressionAtlasi | Q02086, baseline and differential |
Genevisiblei | Q02086, HS |
Organism-specific databases
HPAi | ENSG00000167182, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ02086
With | #Exp. | IntAct |
---|---|---|
BANP [Q8N9N5] | 4 | EBI-8651703,EBI-744695 |
FHL2 [Q14192] | 3 | EBI-8651703,EBI-701903 |
MCM7 [P33993] | 3 | EBI-8651703,EBI-355924 |
Isoform 2 [Q02086-2]
GO - Molecular functioni
- histone deacetylase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112551, 21 interactors |
IntActi | Q02086, 8 interactors |
MINTi | Q02086 |
STRINGi | 9606.ENSP00000365931 |
Miscellaneous databases
RNActi | Q02086, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 361 – 369 | 9aaTAD; inactive1 Publication | 9 |
Domaini
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP2, the motif is inactive.1 Publication
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 525 – 549 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 555 – 579 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 585 – 607 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159590 |
HOGENOMi | CLU_034267_0_0_1 |
InParanoidi | Q02086 |
OMAi | IQYQTVP |
OrthoDBi | 1085860at2759 |
PhylomeDBi | Q02086 |
TreeFami | TF350150 |
Family and domain databases
InterProi | View protein in InterPro IPR030451, SP2_TF IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF1, PTHR23235:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q02086-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ
110 120 130 140 150
LSASYPGGQL VFAIQNPTMI NKGTRSNANI QYQAVPQIQA SNSQTIQVQP
160 170 180 190 200
NLTNQIQIIP GTNQAIITPS PSSHKPVPIK PAPIQKSSTT TTPVQSGANV
210 220 230 240 250
VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL SKTNKKARKK
260 270 280 290 300
SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ
310 320 330 340 350
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT
360 370 380 390 400
PTQVYIRTPS GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK
410 420 430 440 450
HSAAILRKER PLPKIAPAGS IISLNAAQLA AAAQAMQTIN INGVQVQGVP
460 470 480 490 500
VTITNTGGQQ QLTVQNVSGN NLTISGLSPT QIQLQMEQAL AGETQPGEKR
510 520 530 540 550
RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS LLRAHVRLHT
560 570 580 590 600
GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL
610
TKHYKTHLVT KNL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BRW5 | Q9BRW5_HUMAN | SP2 protein | SP2 | 249 | Annotation score: | ||
A0A1B0GTK3 | A0A1B0GTK3_HUMAN | Transcription factor Sp2 | SP2 | 43 | Annotation score: | ||
A0A1B0GV29 | A0A1B0GV29_HUMAN | Transcription factor Sp2 | SP2 | 53 | Annotation score: | ||
A0A1B0GVH1 | A0A1B0GVH1_HUMAN | Transcription factor Sp2 | SP2 | 97 | Annotation score: | ||
A0A286YFJ7 | A0A286YFJ7_HUMAN | Transcription factor Sp2 | SP2 | 88 | Annotation score: |
Sequence cautioni
The sequence AAH16680 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA05923 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022021 | 1 – 7 | Missing in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28588 mRNA Translation: BAA05923.2 Different initiation. AC018521 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94785.1 BC016680 mRNA Translation: AAH16680.1 Different initiation. BC033814 mRNA Translation: AAH33814.1 Different initiation. M97190 mRNA Translation: AAA36629.1 |
CCDSi | CCDS11521.2 [Q02086-1] |
PIRi | A44489 |
RefSeqi | NP_003101.3, NM_003110.5 [Q02086-1] |
Genome annotation databases
Ensembli | ENST00000376741; ENSP00000365931; ENSG00000167182 [Q02086-1] |
GeneIDi | 6668 |
KEGGi | hsa:6668 |
UCSCi | uc002imk.3, human [Q02086-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28588 mRNA Translation: BAA05923.2 Different initiation. AC018521 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94785.1 BC016680 mRNA Translation: AAH16680.1 Different initiation. BC033814 mRNA Translation: AAH33814.1 Different initiation. M97190 mRNA Translation: AAA36629.1 |
CCDSi | CCDS11521.2 [Q02086-1] |
PIRi | A44489 |
RefSeqi | NP_003101.3, NM_003110.5 [Q02086-1] |
3D structure databases
SMRi | Q02086 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112551, 21 interactors |
IntActi | Q02086, 8 interactors |
MINTi | Q02086 |
STRINGi | 9606.ENSP00000365931 |
PTM databases
iPTMneti | Q02086 |
PhosphoSitePlusi | Q02086 |
Polymorphism and mutation databases
BioMutai | SP2 |
DMDMi | 119370531 |
Proteomic databases
EPDi | Q02086 |
jPOSTi | Q02086 |
MassIVEi | Q02086 |
MaxQBi | Q02086 |
PaxDbi | Q02086 |
PeptideAtlasi | Q02086 |
PRIDEi | Q02086 |
ProteomicsDBi | 58047 [Q02086-1] 58048 [Q02086-2] |
Protocols and materials databases
Antibodypediai | 928, 167 antibodies |
DNASUi | 6668 |
Genome annotation databases
Ensembli | ENST00000376741; ENSP00000365931; ENSG00000167182 [Q02086-1] |
GeneIDi | 6668 |
KEGGi | hsa:6668 |
UCSCi | uc002imk.3, human [Q02086-1] |
Organism-specific databases
CTDi | 6668 |
DisGeNETi | 6668 |
EuPathDBi | HostDB:ENSG00000167182.12 |
GeneCardsi | SP2 |
HGNCi | HGNC:11207, SP2 |
HPAi | ENSG00000167182, Low tissue specificity |
MIMi | 601801, gene |
neXtProti | NX_Q02086 |
OpenTargetsi | ENSG00000167182 |
PharmGKBi | PA36044 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159590 |
HOGENOMi | CLU_034267_0_0_1 |
InParanoidi | Q02086 |
OMAi | IQYQTVP |
OrthoDBi | 1085860at2759 |
PhylomeDBi | Q02086 |
TreeFami | TF350150 |
Enzyme and pathway databases
PathwayCommonsi | Q02086 |
SignaLinki | Q02086 |
SIGNORi | Q02086 |
Miscellaneous databases
BioGRID-ORCSi | 6668, 163 hits in 873 CRISPR screens |
ChiTaRSi | SP2, human |
GeneWikii | Sp2_transcription_factor |
GenomeRNAii | 6668 |
Pharosi | Q02086, Tbio |
PROi | PR:Q02086 |
RNActi | Q02086, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167182, Expressed in heart left ventricle and 231 other tissues |
ExpressionAtlasi | Q02086, baseline and differential |
Genevisiblei | Q02086, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030451, SP2_TF IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF1, PTHR23235:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SP2_HUMAN | |
Accessioni | Q02086Primary (citable) accession number: Q02086 Secondary accession number(s): A6NK74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | December 12, 2006 | |
Last modified: | December 2, 2020 | |
This is version 186 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM