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Protein

Transcription factor Sp2

Gene

SP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri525 – 549C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri555 – 579C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri585 – 607C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • immune response Source: ProtInc
  • multicellular organism growth Source: InterPro
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ02086
SIGNORiQ02086

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp2
Gene namesi
Name:SP2
Synonyms:KIAA0048
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167182.12
HGNCiHGNC:11207 SP2
MIMi601801 gene
neXtProtiNX_Q02086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6668
OpenTargetsiENSG00000167182
PharmGKBiPA36044

Polymorphism and mutation databases

BioMutaiSP2
DMDMi119370531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471401 – 613Transcription factor Sp2Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ02086
MaxQBiQ02086
PaxDbiQ02086
PeptideAtlasiQ02086
PRIDEiQ02086
ProteomicsDBi58047
58048 [Q02086-2]

PTM databases

iPTMnetiQ02086
PhosphoSitePlusiQ02086

Expressioni

Gene expression databases

BgeeiENSG00000167182
CleanExiHS_SP2
ExpressionAtlasiQ02086 baseline and differential
GenevisibleiQ02086 HS

Organism-specific databases

HPAiCAB010245
HPA003357

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112551, 14 interactors
IntActiQ02086, 8 interactors
MINTiQ02086
STRINGi9606.ENSP00000365931

Structurei

3D structure databases

ProteinModelPortaliQ02086
SMRiQ02086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri525 – 549C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri555 – 579C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri585 – 607C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiQ02086
KOiK09192
OMAiKRRMACT
OrthoDBiEOG091G0HX6
PhylomeDBiQ02086
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR030451 SP2_TF
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF1 PTHR23235:SF1, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02086-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ
110 120 130 140 150
LSASYPGGQL VFAIQNPTMI NKGTRSNANI QYQAVPQIQA SNSQTIQVQP
160 170 180 190 200
NLTNQIQIIP GTNQAIITPS PSSHKPVPIK PAPIQKSSTT TTPVQSGANV
210 220 230 240 250
VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL SKTNKKARKK
260 270 280 290 300
SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ
310 320 330 340 350
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT
360 370 380 390 400
PTQVYIRTPS GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK
410 420 430 440 450
HSAAILRKER PLPKIAPAGS IISLNAAQLA AAAQAMQTIN INGVQVQGVP
460 470 480 490 500
VTITNTGGQQ QLTVQNVSGN NLTISGLSPT QIQLQMEQAL AGETQPGEKR
510 520 530 540 550
RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS LLRAHVRLHT
560 570 580 590 600
GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL
610
TKHYKTHLVT KNL
Length:613
Mass (Da):64,900
Last modified:December 12, 2006 - v3
Checksum:iDEE6BFCAE3405793
GO
Isoform 2 (identifier: Q02086-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:606
Mass (Da):64,153
Checksum:iA27C6D460D36E186
GO

Sequence cautioni

The sequence AAH16680 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA05923 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0220211 – 7Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28588 mRNA Translation: BAA05923.2 Different initiation.
AC018521 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94785.1
BC016680 mRNA Translation: AAH16680.1 Different initiation.
BC033814 mRNA Translation: AAH33814.1 Different initiation.
M97190 mRNA Translation: AAA36629.1
CCDSiCCDS11521.2 [Q02086-1]
PIRiA44489
RefSeqiNP_003101.3, NM_003110.5 [Q02086-1]
UniGeneiHs.514276

Genome annotation databases

EnsembliENST00000376741; ENSP00000365931; ENSG00000167182 [Q02086-1]
GeneIDi6668
KEGGihsa:6668
UCSCiuc002imk.3 human [Q02086-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSP2_HUMAN
AccessioniPrimary (citable) accession number: Q02086
Secondary accession number(s): A6NK74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 12, 2006
Last modified: June 20, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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