Snai1

Functionⁱ

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	156 – 176	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	180 – 202	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	210 – 230	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	236 – 259	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

kinase binding Source: MGI
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12917416
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 9676199
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17093497
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12917416

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cartilage morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 17376812
cell migration
Source: MGI
Inferred from genetic interactionⁱ
- 17376812
epithelial to mesenchymal transition
Source: UniProtKB
Inferred from direct assayⁱ
- 10655586
epithelial to mesenchymal transition involved in endocardial cushion formation
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 18663143
hair follicle morphogenesis
Source: MGI
Inferred from direct assayⁱ
- 15630473
heterochromatin organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24239292
left/right pattern formation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16801545
mesoderm development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16801545
mesoderm formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11689706
negative regulation of cell differentiation involved in embryonic placenta development
Source: MGI
Inferred from direct assayⁱ
- 9676199
negative regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10655586
- 12832491
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12917416
negative regulation of vitamin D biosynthetic process Source: MGI
Notch signaling involved in heart development
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 20890042
osteoblast differentiation Source: Ensembl
positive regulation of cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20890042
positive regulation of epithelial to mesenchymal transition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24239292
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12832491
regulation of bicellular tight junction assembly Source: MGI
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 9676199
roof of mouth development
Source: MGI
Inferred from genetic interactionⁱ
- 17376812
trophoblast giant cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 9676199

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein SNAI1 Alternative name(s): Protein snail homolog 1 Short name: Protein sna
Gene namesⁱ	Name:Snai1 Synonyms:Sna
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:98330 Snai1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Embryos die early in gestation, exhibiting defects in gastrulation and mesoderm formation. Recessive lethal mutation.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047030	1 – 264	Zinc finger protein SNAI1Add BLAST		264

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	11	PhosphoserineBy similarity	1
Modified residueⁱ	82	PhosphoserineBy similarity	1
Modified residueⁱ	92	PhosphoserineBy similarity	1
Modified residueⁱ	96	PhosphoserineBy similarity	1
Cross-linkⁱ	98	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	100	PhosphoserineBy similarity	1
Modified residueⁱ	104	PhosphoserineBy similarity	1
Modified residueⁱ	107	PhosphoserineBy similarity	1
Modified residueⁱ	111	PhosphoserineBy similarity	1
Glycosylationⁱ	112	O-linked (GlcNAc) serineBy similarity	1
Modified residueⁱ	115	PhosphoserineBy similarity	1
Modified residueⁱ	119	PhosphoserineBy similarity	1
Cross-linkⁱ	137	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	146	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	203	PhosphothreonineBy similarity	1
Modified residueⁱ	246	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-104 positively regulates its function in induction of EMT and/or cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level (By similarity).By similarity

Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction with NOTCH1 or p53 is mediated by MDM2 (By similarity).By similarity

O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.By similarity

ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation.By similarity

Keywords - PTMⁱ

ADP-ribosylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q02085
PRIDEⁱ	Q02085

PTM databases

iPTMnetⁱ	Q02085
PhosphoSitePlusⁱ	Q02085

Expressionⁱ

Tissue specificityⁱ

While expression is completely absent from non-invasive cell lines, it is high in invasive and metastatic cell types.

Developmental stageⁱ

Postimplantation. Expression is observed in undifferentiated mesoderm and in tissues undergoing EMTs, namely the precursors of the neural crest cells and the primitive streak.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000042821 Expressed in 208 organ(s), highest expression level in ectoplacental cone
CleanExⁱ	MM_SNAI1
ExpressionAtlasⁱ	Q02085 baseline and differential
Genevisibleⁱ	Q02085 MM

Interactionⁱ

Subunit structureⁱ

Interacts with LOXL2 and LOXL3 (By similarity). Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Interacts (via N-terminal region) with CSNK2A1. Interacts with EGR1 upon TPA induction. Interacts (via N-terminal region) with LATS2; the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation. Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import. Interacts (via zinc fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in the cytoplasm. Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear import. Interacts with KPNA4; this interaction mediates nuclear import. May interact (via zinc fingers) with IPO7. Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B. Interacts (via SNAG domain) with KDM1A; the interaction is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8. Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion. Interacts with MDM2; the interaction promotes SNAI1 ubiquitination. Interacts (via zinc fingers) with CSNK1E. Interacts with PAK1.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PARP1	P09874	3	EBI-6049807,EBI-355676	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

PARP1

P09874

3

EBI-6049807,EBI-355676

From Homo sapiens.

GO - Molecular functionⁱ

kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203361, 6 interactors
IntActⁱ	Q02085, 1 interactor
STRINGⁱ	10090.ENSMUSP00000050581

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q02085
SMRⁱ	Q02085
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST	20
Regionⁱ	10 – 40	LATS2 bindingBy similarityAdd BLAST	31
Regionⁱ	120 – 151	Required for FBXL14-triggered degradationBy similarityAdd BLAST	32
Regionⁱ	151 – 264	Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1By similarityAdd BLAST	114

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	95 – 100	Destruction motif		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	90 – 120	Ser-richAdd BLAST		31

Sequence similaritiesⁱ

Belongs to the snail C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	156 – 176	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	180 – 202	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	210 – 230	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	236 – 259	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q02085
KEGG Orthology (KO) More...KOⁱ	K05707
OMAⁱ	QPIGWAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q02085
TreeFamⁱ	TF315515

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q02085-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRSFLVRKP SDPRRKPNYS ELQDACVEFT FQQPYDQAHL LAAIPPPEVL 
        60         70         80         90        100
NPAASLPTLI WDSLLVPQVR PVAWATLPLR ESPKAVELTS LSDEDSGKSS 
       110        120        130        140        150
QPPSPPSPAP SSFSSTSASS LEAEAFIAFP GLGQLPKQLA RLSVAKDPQS 
       160        170        180        190        200
RKIFNCKYCN KEYLSLGALK MHIRSHTLPC VCTTCGKAFS RPWLLQGHVR 
       210        220        230        240        250
THTGEKPFSC SHCNRAFADR SNLRAHLQTH SDVKRYQCQA CARTFSRMSL 
       260 
LHKHQESGCS GGPR

Length:264

Mass (Da):29,190

Last modified:October 1, 1996 - v1

Checksum:ⁱ52E2061224A18DEB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	219	D → V in CAA47675 (PubMed:1483390).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95604 mRNA Translation: AAA03481.1 X67253 mRNA Translation: CAA47675.1 BC034857 mRNA Translation: AAH34857.1 U95961 Genomic DNA Translation: AAB58054.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17102.1
PIRⁱ	A49149
NCBI Reference Sequences More...RefSeqⁱ	NP_035557.1, NM_011427.3
UniGeneⁱ	Mm.2093

Genome annotation databases

Ensemblⁱ	ENSMUST00000052631; ENSMUSP00000050581; ENSMUSG00000042821
GeneIDⁱ	20613
KEGGⁱ	mmu:20613
UCSC genome browser More...UCSCⁱ	uc008nzy.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02085	Snai1 protein		MOUSE		264	UniRef100_Q02085

Protein	Similar proteins		Species	Score	Length	Source
Q02085	Snai1 protein		MOUSE		264	UniRef90_Q02085
Zinc finger protein SNAI1		CRIGR		264
Snail family transcriptional repressor 1		RAT		264
zinc finger protein SNAI1		MESAU		264
Uncharacterized protein		NEOLE		264
+7

Protein	Similar proteins		Species	Score	Length	Source
Q02085	Snai1 protein		MOUSE		264	UniRef50_Q02085
Uncharacterized protein		NEOLE		264
Zinc finger protein SNAI1		CRIGR		264
Snail family transcriptional repressor 1		RAT		264
zinc finger protein SNAI1		MESAU		264
+59

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95604 mRNA Translation: AAA03481.1 X67253 mRNA Translation: CAA47675.1 BC034857 mRNA Translation: AAH34857.1 U95961 Genomic DNA Translation: AAB58054.1
CCDSⁱ	CCDS17102.1
PIRⁱ	A49149
RefSeqⁱ	NP_035557.1, NM_011427.3
UniGeneⁱ	Mm.2093

3D structure databases

ProteinModelPortalⁱ	Q02085
SMRⁱ	Q02085
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203361, 6 interactors
IntActⁱ	Q02085, 1 interactor
STRINGⁱ	10090.ENSMUSP00000050581

PTM databases

iPTMnetⁱ	Q02085
PhosphoSitePlusⁱ	Q02085

Proteomic databases

PaxDbⁱ	Q02085
PRIDEⁱ	Q02085

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000052631; ENSMUSP00000050581; ENSMUSG00000042821
GeneIDⁱ	20613
KEGGⁱ	mmu:20613
UCSCⁱ	uc008nzy.1 mouse

Organism-specific databases

CTDⁱ	6615
MGIⁱ	MGI:98330 Snai1

Phylogenomic databases

eggNOGⁱ	KOG2462 Eukaryota ENOG41106JS LUCA
GeneTreeⁱ	ENSGT00390000011027
HOGENOMⁱ	HOG000261665
HOVERGENⁱ	HBG007477
InParanoidⁱ	Q02085
KOⁱ	K05707
OMAⁱ	QPIGWAS
OrthoDBⁱ	EOG091G0Q0V
PhylomeDBⁱ	Q02085
TreeFamⁱ	TF315515

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q02085
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042821 Expressed in 208 organ(s), highest expression level in ectoplacental cone
CleanExⁱ	MM_SNAI1
ExpressionAtlasⁱ	Q02085 baseline and differential
Genevisibleⁱ	Q02085 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNAI1_MOUSE
Accessionⁱ	Q02085Primary (citable) accession number: Q02085
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	October 10, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q02085 (SNAI1_MOUSE)

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Zinc finger protein SNAI1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ