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Protein

N-acylethanolamine-hydrolyzing acid amidase

Gene

NAAA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by DTT and Nonidet P-40.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=97 µM for N-palmitoylethanolamine1 Publication

    pH dependencei

    Optimum pH is 4.5 with N-palmitoylethanolamine as substrate.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei126Nucleophile1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Source: MGI
    • transcription factor binding Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.5.1.4 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-112310 Neurotransmitter release cycle

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    C89.002

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001125

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    N-acylethanolamine-hydrolyzing acid amidase (EC:3.5.1.-)
    Alternative name(s):
    Acid ceramidase-like protein
    N-acylsphingosine amidohydrolase-like
    Short name:
    ASAH-like protein
    Cleaved into the following 2 chains:
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NAAA
    Synonyms:ASAHL, PLT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000138744.14

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:736 NAAA

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    607469 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q02083

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Lysosome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    27163

    Open Targets

    More...
    OpenTargetsi
    ENSG00000138744

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162396672

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4349

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1402

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NAAA

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116241258

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000231829 – 359N-acylethanolamine-hydrolyzing acid amidaseAdd BLAST331
    ChainiPRO_000041965029 – 125N-acylethanolamine-hydrolyzing acid amidase subunit alphaAdd BLAST97
    ChainiPRO_0000419651126 – 349N-acylethanolamine-hydrolyzing acid amidase subunit betaAdd BLAST224

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagine2 Publications1
    Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi309N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi333N-linked (GlcNAc...) asparagine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.3 Publications
    Autoproteolytic cleavage in the acidic lumen of the lysosome activates the enzyme.1 Publication

    Keywords - PTMi

    Autocatalytic cleavage, Glycoprotein, Zymogen

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q02083

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q02083

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q02083

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q02083

    PeptideAtlas

    More...
    PeptideAtlasi
    Q02083

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q02083

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    58044
    58045 [Q02083-2]
    58046 [Q02083-3]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1534

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q02083

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000138744 Expressed in 218 organ(s), highest expression level in leukocyte

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_NAAA

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q02083 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q02083 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB026135

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer of an alpha and a beta subunit, non-covalently linked.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    118042, 59 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000286733

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q02083

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1359
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6DXWX-ray2.30A/B/C/D29-359[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q02083

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q02083

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the acid ceramidase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IJHJ Eukaryota
    ENOG4111HJY LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00530000063548

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000007253

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG050586

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q02083

    KEGG Orthology (KO)

    More...
    KOi
    K13720

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YESTAFC

    Database of Orthologous Groups

    More...
    OrthoDBi
    745108at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q02083

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313219

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016699 Acid_ceramidase-like
    IPR029130 Acid_ceramidase_N
    IPR029132 CBAH/NAAA_C

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02275 CBAH, 1 hit
    PF15508 NAAA-beta, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF017632 Acid_ceramidase-like, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q02083-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MRTADREARP GLPSLLLLLL AGAGLSAASP PAAPRFNVSL DSVPELRWLP
    60 70 80 90 100
    VLRHYDLDLV RAAMAQVIGD RVPKWVHVLI GKVVLELERF LPQPFTGEIR
    110 120 130 140 150
    GMCDFMNLSL ADCLLVNLAY ESSVFCTSIV AQDSRGHIYH GRNLDYPFGN
    160 170 180 190 200
    VLRKLTVDVQ FLKNGQIAFT GTTFIGYVGL WTGQSPHKFT VSGDERDKGW
    210 220 230 240 250
    WWENAIAALF RRHIPVSWLI RATLSESENF EAAVGKLAKT PLIADVYYIV
    260 270 280 290 300
    GGTSPREGVV ITRNRDGPAD IWPLDPLNGA WFRVETNYDH WKPAPKEDDR
    310 320 330 340 350
    RTSAIKALNA TGQANLSLEA LFQILSVVPV YNNFTIYTTV MSAGSPDKYM

    TRIRNPSRK
    Length:359
    Mass (Da):40,066
    Last modified:October 17, 2006 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8E214DB383B872A
    GO
    Isoform 2 (identifier: Q02083-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         324-359: Missing.

    Show »
    Length:323
    Mass (Da):35,963
    Checksum:i453B1D0E4B99AA90
    GO
    Isoform 3 (identifier: Q02083-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         198-199: KG → PE
         200-359: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:199
    Mass (Da):22,020
    Checksum:iC35E612CFC738971
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D6R9S9D6R9S9_HUMAN
    N-acylethanolamine-hydrolyzing acid...
    NAAA
    167Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B4DVL2B4DVL2_HUMAN
    N-acylethanolamine-hydrolyzing acid...
    NAAA
    252Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    R4GNC0R4GNC0_HUMAN
    N-acylethanolamine-hydrolyzing acid...
    NAAA
    222Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y988H0Y988_HUMAN
    N-acylethanolamine-hydrolyzing acid...
    NAAA
    139Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147P → A in AAA60119 (PubMed:1446826).Curated1
    Sequence conflicti240T → S in AAA60119 (PubMed:1446826).Curated1
    Sequence conflicti250V → L in AAA60119 (PubMed:1446826).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048336107N → K. Corresponds to variant dbSNP:rs34751328Ensembl.1
    Natural variantiVAR_028428151V → I. Corresponds to variant dbSNP:rs4859571Ensembl.1
    Natural variantiVAR_048337334F → L. Corresponds to variant dbSNP:rs6823734Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000328198 – 199KG → PE in isoform 3. 1 Publication2
    Alternative sequenceiVSP_000329200 – 359Missing in isoform 3. 1 PublicationAdd BLAST160
    Alternative sequenceiVSP_000330324 – 359Missing in isoform 2. 1 PublicationAdd BLAST36

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB161353 mRNA Translation: BAD88528.1
    BC006388 mRNA Translation: AAH06388.2
    BC011854 mRNA No translation available.
    M92449 mRNA Translation: AAA60119.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS43239.1 [Q02083-1]
    CCDS87233.1 [Q02083-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001035861.1, NM_001042402.1 [Q02083-2]
    NP_055250.2, NM_014435.3 [Q02083-1]
    XP_005262977.1, XM_005262920.3 [Q02083-1]
    XP_005262982.1, XM_005262925.3
    XP_016863517.1, XM_017008028.1 [Q02083-1]

    UniGene gene-oriented nucleotide sequence clusters

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    UniGenei
    Hs.437365

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000286733; ENSP00000286733; ENSG00000138744 [Q02083-1]
    ENST00000507956; ENSP00000427641; ENSG00000138744 [Q02083-2]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    27163

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:27163

    UCSC genome browser

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    UCSCi
    uc003hjb.4 human [Q02083-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB161353 mRNA Translation: BAD88528.1
    BC006388 mRNA Translation: AAH06388.2
    BC011854 mRNA No translation available.
    M92449 mRNA Translation: AAA60119.1
    CCDSiCCDS43239.1 [Q02083-1]
    CCDS87233.1 [Q02083-2]
    RefSeqiNP_001035861.1, NM_001042402.1 [Q02083-2]
    NP_055250.2, NM_014435.3 [Q02083-1]
    XP_005262977.1, XM_005262920.3 [Q02083-1]
    XP_005262982.1, XM_005262925.3
    XP_016863517.1, XM_017008028.1 [Q02083-1]
    UniGeneiHs.437365

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6DXWX-ray2.30A/B/C/D29-359[»]
    ProteinModelPortaliQ02083
    SMRiQ02083
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi118042, 59 interactors
    STRINGi9606.ENSP00000286733

    Chemistry databases

    BindingDBiQ02083
    ChEMBLiCHEMBL4349
    GuidetoPHARMACOLOGYi1402
    SwissLipidsiSLP:000001125

    Protein family/group databases

    MEROPSiC89.002

    PTM databases

    GlyConnecti1534
    iPTMnetiQ02083

    Polymorphism and mutation databases

    BioMutaiNAAA
    DMDMi116241258

    Proteomic databases

    EPDiQ02083
    jPOSTiQ02083
    MaxQBiQ02083
    PaxDbiQ02083
    PeptideAtlasiQ02083
    PRIDEiQ02083
    ProteomicsDBi58044
    58045 [Q02083-2]
    58046 [Q02083-3]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000286733; ENSP00000286733; ENSG00000138744 [Q02083-1]
    ENST00000507956; ENSP00000427641; ENSG00000138744 [Q02083-2]
    GeneIDi27163
    KEGGihsa:27163
    UCSCiuc003hjb.4 human [Q02083-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    27163
    DisGeNETi27163
    EuPathDBiHostDB:ENSG00000138744.14

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NAAA
    HGNCiHGNC:736 NAAA
    HPAiCAB026135
    MIMi607469 gene
    neXtProtiNX_Q02083
    OpenTargetsiENSG00000138744
    PharmGKBiPA162396672

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410IJHJ Eukaryota
    ENOG4111HJY LUCA
    GeneTreeiENSGT00530000063548
    HOGENOMiHOG000007253
    HOVERGENiHBG050586
    InParanoidiQ02083
    KOiK13720
    OMAiYESTAFC
    OrthoDBi745108at2759
    PhylomeDBiQ02083
    TreeFamiTF313219

    Enzyme and pathway databases

    BRENDAi3.5.1.4 2681
    ReactomeiR-HSA-112310 Neurotransmitter release cycle

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NAAA human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ASAHL

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    27163

    Protein Ontology

    More...
    PROi
    PR:Q02083

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000138744 Expressed in 218 organ(s), highest expression level in leukocyte
    CleanExiHS_NAAA
    ExpressionAtlasiQ02083 baseline and differential
    GenevisibleiQ02083 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016699 Acid_ceramidase-like
    IPR029130 Acid_ceramidase_N
    IPR029132 CBAH/NAAA_C
    PfamiView protein in Pfam
    PF02275 CBAH, 1 hit
    PF15508 NAAA-beta, 1 hit
    PIRSFiPIRSF017632 Acid_ceramidase-like, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAAA_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02083
    Secondary accession number(s): Q5KTF2, Q96EY2, Q9BRA8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 17, 2006
    Last modified: January 16, 2019
    This is version 160 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
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