UniProtKB - Q02080 (MEF2B_HUMAN)
Protein
Myocyte-specific enhancer factor 2B
Gene
MEF2B
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 58 – 86 | Mef2-typeSequence analysisAdd BLAST | 29 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- histone deacetylase binding Source: BHF-UCL
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: GO_Central
- muscle organ development Source: ProtInc
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q02080 |
Reactomei | R-HSA-525793, Myogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Myocyte-specific enhancer factor 2BAlternative name(s): RSRFR2 Serum response factor-like protein 2 |
Gene namesi | Name:MEF2B Synonyms:XMEF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000213999.15 |
HGNCi | HGNC:6995, MEF2B |
MIMi | 600661, gene |
neXtProti | NX_Q02080 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cell junction Source: HPA
- transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 100271849 4207 |
OpenTargetsi | ENSG00000213999 |
Miscellaneous databases
Pharosi | Q02080, Tbio |
Polymorphism and mutation databases
BioMutai | MEF2B |
DMDMi | 1346514 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199431 | 1 – 365 | Myocyte-specific enhancer factor 2BAdd BLAST | 365 |
Proteomic databases
MassIVEi | Q02080 |
MaxQBi | Q02080 |
PaxDbi | Q02080 |
PeptideAtlasi | Q02080 |
PRIDEi | Q02080 |
ProteomicsDBi | 58042 [Q02080-1] 58043 [Q02080-2] |
PTM databases
iPTMneti | Q02080 |
PhosphoSitePlusi | Q02080 |
Expressioni
Tissue specificityi
Expressed in skeletal and cardiac muscle and brain.
Gene expression databases
Bgeei | ENSG00000213999, Expressed in muscle tissue and 112 other tissues |
ExpressionAtlasi | Q02080, baseline and differential |
Genevisiblei | Q02080, HS |
Organism-specific databases
HPAi | ENSG00000213999, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts with HDAC7 (By similarity). Heterodimer.
Interacts with HDAC9.
By similarity1 PublicationBinary interactionsi
Hide detailsQ02080
With | #Exp. | IntAct |
---|---|---|
HDAC4 - isoform 2 [P56524-2] | 3 | EBI-6427785,EBI-11953488 |
TEKT4 [Q8WW24] | 3 | EBI-6427785,EBI-750487 |
GO - Molecular functioni
- histone deacetylase binding Source: BHF-UCL
- protein dimerization activity Source: InterPro
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 110371, 9 interactors 938509, 10 interactors |
IntActi | Q02080, 8 interactors |
STRINGi | 9606.ENSP00000390762 |
Miscellaneous databases
RNActi | Q02080, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q02080 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q02080 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 57 | MADS-boxPROSITE-ProRule annotationAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 31 | Lys-rich (basic)Add BLAST | 28 |
Sequence similaritiesi
Belongs to the MEF2 family.Curated
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
GeneTreei | ENSGT00940000160699 |
InParanoidi | Q02080 |
PhylomeDBi | Q02080 |
TreeFami | TF314067 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q02080-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
ANRLFQYAST DMDRVLLKYT EYSEPHESRT NTDILETLKR RGIGLDGPEL
110 120 130 140 150
EPDEGPEEPG EKFRRLAGEG GDPALPRPRL YPAAPAMPSP DVVYGALPPP
160 170 180 190 200
GCDPSGLGEA LPAQSRPSPF RPAAPKAGPP GLVHPLFSPS HLTSKTPPPL
210 220 230 240 250
YLPTEGRRSD LPGGLAGPRG GLNTSRSLYS GLQNPCSTAT PGPPLGSFPF
260 270 280 290 300
LPGGPPVGAE AWARRVPQPA APPRRPPQSA SSLSASLRPP GAPATFLRPS
310 320 330 340 350
PIPCSSPGPW QSLCGLGPPC AGCPWPTAGP GRRSPGGTSP ERSPGTARAR
360
GDPTSLQASS EKTQQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J4J4 | C9J4J4_HUMAN | Myocyte-specific enhancer factor 2B | MEF2B | 375 | Annotation score: | ||
B3KQ23 | B3KQ23_HUMAN | Myocyte-specific enhancer factor 2B | MEF2B | 297 | Annotation score: | ||
B8ZZJ5 | B8ZZJ5_HUMAN | Myocyte-specific enhancer factor 2B | MEF2B | 286 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 195 | K → R in BAG62689 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 195 | K → R in BAH14699 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042322 | 257 – 365 | VGAEA…EKTQQ → EYGLGDPPPPPGLLQPPTLA PWQPSRGDGPPAVSSQPSGG RSLGEEGPPTRGASPPTPPV SIKSERLSPAPGGPGDFPKT FPYPLLLARSLAEPLRPGPA LRRLPLADGWPR in isoform 2. 1 PublicationAdd BLAST | 109 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68502 mRNA Translation: CAA48515.1 X63380 mRNA Translation: CAA44978.1 AK301086 mRNA Translation: BAG62689.1 AK316328 mRNA Translation: BAH14699.1 AC002126 Genomic DNA Translation: AAB86982.1 CH471106 Genomic DNA Translation: EAW84788.1 BC126245 mRNA Translation: AAI26246.1 BC136457 mRNA Translation: AAI36458.1 BC171767 mRNA Translation: AAI71767.1 |
CCDSi | CCDS12394.1 [Q02080-1] CCDS46024.1 [Q02080-2] |
PIRi | A39481 |
RefSeqi | NP_001139257.1, NM_001145785.1 [Q02080-2] NP_005910.1, NM_005919.3 [Q02080-1] |
Genome annotation databases
Ensembli | ENST00000424583; ENSP00000402154; ENSG00000213999 [Q02080-2] ENST00000444486; ENSP00000390762; ENSG00000213999 [Q02080-1] |
GeneIDi | 100271849 4207 |
KEGGi | hsa:100271849 hsa:4207 |
UCSCi | uc002nll.3, human [Q02080-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68502 mRNA Translation: CAA48515.1 X63380 mRNA Translation: CAA44978.1 AK301086 mRNA Translation: BAG62689.1 AK316328 mRNA Translation: BAH14699.1 AC002126 Genomic DNA Translation: AAB86982.1 CH471106 Genomic DNA Translation: EAW84788.1 BC126245 mRNA Translation: AAI26246.1 BC136457 mRNA Translation: AAI36458.1 BC171767 mRNA Translation: AAI71767.1 |
CCDSi | CCDS12394.1 [Q02080-1] CCDS46024.1 [Q02080-2] |
PIRi | A39481 |
RefSeqi | NP_001139257.1, NM_001145785.1 [Q02080-2] NP_005910.1, NM_005919.3 [Q02080-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N6J | X-ray | 2.20 | A/B | 2-94 | [»] | |
1TQE | X-ray | 2.70 | P/Q/R/S | 1-93 | [»] | |
6BYY | X-ray | 2.30 | A/B/C/D | 63-91 | [»] | |
6BZ1 | X-ray | 2.97 | A/B/C/D | 65-91 | [»] | |
6C9L | X-ray | 2.30 | A/B/C/D/E/F | 1-93 | [»] | |
6WC2 | X-ray | 2.10 | A/B/C/D/I/J | 1-8 | [»] | |
A/B/C/D/I/J | 73-91 | [»] | ||||
6WC5 | X-ray | 2.90 | A/B/C/D | 2-91 | [»] | |
SMRi | Q02080 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110371, 9 interactors 938509, 10 interactors |
IntActi | Q02080, 8 interactors |
STRINGi | 9606.ENSP00000390762 |
PTM databases
iPTMneti | Q02080 |
PhosphoSitePlusi | Q02080 |
Polymorphism and mutation databases
BioMutai | MEF2B |
DMDMi | 1346514 |
Proteomic databases
MassIVEi | Q02080 |
MaxQBi | Q02080 |
PaxDbi | Q02080 |
PeptideAtlasi | Q02080 |
PRIDEi | Q02080 |
ProteomicsDBi | 58042 [Q02080-1] 58043 [Q02080-2] |
Protocols and materials databases
Antibodypediai | 47983, 150 antibodies |
DNASUi | 4207 |
Genome annotation databases
Ensembli | ENST00000424583; ENSP00000402154; ENSG00000213999 [Q02080-2] ENST00000444486; ENSP00000390762; ENSG00000213999 [Q02080-1] |
GeneIDi | 100271849 4207 |
KEGGi | hsa:100271849 hsa:4207 |
UCSCi | uc002nll.3, human [Q02080-1] |
Organism-specific databases
CTDi | 100271849 4207 |
DisGeNETi | 100271849 4207 |
EuPathDBi | HostDB:ENSG00000213999.15 |
GeneCardsi | MEF2B |
HGNCi | HGNC:6995, MEF2B |
HPAi | ENSG00000213999, Tissue enriched (lymphoid) |
MIMi | 600661, gene |
neXtProti | NX_Q02080 |
OpenTargetsi | ENSG00000213999 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
GeneTreei | ENSGT00940000160699 |
InParanoidi | Q02080 |
PhylomeDBi | Q02080 |
TreeFami | TF314067 |
Enzyme and pathway databases
PathwayCommonsi | Q02080 |
Reactomei | R-HSA-525793, Myogenesis |
Miscellaneous databases
BioGRID-ORCSi | 100271849, 13 hits in 481 CRISPR screens 4207, 7 hits in 471 CRISPR screens |
EvolutionaryTracei | Q02080 |
GeneWikii | MEF2B |
Pharosi | Q02080, Tbio |
PROi | PR:Q02080 |
RNActi | Q02080, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213999, Expressed in muscle tissue and 112 other tissues |
ExpressionAtlasi | Q02080, baseline and differential |
Genevisiblei | Q02080, HS |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MEF2B_HUMAN | |
Accessioni | Q02080Primary (citable) accession number: Q02080 Secondary accession number(s): A0AV80 G5E9M1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM