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Entry version 197 (16 Oct 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Myocyte-specific enhancer factor 2A

Gene

MEF2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi58 – 86Mef2-typeSequence analysisAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processApoptosis, Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198753 ERK/MAPK targets
R-HSA-525793 Myogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q02078

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q02078

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2A
Alternative name(s):
Serum response factor-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEF2A
Synonyms:MEF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6993 MEF2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600660 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02078

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coronary artery disease, autosomal dominant, 1 (ADCAD1)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi176D → A: Abolishes cleavage at sites 1 and 2 by caspase 3. Increased cleavage at site 3 by caspase 3. 1 Publication1
Mutagenesisi213D → A: Abolishes cleavage at sites 2 and 3 by caspase 7. 1 Publication1
Mutagenesisi255S → A: Slightly increased MEF2A protein level. 1 Publication1
Mutagenesisi255S → D: Decreased MEF2A protein level. 1 Publication1
Mutagenesisi269R → A: Reduced p38 alpha- and beta2-mediated transcriptional activity; when associated with A-270. 1 Publication1
Mutagenesisi270K → A: Reduced p38 alpha- and beta2-mediated transcriptional activity; when associated with A-269. 1 Publication1
Mutagenesisi273L → A: Reduced p38 alpha- and beta2-mediated transcriptional activity; when associated with A-275. 1 Publication1
Mutagenesisi275V → A: Reduced p38 alpha- and beta2-mediated transcriptional activity; when associated with A-273. 1 Publication1
Mutagenesisi277I → A: Reduced p38 alpha- and beta2-mediated transcriptional activity; when associated with A-278. 1 Publication1
Mutagenesisi278P → A: Reduced p38 alpha- and beta2-mediated transcriptional activity; when associated with A-277. 1 Publication1
Mutagenesisi312T → A: Greatly reduced p38-mediated phosphorylation. Abolishes p38-mediated transcriptional activation; when associated with A-319. 2 Publications1
Mutagenesisi319T → A: Greatly reduced p38-mediated phosphorylation. Abolishes P38-mediated transcriptional activation; when associated with A-312. 2 Publications1
Mutagenesisi355S → A: No effect on p38-mediated transcriptional activity. 2 Publications1
Mutagenesisi387S → A: No effect on p38-mediated phosphorylation. 1
Mutagenesisi403K → R: Abolishes sumoylation. No change in subcellular location nor in DNA binding. Loss of transcriptional repression. 2 Publications1
Mutagenesisi408S → A: Loss of sumoylation. 2 Publications1
Mutagenesisi408S → D: Rescues sumoylation. 2 Publications1
Mutagenesisi453S → A: No effect on p38-mediated phosphorylation. 1 Publication1
Mutagenesisi479S → A: No effect on p38-mediated phosphorylation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4205

MalaCards human disease database

More...
MalaCardsi
MEF2A
MIMi608320 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000068305

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
411969 NON RARE IN EUROPE: Metabolic syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30731

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q02078

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MEF2A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001994281 – 507Myocyte-specific enhancer factor 2AAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59Phosphoserine; by CK2By similarity1
Modified residuei98PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Modified residuei249N6-acetyllysineCombined sources1
Modified residuei255Phosphoserine; by MAPK14Combined sources1 Publication1
Modified residuei312Phosphothreonine; by MAPK7 and MAPK145 Publications1
Modified residuei312Phosphothreonine; by NLK5 Publications1
Modified residuei319Phosphothreonine; by MAPK7 and MAPK144 Publications1
Modified residuei355Phosphoserine; by MAPK71 Publication1
Modified residuei403N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki403Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Modified residuei408Phosphoserine; by CDK54 Publications1
Modified residuei415PhosphothreonineBy similarity1
Modified residuei453Phosphoserine; by MAPK1 Publication1
Isoform 7 (identifier: Q02078-7)
Modified residuei30PhosphoserineCombined sources1
Isoform 8 (identifier: Q02078-8)
Modified residuei30PhosphoserineCombined sources1
Isoform MEFA (identifier: Q02078-2)
Modified residuei98PhosphoserineCombined sources1
Isoform RSRFC9 (identifier: Q02078-4)
Modified residuei98PhosphoserineCombined sources1
Isoform 6 (identifier: Q02078-6)
Modified residuei98PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutive phosphorylation on Ser-408 promotes Lys-403 sumoylation thus preventing acetylation at this site. Dephosphorylation on Ser-408 by PPP3CA upon neuron depolarization promotes a switch from sumoylation to acetylation on residue Lys-403 leading to inhibition of dendrite claw differentiation. Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. Phosphorylated on these sites by MAPK14/p38alpha and MAPK11/p38beta, but not by MAPK13/p38delta nor by MAPK12/p38gamma. Phosphorylation on Ser-408 by CDK5 induced by neurotoxicity inhibits MEF2A transcriptional activation leading to apoptosis of cortical neurons. Phosphorylation on Thr-312, Thr-319 and Ser-355 can be induced by EGF.11 Publications
Sumoylation on Lys-403 is enhanced by PIAS1 and represses transcriptional activity. Phosphorylation on Ser-408 is required for sumoylation. Has no effect on nuclear location nor on DNA binding. Sumoylated with SUMO1 and, to a lesser extent with SUMO2 and SUMO3. PIASx facilitates sumoylation in postsynaptic dendrites in the cerebellar cortex and promotes their morphogenesis (By similarity).By similarity
Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). Hyperacetylation by p300 leads to enhanced cardiac myocyte growth and heart failure.By similarity
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei176 – 177CleavageCurated2
Sitei213 – 214CleavageCurated2
Sitei466 – 467CleavageCurated2

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q02078

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q02078

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q02078

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q02078

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02078

PeptideAtlas

More...
PeptideAtlasi
Q02078

PRoteomics IDEntifications database

More...
PRIDEi
Q02078

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
28155
58035 [Q02078-1]
58036 [Q02078-2]
58037 [Q02078-3]
58038 [Q02078-4]
58039 [Q02078-5]
58040 [Q02078-6]
58041 [Q02078-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02078

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02078

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q02078

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000068305 Expressed in 234 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q02078 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q02078 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004499
HPA046597

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D.

Interacts with HDAC7 (By similarity).

Interacts with PIAS1; the interaction enhances sumoylation.

Interacts with HDAC4, HDAC9 and SLC2A4RG.

Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A.

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110369, 55 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q02078

Database of interacting proteins

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DIPi
DIP-40711N

Protein interaction database and analysis system

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IntActi
Q02078, 42 interactors

Molecular INTeraction database

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MINTi
Q02078

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346389

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02078

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q02078

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 283Required for interaction with MAPKsAdd BLAST18
Regioni289 – 296Beta domain8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 31Lys-rich (basic)Add BLAST28
Compositional biasi141 – 186Ser/Thr-richAdd BLAST46
Compositional biasi420 – 446Gln/Pro-richAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0014 Eukaryota
COG5068 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156205

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230620

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02078

KEGG Orthology (KO)

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KOi
K09260

Identification of Orthologs from Complete Genome Data

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OMAi
MMPPLHL

Database of Orthologous Groups

More...
OrthoDBi
729387at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02078

TreeFam database of animal gene trees

More...
TreeFami
TF314067

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00265 MADS_MEF2_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1810.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022102 HJURP_C
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12347 HJURP_C, 1 hit
PF00319 SRF-TF, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00404 MADSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00432 MADS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55455 SSF55455, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform MEF2 (identifier: Q02078-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
SNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD
110 120 130 140 150
PDTSYVLTPH TEEKYKKINE EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS
160 170 180 190 200
PNALSYTNPG SSLVSPSLAA SSTLTDSSML SPPQTTLHRN VSPGAPQRPP
210 220 230 240 250
STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG ATGANSLGKV
260 270 280 290 300
MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR
310 320 330 340 350
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL
360 370 380 390 400
QGFNSPGMLS LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI
410 420 430 440 450
SIKSEPISPP RDRMTPSGFQ QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM
460 470 480 490 500
GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP IVLGRPPNTE DRESPSVKRM

RMDAWVT
Length:507
Mass (Da):54,811
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i362BA4FBCC792CE2
GO
Isoform MEFA (identifier: Q02078-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-132: ALNKKEHRGC...DNMMRNHKIA → TLRKKGLNGC...DSDFIFKRGP

Show »
Length:505
Mass (Da):54,442
Checksum:iE0032FA6F955D7F7
GO
Isoform RSRFC4 (identifier: Q02078-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-296: Missing.
     420-421: Missing.

Show »
Length:497
Mass (Da):53,596
Checksum:iA255A8EDC8B07FB0
GO
Isoform RSRFC9 (identifier: Q02078-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-132: ALNKKEHRGC...DNMMRNHKIA → TLRKKGLNGC...DSDFIFKRGP
     289-296: Missing.
     420-421: Missing.

Show »
Length:495
Mass (Da):53,227
Checksum:i3C083C4EFC3872F0
GO
Isoform 5 (identifier: Q02078-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-296: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):53,852
Checksum:iFE3A83DDCE477C27
GO
Isoform 6 (identifier: Q02078-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-132: ALNKKEHRGC...DNMMRNHKIA → TLRKKGLNGC...DSDFIFKRGP
     289-296: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:497
Mass (Da):53,483
Checksum:iF4A61D805AE448AF
GO
Isoform 7 (identifier: Q02078-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-86: Missing.
     87-132: ALNKKEHRGC...DNMMRNHKIA → TLRKKGLNGC...DSDFIFKRGP

Note: No experimental confirmation available.Combined sources
Show »
Length:437
Mass (Da):46,529
Checksum:iD28A536D0F0188BE
GO
Isoform 8 (identifier: Q02078-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-62: VTFTKRKFGL...KLFQYASTDM → TLRKKGLNGC...DSDFIFKRGP
     63-132: Missing.
     289-296: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:429
Mass (Da):45,570
Checksum:iB356416F17385FCD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKY6H0YKY6_HUMAN
Myocyte-specific enhancer factor 2A
MEF2A
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM62H0YM62_HUMAN
Myocyte-specific enhancer factor 2A
MEF2A
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNI2H0YNI2_HUMAN
Myocyte-specific enhancer factor 2A
MEF2A
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH53871 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD92222 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti430Missing in AAB17195 (Ref. 4) Curated1
Sequence conflicti430Missing in AAB17196 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038407263N → S1 PublicationCorresponds to variant dbSNP:rs121918530EnsemblClinVar.1
Natural variantiVAR_038408279P → L3 PublicationsCorresponds to variant dbSNP:rs121918529EnsemblClinVar.1
Natural variantiVAR_038409283G → D1 Publication1
Natural variantiVAR_017743440 – 446Missing Loss of nuclear localization; 66% decrease in transcription activation; loss of synergistic activation by MEF2A and GATA1 through a dominant-negative mechanism. 7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04333819 – 86Missing in isoform 7. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_04601819 – 62VTFTK…ASTDM → TLRKKGLNGCESPDADDYFE HSPLSEDRFSKLNEDSDFIF KRGP in isoform 8. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_04601963 – 132Missing in isoform 8. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_00624087 – 132ALNKK…NHKIA → TLRKKGLNGCESPDADDYFE HSPLSEDRFSKLNEDSDFIF KRGP in isoform MEFA, isoform RSRFC9, isoform 6 and isoform 7. 5 PublicationsAdd BLAST46
Alternative sequenceiVSP_006241289 – 296Missing in isoform RSRFC4, isoform RSRFC9, isoform 5, isoform 6 and isoform 8. 5 Publications8
Alternative sequenceiVSP_006242420 – 421Missing in isoform RSRFC4 and isoform RSRFC9. 3 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y16312 mRNA Translation: CAA76175.1
X63381 mRNA Translation: CAA44979.1
X68503 mRNA Translation: CAA48516.1
X68505 mRNA Translation: CAA48517.1
U49020
, U44889, U49012, U49013, U49015, U49016, U49017, U49018, U49019 Genomic DNA Translation: AAB17195.1
U49020
, U44889, U49012, U49013, U49015, U49016, U49017, U49018, U49019 Genomic DNA Translation: AAB17196.1
AK294207 mRNA Translation: BAG57518.1
AB208985 mRNA Translation: BAD92222.1 Different initiation.
AC015660 Genomic DNA No translation available.
AC022692 Genomic DNA No translation available.
AC103967 Genomic DNA No translation available.
BC013437 mRNA Translation: AAH13437.1
BC053871 mRNA Translation: AAH53871.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45362.1 [Q02078-5]
CCDS45363.1 [Q02078-7]
CCDS53978.1 [Q02078-6]
CCDS58401.1 [Q02078-8]
CCDS81920.1 [Q02078-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
C39481
S25831

NCBI Reference Sequences

More...
RefSeqi
NP_001124399.1, NM_001130927.2 [Q02078-7]
NP_001124400.1, NM_001130928.2 [Q02078-8]
NP_001165365.1, NM_001171894.2 [Q02078-6]
NP_001306135.1, NM_001319206.1 [Q02078-2]
NP_005578.2, NM_005587.3 [Q02078-5]
XP_011519883.1, XM_011521581.2
XP_011519884.1, XM_011521582.2 [Q02078-1]
XP_011519888.1, XM_011521586.2
XP_016877679.1, XM_017022190.1
XP_016877680.1, XM_017022191.1 [Q02078-1]
XP_016877682.1, XM_017022193.1
XP_016877683.1, XM_017022194.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338042; ENSP00000337202; ENSG00000068305 [Q02078-6]
ENST00000354410; ENSP00000346389; ENSG00000068305 [Q02078-5]
ENST00000449277; ENSP00000399460; ENSG00000068305 [Q02078-8]
ENST00000557785; ENSP00000453441; ENSG00000068305 [Q02078-6]
ENST00000557942; ENSP00000453095; ENSG00000068305 [Q02078-2]
ENST00000558812; ENSP00000454120; ENSG00000068305 [Q02078-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4205

UCSC genome browser

More...
UCSCi
uc002bve.4 human [Q02078-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16312 mRNA Translation: CAA76175.1
X63381 mRNA Translation: CAA44979.1
X68503 mRNA Translation: CAA48516.1
X68505 mRNA Translation: CAA48517.1
U49020
, U44889, U49012, U49013, U49015, U49016, U49017, U49018, U49019 Genomic DNA Translation: AAB17195.1
U49020
, U44889, U49012, U49013, U49015, U49016, U49017, U49018, U49019 Genomic DNA Translation: AAB17196.1
AK294207 mRNA Translation: BAG57518.1
AB208985 mRNA Translation: BAD92222.1 Different initiation.
AC015660 Genomic DNA No translation available.
AC022692 Genomic DNA No translation available.
AC103967 Genomic DNA No translation available.
BC013437 mRNA Translation: AAH13437.1
BC053871 mRNA Translation: AAH53871.1 Different initiation.
CCDSiCCDS45362.1 [Q02078-5]
CCDS45363.1 [Q02078-7]
CCDS53978.1 [Q02078-6]
CCDS58401.1 [Q02078-8]
CCDS81920.1 [Q02078-2]
PIRiC39481
S25831
RefSeqiNP_001124399.1, NM_001130927.2 [Q02078-7]
NP_001124400.1, NM_001130928.2 [Q02078-8]
NP_001165365.1, NM_001171894.2 [Q02078-6]
NP_001306135.1, NM_001319206.1 [Q02078-2]
NP_005578.2, NM_005587.3 [Q02078-5]
XP_011519883.1, XM_011521581.2
XP_011519884.1, XM_011521582.2 [Q02078-1]
XP_011519888.1, XM_011521586.2
XP_016877679.1, XM_017022190.1
XP_016877680.1, XM_017022191.1 [Q02078-1]
XP_016877682.1, XM_017022193.1
XP_016877683.1, XM_017022194.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C7UNMR-A/B2-86[»]
1EGWX-ray1.50A/B/C/D2-78[»]
1LEWX-ray2.30B269-280[»]
3KOVX-ray2.90A/B/I/J2-91[»]
3MU6X-ray2.43A/B/C/D2-70[»]
3P57X-ray2.19A/B/C/D/I/J2-91[»]
6BYYX-ray2.30A/B/C/D1-64[»]
A/B/C/D92-95[»]
6BZ1X-ray2.97A/B/C/D1-64[»]
A/B/C/D92-95[»]
SMRiQ02078
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110369, 55 interactors
CORUMiQ02078
DIPiDIP-40711N
IntActiQ02078, 42 interactors
MINTiQ02078
STRINGi9606.ENSP00000346389

PTM databases

iPTMnetiQ02078
PhosphoSitePlusiQ02078

Polymorphism and mutation databases

BioMutaiMEF2A

Proteomic databases

EPDiQ02078
jPOSTiQ02078
MassIVEiQ02078
MaxQBiQ02078
PaxDbiQ02078
PeptideAtlasiQ02078
PRIDEiQ02078
ProteomicsDBi28155
58035 [Q02078-1]
58036 [Q02078-2]
58037 [Q02078-3]
58038 [Q02078-4]
58039 [Q02078-5]
58040 [Q02078-6]
58041 [Q02078-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4205

Genome annotation databases

EnsembliENST00000338042; ENSP00000337202; ENSG00000068305 [Q02078-6]
ENST00000354410; ENSP00000346389; ENSG00000068305 [Q02078-5]
ENST00000449277; ENSP00000399460; ENSG00000068305 [Q02078-8]
ENST00000557785; ENSP00000453441; ENSG00000068305 [Q02078-6]
ENST00000557942; ENSP00000453095; ENSG00000068305 [Q02078-2]
ENST00000558812; ENSP00000454120; ENSG00000068305 [Q02078-7]
GeneIDi4205
KEGGihsa:4205
UCSCiuc002bve.4 human [Q02078-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4205
DisGeNETi4205

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MEF2A
HGNCiHGNC:6993 MEF2A
HPAiCAB004499
HPA046597
MalaCardsiMEF2A
MIMi600660 gene
608320 phenotype
neXtProtiNX_Q02078
OpenTargetsiENSG00000068305
Orphaneti411969 NON RARE IN EUROPE: Metabolic syndrome
PharmGKBiPA30731

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0014 Eukaryota
COG5068 LUCA
GeneTreeiENSGT00940000156205
HOGENOMiHOG000230620
InParanoidiQ02078
KOiK09260
OMAiMMPPLHL
OrthoDBi729387at2759
PhylomeDBiQ02078
TreeFamiTF314067

Enzyme and pathway databases

ReactomeiR-HSA-198753 ERK/MAPK targets
R-HSA-525793 Myogenesis
SignaLinkiQ02078
SIGNORiQ02078

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MEF2A human
EvolutionaryTraceiQ02078

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Myocyte-specific_enhancer_factor_2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4205
PharosiQ02078
PMAP-CutDBiQ02078

Protein Ontology

More...
PROi
PR:Q02078

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000068305 Expressed in 234 organ(s), highest expression level in heart
ExpressionAtlasiQ02078 baseline and differential
GenevisibleiQ02078 HS

Family and domain databases

CDDicd00265 MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR022102 HJURP_C
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf
PfamiView protein in Pfam
PF12347 HJURP_C, 1 hit
PF00319 SRF-TF, 1 hit
PRINTSiPR00404 MADSDOMAIN
SMARTiView protein in SMART
SM00432 MADS, 1 hit
SUPFAMiSSF55455 SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEF2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02078
Secondary accession number(s): B4DFQ7
, F6XG23, O43814, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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