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Protein

Actinorhodin polyketide putative beta-ketoacyl synthase 1

Gene

SCO5087

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pathwayi: actinorhodin biosynthesis

This protein is involved in the pathway actinorhodin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway actinorhodin biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00173

Names & Taxonomyi

Protein namesi
Recommended name:
Actinorhodin polyketide putative beta-ketoacyl synthase 1 (EC:2.3.1.-)
Alternative name(s):
actI ORF1
Gene namesi
Ordered Locus Names:SCO5087
ORF Names:SCBAC28G1.13
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803421 – 467Actinorhodin polyketide putative beta-ketoacyl synthase 1Add BLAST467

Proteomic databases

PRIDEiQ02059

Interactioni

Protein-protein interaction databases

IntActiQ02059, 1 interactor
STRINGi100226.SCO5087

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ02059
SMRiQ02059
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02059

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiENOG4105C0Q Bacteria
COG0304 LUCA
HOGENOMiHOG000060166
InParanoidiQ02059
KOiK05551
OMAiMNNNFAF
OrthoDBiPOG091H018O
PhylomeDBiQ02059

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q02059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLDAAPVDP ASRGPVSAFE PPSSHGADDD DDHRTNASKE LFGLKRRVVI
60 70 80 90 100
TGVGVRAPGG NGTRQFWELL TSGRTATRRI SFFDPSPYRS QVAAEADFDP
110 120 130 140 150
VAEGFGPREL DRMDRASQFA VACAREAFAA SGLDPDTLDP ARVGVSLGSA
160 170 180 190 200
VAAATSLERE YLLLSDSGRD WEVDAAWLSR HMFDYLVPSV MPAEVAWAVG
210 220 230 240 250
AEGPVTMVST GCTSGLDSVG NAVRAIEEGS ADVMFAGAAD TPITPIVVAC
260 270 280 290 300
FDAIRATTAR NDDPEHASRP FDGTRDGFVL AEGAAMFVLE DYDSALARGA
310 320 330 340 350
RIHAEISGYA TRCNAYHMTG LKADGREMAE TIRVALDESR TDATDIDYIN
360 370 380 390 400
AHGSGTRQND RHETAAYKRA LGEHARRTPV SSIKSMVGHS LGAIGSLEIA
410 420 430 440 450
ACVLALEHGV VPPTANLRTS DPECDLDYVP LEARERKLRS VLTVGSGFGG
460
FQSAMVLRDA ETAGAAA
Length:467
Mass (Da):49,504
Last modified:January 17, 2003 - v2
Checksum:i6B5BEE32B5241C60
GO

Sequence cautioni

The sequence CAA45043 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939122 Genomic DNA Translation: CAC44200.1
X63449 Genomic DNA Translation: CAA45043.1 Different initiation.
PIRiS25840
RefSeqiNP_629237.1, NC_003888.3
WP_003973891.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAC44200; CAC44200; CAC44200
GeneIDi1100528
KEGGisco:SCO5087
PATRICifig|100226.15.peg.5167

Entry informationi

Entry nameiKASA_STRCO
AccessioniPrimary (citable) accession number: Q02059
Secondary accession number(s): Q93IZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 17, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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