AKAP17A

Functionⁱ

Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.2 Publications

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Caution

Was originally thought to be a cell surface protein involved in B-cell activation.1 Publication

GO - Molecular functionⁱ

protein kinase A binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19840947
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell activation
Source: UniProtKB
Non-traceable author statementⁱ
- 1438229
mRNA processing Source: UniProtKB-KW
regulation of RNA splicing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19840947
regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 1438229
RNA splicing Source: UniProtKB-KW
signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 1438229

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: A-kinase anchor protein 17A Short name: AKAP-17A Alternative name(s): 721P B-lymphocyte antigen Protein XE7 Protein kinase A-anchoring protein 17A Short name: PRKA17A Splicing factor, arginine/serine-rich 17A
Gene namesⁱ	Name:AKAP17A Synonyms:CXYorf3, DXYS155E, SFRS17A, XE7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197976.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18783 AKAP17A
MIMⁱ	312095 gene 465000 gene
neXtProtⁱ	NX_Q02040

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	438 – 439	LL → PP: Abolishes binding to PKA-RI; when associated with 445-P-P-446. 1 Publication		2
Mutagenesisⁱ	445 – 446	KK → PP: Abolishes binding to PKA-RI; when associated with 438-P-P-439. 1 Publication		2

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000197976
PharmGKBⁱ	PA162402969

Polymorphism and mutation databases

BioMutaⁱ	AKAP17A
DMDMⁱ	146291102

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000022692	1 – 695	A-kinase anchor protein 17AAdd BLAST		695

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	118	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	118	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	537	PhosphoserineCombined sources	1
Modified residueⁱ	633	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q02040
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q02040
PaxDbⁱ	Q02040
PeptideAtlas More...PeptideAtlasⁱ	Q02040
PRIDEⁱ	Q02040
ProteomicsDBⁱ	58030 58031 [Q02040-2] 58032 [Q02040-3]

PTM databases

iPTMnetⁱ	Q02040
PhosphoSitePlusⁱ	Q02040

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000197976 Expressed in 220 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SFRS17A
ExpressionAtlasⁱ	Q02040 baseline and differential
Genevisibleⁱ	Q02040 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043247 HPA051020

HPAⁱ

HPA043247
HPA051020

Interactionⁱ

Subunit structureⁱ

Monomer. Component of the spliceosome. Interacts with ZRANB2 and SFRS1/ASF through its Arg/Ser-rich domain. Interacts with RI and RII subunits of PKA.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CALCOCO2	Q13137	3	EBI-10222656,EBI-739580
CEP70	Q8NHQ1	5	EBI-1042725,EBI-739624
KRT40	Q6A162	3	EBI-10222656,EBI-10171697
MDFI	Q99750	3	EBI-10222656,EBI-724076
SRRM4	A7MD48	4	EBI-1042725,EBI-3867173
THAP1	Q9NVV9	3	EBI-10222656,EBI-741515
TRAF1	Q13077	3	EBI-10222656,EBI-359224
ZRANB2	O95218	4	EBI-1042725,EBI-1051583

GO - Molecular functionⁱ

protein kinase A binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19840947

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113860, 34 interactors
IntActⁱ	Q02040, 22 interactors
STRINGⁱ	9606.ENSP00000324827

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q02040
SMRⁱ	Q02040
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	147 – 256	RRMAdd BLAST		110

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	83 – 112	PKA-RI and PKA-RII subunit binding domainAdd BLAST		30
Regionⁱ	425 – 454	PKA-RI-alpha subunit binding domainAdd BLAST		30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	587 – 695	Arg-richAdd BLAST		109

Domainⁱ

RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.1 Publication

Phylogenomic databases

eggNOGⁱ	KOG2891 Eukaryota ENOG410XQIN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039314
InParanoidⁱ	Q02040
KEGG Orthology (KO) More...KOⁱ	K13169
OMAⁱ	AASEWMQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DV1
PhylomeDBⁱ	Q02040
TreeFamⁱ	TF320443

Family and domain databases

InterProⁱ	View protein in InterPro IPR034355 AKAP17A IPR035979 RBD_domain_sf
PANTHERⁱ	PTHR12484:SF2 PTHR12484:SF2, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: Q02040-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE 
        60         70         80         90        100
VMERLKGMVQ NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT 
       110        120        130        140        150
IKLSGFSDIL KVRAAEFKID FPTRHDWDSF FRDAKDMNET LPGERPDTIH 
       160        170        180        190        200
LEGLPCKWFA LKESGSEKPS EDVLVKVFEK FGEIRNVDIP MLDPYREEMT 
       210        220        230        240        250
GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM YKGEDGKAVA 
       260        270        280        290        300
CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR 
       310        320        330        340        350
AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK 
       360        370        380        390        400
QLQEKIKLEE RKLLLAQRNL QSIRLIAELL SRAKAVKLRE QEQKEEKLRL 
       410        420        430        440        450
QQQEERRRLQ EAELRRVEEE KERALGLQRK ERELRERLLS ILLSKKPDDS 
       460        470        480        490        500
HTHDELGVAH ADLLQPVLDI LQTVSSGCVS ATTLHPLGGQ PPAGAPKESP 
       510        520        530        540        550
AHPEADGAPK SVNGSVAEEA PCKEVQSSCR VVPEDGSPEK RCPGGVLSCI 
       560        570        580        590        600
PDNNQQPKGI PACEQNVSRK DTRSEQDKCN REPSKGRGRA TGDGLADRHK 
       610        620        630        640        650
RERSRARRAS SREDGRPRKE RRPHKKHAYK DDSPRRRSTS PDHTRSRRSH 
       660        670        680        690 
SKDRHRRERS RERRGSASRK HSRHRRRSER SRSRSPSRHR STWNR

Length:695

Mass (Da):80,735

Last modified:May 1, 2007 - v2

Checksum:ⁱ639E88ECA8006CF2

GO

Isoform 2 (identifier: Q02040-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
385-385: A → L
386-695: Missing.

« Hide

        10         20         30         40         50
MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE 
        60         70         80         90        100
VMERLKGMVQ NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT 
       110        120        130        140        150
IKLSGFSDIL KVRAAEFKID FPTRHDWDSF FRDAKDMNET LPGERPDTIH 
       160        170        180        190        200
LEGLPCKWFA LKESGSEKPS EDVLVKVFEK FGEIRNVDIP MLDPYREEMT 
       210        220        230        240        250
GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM YKGEDGKAVA 
       260        270        280        290        300
CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR 
       310        320        330        340        350
AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK 
       360        370        380 
QLQEKIKLEE RKLLLAQRNL QSIRLIAELL SRAKL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:385

Mass (Da):45,248

Checksum:ⁱ4C1E253616C969A6

GO

Isoform 3 (identifier: Q02040-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
385-445: AVKLREQEQK...ERLLSILLSK → VGGSLCSRQP...EGVALVCRSR
446-695: Missing.

« Hide

        10         20         30         40         50
MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE 
        60         70         80         90        100
VMERLKGMVQ NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT 
       110        120        130        140        150
IKLSGFSDIL KVRAAEFKID FPTRHDWDSF FRDAKDMNET LPGERPDTIH 
       160        170        180        190        200
LEGLPCKWFA LKESGSEKPS EDVLVKVFEK FGEIRNVDIP MLDPYREEMT 
       210        220        230        240        250
GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM YKGEDGKAVA 
       260        270        280        290        300
CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR 
       310        320        330        340        350
AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK 
       360        370        380        390        400
QLQEKIKLEE RKLLLAQRNL QSIRLIAELL SRAKVGGSLC SRQPRPGCPQ 
       410        420        430        440 
CPPLKCGRRH GAVSPPAAAV ATKPALMPRM TAPSREGVAL VCRSR

Note: No experimental confirmation available.

Show »

Length:445

Mass (Da):51,409

Checksum:ⁱ049E8E08BF58DF27

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	X6RAJ1	X6RAJ1_HUMAN		A-kinase anchor protein 17A A-kinase anchor protein 17A (HCG1981394, isoform CRA_d)	AKAP17A hCG_1981394	446	Annotation score:

Sequence cautionⁱ

The sequence AAA36187 differs from that shown. Reason: Frameshift at position 461.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	443	L → Q in AAA36187 (PubMed:1438229).Curated	1
Sequence conflictⁱ	500	P → A in AAA61303 (PubMed:1302606).Curated	1
Sequence conflictⁱ	500	P → A in AAI10497 (PubMed:15489334).Curated	1
Sequence conflictⁱ	502	H → P in AAA36187 (PubMed:1438229).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055353	194	P → S1 PublicationCorresponds to variant dbSNP:rs17852504Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024947	385 – 445	AVKLR…ILLSK → VGGSLCSRQPRPGCPQCPPL KCGRRHGAVSPPAAAVATKP ALMPRMTAPSREGVALVCRS R in isoform 3. 1 PublicationAdd BLAST	61
Alternative sequenceⁱVSP_004490	385	A → L in isoform 2. Curated	1
Alternative sequenceⁱVSP_004491	386 – 695	Missing in isoform 2. CuratedAdd BLAST	310
Alternative sequenceⁱVSP_024948	446 – 695	Missing in isoform 3. 1 PublicationAdd BLAST	250

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L03426 mRNA Translation: AAA61303.1 L03426 mRNA Translation: AAA61304.1 M99578 mRNA Translation: AAA36187.1 Frameshift. AL683807 Genomic DNA No translation available. BC028151 mRNA Translation: AAH28151.1 BC110496 mRNA Translation: AAI10497.1 BC110497 mRNA Translation: AAI10498.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14116.1 [Q02040-1]
PIRⁱ	A46419 I54325
NCBI Reference Sequences More...RefSeqⁱ	NP_005079.2, NM_005088.2 [Q02040-1]
UniGeneⁱ	Hs.522572

Genome annotation databases

Ensemblⁱ	ENST00000313871; ENSP00000324827; ENSG00000197976 [Q02040-1] ENST00000474361; ENSP00000435479; ENSG00000197976 [Q02040-2]
GeneIDⁱ	8227
KEGGⁱ	hsa:8227
UCSC genome browser More...UCSCⁱ	uc004cqa.4 human [Q02040-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02040	A-kinase anchoring protein 17A		MACNE		696	UniRef90_Q02040
A-kinase anchoring protein 17A		CERAT		696
A-kinase anchor protein 17A isoform 1		MACMU		696
A-kinase anchoring protein 17A		MACFA		696
A kinase (PRKA) anchor protein 17A		PANTR		695
+16
Q02040-2	A-kinase anchor protein 17A isoform X2		ALLSI		478	UniRef90_Q02040-2
A-kinase anchor protein 17A		ALLMI		465
A-kinase anchoring protein 17A		CHLSB		386
A-kinase anchoring protein 17A		MACMU		385
AKAP17A isoform 2		PANTR		385
+5
Q02040-3	AKAP17A isoform 3		PANTR		523	UniRef90_Q02040-3
A-kinase anchor protein 17A		HUMAN		446
A-kinase anchoring protein 17A		MANLE		446
AKAP17A isoform 3		PONAB		446
A-kinase anchoring protein 17A		PAPAN		445
+10

Protein	Similar proteins		Species	Score	Length	Source
Q02040	A-kinase anchoring protein 17A		CERAT		696	UniRef50_Q02040
A-kinase anchoring protein 17A		MACFA		696
A-kinase anchor protein 17A isoform 1		MACMU		696
A-kinase anchoring protein 17A		MACNE		696
A kinase (PRKA) anchor protein 17A		PANTR		695
+206
Q02040-2	A-kinase anchor protein 17A isoform X2		ALLSI		478	UniRef50_Q02040-2
A-kinase anchor protein 17A		ALLMI		465
A-kinase anchoring protein 17A		CHLSB		386
A-kinase anchoring protein 17A		MACMU		385
AKAP17A isoform 2		PANTR		385
+13
Q02040-3	AKAP17A isoform 3		PANTR		523	UniRef50_Q02040-3
A-kinase anchoring protein 17A		MANLE		446
AKAP17A isoform 3		PONAB		446
A-kinase anchor protein 17A		HUMAN		446
A-kinase anchoring protein 17A		PAPAN		445
+18

Entry informationⁱ

Entry nameⁱ	AK17A_HUMAN
Accessionⁱ	Q02040Primary (citable) accession number: Q02040 Secondary accession number(s): Q02832 , Q2TB98, Q5JQ74, Q5JQ76, Q8N6U9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	May 1, 2007
	Last modified:	September 12, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q02040 (AK17A_HUMAN)

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A-kinase anchor protein 17A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ