Aquaporin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ammonium transmembrane transporter activity Source: UniProtKB
• carbon dioxide transmembrane transporter activity Source: UniProtKB
• ephrin receptor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.4

    "EphB2 guides axons at the midline and is necessary for normal vestibular function."
    Cowan C.A., Yokoyama N., Bianchi L.M., Henkemeyer M., Fritzsch B.
    Neuron 26:417-430(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH EPHB2.
• glycerol transmembrane transporter activity Source: UniProtKB
• identical protein binding Source: MGI
• intracellular cGMP-activated cation channel activity Source: UniProtKB
• nitric oxide transmembrane transporter activity Source: UniProtKB
• potassium channel activity Source: UniProtKB
• potassium ion transmembrane transporter activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1."
    Radtke A.L., O'Riordan M.X.
    Cell Microbiol 10:2197-2207(2008) [PubMed] [Europe PMC] [Abstract]
• transmembrane transporter activity Source: MGI
• water channel activity Source: UniProtKB
• water transmembrane transporter activity Source: MGIInferred from direct assayⁱ
  • "Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes."
    Yang B., Fukuda N., van Hoek A., Matthay M.A., Ma T., Verkman A.S.
    J Biol Chem 275:2686-2692(2000) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• ammonium transport Source: UniProtKB
• camera-type eye morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling."
    Thiagarajah J.R., Verkman A.S.
    J Biol Chem 277:19139-19144(2002) [PubMed] [Europe PMC] [Abstract]
• carbon dioxide transmembrane transport Source: UniProtKB
• carbon dioxide transport Source: UniProtKB
• cellular homeostasis Source: UniProtKB
• cellular hyperosmotic response Source: UniProtKB
• cellular response to cAMP Source: UniProtKB
• cellular response to copper ion Source: UniProtKB
• cellular response to dexamethasone stimulus Source: UniProtKB
• cellular response to hydrogen peroxide Source: UniProtKB
• cellular response to hypoxia Source: UniProtKB
• cellular response to inorganic substance Source: UniProtKB
• cellular response to mechanical stimulus Source: UniProtKB
• cellular response to mercury ion Source: UniProtKB
• cellular response to nitric oxide Source: MGI
• cellular response to retinoic acid Source: UniProtKB
• cellular response to salt stress Source: UniProtKB
• cellular response to UV Source: UniProtKB
• cellular water homeostasis Source: UniProtKB
• cell volume homeostasis Source: UniProtKB
• cGMP-mediated signaling Source: UniProtKB
• corticotropin secretion Source: MGIInferred from mutant phenotypeⁱ
  • "Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells."
    Arnaoutova I., Cawley N.X., Patel N., Kim T., Rathod T., Loh Y.P.
    Mol Endocrinol 22:1924-1934(2008) [PubMed] [Europe PMC] [Abstract]
• defense response to Gram-negative bacterium Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1."
    Radtke A.L., O'Riordan M.X.
    Cell Microbiol 10:2197-2207(2008) [PubMed] [Europe PMC] [Abstract]
• establishment or maintenance of actin cytoskeleton polarity Source: UniProtKB
• glomerular filtration Source: MGIInferred from mutant phenotypeⁱ
  • "Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR."
    Hashimoto S., Huang Y., Mizel D., Briggs J., Schnermann J.
    Acta Physiol Scand 181:455-462(2004) [PubMed] [Europe PMC] [Abstract]
• glycerol transport Source: UniProtKB
• hyperosmotic response Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• hyperosmotic salinity response Source: Ensembl
• lateral ventricle development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Aquaporin-1 in the choroid plexuses of developing mammalian brain."
    Johansson P.A., Dziegielewska K.M., Ek C.J., Habgood M.D., Mollgard K., Potter A., Schuliga M., Saunders N.R.
    Cell Tissue Res 322:353-364(2005) [PubMed] [Europe PMC] [Abstract]
• lipid digestion Source: MGIInferred from mutant phenotypeⁱ
  • "Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels."
    Ma T., Jayaraman S., Wang K.S., Song Y., Yang B., Li J., Bastidas J.A., Verkman A.S.
    Am J Physiol Cell Physiol 280:C126-34(2001) [PubMed] [Europe PMC] [Abstract]
• maintenance of symbiont-containing vacuole by host Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1."
    Radtke A.L., O'Riordan M.X.
    Cell Microbiol 10:2197-2207(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric descending thin limb development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem Cell Biol 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric glomerulus vasculature development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem Cell Biol 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric proximal convoluted tubule segment 2 development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem Cell Biol 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric proximal straight tubule development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem Cell Biol 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: UniProtKB
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
• nitric oxide transport Source: UniProtKB
• positive regulation of angiogenesis Source: UniProtKB
• positive regulation of cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models."
    Ruiz-Ederra J., Verkman A.S.
    Exp Eye Res 89:159-165(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial cell migration Source: MGI
• positive regulation of fibroblast proliferation Source: UniProtKB
• positive regulation of lamellipodium assembly Source: MGI
• positive regulation of saliva secretion Source: UniProtKB
• potassium ion transport Source: UniProtKBInferred from direct assayⁱ
  • "Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1."
    Radtke A.L., O'Riordan M.X.
    Cell Microbiol 10:2197-2207(2008) [PubMed] [Europe PMC] [Abstract]
• renal water absorption Source: MGIInferred from mutant phenotypeⁱ
  • "Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice."
    Chou C.L., Knepper M.A., Hoek A.N., Brown D., Yang B., Ma T., Verkman A.S.
    J Clin Invest 103:491-496(1999) [PubMed] [Europe PMC] [Abstract]
  • "Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney."
    van Hoek A.N., Ma T., Yang B., Verkman A.S., Brown D.
    Am J Physiol Renal Physiol 278:F310-6(2000) [PubMed] [Europe PMC] [Abstract]
  • "Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery."
    Yang B., Ma T., Dong J.Y., Verkman A.S.
    Hum Gene Ther 11:567-575(2000) [PubMed] [Europe PMC] [Abstract]
  • "Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice."
    Verkman A.S., Yang B., Song Y., Manley G.T., Ma T.
    Exp Physiol 85 Spec No:233S-241S(2000) [PubMed] [Europe PMC] [Abstract]
  • "Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3."
    Yang B., Ma T., Verkman A.S.
    J Biol Chem 276:624-628(2001) [PubMed] [Europe PMC] [Abstract]
  • Ref.5

    "Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes."
    Yang B., Verkman A.S.
    J. Biol. Chem. 277:36782-36786(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • "Urea and urine concentrating ability in mice lacking AQP1 and AQP3."
    Zhao D., Bankir L., Qian L., Yang D., Yang B.
    Am J Physiol Renal Physiol 291:F429-38(2006) [PubMed] [Europe PMC] [Abstract]
  • "Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels."
    Ma T., Yang B., Gillespie A., Carlson E.J., Epstein C.J., Verkman A.S.
    J Biol Chem 273:4296-4299(1998) [PubMed] [Europe PMC] [Abstract]
• renal water transport Source: MGI
• response to drug Source: MGI
• response to estrogen Source: Ensembl
• secretion by cell Source: MGIInferred from mutant phenotypeⁱ
  • "Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells."
    Arnaoutova I., Cawley N.X., Patel N., Kim T., Rathod T., Loh Y.P.
    Mol Endocrinol 22:1924-1934(2008) [PubMed] [Europe PMC] [Abstract]
• secretory granule organization Source: MGIInferred from mutant phenotypeⁱ
  • "Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells."
    Arnaoutova I., Cawley N.X., Patel N., Kim T., Rathod T., Loh Y.P.
    Mol Endocrinol 22:1924-1934(2008) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired pain sensation in mice lacking Aquaporin-1 water channels."
    Oshio K., Watanabe H., Yan D., Verkman A.S., Manley G.T.
    Biochem Biophys Res Commun 341:1022-1028(2006) [PubMed] [Europe PMC] [Abstract]
• transepithelial water transport Source: UniProtKB
• water homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production."
    Zhang D., Vetrivel L., Verkman A.S.
    J Gen Physiol 119:561-569(2002) [PubMed] [Europe PMC] [Abstract]
• water transport Source: MGIInferred from direct assayⁱ
  • "Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes."
    Yang B., Fukuda N., van Hoek A., Matthay M.A., Ma T., Verkman A.S.
    J Biol Chem 275:2686-2692(2000) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: MGIInferred from mutant phenotypeⁱ
  • "Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models."
    Ruiz-Ederra J., Verkman A.S.
    Exp Eye Res 89:159-165(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ephrin receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.4

    "EphB2 guides axons at the midline and is necessary for normal vestibular function."
    Cowan C.A., Yokoyama N., Bianchi L.M., Henkemeyer M., Fritzsch B.
    Neuron 26:417-430(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH EPHB2.
• identical protein binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MASEIKKKLF WRAVVAEFLA MTLFVFISIG SALGFNYPLE RNQTLVQDNV 
        60         70         80         90        100
KVSLAFGLSI ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS ILRAVMYIIA 
       110        120        130        140        150
QCVGAIVATA ILSGITSSLV DNSLGRNDLA HGVNSGQGLG IEIIGTLQLV 
       160        170        180        190        200
LCVLATTDRR RRDLGGSAPL AIGLSVALGH LLAIDYTGCG INPARSFGSA 
       210        220        230        240        250
VLTRNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDFTD RMKVWTSGQV 
       260 
EEYDLDADDI NSRVEMKPK                                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families