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UniProtKB - Q02013 (AQP1_MOUSE)

Entry version 182 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Aquaporin-1

Gene

Aqp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

1 Publication

Miscellaneous

Pharmacologically inhibited by submillimolar concentrations of mercury.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei56Substrate discriminationBy similarity1
Sitei180Substrate discriminationBy similarity1
Sitei189Hg(2+)-sensitive residueBy similarity1
Sitei195Substrate discriminationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1237044, Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673, Erythrocytes take up oxygen and release carbon dioxide
R-MMU-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-432047, Passive transport by Aquaporins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aquaporin-1
Short name:
AQP-1
Alternative name(s):
Aquaporin-CHIP
Delayed early response protein 2
Short name:
DER2
Water channel protein for red blood cells and kidney proximal tubule
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aqp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:103201, Aqp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicBy similarity7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 36Helical; Name=Helix 1By similarityAdd BLAST29
Topological domaini37 – 48ExtracellularBy similarityAdd BLAST12
Transmembranei49 – 66Helical; Name=Helix 2By similarityAdd BLAST18
Topological domaini67 – 70CytoplasmicBy similarity4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei71 – 76By similarity6
Intramembranei77 – 84Helical; Name=Helix BBy similarity8
Topological domaini85 – 94CytoplasmicBy similarity10
Transmembranei95 – 115Helical; Name=Helix 3By similarityAdd BLAST21
Topological domaini116 – 136ExtracellularBy similarityAdd BLAST21
Transmembranei137 – 155Helical; Name=Helix 4By similarityAdd BLAST19
Topological domaini156 – 166CytoplasmicBy similarityAdd BLAST11
Transmembranei167 – 183Helical; Name=Helix 5By similarityAdd BLAST17
Topological domaini184 – 186ExtracellularBy similarity3
Intramembranei187 – 192By similarity6
Intramembranei193 – 200Helical; Name=Helix EBy similarity8
Topological domaini201 – 207ExtracellularBy similarity7
Transmembranei208 – 228Helical; Name=Helix 6By similarityAdd BLAST21
Topological domaini229 – 269CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice are born at the expected Mendelian rate and appear healthy and normal, but display strongly reduced urine osmolality. Besides, their erythrocytes show reduced water permeability. Mice lacking both Aqp1 and Slc14a1 are born at the expected Mendelian ratio, but do not thrive; half of them die within ten days after birth and none are alive after two weeks. Urine osmolality is somewhat lower than that observed with mice lacking only Aqp1. Besides, erythrocyte water permeability is significantly lower than in mice lacking only Aqp1.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000639211 – 269Aquaporin-1Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei247PhosphoserineCombined sources1
Modified residuei253PhosphotyrosineCombined sources1
Modified residuei262PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q02013

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q02013

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q02013

PeptideAtlas

More...PeptideAtlasi		Q02013

PRoteomics IDEntifications database

More...PRIDEi		Q02013

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		283194

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q02013, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q02013

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q02013

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q02013

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in erythrocytes (at protein level) (PubMed:12133842). In the kidney, expressed on luminal and basal borders of proximal tubules and in the thin limb of Henle's loop (at protein level) (PubMed:31605441).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000004655, Expressed in decidua and 267 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q02013, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Identified in a complex with STOM (By similarity).

Interacts with EPHB2; involved in endolymph production in the inner ear.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q02013, 3 interactors

Molecular INTeraction database

More...MINTi		Q02013

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000004774

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q02013, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q02013

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi76 – 78NPA 13
Motifi192 – 194NPA 23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0223, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020019_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q02013

Identification of Orthologs from Complete Genome Data

More...OMAi		ELFGTFW

Database of Orthologous Groups

More...OrthoDBi		1152704at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q02013

TreeFam database of animal gene trees

More...TreeFami		TF312940

Family and domain databases

Conserved Domains Database

More...CDDi		cd00333, MIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023271, Aquaporin-like
IPR023274, Aquaporin_1
IPR034294, Aquaporin_transptr
IPR000425, MIP
IPR022357, MIP_CS

The PANTHER Classification System

More...PANTHERi		PTHR19139, PTHR19139, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00230, MIP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02013, AQUAPORIN1
PR00783, MINTRINSICP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81338, SSF81338, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00861, MIP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00221, MIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02013-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASEIKKKLF WRAVVAEFLA MTLFVFISIG SALGFNYPLE RNQTLVQDNV 
        60         70         80         90        100
KVSLAFGLSI ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS ILRAVMYIIA 
       110        120        130        140        150
QCVGAIVATA ILSGITSSLV DNSLGRNDLA HGVNSGQGLG IEIIGTLQLV 
       160        170        180        190        200
LCVLATTDRR RRDLGGSAPL AIGLSVALGH LLAIDYTGCG INPARSFGSA 
       210        220        230        240        250
VLTRNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDFTD RMKVWTSGQV 
       260 
EEYDLDADDI NSRVEMKPK
Length:269
Mass (Da):28,793
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0499724AD4AB5F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190G → S in AAH07125 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L02914 mRNA Translation: AAB53928.1
AK081886 mRNA Translation: BAC38360.1
AK086688 mRNA Translation: BAC39719.1
AK157333 mRNA Translation: BAE34051.1
AK158226 mRNA Translation: BAE34412.1
AK158389 mRNA Translation: BAE34482.1
AK171627 mRNA Translation: BAE42573.1
AK172361 mRNA Translation: BAE42966.1
BC007125 mRNA Translation: AAH07125.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20164.1

Protein sequence database of the Protein Information Resource

More...PIRi		B44499

NCBI Reference Sequences

More...RefSeqi		NP_031498.1, NM_007472.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000004774; ENSMUSP00000004774; ENSMUSG00000004655

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11826

UCSC genome browser

More...UCSCi		uc009caq.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02914 mRNA Translation: AAB53928.1
AK081886 mRNA Translation: BAC38360.1
AK086688 mRNA Translation: BAC39719.1
AK157333 mRNA Translation: BAE34051.1
AK158226 mRNA Translation: BAE34412.1
AK158389 mRNA Translation: BAE34482.1
AK171627 mRNA Translation: BAE42573.1
AK172361 mRNA Translation: BAE42966.1
BC007125 mRNA Translation: AAH07125.1
CCDSiCCDS20164.1
PIRiB44499
RefSeqiNP_031498.1, NM_007472.2

3D structure databases

SMRiQ02013
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ02013, 3 interactors
MINTiQ02013
STRINGi10090.ENSMUSP00000004774

PTM databases

GlyGeniQ02013, 1 site
iPTMnetiQ02013
PhosphoSitePlusiQ02013
SwissPalmiQ02013

Proteomic databases

jPOSTiQ02013
MaxQBiQ02013
PaxDbiQ02013
PeptideAtlasiQ02013
PRIDEiQ02013
ProteomicsDBi283194

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		11826

Genome annotation databases

EnsembliENSMUST00000004774; ENSMUSP00000004774; ENSMUSG00000004655
GeneIDi11826
KEGGimmu:11826
UCSCiuc009caq.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		358
MGIiMGI:103201, Aqp1

Phylogenomic databases

eggNOGiKOG0223, Eukaryota
GeneTreeiENSGT00940000157015
HOGENOMiCLU_020019_3_3_1
InParanoidiQ02013
OMAiELFGTFW
OrthoDBi1152704at2759
PhylomeDBiQ02013
TreeFamiTF312940

Enzyme and pathway databases

ReactomeiR-MMU-1237044, Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673, Erythrocytes take up oxygen and release carbon dioxide
R-MMU-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-432047, Passive transport by Aquaporins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11826, 0 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Aqp1, mouse

Protein Ontology

More...PROi		PR:Q02013
RNActiQ02013, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000004655, Expressed in decidua and 267 other tissues
GenevisibleiQ02013, MM

Family and domain databases

CDDicd00333, MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271, Aquaporin-like
IPR023274, Aquaporin_1
IPR034294, Aquaporin_transptr
IPR000425, MIP
IPR022357, MIP_CS
PANTHERiPTHR19139, PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230, MIP, 1 hit
PRINTSiPR02013, AQUAPORIN1
PR00783, MINTRINSICP
SUPFAMiSSF81338, SSF81338, 1 hit
TIGRFAMsiTIGR00861, MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221, MIP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAQP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02013
Secondary accession number(s): Q542P1, Q91VY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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