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Entry version 186 (18 Sep 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Transgelin

Gene

TAGLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q01995

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transgelin
Alternative name(s):
22 kDa actin-binding protein
Protein WS3-10
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAGLN
Synonyms:SM22, WS3-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11553 TAGLN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600818 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01995

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6876

Open Targets

More...
OpenTargetsi
ENSG00000149591

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q01995

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638 Artenimol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAGLN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3123283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002047812 – 201TransgelinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei172N6-acetyllysineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei183Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-443
CPTAC-726

Encyclopedia of Proteome Dynamics

More...
EPDi
Q01995

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q01995

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q01995

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01995

PeptideAtlas

More...
PeptideAtlasi
Q01995

PRoteomics IDEntifications database

More...
PRIDEi
Q01995

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58029

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00216138

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
Q01995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q01995

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01995

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q01995

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Overexpressed in senescent human fibroblasts.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149591 Expressed in 231 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q01995 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01995 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001447
HPA019467

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112739, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q01995, 6 interactors

Molecular INTeraction database

More...
MINTi
Q01995

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000432282

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q01995

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 137Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati175 – 200Calponin-likeAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2046 Eukaryota
COG5199 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232113

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01995

KEGG Orthology (KO)

More...
KOi
K20526

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEWIVMQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01995

TreeFam database of animal gene trees

More...
TreeFami
TF313921

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029976 TAGLN

The PANTHER Classification System

More...
PANTHERi
PTHR18959:SF40 PTHR18959:SF40, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00888 SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q01995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN
160 170 180 190 200
WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,611
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AE9E7A9A45602C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCU9H0YCU9_HUMAN
Transgelin
TAGLN
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ32E9PJ32_HUMAN
Transgelin
TAGLN
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49R → P in AAA58351 (PubMed:1520290).Curated1
Sequence conflicti72D → E in AAA58375 (PubMed:1872880).Curated1
Sequence conflicti104Y → C in AAA58375 (PubMed:1872880).Curated1
Sequence conflicti104Y → S in AAA58351 (PubMed:1520290).Curated1
Sequence conflicti179M → V in AAA58375 (PubMed:1872880).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048670182N → S. Corresponds to variant dbSNP:rs12284316Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M95787 mRNA Translation: AAA58351.1
M83106 mRNA Translation: AAA58375.1
AF013711 Genomic DNA Translation: AAC21582.1
D17409 mRNA Translation: BAA21811.1
D84342 Genomic DNA Translation: BAA21839.1
BC004927 mRNA Translation: AAH04927.1
BC065829 mRNA Translation: AAH65829.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8381.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5577 JS0774

NCBI Reference Sequences

More...
RefSeqi
NP_001001522.1, NM_001001522.1
NP_003177.2, NM_003186.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278968; ENSP00000278968; ENSG00000149591
ENST00000392951; ENSP00000376678; ENSG00000149591
ENST00000525531; ENSP00000432054; ENSG00000149591
ENST00000530649; ENSP00000431941; ENSG00000149591
ENST00000532870; ENSP00000432282; ENSG00000149591

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6876

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95787 mRNA Translation: AAA58351.1
M83106 mRNA Translation: AAA58375.1
AF013711 Genomic DNA Translation: AAC21582.1
D17409 mRNA Translation: BAA21811.1
D84342 Genomic DNA Translation: BAA21839.1
BC004927 mRNA Translation: AAH04927.1
BC065829 mRNA Translation: AAH65829.1
CCDSiCCDS8381.1
PIRiJC5577 JS0774
RefSeqiNP_001001522.1, NM_001001522.1
NP_003177.2, NM_003186.3

3D structure databases

SMRiQ01995
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112739, 51 interactors
IntActiQ01995, 6 interactors
MINTiQ01995
STRINGi9606.ENSP00000432282

Chemistry databases

DrugBankiDB11638 Artenimol

PTM databases

iPTMnetiQ01995
PhosphoSitePlusiQ01995
SwissPalmiQ01995

Polymorphism and mutation databases

BioMutaiTAGLN
DMDMi3123283

2D gel databases

REPRODUCTION-2DPAGEiIPI00216138
UCD-2DPAGEiQ01995

Proteomic databases

CPTACiCPTAC-443
CPTAC-726
EPDiQ01995
jPOSTiQ01995
MassIVEiQ01995
PaxDbiQ01995
PeptideAtlasiQ01995
PRIDEiQ01995
ProteomicsDBi58029

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q01995

The DNASU plasmid repository

More...
DNASUi
6876

Genome annotation databases

EnsembliENST00000278968; ENSP00000278968; ENSG00000149591
ENST00000392951; ENSP00000376678; ENSG00000149591
ENST00000525531; ENSP00000432054; ENSG00000149591
ENST00000530649; ENSP00000431941; ENSG00000149591
ENST00000532870; ENSP00000432282; ENSG00000149591
GeneIDi6876
KEGGihsa:6876

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6876
DisGeNETi6876

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAGLN
HGNCiHGNC:11553 TAGLN
HPAiCAB001447
HPA019467
MIMi600818 gene
neXtProtiNX_Q01995
OpenTargetsiENSG00000149591
PharmGKBiPA36324

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00940000155162
HOGENOMiHOG000232113
InParanoidiQ01995
KOiK20526
OMAiVEWIVMQ
PhylomeDBiQ01995
TreeFamiTF313921

Enzyme and pathway databases

SIGNORiQ01995

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TAGLN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAGLN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6876
PharosiQ01995

Protein Ontology

More...
PROi
PR:Q01995

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149591 Expressed in 231 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ01995 baseline and differential
GenevisibleiQ01995 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029976 TAGLN
PANTHERiPTHR18959:SF40 PTHR18959:SF40, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAGL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01995
Secondary accession number(s): O15542
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 186 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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