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UniProtKB - Q01995 (TAGL_HUMAN)

Entry version 197 (29 Sep 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

Transgelin

Gene

TAGLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin cross-linking/gelling protein (By similarity).

Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01995

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01995

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transgelin
Alternative name(s):
22 kDa actin-binding protein
Protein WS3-10
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAGLN
Synonyms:SM22, WS3-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11553, TAGLN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600818, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01995

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149591

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6876

Open Targets

More...OpenTargetsi		ENSG00000149591

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01995, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11638, Artenimol

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAGLN

Domain mapping of disease mutations (DMDM)

More...DMDMi		3123283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002047812 – 201TransgelinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei172N6-acetyllysineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei183Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-443
CPTAC-726

Encyclopedia of Proteome Dynamics

More...EPDi		Q01995

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01995

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01995

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01995

PeptideAtlas

More...PeptideAtlasi		Q01995

PRoteomics IDEntifications database

More...PRIDEi		Q01995

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58029

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00216138

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		Q01995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01995

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q01995

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01995

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q01995

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Overexpressed in senescent human fibroblasts.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149591, Expressed in left coronary artery and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01995, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01995, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149591, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112739, 52 interactors

Protein interaction database and analysis system

More...IntActi		Q01995, 291 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000432282

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01995, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q01995

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01995

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 137Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati175 – 200Calponin-likeAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2046, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055232_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01995

Identification of Orthologs from Complete Genome Data

More...OMAi		SWFFKKA

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01995

TreeFam database of animal gene trees

More...TreeFami		TF313921

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000557, Calponin_repeat
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR003096, SM22_calponin
IPR029976, TAGLN

The PANTHER Classification System

More...PANTHERi		PTHR18959:SF40, PTHR18959:SF40, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00402, Calponin, 1 hit
PF00307, CH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00888, SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01052, CALPONIN_1, 1 hit
PS51122, CALPONIN_2, 1 hit
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q01995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL 
        60         70         80         90        100
GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA 
       110        120        130        140        150
AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN 
       160        170        180        190        200
WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII 

S
Length:201
Mass (Da):22,611
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AE9E7A9A45602C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCU9H0YCU9_HUMAN
Transgelin
TAGLN
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ32E9PJ32_HUMAN
Transgelin
TAGLN
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49R → P in AAA58351 (PubMed:1520290).Curated1
Sequence conflicti72D → E in AAA58375 (PubMed:1872880).Curated1
Sequence conflicti104Y → C in AAA58375 (PubMed:1872880).Curated1
Sequence conflicti104Y → S in AAA58351 (PubMed:1520290).Curated1
Sequence conflicti179M → V in AAA58375 (PubMed:1872880).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048670182N → S. Corresponds to variant dbSNP:rs12284316EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M95787 mRNA Translation: AAA58351.1
M83106 mRNA Translation: AAA58375.1
AF013711 Genomic DNA Translation: AAC21582.1
D17409 mRNA Translation: BAA21811.1
D84342 Genomic DNA Translation: BAA21839.1
BC004927 mRNA Translation: AAH04927.1
BC065829 mRNA Translation: AAH65829.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8381.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC5577, JS0774

NCBI Reference Sequences

More...RefSeqi		NP_001001522.1, NM_001001522.1
NP_003177.2, NM_003186.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000278968; ENSP00000278968; ENSG00000149591
ENST00000392951; ENSP00000376678; ENSG00000149591
ENST00000525531; ENSP00000432054; ENSG00000149591
ENST00000530649; ENSP00000431941; ENSG00000149591
ENST00000532870; ENSP00000432282; ENSG00000149591

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6876

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95787 mRNA Translation: AAA58351.1
M83106 mRNA Translation: AAA58375.1
AF013711 Genomic DNA Translation: AAC21582.1
D17409 mRNA Translation: BAA21811.1
D84342 Genomic DNA Translation: BAA21839.1
BC004927 mRNA Translation: AAH04927.1
BC065829 mRNA Translation: AAH65829.1
CCDSiCCDS8381.1
PIRiJC5577, JS0774
RefSeqiNP_001001522.1, NM_001001522.1
NP_003177.2, NM_003186.3

3D structure databases

BMRBiQ01995
SMRiQ01995
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112739, 52 interactors
IntActiQ01995, 291 interactors
STRINGi9606.ENSP00000432282

Chemistry databases

DrugBankiDB11638, Artenimol

PTM databases

iPTMnetiQ01995
MetOSiteiQ01995
PhosphoSitePlusiQ01995
SwissPalmiQ01995

Genetic variation databases

BioMutaiTAGLN
DMDMi3123283

2D gel databases

REPRODUCTION-2DPAGEiIPI00216138
UCD-2DPAGEiQ01995

Proteomic databases

CPTACiCPTAC-443
CPTAC-726
EPDiQ01995
jPOSTiQ01995
MassIVEiQ01995
PaxDbiQ01995
PeptideAtlasiQ01995
PRIDEiQ01995
ProteomicsDBi58029

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q01995, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3666, 708 antibodies

The CPTC Antibody Portal

More...CPTCi		Q01995, 1 antibody

The DNASU plasmid repository

More...DNASUi		6876

Genome annotation databases

EnsembliENST00000278968; ENSP00000278968; ENSG00000149591
ENST00000392951; ENSP00000376678; ENSG00000149591
ENST00000525531; ENSP00000432054; ENSG00000149591
ENST00000530649; ENSP00000431941; ENSG00000149591
ENST00000532870; ENSP00000432282; ENSG00000149591
GeneIDi6876
KEGGihsa:6876

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6876
DisGeNETi6876

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAGLN
HGNCiHGNC:11553, TAGLN
HPAiENSG00000149591, Low tissue specificity
MIMi600818, gene
neXtProtiNX_Q01995
OpenTargetsiENSG00000149591
PharmGKBiPA36324
VEuPathDBiHostDB:ENSG00000149591

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2046, Eukaryota
GeneTreeiENSGT00940000155162
HOGENOMiCLU_055232_1_0_1
InParanoidiQ01995
OMAiSWFFKKA
PhylomeDBiQ01995
TreeFamiTF313921

Enzyme and pathway databases

PathwayCommonsiQ01995
SIGNORiQ01995

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6876, 6 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TAGLN, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TAGLN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6876
PharosiQ01995, Tbio

Protein Ontology

More...PROi		PR:Q01995
RNActiQ01995, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149591, Expressed in left coronary artery and 243 other tissues
ExpressionAtlasiQ01995, baseline and differential
GenevisibleiQ01995, HS

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557, Calponin_repeat
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR003096, SM22_calponin
IPR029976, TAGLN
PANTHERiPTHR18959:SF40, PTHR18959:SF40, 1 hit
PfamiView protein in Pfam
PF00402, Calponin, 1 hit
PF00307, CH, 1 hit
PRINTSiPR00888, SM22CALPONIN
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052, CALPONIN_1, 1 hit
PS51122, CALPONIN_2, 1 hit
PS50021, CH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAGL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01995
Secondary accession number(s): O15542
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 197 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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