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Protein

Transgelin

Gene

TAGLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.By similarity

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • muscle organ development Source: ProtInc

Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

SIGNORiQ01995

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
22 kDa actin-binding protein
Protein WS3-10
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
Gene namesi
Name:TAGLN
Synonyms:SM22, WS3-10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149591.16
HGNCiHGNC:11553 TAGLN
MIMi600818 gene
neXtProtiNX_Q01995

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6876
OpenTargetsiENSG00000149591
PharmGKBiPA36324

Polymorphism and mutation databases

BioMutaiTAGLN
DMDMi3123283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002047812 – 201TransgelinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei172N6-acetyllysineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei183Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ01995
PaxDbiQ01995
PeptideAtlasiQ01995
PRIDEiQ01995
ProteomicsDBi58029

2D gel databases

REPRODUCTION-2DPAGEiIPI00216138
UCD-2DPAGEiQ01995

PTM databases

iPTMnetiQ01995
PhosphoSitePlusiQ01995
SwissPalmiQ01995

Expressioni

Inductioni

Overexpressed in senescent human fibroblasts.

Gene expression databases

BgeeiENSG00000149591 Expressed in 231 organ(s), highest expression level in left coronary artery
CleanExiHS_TAGLN
ExpressionAtlasiQ01995 baseline and differential
GenevisibleiQ01995 HS

Organism-specific databases

HPAiCAB001447
HPA019467

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112739, 51 interactors
IntActiQ01995, 6 interactors
MINTiQ01995
STRINGi9606.ENSP00000278968

Structurei

3D structure databases

ProteinModelPortaliQ01995
SMRiQ01995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 137Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114
Repeati175 – 200Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ01995
KOiK20526
OMAiVEWIVMQ
OrthoDBiEOG091G0LY2
PhylomeDBiQ01995
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029976 TAGLN
PANTHERiPTHR18959:SF40 PTHR18959:SF40, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q01995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN
160 170 180 190 200
WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,611
Last modified:January 23, 2007 - v4
Checksum:i7AE9E7A9A45602C3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCU9H0YCU9_HUMAN
Transgelin
TAGLN
151Annotation score:
E9PJ32E9PJ32_HUMAN
Transgelin
TAGLN
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49R → P in AAA58351 (PubMed:1520290).Curated1
Sequence conflicti72D → E in AAA58375 (PubMed:1872880).Curated1
Sequence conflicti104Y → C in AAA58375 (PubMed:1872880).Curated1
Sequence conflicti104Y → S in AAA58351 (PubMed:1520290).Curated1
Sequence conflicti179M → V in AAA58375 (PubMed:1872880).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048670182N → S. Corresponds to variant dbSNP:rs12284316Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95787 mRNA Translation: AAA58351.1
M83106 mRNA Translation: AAA58375.1
AF013711 Genomic DNA Translation: AAC21582.1
D17409 mRNA Translation: BAA21811.1
D84342 Genomic DNA Translation: BAA21839.1
BC004927 mRNA Translation: AAH04927.1
BC065829 mRNA Translation: AAH65829.1
CCDSiCCDS8381.1
PIRiJC5577 JS0774
RefSeqiNP_001001522.1, NM_001001522.1
NP_003177.2, NM_003186.3
UniGeneiHs.410977

Genome annotation databases

EnsembliENST00000278968; ENSP00000278968; ENSG00000149591
ENST00000392951; ENSP00000376678; ENSG00000149591
ENST00000525531; ENSP00000432054; ENSG00000149591
ENST00000530649; ENSP00000431941; ENSG00000149591
ENST00000532870; ENSP00000432282; ENSG00000149591
GeneIDi6876
KEGGihsa:6876

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95787 mRNA Translation: AAA58351.1
M83106 mRNA Translation: AAA58375.1
AF013711 Genomic DNA Translation: AAC21582.1
D17409 mRNA Translation: BAA21811.1
D84342 Genomic DNA Translation: BAA21839.1
BC004927 mRNA Translation: AAH04927.1
BC065829 mRNA Translation: AAH65829.1
CCDSiCCDS8381.1
PIRiJC5577 JS0774
RefSeqiNP_001001522.1, NM_001001522.1
NP_003177.2, NM_003186.3
UniGeneiHs.410977

3D structure databases

ProteinModelPortaliQ01995
SMRiQ01995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112739, 51 interactors
IntActiQ01995, 6 interactors
MINTiQ01995
STRINGi9606.ENSP00000278968

PTM databases

iPTMnetiQ01995
PhosphoSitePlusiQ01995
SwissPalmiQ01995

Polymorphism and mutation databases

BioMutaiTAGLN
DMDMi3123283

2D gel databases

REPRODUCTION-2DPAGEiIPI00216138
UCD-2DPAGEiQ01995

Proteomic databases

EPDiQ01995
PaxDbiQ01995
PeptideAtlasiQ01995
PRIDEiQ01995
ProteomicsDBi58029

Protocols and materials databases

DNASUi6876
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278968; ENSP00000278968; ENSG00000149591
ENST00000392951; ENSP00000376678; ENSG00000149591
ENST00000525531; ENSP00000432054; ENSG00000149591
ENST00000530649; ENSP00000431941; ENSG00000149591
ENST00000532870; ENSP00000432282; ENSG00000149591
GeneIDi6876
KEGGihsa:6876

Organism-specific databases

CTDi6876
DisGeNETi6876
EuPathDBiHostDB:ENSG00000149591.16
GeneCardsiTAGLN
HGNCiHGNC:11553 TAGLN
HPAiCAB001447
HPA019467
MIMi600818 gene
neXtProtiNX_Q01995
OpenTargetsiENSG00000149591
PharmGKBiPA36324
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ01995
KOiK20526
OMAiVEWIVMQ
OrthoDBiEOG091G0LY2
PhylomeDBiQ01995
TreeFamiTF313921

Enzyme and pathway databases

SIGNORiQ01995

Miscellaneous databases

ChiTaRSiTAGLN human
GeneWikiiTAGLN
GenomeRNAii6876
PROiPR:Q01995
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149591 Expressed in 231 organ(s), highest expression level in left coronary artery
CleanExiHS_TAGLN
ExpressionAtlasiQ01995 baseline and differential
GenevisibleiQ01995 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029976 TAGLN
PANTHERiPTHR18959:SF40 PTHR18959:SF40, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL_HUMAN
AccessioniPrimary (citable) accession number: Q01995
Secondary accession number(s): O15542
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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