UniProtKB - Q01995 (TAGL_HUMAN)
Protein
Transgelin
Gene
TAGLN
Organism
Homo sapiens (Human)
Status
Functioni
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.By similarity
GO - Molecular functioni
- actin filament binding Source: InterPro
GO - Biological processi
- epithelial cell differentiation Source: UniProtKB
- muscle organ development Source: ProtInc
Keywordsi
Molecular function | Actin-binding, Muscle protein |
Enzyme and pathway databases
PathwayCommonsi | Q01995 |
SIGNORi | Q01995 |
Names & Taxonomyi
Protein namesi | Recommended name: TransgelinAlternative name(s): 22 kDa actin-binding protein Protein WS3-10 Smooth muscle protein 22-alpha Short name: SM22-alpha |
Gene namesi | Name:TAGLN Synonyms:SM22, WS3-10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11553, TAGLN |
MIMi | 600818, gene |
neXtProti | NX_Q01995 |
VEuPathDBi | HostDB:ENSG00000149591.16 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 6876 |
OpenTargetsi | ENSG00000149591 |
PharmGKBi | PA36324 |
Miscellaneous databases
Pharosi | Q01995, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Genetic variation databases
BioMutai | TAGLN |
DMDMi | 3123283 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000204781 | 2 – 201 | TransgelinAdd BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 181 | PhosphoserineCombined sources | 1 | |
Modified residuei | 183 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-443 CPTAC-726 |
EPDi | Q01995 |
jPOSTi | Q01995 |
MassIVEi | Q01995 |
PaxDbi | Q01995 |
PeptideAtlasi | Q01995 |
PRIDEi | Q01995 |
ProteomicsDBi | 58029 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00216138 |
UCD-2DPAGEi | Q01995 |
PTM databases
iPTMneti | Q01995 |
MetOSitei | Q01995 |
PhosphoSitePlusi | Q01995 |
SwissPalmi | Q01995 |
Expressioni
Inductioni
Overexpressed in senescent human fibroblasts.
Gene expression databases
Bgeei | ENSG00000149591, Expressed in left coronary artery and 243 other tissues |
ExpressionAtlasi | Q01995, baseline and differential |
Genevisiblei | Q01995, HS |
Organism-specific databases
HPAi | ENSG00000149591, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ01995
With | #Exp. | IntAct |
---|---|---|
GORASP2 [Q9H8Y8] | 6 | EBI-1054248,EBI-739467 |
IGF1R [P08069] | 2 | EBI-1054248,EBI-475981 |
TINF2 [Q9BSI4] | 2 | EBI-1054248,EBI-717399 |
GO - Molecular functioni
- actin filament binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 112739, 52 interactors |
IntActi | Q01995, 7 interactors |
MINTi | Q01995 |
STRINGi | 9606.ENSP00000432282 |
Miscellaneous databases
RNActi | Q01995, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 137 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 114 | |
Repeati | 175 – 200 | Calponin-likeAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the calponin family.Curated
Phylogenomic databases
eggNOGi | KOG2046, Eukaryota |
GeneTreei | ENSGT00940000155162 |
HOGENOMi | CLU_055232_1_0_1 |
InParanoidi | Q01995 |
OMAi | VEWIVMQ |
PhylomeDBi | Q01995 |
TreeFami | TF313921 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin IPR029976, TAGLN |
PANTHERi | PTHR18959:SF40, PTHR18959:SF40, 1 hit |
Pfami | View protein in Pfam PF00402, Calponin, 1 hit PF00307, CH, 1 hit |
PRINTSi | PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 1 hit PS51122, CALPONIN_2, 1 hit PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q01995-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN
160 170 180 190 200
WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII
S
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCU9 | H0YCU9_HUMAN | Transgelin | TAGLN | 151 | Annotation score: | ||
E9PJ32 | E9PJ32_HUMAN | Transgelin | TAGLN | 91 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | R → P in AAA58351 (PubMed:1520290).Curated | 1 | |
Sequence conflicti | 72 | D → E in AAA58375 (PubMed:1872880).Curated | 1 | |
Sequence conflicti | 104 | Y → C in AAA58375 (PubMed:1872880).Curated | 1 | |
Sequence conflicti | 104 | Y → S in AAA58351 (PubMed:1520290).Curated | 1 | |
Sequence conflicti | 179 | M → V in AAA58375 (PubMed:1872880).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048670 | 182 | N → S. Corresponds to variant dbSNP:rs12284316EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95787 mRNA Translation: AAA58351.1 M83106 mRNA Translation: AAA58375.1 AF013711 Genomic DNA Translation: AAC21582.1 D17409 mRNA Translation: BAA21811.1 D84342 Genomic DNA Translation: BAA21839.1 BC004927 mRNA Translation: AAH04927.1 BC065829 mRNA Translation: AAH65829.1 |
CCDSi | CCDS8381.1 |
PIRi | JC5577, JS0774 |
RefSeqi | NP_001001522.1, NM_001001522.1 NP_003177.2, NM_003186.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95787 mRNA Translation: AAA58351.1 M83106 mRNA Translation: AAA58375.1 AF013711 Genomic DNA Translation: AAC21582.1 D17409 mRNA Translation: BAA21811.1 D84342 Genomic DNA Translation: BAA21839.1 BC004927 mRNA Translation: AAH04927.1 BC065829 mRNA Translation: AAH65829.1 |
CCDSi | CCDS8381.1 |
PIRi | JC5577, JS0774 |
RefSeqi | NP_001001522.1, NM_001001522.1 NP_003177.2, NM_003186.3 |
3D structure databases
BMRBi | Q01995 |
SMRi | Q01995 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112739, 52 interactors |
IntActi | Q01995, 7 interactors |
MINTi | Q01995 |
STRINGi | 9606.ENSP00000432282 |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
iPTMneti | Q01995 |
MetOSitei | Q01995 |
PhosphoSitePlusi | Q01995 |
SwissPalmi | Q01995 |
Genetic variation databases
BioMutai | TAGLN |
DMDMi | 3123283 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00216138 |
UCD-2DPAGEi | Q01995 |
Proteomic databases
CPTACi | CPTAC-443 CPTAC-726 |
EPDi | Q01995 |
jPOSTi | Q01995 |
MassIVEi | Q01995 |
PaxDbi | Q01995 |
PeptideAtlasi | Q01995 |
PRIDEi | Q01995 |
ProteomicsDBi | 58029 |
Protocols and materials databases
ABCDi | Q01995, 1 sequenced antibody |
Antibodypediai | 3666, 687 antibodies |
CPTCi | Q01995, 1 antibody |
DNASUi | 6876 |
Genome annotation databases
Organism-specific databases
CTDi | 6876 |
DisGeNETi | 6876 |
GeneCardsi | TAGLN |
HGNCi | HGNC:11553, TAGLN |
HPAi | ENSG00000149591, Low tissue specificity |
MIMi | 600818, gene |
neXtProti | NX_Q01995 |
OpenTargetsi | ENSG00000149591 |
PharmGKBi | PA36324 |
VEuPathDBi | HostDB:ENSG00000149591.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2046, Eukaryota |
GeneTreei | ENSGT00940000155162 |
HOGENOMi | CLU_055232_1_0_1 |
InParanoidi | Q01995 |
OMAi | VEWIVMQ |
PhylomeDBi | Q01995 |
TreeFami | TF313921 |
Enzyme and pathway databases
PathwayCommonsi | Q01995 |
SIGNORi | Q01995 |
Miscellaneous databases
BioGRID-ORCSi | 6876, 4 hits in 877 CRISPR screens |
ChiTaRSi | TAGLN, human |
GeneWikii | TAGLN |
GenomeRNAii | 6876 |
Pharosi | Q01995, Tbio |
PROi | PR:Q01995 |
RNActi | Q01995, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149591, Expressed in left coronary artery and 243 other tissues |
ExpressionAtlasi | Q01995, baseline and differential |
Genevisiblei | Q01995, HS |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin IPR029976, TAGLN |
PANTHERi | PTHR18959:SF40, PTHR18959:SF40, 1 hit |
Pfami | View protein in Pfam PF00402, Calponin, 1 hit PF00307, CH, 1 hit |
PRINTSi | PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 1 hit PS51122, CALPONIN_2, 1 hit PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAGL_HUMAN | |
Accessioni | Q01995Primary (citable) accession number: Q01995 Secondary accession number(s): O15542 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 194 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families