TAGLN

Functionⁱ

Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.By similarity

GO - Molecular functionⁱ

actin filament binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epithelial cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 21492153
muscle organ development
Source: ProtInc
Traceable author statementⁱ
- 9615232

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Muscle protein

Molecular function

Actin-binding, Muscle protein

Enzyme and pathway databases

SIGNORⁱ	Q01995

SIGNORⁱ

Q01995

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transgelin Alternative name(s): 22 kDa actin-binding protein Protein WS3-10 Smooth muscle protein 22-alpha Short name: SM22-alpha
Gene namesⁱ	Name:TAGLN Synonyms:SM22, WS3-10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149591.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11553 TAGLN
MIMⁱ	600818 gene
neXtProtⁱ	NX_Q01995

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6876
Open Targets More...OpenTargetsⁱ	ENSG00000149591
PharmGKBⁱ	PA36324

Polymorphism and mutation databases

BioMutaⁱ	TAGLN
DMDMⁱ	3123283

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000204781	2 – 201	TransgelinAdd BLAST		200

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	166	PhosphoserineCombined sources	1
Modified residueⁱ	172	N6-acetyllysineBy similarity	1
Modified residueⁱ	181	PhosphoserineCombined sources	1
Modified residueⁱ	183	Omega-N-methylarginineCombined sources	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q01995
PaxDbⁱ	Q01995
PeptideAtlas More...PeptideAtlasⁱ	Q01995
PRIDEⁱ	Q01995
ProteomicsDBⁱ	58029

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00216138
UCD-2DPAGEⁱ	Q01995

PTM databases

iPTMnetⁱ	Q01995
PhosphoSitePlusⁱ	Q01995
SwissPalmⁱ	Q01995

Expressionⁱ

Inductionⁱ

Overexpressed in senescent human fibroblasts.

Gene expression databases

Bgeeⁱ	ENSG00000149591 Expressed in 231 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_TAGLN
ExpressionAtlasⁱ	Q01995 baseline and differential
Genevisibleⁱ	Q01995 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB001447 HPA019467

HPAⁱ

CAB001447
HPA019467

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IGF1R	P08069	2	EBI-1054248,EBI-475981
TINF2	Q9BSI4	2	EBI-1054248,EBI-717399

GO - Molecular functionⁱ

actin filament binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112739, 51 interactors
IntActⁱ	Q01995, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q01995
STRINGⁱ	9606.ENSP00000278968

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q01995
SMRⁱ	Q01995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 137	Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST		114
Repeatⁱ	175 – 200	Calponin-likeAdd BLAST		26

Sequence similaritiesⁱ

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2046 Eukaryota COG5199 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074447
HOGENOMⁱ	HOG000232113
HOVERGENⁱ	HBG005186
InParanoidⁱ	Q01995
KEGG Orthology (KO) More...KOⁱ	K20526
OMAⁱ	VEWIVMQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LY2
PhylomeDBⁱ	Q01995
TreeFamⁱ	TF313921

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014 CH, 1 hit
Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR000557 Calponin_repeat IPR001715 CH-domain IPR036872 CH_dom_sf IPR003096 SM22_calponin IPR029976 TAGLN
PANTHERⁱ	PTHR18959:SF40 PTHR18959:SF40, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00402 Calponin, 1 hit PF00307 CH, 1 hit
PRINTSⁱ	PR00888 SM22CALPONIN
SMARTⁱ	View protein in SMART SM00033 CH, 1 hit
SUPFAMⁱ	SSF47576 SSF47576, 1 hit
PROSITEⁱ	View protein in PROSITE PS01052 CALPONIN_1, 1 hit PS51122 CALPONIN_2, 1 hit PS50021 CH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q01995-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL 
        60         70         80         90        100
GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA 
       110        120        130        140        150
AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN 
       160        170        180        190        200
WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII 

S

Length:201

Mass (Da):22,611

Last modified:January 23, 2007 - v4

Checksum:ⁱ7AE9E7A9A45602C3

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YCU9	H0YCU9_HUMAN	Transgelin Transgelin	TAGLN	151	Annotation score:
E9PJ32	E9PJ32_HUMAN	Transgelin Transgelin	TAGLN	91	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	49	R → P in AAA58351 (PubMed:1520290).Curated	1
Sequence conflictⁱ	72	D → E in AAA58375 (PubMed:1872880).Curated	1
Sequence conflictⁱ	104	Y → C in AAA58375 (PubMed:1872880).Curated	1
Sequence conflictⁱ	104	Y → S in AAA58351 (PubMed:1520290).Curated	1
Sequence conflictⁱ	179	M → V in AAA58375 (PubMed:1872880).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048670	182	N → S. Corresponds to variant dbSNP:rs12284316Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95787 mRNA Translation: AAA58351.1 M83106 mRNA Translation: AAA58375.1 AF013711 Genomic DNA Translation: AAC21582.1 D17409 mRNA Translation: BAA21811.1 D84342 Genomic DNA Translation: BAA21839.1 BC004927 mRNA Translation: AAH04927.1 BC065829 mRNA Translation: AAH65829.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8381.1
PIRⁱ	JC5577 JS0774
NCBI Reference Sequences More...RefSeqⁱ	NP_001001522.1, NM_001001522.1 NP_003177.2, NM_003186.3
UniGeneⁱ	Hs.410977

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01995	Transgelin		PANTR		205	UniRef100_Q01995
Transgelin		PANPA		205
Transgelin		GORGO		205
Transgelin		HUMAN		201
Transgelin		PONAB		201
+5

Protein	Similar proteins		Species	Score	Length	Source
Q01995	Transgelin	)	MOUSE		201	UniRef90_Q01995
Transgelin		RAT		201
Transgelin		BOVIN		201
Transgelin		PANTR		205
Transgelin		PANPA		205
+75

Protein	Similar proteins		Species	Score	Length	Source
Q01995	Transgelin	)	MOUSE		201	UniRef50_Q01995
Transgelin		RAT		201
Transgelin		BOVIN		201
Transgelin		PANTR		205
Transgelin		PANPA		205
+77

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95787 mRNA Translation: AAA58351.1 M83106 mRNA Translation: AAA58375.1 AF013711 Genomic DNA Translation: AAC21582.1 D17409 mRNA Translation: BAA21811.1 D84342 Genomic DNA Translation: BAA21839.1 BC004927 mRNA Translation: AAH04927.1 BC065829 mRNA Translation: AAH65829.1
CCDSⁱ	CCDS8381.1
PIRⁱ	JC5577 JS0774
RefSeqⁱ	NP_001001522.1, NM_001001522.1 NP_003177.2, NM_003186.3
UniGeneⁱ	Hs.410977

3D structure databases

ProteinModelPortalⁱ	Q01995
SMRⁱ	Q01995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112739, 51 interactors
IntActⁱ	Q01995, 6 interactors
MINTⁱ	Q01995
STRINGⁱ	9606.ENSP00000278968

PTM databases

iPTMnetⁱ	Q01995
PhosphoSitePlusⁱ	Q01995
SwissPalmⁱ	Q01995

Polymorphism and mutation databases

BioMutaⁱ	TAGLN
DMDMⁱ	3123283

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00216138
UCD-2DPAGEⁱ	Q01995

Proteomic databases

EPDⁱ	Q01995
PaxDbⁱ	Q01995
PeptideAtlasⁱ	Q01995
PRIDEⁱ	Q01995
ProteomicsDBⁱ	58029

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6876
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000278968; ENSP00000278968; ENSG00000149591 ENST00000392951; ENSP00000376678; ENSG00000149591 ENST00000525531; ENSP00000432054; ENSG00000149591 ENST00000530649; ENSP00000431941; ENSG00000149591 ENST00000532870; ENSP00000432282; ENSG00000149591
GeneIDⁱ	6876
KEGGⁱ	hsa:6876

Organism-specific databases

CTDⁱ	6876
DisGeNETⁱ	6876
EuPathDBⁱ	HostDB:ENSG00000149591.16
GeneCardsⁱ	TAGLN
HGNCⁱ	HGNC:11553 TAGLN
HPAⁱ	CAB001447 HPA019467
MIMⁱ	600818 gene
neXtProtⁱ	NX_Q01995
OpenTargetsⁱ	ENSG00000149591
PharmGKBⁱ	PA36324
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2046 Eukaryota COG5199 LUCA
GeneTreeⁱ	ENSGT00550000074447
HOGENOMⁱ	HOG000232113
HOVERGENⁱ	HBG005186
InParanoidⁱ	Q01995
KOⁱ	K20526
OMAⁱ	VEWIVMQ
OrthoDBⁱ	EOG091G0LY2
PhylomeDBⁱ	Q01995
TreeFamⁱ	TF313921

Enzyme and pathway databases

SIGNORⁱ	Q01995

SIGNORⁱ

Q01995

Miscellaneous databases

ChiTaRSⁱ	TAGLN human
GeneWikiⁱ	TAGLN
GenomeRNAiⁱ	6876
Protein Ontology More...PROⁱ	PR:Q01995
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149591 Expressed in 231 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_TAGLN
ExpressionAtlasⁱ	Q01995 baseline and differential
Genevisibleⁱ	Q01995 HS

Family and domain databases

CDDⁱ	cd00014 CH, 1 hit
Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR000557 Calponin_repeat IPR001715 CH-domain IPR036872 CH_dom_sf IPR003096 SM22_calponin IPR029976 TAGLN
PANTHERⁱ	PTHR18959:SF40 PTHR18959:SF40, 1 hit
Pfamⁱ	View protein in Pfam PF00402 Calponin, 1 hit PF00307 CH, 1 hit
PRINTSⁱ	PR00888 SM22CALPONIN
SMARTⁱ	View protein in SMART SM00033 CH, 1 hit
SUPFAMⁱ	SSF47576 SSF47576, 1 hit
PROSITEⁱ	View protein in PROSITE PS01052 CALPONIN_1, 1 hit PS51122 CALPONIN_2, 1 hit PS50021 CH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAGL_HUMAN
Accessionⁱ	Q01995Primary (citable) accession number: Q01995 Secondary accession number(s): O15542
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q01995 (TAGL_HUMAN)

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Transgelin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ