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Entry version 198 (13 Nov 2019)
Sequence version 4 (19 Oct 2011)
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Protein

Myosin heavy chain 95F

Gene

jar

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi151 – 158ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Developmental protein, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-190873 Gap junction degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin heavy chain 95F
Alternative name(s):
95F MHC
Protein jaguar
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:jar
Synonyms:Mhc95F
ORF Names:CG5695
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011225 jar

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001233891 – 1253Myosin heavy chain 95FAdd BLAST1253

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01989

PRoteomics IDEntifications database

More...
PRIDEi
Q01989

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform B is present at a higher level in the head and gonads than in the thoraxes. Isoform 145 kDa is found only in the head. CLIP-190 and jar are coexpressed at several times in development and in a number of tissues, including embryonic axonal neuron processes and posterior pole.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform B is expressed both maternally and zygotically throughout development with highest level during mid-embryogenesis and adulthood. At these zygotic stages isoform D is also expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011225 Expressed in 29 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q01989 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01989 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
67817, 32 interactors

Protein interaction database and analysis system

More...
IntActi
Q01989, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q01989

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 54Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST52
Domaini57 – 766Myosin motorPROSITE-ProRule annotationAdd BLAST710
Domaini808 – 837IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni647 – 666Actin-bindingAdd BLAST20
Regioni1187 – 1193Hydrophobic region7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili900 – 1022Sequence analysisAdd BLAST123

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0163 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01989

KEGG Orthology (KO)

More...
KOi
K10358

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMGRDEI

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01382 MYSc_Myo6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q01989-1) [UniParc]FASTAAdd to basket
Also known as: G, J, K, Em-3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEDTQLVWV RDAAEGYIQG RITEIGAKEF EVTPTDRKYP KRTCHFDDIH
60 70 80 90 100
SSCDGPQDHD DNCELMLLNE ATFLDNLKTR YYKDKIYTYV ANILIAVNPY
110 120 130 140 150
REIKELYAPD TIKKYNGRSL GELPPHVFAI ADKAIRDMRV YKLSQSIIVS
160 170 180 190 200
GESGAGKTES TKYLLKYLCY SHDSAGPIET KILDANPVLE AFGNAKTTRN
210 220 230 240 250
NNSSRFGKFI EVHYDAKCQV VGGYISHYLL EKSRICTQSA EERNYHVFYM
260 270 280 290 300
LLAGAPQQLR DKLSLGKPDD YRYLSGCTQY FANAKTEQLI PGSQKSKNHQ
310 320 330 340 350
QKGPLKDPII DDYQHFHNLD KALGRLGLSD TEKLGIYSLV AAVLHLGNIA
360 370 380 390 400
FEEIPDDVRG GCQVSEASEQ SLTITSGLLG VDQTELRTAL VSRVMQSKGG
410 420 430 440 450
GFKGTVIMVP LKIYEASNAR DALAKAIYSR LFDRIVGLIN QSIPFQASNF
460 470 480 490 500
YIGVLDIAGF EYFTVNSFEQ FCINYCNEKL QKFFNDNILK NEQELYKREG
510 520 530 540 550
LNVPEITFTD NQDIIELIEA KSNGIFTLLD EESKLPKPSY SHFTAEVHKS
560 570 580 590 600
WANHYRLGLP RSSRLKAHRT LRDEEGFLVR HFAGAVCYNT EQFIEKNNDA
610 620 630 640 650
LHASLEGLVQ ECDNPLLQTL FPSGSSTSVR GKLNFISVGS KFKTQLGELM
660 670 680 690 700
EKLEQNGTNF IRCIKPNSKM IDRQFEGSLA LAQLKCSGTI SVLELMEHGY
710 720 730 740 750
PSRVLFADLY SMYKSVLPPE LVSLPARTFC EAMFQSLNLS AKDFKFGITK
760 770 780 790 800
VFFRPGKFVE FDRIMRSDPE NMLAIVAKVK KWLIRSRWVK SALGALCVIK
810 820 830 840 850
LRNRIIYRNK CVLIAQRIAR GFLARKQHRP RYQGIGKINK IRTNTLKTIE
860 870 880 890 900
IASGLKMGRE EIISGVNDIY RQIDDAIKKI KMNPRITQRE MDSMYTVVMA
910 920 930 940 950
NMNKLTVDLN TKLKEQQQAE EQERLRKIQE ALEAERAAKE AEEQRQREEI
960 970 980 990 1000
ENKRLKAEME TRRKAAEAQR LRQEEEDRRA ALALQEQLEK EAKDDAKYRQ
1010 1020 1030 1040 1050
QLEQERRDHE LALRLANESN GQVEDSPPVI RNGVNDASPM GPNKLIRSEN
1060 1070 1080 1090 1100
VRAQQQALGK QKYDLSKWKY SELRDAINTS CDIELLEACR QEFHRRLKVY
1110 1120 1130 1140 1150
HAWKAKNRKR TTMDENERAP RSVMEAAFKQ PPLVQPIQEI VTAQHRYFRI
1160 1170 1180 1190 1200
PFMRANAPDN TKRGLWYAHF DGQWIARQME LHADKPPILL VAGTDDMQMC
1210 1220 1230 1240 1250
ELSLEETGLT RKRGAEILEH EFNREWERNG GKAYKNLGAA KPNGPAAAMQ

KQQ
Note: No experimental confirmation available.
Length:1,253
Mass (Da):143,299
Last modified:October 19, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7586E03ECE8DCC59
GO
Isoform H (identifier: Q01989-2) [UniParc]FASTAAdd to basket
Also known as: C, Em-1

The sequence of this isoform differs from the canonical sequence as follows:
     1047-1047: R → SFSQVVSNIASRYLNK

Show »
Length:1,268
Mass (Da):144,937
Checksum:iFB357C94B7605F1B
GO
Isoform I (identifier: Q01989-3) [UniParc]FASTAAdd to basket
Also known as: D, Em-5

The sequence of this isoform differs from the canonical sequence as follows:
     1048-1073: SENVRAQQQALGKQKYDLSKWKYSEL → YSTLYELPMSTTLVNFVNLFLLSQKH
     1074-1253: Missing.

Show »
Length:1,073
Mass (Da):122,393
Checksum:i2C423D534BE160CE
GO
Isoform 145 kDa (identifier: Q01989-4)
Sequence is not available
Length:
Mass (Da):

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H1UUJ8H1UUJ8_DROME
FI18104p1
jar 95F, 95F MHC, Dm 95F, Dm95F, Dmel\CG5695
1,253Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LHV4A0A0B4LHV4_DROME
Jaguar, isoform N
jar 95F, 95F MHC, Dm 95F, Dm95F, Dmel\CG5695
1,238Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGX1A0A0B4KGX1_DROME
Jaguar, isoform L
jar 95F, 95F MHC, Dm 95F, Dm95F, Dmel\CG5695
1,268Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO45215 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220V → M in CAA47462 (PubMed:1429838).Curated1
Sequence conflicti1051V → L in CAA47462 (PubMed:1429838).Curated1
Sequence conflicti1121R → P in CAA47462 (PubMed:1429838).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0033431047R → SFSQVVSNIASRYLNK in isoform H. Curated1
Alternative sequenceiVSP_0033441048 – 1073SENVR…KYSEL → YSTLYELPMSTTLVNFVNLF LLSQKH in isoform I. CuratedAdd BLAST26
Alternative sequenceiVSP_0033451074 – 1253Missing in isoform I. CuratedAdd BLAST180

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67077 mRNA Translation: CAA47462.1
AE014297 Genomic DNA Translation: AAF56269.3
AE014297 Genomic DNA Translation: AAN13992.1
AE014297 Genomic DNA Translation: AAX52973.2
AE014297 Genomic DNA Translation: AAX52974.2
AE014297 Genomic DNA Translation: AAX52975.2
AE014297 Genomic DNA Translation: AAX52976.2
BT004859 mRNA Translation: AAO45215.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
A44400

NCBI Reference Sequences

More...
RefSeqi
NP_001014647.2, NM_001014647.3 [Q01989-1]
NP_001014648.2, NM_001014648.3 [Q01989-1]
NP_001014649.2, NM_001014649.3 [Q01989-3]
NP_001014650.2, NM_001014650.3 [Q01989-2]
NP_001262905.1, NM_001275976.1 [Q01989-2]
NP_001262906.1, NM_001275977.2 [Q01989-1]
NP_524478.4, NM_079754.4 [Q01989-1]
NP_732976.1, NM_170138.3 [Q01989-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084636; FBpp0084020; FBgn0011225 [Q01989-1]
FBtr0301367; FBpp0290581; FBgn0011225 [Q01989-1]
FBtr0301368; FBpp0290582; FBgn0011225 [Q01989-2]
FBtr0301369; FBpp0290583; FBgn0011225 [Q01989-3]
FBtr0301370; FBpp0290584; FBgn0011225 [Q01989-1]
FBtr0301371; FBpp0290585; FBgn0011225 [Q01989-1]
FBtr0334871; FBpp0306894; FBgn0011225 [Q01989-2]
FBtr0334872; FBpp0306895; FBgn0011225 [Q01989-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42889

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5695

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67077 mRNA Translation: CAA47462.1
AE014297 Genomic DNA Translation: AAF56269.3
AE014297 Genomic DNA Translation: AAN13992.1
AE014297 Genomic DNA Translation: AAX52973.2
AE014297 Genomic DNA Translation: AAX52974.2
AE014297 Genomic DNA Translation: AAX52975.2
AE014297 Genomic DNA Translation: AAX52976.2
BT004859 mRNA Translation: AAO45215.1 Frameshift.
PIRiA44400
RefSeqiNP_001014647.2, NM_001014647.3 [Q01989-1]
NP_001014648.2, NM_001014648.3 [Q01989-1]
NP_001014649.2, NM_001014649.3 [Q01989-3]
NP_001014650.2, NM_001014650.3 [Q01989-2]
NP_001262905.1, NM_001275976.1 [Q01989-2]
NP_001262906.1, NM_001275977.2 [Q01989-1]
NP_524478.4, NM_079754.4 [Q01989-1]
NP_732976.1, NM_170138.3 [Q01989-1]

3D structure databases

SMRiQ01989
ModBaseiSearch...

Protein-protein interaction databases

BioGridi67817, 32 interactors
IntActiQ01989, 4 interactors
STRINGi7227.FBpp0290582

Proteomic databases

PaxDbiQ01989
PRIDEiQ01989

Genome annotation databases

EnsemblMetazoaiFBtr0084636; FBpp0084020; FBgn0011225 [Q01989-1]
FBtr0301367; FBpp0290581; FBgn0011225 [Q01989-1]
FBtr0301368; FBpp0290582; FBgn0011225 [Q01989-2]
FBtr0301369; FBpp0290583; FBgn0011225 [Q01989-3]
FBtr0301370; FBpp0290584; FBgn0011225 [Q01989-1]
FBtr0301371; FBpp0290585; FBgn0011225 [Q01989-1]
FBtr0334871; FBpp0306894; FBgn0011225 [Q01989-2]
FBtr0334872; FBpp0306895; FBgn0011225 [Q01989-1]
GeneIDi42889
KEGGidme:Dmel_CG5695

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42889
FlyBaseiFBgn0011225 jar

Phylogenomic databases

eggNOGiKOG0163 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000156078
InParanoidiQ01989
KOiK10358
OMAiKMGRDEI

Enzyme and pathway databases

ReactomeiR-DME-190873 Gap junction degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
42889

Protein Ontology

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PROi
PR:Q01989

Gene expression databases

BgeeiFBgn0011225 Expressed in 29 organ(s), highest expression level in embryo
ExpressionAtlasiQ01989 baseline and differential
GenevisibleiQ01989 DM

Family and domain databases

CDDicd01382 MYSc_Myo6, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYS9_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01989
Secondary accession number(s): A4V3C6
, Q59DV3, Q59DV4, Q9VCA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 19, 2011
Last modified: November 13, 2019
This is version 198 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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