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Protein

Tyrosine-protein kinase transmembrane receptor ROR2

Gene

ROR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).By similarity2 Publications

Caution

The catalytic activity of the kinase domain is controversial.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei507ATPPROSITE-ProRule annotation1
Active sitei615Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi479 – 487ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processWnt signaling pathway
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-4086400 PCP/CE pathway
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
SignaLinkiQ01974
SIGNORiQ01974

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor ROR2 (EC:2.7.10.11 Publication)
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 2
Gene namesi
Name:ROR2
Synonyms:NTRKR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000169071.14
HGNCiHGNC:10257 ROR2
MIMi602337 gene
neXtProtiNX_Q01974

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 403ExtracellularSequence analysisAdd BLAST370
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 943CytoplasmicSequence analysisAdd BLAST519

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Brachydactyly B1 (BDB1)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type B1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Symphalangism is also a feature.
See also OMIM:113000
Robinow syndrome autosomal recessive (RRS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA recessive form of Robinow syndrome, a disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally far more severe in recessive cases, particularly skeletal abnormalities. All patients with the recessive form suffer from vertebral segmentation abnormalities, resulting in scoliosis and chest deformities. Rib fusions are considered to be characteristic of the autosomal recessive form. Patients can also present brachydactyly, with extensive aplasia/hypoplasia of the phalanges and metacarpals/metatarsals, and brachy-syn-polydactyly of the hands and oligodactyly of the feet.
See also OMIM:268310
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010911182C → Y in RRS. 1 Publication1
Natural variantiVAR_010768184R → C in RRS. 1 PublicationCorresponds to variant dbSNP:rs121909084EnsemblClinVar.1
Natural variantiVAR_010769189R → W in RRS. 1 PublicationCorresponds to variant dbSNP:rs199975149Ensembl.1
Natural variantiVAR_010770366R → W in RRS. 1 Publication1
Natural variantiVAR_010771620N → K in RRS. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi482D → G: Slight increase in kinase activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi4920
GeneReviewsiROR2
MalaCardsiROR2
MIMi113000 phenotype
268310 phenotype
OpenTargetsiENSG00000169071
Orphaneti1507 Autosomal recessive Robinow syndrome
93383 Brachydactyly type B
PharmGKBiPA34629

Chemistry databases

ChEMBLiCHEMBL2375201

Polymorphism and mutation databases

BioMutaiROR2
DMDMi90110767

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000002446034 – 943Tyrosine-protein kinase transmembrane receptor ROR2Add BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 135By similarity
Disulfide bondi174 ↔ 239By similarity
Disulfide bondi182 ↔ 232By similarity
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 264By similarity
Disulfide bondi252 ↔ 300By similarity
Disulfide bondi256 ↔ 286By similarity
Disulfide bondi316 ↔ 394By similarity
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 377By similarity
Disulfide bondi365 ↔ 389By similarity
Modified residuei469Sulfoserine; partial1 Publication1
Modified residuei471Sulfoserine; partial1 Publication1
Modified residuei646Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei785Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein, Sulfation

Proteomic databases

EPDiQ01974
MaxQBiQ01974
PaxDbiQ01974
PeptideAtlasiQ01974
PRIDEiQ01974
ProteomicsDBi58028

PTM databases

iPTMnetiQ01974
PhosphoSitePlusiQ01974

Expressioni

Developmental stagei

Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

Gene expression databases

BgeeiENSG00000169071 Expressed in 131 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_ROR2
ExpressionAtlasiQ01974 baseline and differential
GenevisibleiQ01974 HS

Organism-specific databases

HPAiHPA021868

Interactioni

Subunit structurei

Homodimer; promotes osteogenesis. Binds YWHAB (PubMed:17717073). Interacts with WTIP (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110974, 50 interactors
IntActiQ01974, 34 interactors
STRINGi9606.ENSP00000364860

Structurei

Secondary structure

1943
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01974
SMRiQ01974
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 145Ig-like C2-typeAdd BLAST91
Domaini169 – 303FZPROSITE-ProRule annotationAdd BLAST135
Domaini316 – 394KringlePROSITE-ProRule annotationAdd BLAST79
Domaini473 – 746Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 782Ser/Thr-richAdd BLAST30
Compositional biasi784 – 857Pro-richAdd BLAST74
Compositional biasi859 – 882Ser/Thr-richAdd BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000049104
HOVERGENiHBG017736
InParanoidiQ01974
KOiK05123
OMAiFIPMKGQ
OrthoDBiEOG091G02W3
PhylomeDBiQ01974
TreeFamiTF106465

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR016247 Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000624 TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00130 KR, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q01974-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGSALPRR PLLCIPAVWA AAALLLSVSR TSGEVEVLDP NDPLGPLDGQ
60 70 80 90 100
DGPIPTLKGY FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA
110 120 130 140 150
PVVQEPRRII IRKTEYGSRL RIQDLDTTDT GYYQCVATNG MKTITATGVL
160 170 180 190 200
FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
210 220 230 240 250
EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD ARSRTPKPRE
260 270 280 290 300
LCRDECEVLE SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC
310 320 330 340 350
MRIGIPAERL GRYHQCYNGS GMDYRGTAST TKSGHQCQPW ALQHPHSHHL
360 370 380 390 400
SSTDFPELGG GHAYCRNPGG QMEGPWCFTQ NKNVRMELCD VPSCSPRDSS
410 420 430 440 450
KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ RRQLMASPSQ
460 470 480 490 500
DMEMPLINQH KQAKLKEISL SAVRFMEELG EDRFGKVYKG HLFGPAPGEQ
510 520 530 540 550
TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNVVCLL GVVTKDQPLS
560 570 580 590 600
MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA
610 620 630 640 650
AGMEYLSSHH VVHKDLATRN VLVYDKLNVK ISDLGLFREV YAADYYKLLG
660 670 680 690 700
NSLLPIRWMA PEAIMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD
710 720 730 740 750
VVEMIRNRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK DIHSRLRAWG
760 770 780 790 800
NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN VSNARYVGPK QKAPPFPQPQ
810 820 830 840 850
FIPMKGQIRP MVPPPQLYVP VNGYQPVPAY GAYLPNFYPV QIPMQMAPQQ
860 870 880 890 900
VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSMADRAALL SEGADDTQNA
910 920 930 940
PEDGAQSTVQ EAEEEEEGSV PETELLGDCD TLQVDEAQVQ LEA
Length:943
Mass (Da):104,757
Last modified:March 7, 2006 - v2
Checksum:iF926FB681A8312FE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1APY4B1APY4_HUMAN
Receptor tyrosine kinase-like orpha...
ROR2 hCG_1985325
704Annotation score:

Sequence cautioni

The sequence BAD92391 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010911182C → Y in RRS. 1 Publication1
Natural variantiVAR_010768184R → C in RRS. 1 PublicationCorresponds to variant dbSNP:rs121909084EnsemblClinVar.1
Natural variantiVAR_010769189R → W in RRS. 1 PublicationCorresponds to variant dbSNP:rs199975149Ensembl.1
Natural variantiVAR_041787244R → Q1 PublicationCorresponds to variant dbSNP:rs55737262Ensembl.1
Natural variantiVAR_010912245T → A5 PublicationsCorresponds to variant dbSNP:rs10820900EnsemblClinVar.1
Natural variantiVAR_041788349H → D1 PublicationCorresponds to variant dbSNP:rs55983376EnsemblClinVar.1
Natural variantiVAR_010770366R → W in RRS. 1 Publication1
Natural variantiVAR_041789490G → A1 PublicationCorresponds to variant dbSNP:rs56197744Ensembl.1
Natural variantiVAR_041790530R → Q1 PublicationCorresponds to variant dbSNP:rs35852786EnsemblClinVar.1
Natural variantiVAR_041791542V → M in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs140213020Ensembl.1
Natural variantiVAR_041792548P → S1 PublicationCorresponds to variant dbSNP:rs35764413EnsemblClinVar.1
Natural variantiVAR_041793557S → L1 PublicationCorresponds to variant dbSNP:rs56099091EnsemblClinVar.1
Natural variantiVAR_010771620N → K in RRS. 1 Publication1
Natural variantiVAR_041794644D → N1 PublicationCorresponds to variant dbSNP:rs55798732Ensembl.1
Natural variantiVAR_041795672D → N1 PublicationCorresponds to variant dbSNP:rs55651110Ensembl.1
Natural variantiVAR_041796695G → R1 PublicationCorresponds to variant dbSNP:rs34431454EnsemblClinVar.1
Natural variantiVAR_041797738R → C1 PublicationCorresponds to variant dbSNP:rs56231927EnsemblClinVar.1
Natural variantiVAR_041798762S → L1 PublicationCorresponds to variant dbSNP:rs34491822EnsemblClinVar.1
Natural variantiVAR_010913819V → I3 PublicationsCorresponds to variant dbSNP:rs10761129EnsemblClinVar.1
Natural variantiVAR_041799935D → E1 PublicationCorresponds to variant dbSNP:rs41277835EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97639 mRNA Translation: AAA60276.1
AL391219 Genomic DNA No translation available.
AL928802 Genomic DNA No translation available.
AL583841 Genomic DNA No translation available.
AB209154 mRNA Translation: BAD92391.1 Different initiation.
AH009681 Genomic DNA Translation: AAG01184.2
AH010002 Genomic DNA Translation: AAG33132.1
CCDSiCCDS6691.1
PIRiB45082
RefSeqiNP_001305133.1, NM_001318204.1
NP_004551.2, NM_004560.3
UniGeneiHs.644776
Hs.98255

Genome annotation databases

EnsembliENST00000375708; ENSP00000364860; ENSG00000169071
GeneIDi4920
KEGGihsa:4920
UCSCiuc004arj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97639 mRNA Translation: AAA60276.1
AL391219 Genomic DNA No translation available.
AL928802 Genomic DNA No translation available.
AL583841 Genomic DNA No translation available.
AB209154 mRNA Translation: BAD92391.1 Different initiation.
AH009681 Genomic DNA Translation: AAG01184.2
AH010002 Genomic DNA Translation: AAG33132.1
CCDSiCCDS6691.1
PIRiB45082
RefSeqiNP_001305133.1, NM_001318204.1
NP_004551.2, NM_004560.3
UniGeneiHs.644776
Hs.98255

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZZWX-ray2.90A/B464-751[»]
4GT4X-ray2.41A/B452-753[»]
ProteinModelPortaliQ01974
SMRiQ01974
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110974, 50 interactors
IntActiQ01974, 34 interactors
STRINGi9606.ENSP00000364860

Chemistry databases

ChEMBLiCHEMBL2375201

PTM databases

iPTMnetiQ01974
PhosphoSitePlusiQ01974

Polymorphism and mutation databases

BioMutaiROR2
DMDMi90110767

Proteomic databases

EPDiQ01974
MaxQBiQ01974
PaxDbiQ01974
PeptideAtlasiQ01974
PRIDEiQ01974
ProteomicsDBi58028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375708; ENSP00000364860; ENSG00000169071
GeneIDi4920
KEGGihsa:4920
UCSCiuc004arj.3 human

Organism-specific databases

CTDi4920
DisGeNETi4920
EuPathDBiHostDB:ENSG00000169071.14
GeneCardsiROR2
GeneReviewsiROR2
H-InvDBiHIX0034840
HGNCiHGNC:10257 ROR2
HPAiHPA021868
MalaCardsiROR2
MIMi113000 phenotype
268310 phenotype
602337 gene
neXtProtiNX_Q01974
OpenTargetsiENSG00000169071
Orphaneti1507 Autosomal recessive Robinow syndrome
93383 Brachydactyly type B
PharmGKBiPA34629
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000049104
HOVERGENiHBG017736
InParanoidiQ01974
KOiK05123
OMAiFIPMKGQ
OrthoDBiEOG091G02W3
PhylomeDBiQ01974
TreeFamiTF106465

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-4086400 PCP/CE pathway
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
SignaLinkiQ01974
SIGNORiQ01974

Miscellaneous databases

ChiTaRSiROR2 human
GeneWikiiROR2
GenomeRNAii4920
PROiPR:Q01974
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169071 Expressed in 131 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_ROR2
ExpressionAtlasiQ01974 baseline and differential
GenevisibleiQ01974 HS

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR016247 Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000624 TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00130 KR, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiROR2_HUMAN
AccessioniPrimary (citable) accession number: Q01974
Secondary accession number(s): Q59GF5
, Q5SPI5, Q9HAY7, Q9HB61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 7, 2006
Last modified: September 12, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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