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UniProtKB - Q01973 (ROR1_HUMAN)

Entry version 206 (02 Dec 2020)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
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Protein

Inactive tyrosine-protein kinase transmembrane receptor ROR1

Gene

ROR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).2 Publications

Caution

The kinase domain has very low catalytic activity in vitro.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei506ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi479 – 487ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.10.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01973

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q01973

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01973

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive tyrosine-protein kinase transmembrane receptor ROR1Curated
Alternative name(s):
Neurotrophic tyrosine kinase, receptor-related 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROR1
Synonyms:NTRKR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000185483.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:10256, ROR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602336, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01973

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 406ExtracellularSequence analysisAdd BLAST377
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 937CytoplasmicSequence analysisAdd BLAST510

Keywords - Cellular componenti

Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 108 (DFNB108)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079530736R → T in DFNB108; impairs plasma membrane location; abolishes downstream NFkB activation. 1 PublicationCorresponds to variant dbSNP:rs1553163562EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi482C → G: No effect on kinase activity. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		4919

MalaCards human disease database

More...MalaCardsi		ROR1
MIMi617654, phenotype

Open Targets

More...OpenTargetsi		ENSG00000185483

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34628

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01973, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ROR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572711

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002445830 – 937Inactive tyrosine-protein kinase transmembrane receptor ROR1Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi79 ↔ 131By similarity
Disulfide bondi170 ↔ 235By similarity
Disulfide bondi178 ↔ 228By similarity
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi219 ↔ 260By similarity
Disulfide bondi248 ↔ 296By similarity
Disulfide bondi252 ↔ 282By similarity
Disulfide bondi313 ↔ 391By similarity
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 374By similarity
Disulfide bondi362 ↔ 386By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei645Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q01973

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01973

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01973

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q01973

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01973

PeptideAtlas

More...PeptideAtlasi		Q01973

PRoteomics IDEntifications database

More...PRIDEi		Q01973

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58025 [Q01973-1]
58026 [Q01973-2]
58027 [Q01973-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q01973, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01973

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01973

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q01973

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185483, Expressed in lung and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01973, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01973, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185483, Tissue enhanced (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110973, 31 interactors

Database of interacting proteins

More...DIPi		DIP-29734N

Protein interaction database and analysis system

More...IntActi		Q01973, 27 interactors

Molecular INTeraction database

More...MINTi		Q01973

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360120

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01973, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1937
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01973

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 147Ig-like C2-typeAdd BLAST106
Domaini165 – 299FZPROSITE-ProRule annotationAdd BLAST135
Domaini312 – 391KringlePROSITE-ProRule annotationAdd BLAST80
Domaini473 – 746Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi753 – 782Ser/Thr-richAdd BLAST30
Compositional biasi784 – 851Pro-richAdd BLAST68
Compositional biasi853 – 876Ser/Thr-richAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1026, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_701993_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01973

Identification of Orthologs from Complete Genome Data

More...OMAi		ECWHEQS

Database of Orthologous Groups

More...OrthoDBi		471114at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01973

TreeFam database of animal gene trees

More...TreeFami		TF106465

Family and domain databases

Conserved Domains Database

More...CDDi		cd00108, KR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR016247, Tyr_kinase_rcpt_ROR

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01392, Fz, 1 hit
PF07679, I-set, 1 hit
PF00051, Kringle, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000624, TyrPK_TMrec_ROR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00130, KR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF56112, SSF56112, 1 hit
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50038, FZ, 1 hit
PS50835, IG_LIKE, 1 hit
PS00021, KRINGLE_1, 1 hit
PS50070, KRINGLE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: Q01973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS 
        60         70         80         90        100
ELNKDSYLTL DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ 
       110        120        130        140        150
EPRRLSFRST IYGSRLRIRN LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF 
       160        170        180        190        200
GPPPTASPGY SDEYEEDGFC QPYRGIACAR FIGNRTVYME SLHMQGEIEN 
       210        220        230        240        250
QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS VPKPRDLCRD 
       260        270        280        290        300
ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG 
       310        320        330        340        350
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL 
       360        370        380        390        400
RFPELNGGHS YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN 
       410        420        430        440        450
KMEILYILVP SVAIPLAIAL LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN 
       460        470        480        490        500
VEMSMLNAYK PKSKAKELPL SAVRFMEELG ECAFGKIYKG HLYLPGMDHA 
       510        520        530        540        550
QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG AVTQEQPVCM 
       560        570        580        590        600
LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA 
       610        620        630        640        650
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS 
       660        670        680        690        700
KSLLPIRWMP PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE 
       710        720        730        740        750
VIEMVRKRQL LPCSEDCPPR MYSLMTECWN EIPSRRPRFK DIHVRLRSWE 
       760        770        780        790        800
GLSSHTSSTT PSGGNATTQT TSLSASPVSN LSNPRYPNYM FPSQGITPQG 
       810        820        830        840        850
QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG PPRVIQHCPP 
       860        870        880        890        900
PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT 
       910        920        930 
VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL
Length:937
Mass (Da):104,283
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC0E4762A90C6C7
GO
Isoform Short (identifier: Q01973-2) [UniParc]FASTAAdd to basket
Also known as: T-ROR1

The sequence of this isoform differs from the canonical sequence as follows:
     1-549: Missing.

Show »
Length:388
Mass (Da):42,833
Checksum:i8DC1D0BA14085BD2
GO
Isoform 3 (identifier: Q01973-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     392-393: DS → GK
     394-937: Missing.

Show »
Length:393
Mass (Da):43,826
Checksum:i1F93DCBBBBF53855
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTJ5A0A0A0MTJ5_HUMAN
Inactive tyrosine-protein kinase tr...
ROR1
882Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041779144G → E in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041780150F → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041781301I → V in a renal clear cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041782518T → M2 PublicationsCorresponds to variant dbSNP:rs7527017Ensembl.1
Natural variantiVAR_035713562E → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760789417Ensembl.1
Natural variantiVAR_041783567R → I in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041784624G → R1 PublicationCorresponds to variant dbSNP:rs55832740Ensembl.1
Natural variantiVAR_041785646Y → C1 PublicationCorresponds to variant dbSNP:rs34109134Ensembl.1
Natural variantiVAR_079530736R → T in DFNB108; impairs plasma membrane location; abolishes downstream NFkB activation. 1 PublicationCorresponds to variant dbSNP:rs1553163562EnsemblClinVar.1
Natural variantiVAR_041786776S → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0050081 – 549Missing in isoform Short. 1 PublicationAdd BLAST549
Alternative sequenceiVSP_043663392 – 393DS → GK in isoform 3. 1 Publication2
Alternative sequenceiVSP_043664394 – 937Missing in isoform 3. 1 PublicationAdd BLAST544

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M97675 mRNA Translation: AAA60275.1
U38894 mRNA Translation: AAC50714.1
AL137859 Genomic DNA No translation available.
AL161742 Genomic DNA No translation available.
AL445205 Genomic DNA No translation available.
AL138793 Genomic DNA No translation available.
AL353713 Genomic DNA No translation available.
AL808029 Genomic DNA No translation available.
AL808030 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06556.1
BC080541 mRNA Translation: AAH80541.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41344.1 [Q01973-3]
CCDS626.1 [Q01973-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A45082

NCBI Reference Sequences

More...RefSeqi		NP_001077061.1, NM_001083592.1 [Q01973-3]
NP_005003.2, NM_005012.3 [Q01973-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371079; ENSP00000360120; ENSG00000185483 [Q01973-1]
ENST00000371080; ENSP00000360121; ENSG00000185483 [Q01973-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4919

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4919

UCSC genome browser

More...UCSCi		uc001dbi.5, human [Q01973-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97675 mRNA Translation: AAA60275.1
U38894 mRNA Translation: AAC50714.1
AL137859 Genomic DNA No translation available.
AL161742 Genomic DNA No translation available.
AL445205 Genomic DNA No translation available.
AL138793 Genomic DNA No translation available.
AL353713 Genomic DNA No translation available.
AL808029 Genomic DNA No translation available.
AL808030 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06556.1
BC080541 mRNA Translation: AAH80541.1
CCDSiCCDS41344.1 [Q01973-3]
CCDS626.1 [Q01973-1]
PIRiA45082
RefSeqiNP_001077061.1, NM_001083592.1 [Q01973-3]
NP_005003.2, NM_005012.3 [Q01973-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z55NMR-A312-394[»]
6BA5X-ray1.62M/N/O/P311-391[»]
6BANX-ray1.95M/N/O/P311-391[»]
6TU9X-ray1.94A/B453-752[»]
SMRiQ01973
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110973, 31 interactors
DIPiDIP-29734N
IntActiQ01973, 27 interactors
MINTiQ01973
STRINGi9606.ENSP00000360120

PTM databases

GlyGeniQ01973, 4 sites
iPTMnetiQ01973
PhosphoSitePlusiQ01973
SwissPalmiQ01973

Polymorphism and mutation databases

BioMutaiROR1
DMDMi118572711

Proteomic databases

EPDiQ01973
jPOSTiQ01973
MassIVEiQ01973
MaxQBiQ01973
PaxDbiQ01973
PeptideAtlasiQ01973
PRIDEiQ01973
ProteomicsDBi58025 [Q01973-1]
58026 [Q01973-2]
58027 [Q01973-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q01973, 21 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33360, 861 antibodies

The DNASU plasmid repository

More...DNASUi		4919

Genome annotation databases

EnsembliENST00000371079; ENSP00000360120; ENSG00000185483 [Q01973-1]
ENST00000371080; ENSP00000360121; ENSG00000185483 [Q01973-3]
GeneIDi4919
KEGGihsa:4919
UCSCiuc001dbi.5, human [Q01973-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4919
DisGeNETi4919
EuPathDBiHostDB:ENSG00000185483.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		ROR1
HGNCiHGNC:10256, ROR1
HPAiENSG00000185483, Tissue enhanced (parathyroid)
MalaCardsiROR1
MIMi602336, gene
617654, phenotype
neXtProtiNX_Q01973
OpenTargetsiENSG00000185483
Orphaneti90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA34628

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1026, Eukaryota
GeneTreeiENSGT00940000153947
HOGENOMiCLU_701993_0_0_1
InParanoidiQ01973
OMAiECWHEQS
OrthoDBi471114at2759
PhylomeDBiQ01973
TreeFamiTF106465

Enzyme and pathway databases

BRENDAi2.7.10.1, 2681
PathwayCommonsiQ01973
ReactomeiR-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
SignaLinkiQ01973
SIGNORiQ01973

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4919, 6 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ROR1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ROR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4919
PharosiQ01973, Tbio

Protein Ontology

More...PROi		PR:Q01973
RNActiQ01973, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185483, Expressed in lung and 181 other tissues
ExpressionAtlasiQ01973, baseline and differential
GenevisibleiQ01973, HS

Family and domain databases

CDDicd00108, KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR016247, Tyr_kinase_rcpt_ROR
PfamiView protein in Pfam
PF01392, Fz, 1 hit
PF07679, I-set, 1 hit
PF00051, Kringle, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
PIRSFiPIRSF000624, TyrPK_TMrec_ROR, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00130, KR, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56112, SSF56112, 1 hit
SSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038, FZ, 1 hit
PS50835, IG_LIKE, 1 hit
PS00021, KRINGLE_1, 1 hit
PS50070, KRINGLE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01973
Secondary accession number(s): Q5VVX6, Q66K77, Q92776
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 28, 2006
Last modified: December 2, 2020
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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