UniProtKB - Q01973 (ROR1_HUMAN)
Protein
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Gene
ROR1
Organism
Homo sapiens (Human)
Status
Functioni
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).2 Publications
Caution
The kinase domain has very low catalytic activity in vitro.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 506 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 479 – 487 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL
- transmembrane receptor protein tyrosine kinase activity Source: ProtInc
- Wnt-activated receptor activity Source: UniProtKB
- Wnt-protein binding Source: UniProtKB
GO - Biological processi
- astrocyte development Source: Ensembl
- inner ear development Source: UniProtKB
- multicellular organism development Source: GO_Central
- nervous system development Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: GO_Central
- positive regulation of neuron projection development Source: GO_Central
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: GO_Central
- regulation of MAPK cascade Source: GO_Central
- sensory perception of sound Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
Keywordsi
Molecular function | Kinase, Receptor, Transferase |
Biological process | Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | Q01973 |
Reactomei | R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
SignaLinki | Q01973 |
SIGNORi | Q01973 |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive tyrosine-protein kinase transmembrane receptor ROR1CuratedAlternative name(s): Neurotrophic tyrosine kinase, receptor-related 1 |
Gene namesi | Name:ROR1 Synonyms:NTRKR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185483.11 |
HGNCi | HGNC:10256, ROR1 |
MIMi | 602336, gene |
neXtProti | NX_Q01973 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Single-pass type I membrane protein
- axon By similarity
Cytoskeleton
- stress fiber Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- axon terminus Source: UniProtKB
- cell surface Source: Ensembl
- cytoplasm Source: ProtInc
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 406 | ExtracellularSequence analysisAdd BLAST | 377 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 937 | CytoplasmicSequence analysisAdd BLAST | 510 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Involvement in diseasei
Deafness, autosomal recessive, 108 (DFNB108)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079530 | 736 | R → T in DFNB108; impairs plasma membrane location; abolishes downstream NFkB activation. 1 PublicationCorresponds to variant dbSNP:rs1553163562EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 482 | C → G: No effect on kinase activity. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Disease mutation, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 4919 |
MalaCardsi | ROR1 |
MIMi | 617654, phenotype |
OpenTargetsi | ENSG00000185483 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA34628 |
Miscellaneous databases
Pharosi | Q01973, Tbio |
Polymorphism and mutation databases
BioMutai | ROR1 |
DMDMi | 118572711 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000024458 | 30 – 937 | Inactive tyrosine-protein kinase transmembrane receptor ROR1Add BLAST | 908 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 47 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 79 ↔ 131 | By similarity | ||
Disulfide bondi | 170 ↔ 235 | By similarity | ||
Disulfide bondi | 178 ↔ 228 | By similarity | ||
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 219 ↔ 260 | By similarity | ||
Disulfide bondi | 248 ↔ 296 | By similarity | ||
Disulfide bondi | 252 ↔ 282 | By similarity | ||
Disulfide bondi | 313 ↔ 391 | By similarity | ||
Glycosylationi | 315 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 334 ↔ 374 | By similarity | ||
Disulfide bondi | 362 ↔ 386 | By similarity | ||
Modified residuei | 645 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q01973 |
jPOSTi | Q01973 |
MassIVEi | Q01973 |
MaxQBi | Q01973 |
PaxDbi | Q01973 |
PeptideAtlasi | Q01973 |
PRIDEi | Q01973 |
ProteomicsDBi | 58025 [Q01973-1] 58026 [Q01973-2] 58027 [Q01973-3] |
PTM databases
GlyGeni | Q01973, 4 sites |
iPTMneti | Q01973 |
PhosphoSitePlusi | Q01973 |
SwissPalmi | Q01973 |
Expressioni
Tissue specificityi
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Developmental stagei
Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
Gene expression databases
Bgeei | ENSG00000185483, Expressed in lung and 181 other tissues |
ExpressionAtlasi | Q01973, baseline and differential |
Genevisiblei | Q01973, HS |
Organism-specific databases
HPAi | ENSG00000185483, Tissue enhanced (parathyroid) |
Interactioni
Binary interactionsi
Hide detailsQ01973
With | #Exp. | IntAct |
---|---|---|
EGFR [P00533] | 8 | EBI-6082337,EBI-297353 |
SRC [P12931] | 9 | EBI-6082337,EBI-621482 |
Src [P05480] from Mus musculus. | 3 | EBI-6082337,EBI-298680 |
GO - Molecular functioni
- Wnt-protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110973, 31 interactors |
DIPi | DIP-29734N |
IntActi | Q01973, 27 interactors |
MINTi | Q01973 |
STRINGi | 9606.ENSP00000360120 |
Miscellaneous databases
RNActi | Q01973, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q01973 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 147 | Ig-like C2-typeAdd BLAST | 106 | |
Domaini | 165 – 299 | FZPROSITE-ProRule annotationAdd BLAST | 135 | |
Domaini | 312 – 391 | KringlePROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 473 – 746 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 274 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 753 – 782 | Ser/Thr-richAdd BLAST | 30 | |
Compositional biasi | 784 – 851 | Pro-richAdd BLAST | 68 | |
Compositional biasi | 853 – 876 | Ser/Thr-richAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Immunoglobulin domain, Kringle, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000153947 |
HOGENOMi | CLU_701993_0_0_1 |
InParanoidi | Q01973 |
OMAi | ECWHEQS |
OrthoDBi | 471114at2759 |
PhylomeDBi | Q01973 |
TreeFami | TF106465 |
Family and domain databases
CDDi | cd00108, KR, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.20.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR016247, Tyr_kinase_rcpt_ROR |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF07679, I-set, 1 hit PF00051, Kringle, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000624, TyrPK_TMrec_ROR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00130, KR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56112, SSF56112, 1 hit SSF57440, SSF57440, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50835, IG_LIKE, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform Long (identifier: Q01973-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS
60 70 80 90 100
ELNKDSYLTL DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ
110 120 130 140 150
EPRRLSFRST IYGSRLRIRN LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF
160 170 180 190 200
GPPPTASPGY SDEYEEDGFC QPYRGIACAR FIGNRTVYME SLHMQGEIEN
210 220 230 240 250
QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS VPKPRDLCRD
260 270 280 290 300
ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG
310 320 330 340 350
IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL
360 370 380 390 400
RFPELNGGHS YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN
410 420 430 440 450
KMEILYILVP SVAIPLAIAL LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN
460 470 480 490 500
VEMSMLNAYK PKSKAKELPL SAVRFMEELG ECAFGKIYKG HLYLPGMDHA
510 520 530 540 550
QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG AVTQEQPVCM
560 570 580 590 600
LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA
610 620 630 640 650
AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS
660 670 680 690 700
KSLLPIRWMP PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE
710 720 730 740 750
VIEMVRKRQL LPCSEDCPPR MYSLMTECWN EIPSRRPRFK DIHVRLRSWE
760 770 780 790 800
GLSSHTSSTT PSGGNATTQT TSLSASPVSN LSNPRYPNYM FPSQGITPQG
810 820 830 840 850
QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG PPRVIQHCPP
860 870 880 890 900
PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT
910 920 930
VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL
Isoform Short (identifier: Q01973-2) [UniParc]FASTAAdd to basket
Also known as: T-ROR1
The sequence of this isoform differs from the canonical sequence as follows:
1-549: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTJ5 | A0A0A0MTJ5_HUMAN | Inactive tyrosine-protein kinase tr... | ROR1 | 882 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041779 | 144 | G → E in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041780 | 150 | F → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041781 | 301 | I → V in a renal clear cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041782 | 518 | T → M2 PublicationsCorresponds to variant dbSNP:rs7527017Ensembl. | 1 | |
Natural variantiVAR_035713 | 562 | E → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760789417Ensembl. | 1 | |
Natural variantiVAR_041783 | 567 | R → I in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041784 | 624 | G → R1 PublicationCorresponds to variant dbSNP:rs55832740Ensembl. | 1 | |
Natural variantiVAR_041785 | 646 | Y → C1 PublicationCorresponds to variant dbSNP:rs34109134Ensembl. | 1 | |
Natural variantiVAR_079530 | 736 | R → T in DFNB108; impairs plasma membrane location; abolishes downstream NFkB activation. 1 PublicationCorresponds to variant dbSNP:rs1553163562EnsemblClinVar. | 1 | |
Natural variantiVAR_041786 | 776 | S → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005008 | 1 – 549 | Missing in isoform Short. 1 PublicationAdd BLAST | 549 | |
Alternative sequenceiVSP_043663 | 392 – 393 | DS → GK in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_043664 | 394 – 937 | Missing in isoform 3. 1 PublicationAdd BLAST | 544 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97675 mRNA Translation: AAA60275.1 U38894 mRNA Translation: AAC50714.1 AL137859 Genomic DNA No translation available. AL161742 Genomic DNA No translation available. AL445205 Genomic DNA No translation available. AL138793 Genomic DNA No translation available. AL353713 Genomic DNA No translation available. AL808029 Genomic DNA No translation available. AL808030 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06556.1 BC080541 mRNA Translation: AAH80541.1 |
CCDSi | CCDS41344.1 [Q01973-3] CCDS626.1 [Q01973-1] |
PIRi | A45082 |
RefSeqi | NP_001077061.1, NM_001083592.1 [Q01973-3] NP_005003.2, NM_005012.3 [Q01973-1] |
Genome annotation databases
Ensembli | ENST00000371079; ENSP00000360120; ENSG00000185483 [Q01973-1] ENST00000371080; ENSP00000360121; ENSG00000185483 [Q01973-3] |
GeneIDi | 4919 |
KEGGi | hsa:4919 |
UCSCi | uc001dbi.5, human [Q01973-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97675 mRNA Translation: AAA60275.1 U38894 mRNA Translation: AAC50714.1 AL137859 Genomic DNA No translation available. AL161742 Genomic DNA No translation available. AL445205 Genomic DNA No translation available. AL138793 Genomic DNA No translation available. AL353713 Genomic DNA No translation available. AL808029 Genomic DNA No translation available. AL808030 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06556.1 BC080541 mRNA Translation: AAH80541.1 |
CCDSi | CCDS41344.1 [Q01973-3] CCDS626.1 [Q01973-1] |
PIRi | A45082 |
RefSeqi | NP_001077061.1, NM_001083592.1 [Q01973-3] NP_005003.2, NM_005012.3 [Q01973-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Z55 | NMR | - | A | 312-394 | [»] | |
6BA5 | X-ray | 1.62 | M/N/O/P | 311-391 | [»] | |
6BAN | X-ray | 1.95 | M/N/O/P | 311-391 | [»] | |
6TU9 | X-ray | 1.94 | A/B | 453-752 | [»] | |
SMRi | Q01973 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110973, 31 interactors |
DIPi | DIP-29734N |
IntActi | Q01973, 27 interactors |
MINTi | Q01973 |
STRINGi | 9606.ENSP00000360120 |
PTM databases
GlyGeni | Q01973, 4 sites |
iPTMneti | Q01973 |
PhosphoSitePlusi | Q01973 |
SwissPalmi | Q01973 |
Polymorphism and mutation databases
BioMutai | ROR1 |
DMDMi | 118572711 |
Proteomic databases
EPDi | Q01973 |
jPOSTi | Q01973 |
MassIVEi | Q01973 |
MaxQBi | Q01973 |
PaxDbi | Q01973 |
PeptideAtlasi | Q01973 |
PRIDEi | Q01973 |
ProteomicsDBi | 58025 [Q01973-1] 58026 [Q01973-2] 58027 [Q01973-3] |
Protocols and materials databases
ABCDi | Q01973, 21 sequenced antibodies |
Antibodypediai | 33360, 861 antibodies |
DNASUi | 4919 |
Genome annotation databases
Ensembli | ENST00000371079; ENSP00000360120; ENSG00000185483 [Q01973-1] ENST00000371080; ENSP00000360121; ENSG00000185483 [Q01973-3] |
GeneIDi | 4919 |
KEGGi | hsa:4919 |
UCSCi | uc001dbi.5, human [Q01973-1] |
Organism-specific databases
CTDi | 4919 |
DisGeNETi | 4919 |
EuPathDBi | HostDB:ENSG00000185483.11 |
GeneCardsi | ROR1 |
HGNCi | HGNC:10256, ROR1 |
HPAi | ENSG00000185483, Tissue enhanced (parathyroid) |
MalaCardsi | ROR1 |
MIMi | 602336, gene 617654, phenotype |
neXtProti | NX_Q01973 |
OpenTargetsi | ENSG00000185483 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA34628 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000153947 |
HOGENOMi | CLU_701993_0_0_1 |
InParanoidi | Q01973 |
OMAi | ECWHEQS |
OrthoDBi | 471114at2759 |
PhylomeDBi | Q01973 |
TreeFami | TF106465 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | Q01973 |
Reactomei | R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
SignaLinki | Q01973 |
SIGNORi | Q01973 |
Miscellaneous databases
BioGRID-ORCSi | 4919, 6 hits in 873 CRISPR screens |
ChiTaRSi | ROR1, human |
GeneWikii | ROR1 |
GenomeRNAii | 4919 |
Pharosi | Q01973, Tbio |
PROi | PR:Q01973 |
RNActi | Q01973, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185483, Expressed in lung and 181 other tissues |
ExpressionAtlasi | Q01973, baseline and differential |
Genevisiblei | Q01973, HS |
Family and domain databases
CDDi | cd00108, KR, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.20.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR016247, Tyr_kinase_rcpt_ROR |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF07679, I-set, 1 hit PF00051, Kringle, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000624, TyrPK_TMrec_ROR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00130, KR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56112, SSF56112, 1 hit SSF57440, SSF57440, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50835, IG_LIKE, 1 hit PS00021, KRINGLE_1, 1 hit PS50070, KRINGLE_2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROR1_HUMAN | |
Accessioni | Q01973Primary (citable) accession number: Q01973 Secondary accession number(s): Q5VVX6, Q66K77, Q92776 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 28, 2006 | |
Last modified: | December 2, 2020 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index