UniProtKB - Q01970 (PLCB3_HUMAN)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
PLCB3
Functioni
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
2 PublicationsCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationEC:3.1.4.111 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 332 | PROSITE-ProRule annotation | 1 | |
Active sitei | 379 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calcium ion binding Source: InterPro
- calmodulin binding Source: BHF-UCL
- phosphatidylinositol phospholipase C activity Source: UniProtKB
- phospholipase C activity Source: Reactome
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol metabolic process Source: UniProtKB
- regulation of systemic arterial blood pressure Source: MGI
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | Q01970 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors |
SignaLinki | Q01970 |
SIGNORi | Q01970 |
Chemistry databases
SwissLipidsi | SLP:000001756 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Curated (EC:3.1.4.111 Publication)Alternative name(s): Phosphoinositide phospholipase C-beta-3 Phospholipase C-beta-3 Short name: PLC-beta-3 |
Gene namesi | Name:PLCB3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9056, PLCB3 |
MIMi | 600230, gene |
neXtProti | NX_Q01970 |
VEuPathDBi | HostDB:ENSG00000149782 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- postsynaptic cytosol Source: Ensembl
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- membrane Source: UniProtKB-SubCell
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Spondylometaphyseal dysplasia with corneal dystrophy (SMDCD)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084509 | 878 | A → S in SMDCD; strong reduction in protein levels and marked increase in cellular phosphatidylinositol 4,5 bisphosphate levels in patient cells. 1 Publication | 1 |
Keywords - Diseasei
DwarfismOrganism-specific databases
DisGeNETi | 5331 |
MalaCardsi | PLCB3 |
MIMi | 618961, phenotype |
OpenTargetsi | ENSG00000149782 |
Orphaneti | 589435, Spondylometaphyseal dysplasia-corneal dystrophy syndrome |
PharmGKBi | PA33386 |
Miscellaneous databases
Pharosi | Q01970, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5449 |
Genetic variation databases
BioMutai | PLCB3 |
DMDMi | 1730573 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000088491 | 2 – 1234 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Add BLAST | 1233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 474 | PhosphoserineCombined sources | 1 | |
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 | |
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 926 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1105 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q01970 |
jPOSTi | Q01970 |
MassIVEi | Q01970 |
MaxQBi | Q01970 |
PaxDbi | Q01970 |
PeptideAtlasi | Q01970 |
PRIDEi | Q01970 |
ProteomicsDBi | 33840 58024 [Q01970-1] |
PTM databases
iPTMneti | Q01970 |
PhosphoSitePlusi | Q01970 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149782, Expressed in duodenum and 196 other tissues |
Genevisiblei | Q01970, HS |
Organism-specific databases
HPAi | ENSG00000149782, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Interacts with SHANK2 (By similarity).
Interacts with LPAR2 (PubMed:15143197).
By similarity1 PublicationBinary interactionsi
Q01970
With | #Exp. | IntAct |
---|---|---|
Gnaq [P21279] from Mus musculus. | 6 | EBI-4289548,EBI-771975 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111347, 60 interactors |
CORUMi | Q01970 |
DIPi | DIP-41928N |
IntActi | Q01970, 8 interactors |
MINTi | Q01970 |
STRINGi | 9606.ENSP00000443631 |
Chemistry databases
BindingDBi | Q01970 |
Miscellaneous databases
RNActi | Q01970, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q01970 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 318 – 468 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 151 | |
Domaini | 590 – 706 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 707 – 835 | C2PROSITE-ProRule annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 467 – 587 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 887 – 937 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 1198 – 1234 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1231 – 1234 | Interaction with SHANK2By similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 485 – 519 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 887 – 909 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 910 – 924 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1214 – 1234 | Polar residuesSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG1265, Eukaryota |
GeneTreei | ENSGT00940000160539 |
HOGENOMi | CLU_002738_2_0_1 |
InParanoidi | Q01970 |
OMAi | TWEVFLK |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q01970 |
TreeFami | TF313216 |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
DisProti | DP02477 |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF
60 70 80 90 100
FLYWTGPNME VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE
110 120 130 140 150
EKLMTVVSGP DPVNTVFLNF MAVQDDTAKV WSEELFKLAM NILAQNASRN
160 170 180 190 200
TFLRKAYTKL KLQVNQDGRI PVKNILKMFS ADKKRVETAL ESCGLKFNRS
210 220 230 240 250
ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY LTLEQLMDFI
260 270 280 290 300
NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL
310 320 330 340 350
GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY
360 370 380 390 400
RQALLWGCRC VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA
410 420 430 440 450
FKTSPYPVIL SFENHVDSAK QQAKMAEYCR SIFGDALLIE PLDKYPLAPG
460 470 480 490 500
VPLPSPQDLM GRILVKNKKR HRPSAGGPDS AGRKRPLEQS NSALSESSAA
510 520 530 540 550
TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD EGLNRGPYVL
560 570 580 590 600
GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV
610 620 630 640 650
KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK
660 670 680 690 700
GTRVDSSNYM PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL
710 720 730 740 750
KPEFMRRPDK SFDPFTEVIV DGIVANALRV KVISGQFLSD RKVGIYVEVD
760 770 780 790 800
MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP FDFPKVVLPT LASLRIAAFE
810 820 830 840 850
EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI YTEASDYIPD
860 870 880 890 900
DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL
910 920 930 940 950
GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA
960 970 980 990 1000
PTPLDELRGH KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ
1010 1020 1030 1040 1050
AEGRCRLRPG ALGGAADVED TKEGEDEAKR YQEFQNRQVQ SLLELREAQV
1060 1070 1080 1090 1100
DAEAQRRLEH LRQALQRLRE VVLDANTTQF KRLKEMNERE KKELQKILDR
1110 1120 1130 1140 1150
KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE EAQKQRHDRL
1160 1170 1180 1190 1200
VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG
1210 1220 1230
DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 845 | S → L in CAA78903 (PubMed:1333955).Curated | 1 | |
Sequence conflicti | 881 | G → E in CAA85776 (PubMed:7607669).Curated | 1 | |
Sequence conflicti | 1089 – 1119 | REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776 (PubMed:7607669).CuratedAdd BLAST | 31 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029229 | 483 | R → H. Corresponds to variant dbSNP:rs12146487Ensembl. | 1 | |
Natural variantiVAR_084509 | 878 | A → S in SMDCD; strong reduction in protein levels and marked increase in cellular phosphatidylinositol 4,5 bisphosphate levels in patient cells. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046054 | 33 – 99 | Missing in isoform 2. 1 PublicationAdd BLAST | 67 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26425 Genomic DNA Translation: AAA77683.1 Z37544 , Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA Translation: CAA85776.1 AP001453 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74230.1 CH471076 Genomic DNA Translation: EAW74231.1 BC032659 mRNA Translation: AAH32659.1 Different initiation. BC142681 mRNA Translation: AAI42682.1 Z16411 mRNA Translation: CAA78903.1 |
CCDSi | CCDS53654.1 [Q01970-2] CCDS8064.1 [Q01970-1] |
PIRi | I38994 S27002 S52099 |
RefSeqi | NP_000923.1, NM_000932.2 [Q01970-1] NP_001171812.1, NM_001184883.1 [Q01970-2] NP_001303243.1, NM_001316314.1 [Q01970-1] |
Genome annotation databases
Ensembli | ENST00000279230; ENSP00000279230; ENSG00000149782 ENST00000325234; ENSP00000324660; ENSG00000149782 [Q01970-2] ENST00000540288; ENSP00000443631; ENSG00000149782 |
GeneIDi | 5331 |
KEGGi | hsa:5331 |
MANE-Selecti | ENST00000279230.12; ENSP00000279230.6; NM_000932.5; NP_000923.1 |
UCSCi | uc009ypg.3, human [Q01970-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26425 Genomic DNA Translation: AAA77683.1 Z37544 , Z37545, Z37546, Z37547, Z37548, Z37549, Z37550, Z37551, Z37552, Z37553, Z37554, Z37555, Z37556, Z37557, Z37558, Z37559, Z37560, Z37561, Z37562, Z37564, Z37565, Z37566, Z37567, Z37568, Z37569, Z37570, Z37571, Z37572, Z37573, Z37574 Genomic DNA Translation: CAA85776.1 AP001453 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74230.1 CH471076 Genomic DNA Translation: EAW74231.1 BC032659 mRNA Translation: AAH32659.1 Different initiation. BC142681 mRNA Translation: AAI42682.1 Z16411 mRNA Translation: CAA78903.1 |
CCDSi | CCDS53654.1 [Q01970-2] CCDS8064.1 [Q01970-1] |
PIRi | I38994 S27002 S52099 |
RefSeqi | NP_000923.1, NM_000932.2 [Q01970-1] NP_001171812.1, NM_001184883.1 [Q01970-2] NP_001303243.1, NM_001316314.1 [Q01970-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4GNK | X-ray | 4.00 | B/D | 10-1234 | [»] | |
E | 934-1192 | [»] | ||||
4QJ3 | X-ray | 3.00 | B | 10-891 | [»] | |
4QJ4 | X-ray | 3.30 | B | 10-891 | [»] | |
4QJ5 | X-ray | 3.41 | B | 10-891 | [»] | |
7SQ2 | X-ray | 2.60 | B | 10-886 | [»] | |
SMRi | Q01970 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111347, 60 interactors |
CORUMi | Q01970 |
DIPi | DIP-41928N |
IntActi | Q01970, 8 interactors |
MINTi | Q01970 |
STRINGi | 9606.ENSP00000443631 |
Chemistry databases
BindingDBi | Q01970 |
ChEMBLi | CHEMBL5449 |
SwissLipidsi | SLP:000001756 |
PTM databases
iPTMneti | Q01970 |
PhosphoSitePlusi | Q01970 |
Genetic variation databases
BioMutai | PLCB3 |
DMDMi | 1730573 |
Proteomic databases
EPDi | Q01970 |
jPOSTi | Q01970 |
MassIVEi | Q01970 |
MaxQBi | Q01970 |
PaxDbi | Q01970 |
PeptideAtlasi | Q01970 |
PRIDEi | Q01970 |
ProteomicsDBi | 33840 58024 [Q01970-1] |
Protocols and materials databases
Antibodypediai | 3983, 404 antibodies from 36 providers |
DNASUi | 5331 |
Genome annotation databases
Ensembli | ENST00000279230; ENSP00000279230; ENSG00000149782 ENST00000325234; ENSP00000324660; ENSG00000149782 [Q01970-2] ENST00000540288; ENSP00000443631; ENSG00000149782 |
GeneIDi | 5331 |
KEGGi | hsa:5331 |
MANE-Selecti | ENST00000279230.12; ENSP00000279230.6; NM_000932.5; NP_000923.1 |
UCSCi | uc009ypg.3, human [Q01970-1] |
Organism-specific databases
CTDi | 5331 |
DisGeNETi | 5331 |
GeneCardsi | PLCB3 |
HGNCi | HGNC:9056, PLCB3 |
HPAi | ENSG00000149782, Tissue enhanced (intestine) |
MalaCardsi | PLCB3 |
MIMi | 600230, gene 618961, phenotype |
neXtProti | NX_Q01970 |
OpenTargetsi | ENSG00000149782 |
Orphaneti | 589435, Spondylometaphyseal dysplasia-corneal dystrophy syndrome |
PharmGKBi | PA33386 |
VEuPathDBi | HostDB:ENSG00000149782 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1265, Eukaryota |
GeneTreei | ENSGT00940000160539 |
HOGENOMi | CLU_002738_2_0_1 |
InParanoidi | Q01970 |
OMAi | TWEVFLK |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q01970 |
TreeFami | TF313216 |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | Q01970 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors |
SignaLinki | Q01970 |
SIGNORi | Q01970 |
Miscellaneous databases
BioGRID-ORCSi | 5331, 15 hits in 1043 CRISPR screens |
ChiTaRSi | PLCB3, human |
GeneWikii | PLCB3 |
GenomeRNAii | 5331 |
Pharosi | Q01970, Tbio |
PROi | PR:Q01970 |
RNActi | Q01970, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149782, Expressed in duodenum and 196 other tissues |
Genevisiblei | Q01970, HS |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
DisProti | DP02477 |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCB3_HUMAN | |
Accessioni | Q01970Primary (citable) accession number: Q01970 Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 212 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references