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UniProtKB - Q01970 (PLCB3_HUMAN)

Entry version 212 (23 Feb 2022)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Gene

PLCB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei332PROSITE-ProRule annotation1
Active sitei379PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.4.11, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01970

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-112043, PLC beta mediated events
R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol
R-HSA-399997, Acetylcholine regulates insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-500657, Presynaptic function of Kainate receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q01970

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01970

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001756

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Curated (EC:3.1.4.111 Publication)
Alternative name(s):
Phosphoinositide phospholipase C-beta-3
Phospholipase C-beta-3
Short name:
PLC-beta-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLCB3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9056, PLCB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600230, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01970

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149782

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondylometaphyseal dysplasia with corneal dystrophy (SMDCD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by postnatal growth deficiency, profound limb shortening with proximal and distal segments involvement, narrow chest, radiological abnormalities involving the spine, pelvis and metaphyses, corneal clouding, and intellectual disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_084509878A → S in SMDCD; strong reduction in protein levels and marked increase in cellular phosphatidylinositol 4,5 bisphosphate levels in patient cells. 1 Publication1

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		5331

MalaCards human disease database

More...MalaCardsi		PLCB3
MIMi618961, phenotype

Open Targets

More...OpenTargetsi		ENSG00000149782

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		589435, Spondylometaphyseal dysplasia-corneal dystrophy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33386

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01970, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5449

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLCB3

Domain mapping of disease mutations (DMDM)

More...DMDMi		1730573

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000884912 – 12341-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Add BLAST1233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei926PhosphoserineCombined sources1
Modified residuei1105PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q01970

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01970

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01970

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q01970

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01970

PeptideAtlas

More...PeptideAtlasi		Q01970

PRoteomics IDEntifications database

More...PRIDEi		Q01970

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33840
58024 [Q01970-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01970

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01970

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149782, Expressed in duodenum and 196 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01970, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149782, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHANK2 (By similarity).

Interacts with LPAR2 (PubMed:15143197).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111347, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q01970

Database of interacting proteins

More...DIPi		DIP-41928N

Protein interaction database and analysis system

More...IntActi		Q01970, 8 interactors

Molecular INTeraction database

More...MINTi		Q01970

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000443631

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q01970

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01970, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01970

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini318 – 468PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST151
Domaini590 – 706PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini707 – 835C2PROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni467 – 587DisorderedSequence analysisAdd BLAST121
Regioni887 – 937DisorderedSequence analysisAdd BLAST51
Regioni1198 – 1234DisorderedSequence analysisAdd BLAST37
Regioni1231 – 1234Interaction with SHANK2By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi485 – 519Polar residuesSequence analysisAdd BLAST35
Compositional biasi887 – 909Polar residuesSequence analysisAdd BLAST23
Compositional biasi910 – 924Pro residuesSequence analysisAdd BLAST15
Compositional biasi1214 – 1234Polar residuesSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1265, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002738_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01970

Identification of Orthologs from Complete Genome Data

More...OMAi		TWEVFLK

Database of Orthologous Groups

More...OrthoDBi		368239at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01970

TreeFam database of animal gene trees

More...TreeFami		TF313216

Family and domain databases

Conserved Domains Database

More...CDDi		cd13361, PH_PLC_beta, 1 hit

Database of protein disorder

More...DisProti		DP02477

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1230.10, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR016280, PLC-beta
IPR014815, PLC-beta_C
IPR042531, PLC-beta_C_sf
IPR037862, PLC-beta_PH
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...PANTHERi		PTHR10336, PTHR10336, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF09279, EF-hand_like, 1 hit
PF17787, PH_14, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PF08703, PLC-beta_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000956, PLC-beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00390, PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF49562, SSF49562, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q01970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF 
        60         70         80         90        100
FLYWTGPNME VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE 
       110        120        130        140        150
EKLMTVVSGP DPVNTVFLNF MAVQDDTAKV WSEELFKLAM NILAQNASRN 
       160        170        180        190        200
TFLRKAYTKL KLQVNQDGRI PVKNILKMFS ADKKRVETAL ESCGLKFNRS 
       210        220        230        240        250
ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY LTLEQLMDFI 
       260        270        280        290        300
NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL 
       310        320        330        340        350
GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY 
       360        370        380        390        400
RQALLWGCRC VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA 
       410        420        430        440        450
FKTSPYPVIL SFENHVDSAK QQAKMAEYCR SIFGDALLIE PLDKYPLAPG 
       460        470        480        490        500
VPLPSPQDLM GRILVKNKKR HRPSAGGPDS AGRKRPLEQS NSALSESSAA 
       510        520        530        540        550
TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD EGLNRGPYVL 
       560        570        580        590        600
GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV 
       610        620        630        640        650
KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK 
       660        670        680        690        700
GTRVDSSNYM PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL 
       710        720        730        740        750
KPEFMRRPDK SFDPFTEVIV DGIVANALRV KVISGQFLSD RKVGIYVEVD 
       760        770        780        790        800
MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP FDFPKVVLPT LASLRIAAFE 
       810        820        830        840        850
EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI YTEASDYIPD 
       860        870        880        890        900
DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL 
       910        920        930        940        950
GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA 
       960        970        980        990       1000
PTPLDELRGH KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ 
      1010       1020       1030       1040       1050
AEGRCRLRPG ALGGAADVED TKEGEDEAKR YQEFQNRQVQ SLLELREAQV 
      1060       1070       1080       1090       1100
DAEAQRRLEH LRQALQRLRE VVLDANTTQF KRLKEMNERE KKELQKILDR 
      1110       1120       1130       1140       1150
KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE EAQKQRHDRL 
      1160       1170       1180       1190       1200
VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG 
      1210       1220       1230 
DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL
Length:1,234
Mass (Da):138,799
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5106EFBA8037788
GO
Isoform 2 (identifier: Q01970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-99: Missing.

Show »
Length:1,167
Mass (Da):131,205
Checksum:i597C35D7C25D4773
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32659 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti845S → L in CAA78903 (PubMed:1333955).Curated1
Sequence conflicti881G → E in CAA85776 (PubMed:7607669).Curated1
Sequence conflicti1089 – 1119REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776 (PubMed:7607669).CuratedAdd BLAST31

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029229483R → H. Corresponds to variant dbSNP:rs12146487Ensembl.1
Natural variantiVAR_084509878A → S in SMDCD; strong reduction in protein levels and marked increase in cellular phosphatidylinositol 4,5 bisphosphate levels in patient cells. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04605433 – 99Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U26425 Genomic DNA Translation: AAA77683.1
Z37544 Z37574 Genomic DNA Translation: CAA85776.1
AP001453 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74230.1
CH471076 Genomic DNA Translation: EAW74231.1
BC032659 mRNA Translation: AAH32659.1 Different initiation.
BC142681 mRNA Translation: AAI42682.1
Z16411 mRNA Translation: CAA78903.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53654.1 [Q01970-2]
CCDS8064.1 [Q01970-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38994
S27002
S52099

NCBI Reference Sequences

More...RefSeqi		NP_000923.1, NM_000932.2 [Q01970-1]
NP_001171812.1, NM_001184883.1 [Q01970-2]
NP_001303243.1, NM_001316314.1 [Q01970-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000279230; ENSP00000279230; ENSG00000149782
ENST00000325234; ENSP00000324660; ENSG00000149782 [Q01970-2]
ENST00000540288; ENSP00000443631; ENSG00000149782

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5331

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000279230.12; ENSP00000279230.6; NM_000932.5; NP_000923.1

UCSC genome browser

More...UCSCi		uc009ypg.3, human [Q01970-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26425 Genomic DNA Translation: AAA77683.1
Z37544 Z37574 Genomic DNA Translation: CAA85776.1
AP001453 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74230.1
CH471076 Genomic DNA Translation: EAW74231.1
BC032659 mRNA Translation: AAH32659.1 Different initiation.
BC142681 mRNA Translation: AAI42682.1
Z16411 mRNA Translation: CAA78903.1
CCDSiCCDS53654.1 [Q01970-2]
CCDS8064.1 [Q01970-1]
PIRiI38994
S27002
S52099
RefSeqiNP_000923.1, NM_000932.2 [Q01970-1]
NP_001171812.1, NM_001184883.1 [Q01970-2]
NP_001303243.1, NM_001316314.1 [Q01970-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GNKX-ray4.00B/D10-1234[»]
E934-1192[»]
4QJ3X-ray3.00B10-891[»]
4QJ4X-ray3.30B10-891[»]
4QJ5X-ray3.41B10-891[»]
7SQ2X-ray2.60B10-886[»]
SMRiQ01970
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111347, 60 interactors
CORUMiQ01970
DIPiDIP-41928N
IntActiQ01970, 8 interactors
MINTiQ01970
STRINGi9606.ENSP00000443631

Chemistry databases

BindingDBiQ01970
ChEMBLiCHEMBL5449
SwissLipidsiSLP:000001756

PTM databases

iPTMnetiQ01970
PhosphoSitePlusiQ01970

Genetic variation databases

BioMutaiPLCB3
DMDMi1730573

Proteomic databases

EPDiQ01970
jPOSTiQ01970
MassIVEiQ01970
MaxQBiQ01970
PaxDbiQ01970
PeptideAtlasiQ01970
PRIDEiQ01970
ProteomicsDBi33840
58024 [Q01970-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3983, 404 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		5331

Genome annotation databases

EnsembliENST00000279230; ENSP00000279230; ENSG00000149782
ENST00000325234; ENSP00000324660; ENSG00000149782 [Q01970-2]
ENST00000540288; ENSP00000443631; ENSG00000149782
GeneIDi5331
KEGGihsa:5331
MANE-SelectiENST00000279230.12; ENSP00000279230.6; NM_000932.5; NP_000923.1
UCSCiuc009ypg.3, human [Q01970-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5331
DisGeNETi5331

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLCB3
HGNCiHGNC:9056, PLCB3
HPAiENSG00000149782, Tissue enhanced (intestine)
MalaCardsiPLCB3
MIMi600230, gene
618961, phenotype
neXtProtiNX_Q01970
OpenTargetsiENSG00000149782
Orphaneti589435, Spondylometaphyseal dysplasia-corneal dystrophy syndrome
PharmGKBiPA33386
VEuPathDBiHostDB:ENSG00000149782

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1265, Eukaryota
GeneTreeiENSGT00940000160539
HOGENOMiCLU_002738_2_0_1
InParanoidiQ01970
OMAiTWEVFLK
OrthoDBi368239at2759
PhylomeDBiQ01970
TreeFamiTF313216

Enzyme and pathway databases

BRENDAi3.1.4.11, 2681
PathwayCommonsiQ01970
ReactomeiR-HSA-112043, PLC beta mediated events
R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol
R-HSA-399997, Acetylcholine regulates insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-500657, Presynaptic function of Kainate receptors
SignaLinkiQ01970
SIGNORiQ01970

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5331, 15 hits in 1043 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLCB3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PLCB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5331
PharosiQ01970, Tbio

Protein Ontology

More...PROi		PR:Q01970
RNActiQ01970, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149782, Expressed in duodenum and 196 other tissues
GenevisibleiQ01970, HS

Family and domain databases

CDDicd13361, PH_PLC_beta, 1 hit
DisProtiDP02477
Gene3Di1.20.1230.10, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR016280, PLC-beta
IPR014815, PLC-beta_C
IPR042531, PLC-beta_C_sf
IPR037862, PLC-beta_PH
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336, PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF09279, EF-hand_like, 1 hit
PF17787, PH_14, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PF08703, PLC-beta_C, 1 hit
PIRSFiPIRSF000956, PLC-beta, 1 hit
PRINTSiPR00390, PHPHLIPASEC
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49562, SSF49562, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCB3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01970
Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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