PLCB3

Functionⁱ

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.1 Publication

Catalytic activityⁱ

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
1D-myo-inositol 1,4,5-trisphosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs."
  Tall E., Dorman G., Garcia P., Runnels L., Shah S., Chen J., Profit A., Gu Q.M., Chaudhary A., Prestwich G.D., Rebecchi M.J.
  Biochemistry 36:7239-7248(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
EC:
3.1.4.11
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs."
  Tall E., Dorman G., Garcia P., Runnels L., Shah S., Chen J., Profit A., Gu Q.M., Chaudhary A., Prestwich G.D., Rebecchi M.J.
  Biochemistry 36:7239-7248(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.7
  "Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs."
  Tall E., Dorman G., Garcia P., Runnels L., Shah S., Chen J., Profit A., Gu Q.M., Chaudhary A., Prestwich G.D., Rebecchi M.J.
  Biochemistry 36:7239-7248(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
zoom
+
H₂O
=
1D-myo-inositol 1,4,5-trisphosphate
zoom
+
a 1,2-diacyl-sn-glycerol
zoom
+
H⁺
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
1D-myo-inositol 1-phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q99JE6 (PLCB3_RAT)
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q99JE6 (PLCB3_RAT)
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
zoom
+
H₂O
=
1D-myo-inositol 1-phosphate
zoom
+
a 1,2-diacyl-sn-glycerol
zoom
+
H⁺

Cofactorⁱ

Ca²⁺

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	332	PROSITE-ProRule annotation		1
Active siteⁱ	379	PROSITE-ProRule annotation		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Transducer
Biological process	Lipid degradation, Lipid metabolism
Ligand	Calcium

Enzyme and pathway databases

BRENDAⁱ	3.1.4.11, 2681
PathwayCommonsⁱ	Q01970
Reactomeⁱ	R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors
SIGNORⁱ	Q01970

Chemistry databases

SwissLipidsⁱ	SLP:000001756

SwissLipidsⁱ

SLP:000001756

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Curated (EC:3.1.4.111 Publication) Alternative name(s): Phosphoinositide phospholipase C-beta-3 Phospholipase C-beta-3 Short name: PLC-beta-3
Gene namesⁱ	Name:PLCB3Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9056, PLCB3
MIMⁱ	600230, gene
neXtProtⁱ	NX_Q01970
VEuPathDBⁱ	HostDB:ENSG00000149782.11

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5331
Open Targets More...OpenTargetsⁱ	ENSG00000149782
PharmGKBⁱ	PA33386

Miscellaneous databases

Pharosⁱ	Q01970, Tbio

Pharosⁱ

Q01970, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL5449

ChEMBLⁱ

CHEMBL5449

Genetic variation databases

BioMutaⁱ	PLCB3
DMDMⁱ	1730573

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000088491	2 – 1234	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3Add BLAST		1233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	474	PhosphoserineCombined sources	1
Modified residueⁱ	490	PhosphoserineCombined sources	1
Modified residueⁱ	495	PhosphoserineCombined sources	1
Modified residueⁱ	537	PhosphoserineCombined sources	1
Modified residueⁱ	926	PhosphoserineCombined sources	1
Modified residueⁱ	1105	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q01970
jPOSTⁱ	Q01970
MassIVEⁱ	Q01970
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01970
PaxDbⁱ	Q01970
PeptideAtlas More...PeptideAtlasⁱ	Q01970
PRIDEⁱ	Q01970
ProteomicsDBⁱ	33840 58024 [Q01970-1]

PTM databases

iPTMnetⁱ	Q01970
PhosphoSitePlusⁱ	Q01970

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000149782, Expressed in duodenum and 195 other tissues
Genevisibleⁱ	Q01970, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000149782, Tissue enriched (intestine)

HPAⁱ

ENSG00000149782, Tissue enriched (intestine)

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

Q01970

With	#Exp.	IntAct
Gnaq [P21279] from Mus musculus.	6	EBI-4289548,EBI-771975

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111347, 29 interactors
CORUMⁱ	Q01970
Database of interacting proteins More...DIPⁱ	DIP-41928N
IntActⁱ	Q01970, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q01970
STRINGⁱ	9606.ENSP00000443631

Chemistry databases

BindingDBⁱ

Q01970

Miscellaneous databases

RNActⁱ	Q01970, protein

RNActⁱ

Q01970, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	20 – 24	Combined sources	5
Beta strandⁱ	26 – 31	Combined sources	6
Beta strandⁱ	33 – 35	Combined sources	3
Beta strandⁱ	40 – 45	Combined sources	6
Beta strandⁱ	51 – 55	Combined sources	5
Helixⁱ	57 – 59	Combined sources	3
Beta strandⁱ	61 – 65	Combined sources	5
Helixⁱ	66 – 68	Combined sources	3
Beta strandⁱ	69 – 74	Combined sources	6
Turnⁱ	75 – 77	Combined sources	3
Helixⁱ	84 – 88	Combined sources	5
Helixⁱ	97 – 101	Combined sources	5
Beta strandⁱ	103 – 108	Combined sources	6
Helixⁱ	112 – 114	Combined sources	3
Beta strandⁱ	116 – 126	Combined sources	11
Helixⁱ	127 – 140	Combined sources	14
Helixⁱ	142 – 145	Combined sources	4
Helixⁱ	149 – 162	Combined sources	14
Helixⁱ	172 – 177	Combined sources	6
Helixⁱ	180 – 182	Combined sources	3
Helixⁱ	183 – 191	Combined sources	9
Turnⁱ	192 – 194	Combined sources	3
Helixⁱ	205 – 207	Combined sources	3
Helixⁱ	210 – 220	Combined sources	11
Helixⁱ	224 – 232	Combined sources	9
Helixⁱ	243 – 253	Combined sources	11
Turnⁱ	261 – 263	Combined sources	3
Helixⁱ	269 – 279	Combined sources	11
Helixⁱ	283 – 287	Combined sources	5
Helixⁱ	293 – 300	Combined sources	8
Beta strandⁱ	302 – 305	Combined sources	4
Helixⁱ	310 – 313	Combined sources	4
Helixⁱ	323 – 325	Combined sources	3
Beta strandⁱ	326 – 328	Combined sources	3
Beta strandⁱ	331 – 333	Combined sources	3
Beta strandⁱ	336 – 338	Combined sources	3
Beta strandⁱ	340 – 343	Combined sources	4
Helixⁱ	348 – 355	Combined sources	8
Beta strandⁱ	360 – 366	Combined sources	7
Beta strandⁱ	370 – 372	Combined sources	3
Beta strandⁱ	382 – 384	Combined sources	3
Helixⁱ	389 – 399	Combined sources	11
Turnⁱ	400 – 402	Combined sources	3
Beta strandⁱ	408 – 415	Combined sources	8
Helixⁱ	421 – 433	Combined sources	13
Helixⁱ	434 – 436	Combined sources	3
Beta strandⁱ	443 – 445	Combined sources	3
Beta strandⁱ	447 – 450	Combined sources	4
Turnⁱ	456 – 461	Combined sources	6
Beta strandⁱ	463 – 466	Combined sources	4
Helixⁱ	578 – 580	Combined sources	3
Helixⁱ	588 – 591	Combined sources	4
Beta strandⁱ	596 – 599	Combined sources	4
Helixⁱ	605 – 611	Combined sources	7
Beta strandⁱ	616 – 621	Combined sources	6
Helixⁱ	622 – 631	Combined sources	10
Helixⁱ	633 – 642	Combined sources	10
Beta strandⁱ	645 – 648	Combined sources	4
Helixⁱ	662 – 665	Combined sources	4
Turnⁱ	666 – 668	Combined sources	3
Beta strandⁱ	670 – 672	Combined sources	3
Helixⁱ	681 – 690	Combined sources	10
Helixⁱ	693 – 695	Combined sources	3
Beta strandⁱ	697 – 700	Combined sources	4
Helixⁱ	703 – 705	Combined sources	3
Beta strandⁱ	726 – 737	Combined sources	12
Beta strandⁱ	740 – 742	Combined sources	3
Beta strandⁱ	745 – 754	Combined sources	10
Turnⁱ	755 – 757	Combined sources	3
Beta strandⁱ	759 – 763	Combined sources	5
Beta strandⁱ	771 – 773	Combined sources	3
Beta strandⁱ	781 – 787	Combined sources	7
Helixⁱ	789 – 791	Combined sources	3
Beta strandⁱ	793 – 800	Combined sources	8
Turnⁱ	801 – 803	Combined sources	3
Beta strandⁱ	804 – 812	Combined sources	9
Turnⁱ	813 – 815	Combined sources	3
Beta strandⁱ	819 – 826	Combined sources	8
Beta strandⁱ	832 – 846	Combined sources	15
Helixⁱ	850 – 852	Combined sources	3
Helixⁱ	853 – 860	Combined sources	8
Helixⁱ	862 – 875	Combined sources	14
Helixⁱ	877 – 880	Combined sources	4

Show more details

3D structure databases

SMRⁱ	Q01970
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	318 – 468	PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST	151
Domainⁱ	590 – 706	PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST	117
Domainⁱ	707 – 835	C2PROSITE-ProRule annotationAdd BLAST	129

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1231 – 1234	Interaction with SHANK2By similarity		4

Phylogenomic databases

eggNOGⁱ	KOG1265, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000160539
HOGENOMⁱ	CLU_002738_2_0_1
InParanoidⁱ	Q01970
OMAⁱ	DFWNGKF
Database of Orthologous Groups More...OrthoDBⁱ	368239at2759
PhylomeDBⁱ	Q01970
TreeFamⁱ	TF313216

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13361, PH_PLC_beta, 1 hit
Database of protein disorder More...DisProtⁱ	DP02477
Gene3Dⁱ	1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336, PTHR10336, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit
PIRSFⁱ	PIRSF000956, PLC-beta, 1 hit
PRINTSⁱ	PR00390, PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit
SUPFAMⁱ	SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q01970-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF 
        60         70         80         90        100
FLYWTGPNME VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE 
       110        120        130        140        150
EKLMTVVSGP DPVNTVFLNF MAVQDDTAKV WSEELFKLAM NILAQNASRN 
       160        170        180        190        200
TFLRKAYTKL KLQVNQDGRI PVKNILKMFS ADKKRVETAL ESCGLKFNRS 
       210        220        230        240        250
ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY LTLEQLMDFI 
       260        270        280        290        300
NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL 
       310        320        330        340        350
GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY 
       360        370        380        390        400
RQALLWGCRC VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA 
       410        420        430        440        450
FKTSPYPVIL SFENHVDSAK QQAKMAEYCR SIFGDALLIE PLDKYPLAPG 
       460        470        480        490        500
VPLPSPQDLM GRILVKNKKR HRPSAGGPDS AGRKRPLEQS NSALSESSAA 
       510        520        530        540        550
TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD EGLNRGPYVL 
       560        570        580        590        600
GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV 
       610        620        630        640        650
KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK 
       660        670        680        690        700
GTRVDSSNYM PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL 
       710        720        730        740        750
KPEFMRRPDK SFDPFTEVIV DGIVANALRV KVISGQFLSD RKVGIYVEVD 
       760        770        780        790        800
MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP FDFPKVVLPT LASLRIAAFE 
       810        820        830        840        850
EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI YTEASDYIPD 
       860        870        880        890        900
DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL 
       910        920        930        940        950
GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA 
       960        970        980        990       1000
PTPLDELRGH KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ 
      1010       1020       1030       1040       1050
AEGRCRLRPG ALGGAADVED TKEGEDEAKR YQEFQNRQVQ SLLELREAQV 
      1060       1070       1080       1090       1100
DAEAQRRLEH LRQALQRLRE VVLDANTTQF KRLKEMNERE KKELQKILDR 
      1110       1120       1130       1140       1150
KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE EAQKQRHDRL 
      1160       1170       1180       1190       1200
VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG 
      1210       1220       1230 
DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL

Length:1,234

Mass (Da):138,799

Last modified:October 1, 1996 - v2

Checksum:ⁱC5106EFBA8037788

GO

Isoform 2 (identifier: Q01970-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
33-99: Missing.

« Hide

        10         20         30         40         50
MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEEKLMTVV SGPDPVNTVF 
        60         70         80         90        100
LNFMAVQDDT AKVWSEELFK LAMNILAQNA SRNTFLRKAY TKLKLQVNQD 
       110        120        130        140        150
GRIPVKNILK MFSADKKRVE TALESCGLKF NRSESIRPDE FSLEIFERFL 
       160        170        180        190        200
NKLCLRPDID KILLEIGAKG KPYLTLEQLM DFINQKQRDP RLNEVLYPPL 
       210        220        230        240        250
RPSQARLLIE KYEPNQQFLE RDQMSMEGFS RYLGGEENGI LPLEALDLST 
       260        270        280        290        300
DMTQPLSAYF INSSHNTYLT AGQLAGTSSV EMYRQALLWG CRCVELDVWK 
       310        320        330        340        350
GRPPEEEPFI THGFTMTTEV PLRDVLEAIA ETAFKTSPYP VILSFENHVD 
       360        370        380        390        400
SAKQQAKMAE YCRSIFGDAL LIEPLDKYPL APGVPLPSPQ DLMGRILVKN 
       410        420        430        440        450
KKRHRPSAGG PDSAGRKRPL EQSNSALSES SAATEPSSPQ LGSPSSDSCP 
       460        470        480        490        500
GLSNGEEVGL EKPSLEPQKS LGDEGLNRGP YVLGPADRED EEEDEEEEEQ 
       510        520        530        540        550
TDPKKPTTDE GTASSEVNAT EEMSTLVNYI EPVKFKSFEA ARKRNKCFEM 
       560        570        580        590        600
SSFVETKAME QLTKSPMEFV EYNKQQLSRI YPKGTRVDSS NYMPQLFWNV 
       610        620        630        640        650
GCQLVALNFQ TLDVAMQLNA GVFEYNGRSG YLLKPEFMRR PDKSFDPFTE 
       660        670        680        690        700
VIVDGIVANA LRVKVISGQF LSDRKVGIYV EVDMFGLPVD TRRKYRTRTS 
       710        720        730        740        750
QGNSFNPVWD EEPFDFPKVV LPTLASLRIA AFEEGGKFVG HRILPVSAIR 
       760        770        780        790        800
SGYHYVCLRN EANQPLCLPA LLIYTEASDY IPDDHQDYAE ALINPIKHVS 
       810        820        830        840        850
LMDQRARQLA ALIGESEAQA GQETCQDTQS QQLGSQPSSN PTPSPLDASP 
       860        870        880        890        900
RRPPGPTTSP ASTSLSSPGQ RDDLIASILS EVAPTPLDEL RGHKALVKLR 
       910        920        930        940        950
SRQERDLREL RKKHQRKAVT LTRRLLDGLA QAQAEGRCRL RPGALGGAAD 
       960        970        980        990       1000
VEDTKEGEDE AKRYQEFQNR QVQSLLELRE AQVDAEAQRR LEHLRQALQR 
      1010       1020       1030       1040       1050
LREVVLDANT TQFKRLKEMN EREKKELQKI LDRKRHNSIS EAKMRDKHKK 
      1060       1070       1080       1090       1100
EAELTEINRR HITESVNSIR RLEEAQKQRH DRLVAGQQQV LQQLAEEEPK 
      1110       1120       1130       1140       1150
LLAQLAQECQ EQRARLPQEI RRSLLGEMPE GLGDGPLVAC ASNGHAPGSS 
      1160 
GHLSGADSES QEENTQL

Show »

Length:1,167

Mass (Da):131,205

Checksum:ⁱ597C35D7C25D4773

GO

Sequence cautionⁱ

The sequence AAH32659 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	845	S → L in CAA78903 (PubMed:1333955).Curated	1
Sequence conflictⁱ	881	G → E in CAA85776 (PubMed:7607669).Curated	1
Sequence conflictⁱ	1089 – 1119	REKKE…HKKEA → SWPSWPRSVRSSGRGSPRRS AGACWARCRRG in CAA85776 (PubMed:7607669).CuratedAdd BLAST	31

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029229	483	R → H. Corresponds to variant dbSNP:rs12146487Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046054	33 – 99	Missing in isoform 2. 1 PublicationAdd BLAST		67

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U26425 Genomic DNA Translation: AAA77683.1 Z37544 Z37574 Genomic DNA Translation: CAA85776.1 AP001453 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74230.1 CH471076 Genomic DNA Translation: EAW74231.1 BC032659 mRNA Translation: AAH32659.1 Different initiation. BC142681 mRNA Translation: AAI42682.1 Z16411 mRNA Translation: CAA78903.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53654.1 [Q01970-2] CCDS8064.1 [Q01970-1]
PIRⁱ	I38994 S27002 S52099
NCBI Reference Sequences More...RefSeqⁱ	NP_000923.1, NM_000932.2 [Q01970-1] NP_001171812.1, NM_001184883.1 [Q01970-2] NP_001303243.1, NM_001316314.1 [Q01970-1]

Genome annotation databases

Ensemblⁱ	ENST00000279230; ENSP00000279230; ENSG00000149782 [Q01970-1] ENST00000325234; ENSP00000324660; ENSG00000149782 [Q01970-2] ENST00000540288; ENSP00000443631; ENSG00000149782 [Q01970-1]
GeneIDⁱ	5331
KEGGⁱ	hsa:5331
UCSC genome browser More...UCSCⁱ	uc009ypg.3, human [Q01970-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		ICTTR		1255	UniRef90_Q01970
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		PANPR		1249
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		ACIJB		1249
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		MACFA		1247
Phosphoinositide phospholipase C (Fragment)		MACMU		206
+157

Protein	Similar proteins		Species	Score	Length	Source
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		ICTTR		1255	UniRef50_Q01970
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		PANPR		1249
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		ACIJB		1249
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		MACFA		1247
Phosphoinositide phospholipase C (Fragment)		MACMU		206
+260

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U26425 Genomic DNA Translation: AAA77683.1 Z37544 Z37574 Genomic DNA Translation: CAA85776.1 AP001453 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74230.1 CH471076 Genomic DNA Translation: EAW74231.1 BC032659 mRNA Translation: AAH32659.1 Different initiation. BC142681 mRNA Translation: AAI42682.1 Z16411 mRNA Translation: CAA78903.1
CCDSⁱ	CCDS53654.1 [Q01970-2] CCDS8064.1 [Q01970-1]
PIRⁱ	I38994 S27002 S52099
RefSeqⁱ	NP_000923.1, NM_000932.2 [Q01970-1] NP_001171812.1, NM_001184883.1 [Q01970-2] NP_001303243.1, NM_001316314.1 [Q01970-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3OHM	X-ray	2.70	B	10-886	[»]
	4GNK	X-ray	4.00	B/D	10-1234	[»]
				E	934-1192	[»]
	4QJ3	X-ray	3.00	B	10-891	[»]
	4QJ4	X-ray	3.30	B	10-891	[»]
	4QJ5	X-ray	3.41	B	10-891	[»]
SMRⁱ	Q01970
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111347, 29 interactors
CORUMⁱ	Q01970
DIPⁱ	DIP-41928N
IntActⁱ	Q01970, 7 interactors
MINTⁱ	Q01970
STRINGⁱ	9606.ENSP00000443631

Chemistry databases

BindingDBⁱ	Q01970
ChEMBLⁱ	CHEMBL5449
SwissLipidsⁱ	SLP:000001756

PTM databases

iPTMnetⁱ	Q01970
PhosphoSitePlusⁱ	Q01970

Genetic variation databases

BioMutaⁱ	PLCB3
DMDMⁱ	1730573

Proteomic databases

EPDⁱ	Q01970
jPOSTⁱ	Q01970
MassIVEⁱ	Q01970
MaxQBⁱ	Q01970
PaxDbⁱ	Q01970
PeptideAtlasⁱ	Q01970
PRIDEⁱ	Q01970
ProteomicsDBⁱ	33840 58024 [Q01970-1]

Protocols and materials databases

Antibodypediaⁱ	3983, 393 antibodies

Antibodypediaⁱ

3983, 393 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000279230; ENSP00000279230; ENSG00000149782 [Q01970-1] ENST00000325234; ENSP00000324660; ENSG00000149782 [Q01970-2] ENST00000540288; ENSP00000443631; ENSG00000149782 [Q01970-1]
GeneIDⁱ	5331
KEGGⁱ	hsa:5331
UCSCⁱ	uc009ypg.3, human [Q01970-1]

Organism-specific databases

CTDⁱ	5331
DisGeNETⁱ	5331
GeneCardsⁱ	PLCB3
HGNCⁱ	HGNC:9056, PLCB3
HPAⁱ	ENSG00000149782, Tissue enriched (intestine)
MIMⁱ	600230, gene
neXtProtⁱ	NX_Q01970
OpenTargetsⁱ	ENSG00000149782
PharmGKBⁱ	PA33386
VEuPathDBⁱ	HostDB:ENSG00000149782.11
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1265, Eukaryota
GeneTreeⁱ	ENSGT00940000160539
HOGENOMⁱ	CLU_002738_2_0_1
InParanoidⁱ	Q01970
OMAⁱ	DFWNGKF
OrthoDBⁱ	368239at2759
PhylomeDBⁱ	Q01970
TreeFamⁱ	TF313216

Enzyme and pathway databases

BRENDAⁱ	3.1.4.11, 2681
PathwayCommonsⁱ	Q01970
Reactomeⁱ	R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors
SIGNORⁱ	Q01970

Miscellaneous databases

BioGRID-ORCSⁱ	5331, 14 hits in 993 CRISPR screens
ChiTaRSⁱ	PLCB3, human
GeneWikiⁱ	PLCB3
GenomeRNAiⁱ	5331
Pharosⁱ	Q01970, Tbio
Protein Ontology More...PROⁱ	PR:Q01970
RNActⁱ	Q01970, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149782, Expressed in duodenum and 195 other tissues
Genevisibleⁱ	Q01970, HS

Family and domain databases

CDDⁱ	cd13361, PH_PLC_beta, 1 hit
DisProtⁱ	DP02477
Gene3Dⁱ	1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336, PTHR10336, 1 hit
Pfamⁱ	View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit
PIRSFⁱ	PIRSF000956, PLC-beta, 1 hit
PRINTSⁱ	PR00390, PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit
SUPFAMⁱ	SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLCB3_HUMAN
Accessionⁱ	Q01970Primary (citable) accession number: Q01970 Secondary accession number(s): A5PKZ6, G5E960, Q8N1A4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	October 1, 1996
	Last modified:	April 7, 2021
	This is version 209 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q01970 (PLCB3_HUMAN)

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoplasm and Cytosol

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q01970

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ