SLC6A3

Functionⁱ

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.3 Publications

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	75	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	77	Sodium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	78	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	82	Sodium 2By similarity	1
Siteⁱ	105	Contributes to high-affinity binding to cocaineBy similarity	1
Metal bindingⁱ	321	Sodium 2By similarity	1
Metal bindingⁱ	353	Sodium 2By similarity	1
Metal bindingⁱ	418	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	421	Sodium 1By similarity	1
Metal bindingⁱ	422	Sodium 1By similarity	1

GO - Molecular functionⁱ

dopamine:sodium symporter activity Source: GO_Central
dopamine binding Source: Ensembl
dopamine transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15505207
metal ion binding Source: UniProtKB-KW
monoamine transmembrane transporter activity
Source: MGI
Inferred from direct assayⁱ
- 16024787
neurotransmitter:sodium symporter activity Source: InterPro
protease binding Source: Ensembl
protein-containing complex binding Source: Ensembl
protein N-terminus binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenohypophysis development Source: Ensembl
aging Source: Ensembl
dopamine biosynthetic process Source: Ensembl
dopamine catabolic process Source: Ensembl
dopamine transport
Source: UniProtKB
Inferred from direct assayⁱ
- 15505207
dopamine uptake
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 21957239
dopamine uptake involved in synaptic transmission Source: GO_Central
lactation Source: Ensembl
locomotory behavior Source: Ensembl
monoamine transport
Source: MGI
Inferred from direct assayⁱ
- 16024787
neurotransmitter biosynthetic process Source: Reactome
positive regulation of multicellular organism growth Source: Ensembl
prepulse inhibition Source: Ensembl
regulation of dopamine metabolic process Source: Ensembl
response to cAMP Source: Ensembl
response to cocaine Source: Ensembl
response to ethanol Source: Ensembl
response to iron ion Source: Ensembl
response to nicotine Source: Ensembl
sensory perception of smell Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurotransmitter transport, Symport, Transport
Ligand	Metal-binding, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-379401 Dopamine clearance from the synaptic cleft R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619081 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
SABIO-RKⁱ	Q01959

Protein family/group databases

TCDBⁱ	2.A.22.1.3 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.1.3 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium-dependent dopamine transporter Short name: DA transporter Short name: DAT Alternative name(s): Solute carrier family 6 member 3
Gene namesⁱ	Name:SLC6A3 Synonyms:DAT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142319.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11049 SLC6A3
MIMⁱ	126455 gene
neXtProtⁱ	NX_Q01959

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 68	CytoplasmicSequence analysisAdd BLAST	68
Transmembraneⁱ	69 – 89	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	96 – 116	Helical; Name=2Sequence analysisAdd BLAST	21
Transmembraneⁱ	140 – 160	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 237	ExtracellularSequence analysisAdd BLAST	77
Transmembraneⁱ	238 – 256	Helical; Name=4Sequence analysisAdd BLAST	19
Transmembraneⁱ	265 – 282	Helical; Name=5Sequence analysisAdd BLAST	18
Transmembraneⁱ	318 – 335	Helical; Name=6Sequence analysisAdd BLAST	18
Transmembraneⁱ	347 – 368	Helical; Name=7Sequence analysisAdd BLAST	22
Transmembraneⁱ	401 – 420	Helical; Name=8Sequence analysisAdd BLAST	20
Transmembraneⁱ	447 – 465	Helical; Name=9Sequence analysisAdd BLAST	19
Transmembraneⁱ	481 – 501	Helical; Name=10Sequence analysisAdd BLAST	21
Transmembraneⁱ	522 – 541	Helical; Name=11Sequence analysisAdd BLAST	20
Transmembraneⁱ	560 – 578	Helical; Name=12Sequence analysisAdd BLAST	19
Topological domainⁱ	579 – 620	CytoplasmicSequence analysisAdd BLAST	42

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Parkinsonism-dystonia infantile (PKDYS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063771	368	L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar.		1
Natural variantⁱVAR_063772	395	P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Dystonia, Neurodegeneration, Parkinsonism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6531
MalaCards human disease database More...MalaCardsⁱ	SLC6A3
MIMⁱ	613135 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000142319
Orphanetⁱ	238455 Infantile dystonia-parkinsonism
PharmGKBⁱ	PA311

Chemistry databases

ChEMBLⁱ	CHEMBL238
Drug and drug target database More...DrugBankⁱ	DB01472 4-Methoxyamphetamine DB04947 Altropane DB00543 Amoxapine DB00182 Amphetamine DB06413 Armodafinil DB00289 Atomoxetine DB00245 Benzatropine DB00865 Benzphetamine DB01156 Bupropion DB01161 Chloroprocaine DB01114 Chlorphenamine DB00215 Citalopram DB00907 Cocaine DB06701 Dexmethylphenidate DB01576 Dextroamphetamine DB00937 Diethylpropion DB01146 Diphenylpyraline DB00988 Dopamine DB00476 Duloxetine DB01363 Ephedra DB01175 Escitalopram DB01463 Fencamfamine DB00458 Imipramine DB08824 Ioflupane I-123 DB01255 Lisdexamfetamine DB00408 Loxapine DB00579 Mazindol DB01577 Methamphetamine DB09543 Methyl salicylate DB00422 Methylphenidate DB06148 Mianserin DB00370 Mirtazapine DB01442 MMDA DB00745 Modafinil DB01149 Nefazodone DB04821 Nomifensine DB00454 Pethidine DB00830 Phenmetrazine DB00191 Phentermine DB00721 Procaine DB00852 Pseudoephedrine DB01104 Sertraline DB01105 Sibutramine DB00726 Trimipramine DB00285 Venlafaxine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	927

Polymorphism and mutation databases

BioMutaⁱ	SLC6A3
DMDMⁱ	266667

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214751	1 – 620	Sodium-dependent dopamine transporterAdd BLAST		620

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	180 ↔ 189	By similarity
Glycosylationⁱ	181	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	188	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	205	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	306	Interchain1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q01959
PeptideAtlas More...PeptideAtlasⁱ	Q01959
PRIDEⁱ	Q01959
ProteomicsDBⁱ	58021

PTM databases

iPTMnetⁱ	Q01959
PhosphoSitePlusⁱ	Q01959

Miscellaneous databases

PMAP-CutDBⁱ	Q01959

PMAP-CutDBⁱ

Q01959

Expressionⁱ

Tissue specificityⁱ

Highly expressed in substantia nigra.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000142319 Expressed in 60 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_SLC6A3
Genevisibleⁱ	Q01959 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016249 CAB078172 HPA012763 HPA013602

HPAⁱ

CAB016249
CAB078172
HPA012763
HPA013602

Interactionⁱ

Subunit structureⁱ

Homooligomer; disulfide-linked (Ref. 14). Interacts with PRKCABP and TGFB1I1 (PubMed:11343649, PubMed:12177201). Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2. Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DRD2	P14416	4	EBI-6661445,EBI-2928178
GPR37	O15354	2	EBI-6661445,EBI-15639515
Pick1	Q9EP80	2	EBI-6661445,EBI-77728	From Rattus norvegicus.
RIT2	Q99578	5	EBI-6661445,EBI-365914
Rit2	Q5BJQ5	2	EBI-6661445,EBI-11686902	From Rattus norvegicus.
SNCA	P37840	3	EBI-6661445,EBI-985879

GO - Molecular functionⁱ

protease binding Source: Ensembl
protein N-terminus binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112422, 14 interactors
Database of interacting proteins More...DIPⁱ	DIP-41827N
IntActⁱ	Q01959, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q01959
STRINGⁱ	9606.ENSP00000270349

Chemistry databases

BindingDBⁱ

Q01959

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q01959
SMRⁱ	Q01959
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	561 – 590	Interaction with TGFB1I11 PublicationAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q01959
KEGG Orthology (KO) More...KOⁱ	K05036
OMAⁱ	GMATFIF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q01959
TreeFamⁱ	TF343812

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002436 Na/ntran_symport_dopamine IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR01202 DOPTRANSPORT PR00176 NANEUSMPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q01959-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP 
        60         70         80         90        100
RQSPVEAQDR ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV 
       110        120        130        140        150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPILKG VGFTVILISL 
       160        170        180        190        200
YVGFFYNVII AWALHYLFSS FTTELPWIHC NNSWNSPNCS DAHPGDSSGD 
       210        220        230        240        250
SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL TACLVLVIVL 
       260        270        280        290        300
LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV 
       310        320        330        340        350
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT 
       360        370        380        390        400
SINSLTSFSS GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT 
       410        420        430        440        450
LPLSSAWAVV FFIMLLTLGI DSAMGGMESV ITGLIDEFQL LHRHRELFTL 
       460        470        480        490        500
FIVLATFLLS LFCVTNGGIY VFTLLDHFAA GTSILFGVLI EAIGVAWFYG 
       510        520        530        540        550
VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI VTFRPPHYGA 
       560        570        580        590        600
YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 
       610        620
RELVDRGEVR QFTLRHWLKV

Length:620

Mass (Da):68,495

Last modified:April 1, 1993 - v1

Checksum:ⁱCD95009B6BA93108

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	35	K → M in AAB23443 (PubMed:1406597).Curated		1
Sequence conflictⁱ	354	S → C in AAB23443 (PubMed:1406597).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036158	121	G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760871529Ensembl.	1
Natural variantⁱVAR_014180	237	R → Q1 PublicationCorresponds to variant dbSNP:rs6345Ensembl.	1
Natural variantⁱVAR_063771	368	L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar.	1
Natural variantⁱVAR_063772	395	P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar.	1
Natural variantⁱVAR_064580	471	V → I1 PublicationCorresponds to variant dbSNP:rs75916702Ensembl.	1
Natural variantⁱVAR_036159	544	R → S in a breast cancer sample; somatic mutation. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95167 mRNA Translation: AAC41720.1 S46955 mRNA Translation: AAA11754.1 S44626 mRNA Translation: AAB23443.1 L24178 mRNA Translation: AAA19560.1 D88570 Genomic DNA Translation: BAA22511.1 AF119117 Genomic DNA Translation: AAC50179.2 AF321321 AF306564 Genomic DNA Translation: AAG33844.1 EF174603 mRNA Translation: ABO77644.1 AY623110 Genomic DNA Translation: AAT38106.1 CH471102 Genomic DNA Translation: EAX08159.1 BC132977 mRNA Translation: AAI32978.1 BC133003 mRNA Translation: AAI33004.1 M96670 mRNA Translation: AAA35770.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3863.1
PIRⁱ	A48980 I57937 I84455
NCBI Reference Sequences More...RefSeqⁱ	NP_001035.1, NM_001044.4
UniGeneⁱ	Hs.406

Genome annotation databases

Ensemblⁱ	ENST00000270349; ENSP00000270349; ENSG00000142319 ENST00000621716; ENSP00000479597; ENSG00000276996
GeneIDⁱ	6531
KEGGⁱ	hsa:6531
UCSC genome browser More...UCSCⁱ	uc003jck.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01959	Sodium-dependent dopamine transporter		MACFA		620	UniRef90_Q01959
Sodium-dependent dopamine transporter		MOUSE		619
Sodium-dependent dopamine transporter		RAT		619
Dopamine transporter (Fragment)		HUMAN		95
Transporter		FUKDA		766
+41

Protein	Similar proteins		Species	Score	Length	Source
Q01959	Sodium-dependent dopamine transporter		MACFA		620	UniRef50_Q01959
Sodium-dependent dopamine transporter		RAT		619
Sodium-dependent dopamine transporter		MOUSE		619
Dopamine transporter (Fragment)		HUMAN		95
Transporter		FUKDA		766
+76

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Dopamine transporter entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95167 mRNA Translation: AAC41720.1 S46955 mRNA Translation: AAA11754.1 S44626 mRNA Translation: AAB23443.1 L24178 mRNA Translation: AAA19560.1 D88570 Genomic DNA Translation: BAA22511.1 AF119117 Genomic DNA Translation: AAC50179.2 AF321321 AF306564 Genomic DNA Translation: AAG33844.1 EF174603 mRNA Translation: ABO77644.1 AY623110 Genomic DNA Translation: AAT38106.1 CH471102 Genomic DNA Translation: EAX08159.1 BC132977 mRNA Translation: AAI32978.1 BC133003 mRNA Translation: AAI33004.1 M96670 mRNA Translation: AAA35770.1
CCDSⁱ	CCDS3863.1
PIRⁱ	A48980 I57937 I84455
RefSeqⁱ	NP_001035.1, NM_001044.4
UniGeneⁱ	Hs.406

3D structure databases

ProteinModelPortalⁱ	Q01959
SMRⁱ	Q01959
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112422, 14 interactors
DIPⁱ	DIP-41827N
IntActⁱ	Q01959, 8 interactors
MINTⁱ	Q01959
STRINGⁱ	9606.ENSP00000270349

Chemistry databases

BindingDBⁱ	Q01959
ChEMBLⁱ	CHEMBL238
DrugBankⁱ	DB01472 4-Methoxyamphetamine DB04947 Altropane DB00543 Amoxapine DB00182 Amphetamine DB06413 Armodafinil DB00289 Atomoxetine DB00245 Benzatropine DB00865 Benzphetamine DB01156 Bupropion DB01161 Chloroprocaine DB01114 Chlorphenamine DB00215 Citalopram DB00907 Cocaine DB06701 Dexmethylphenidate DB01576 Dextroamphetamine DB00937 Diethylpropion DB01146 Diphenylpyraline DB00988 Dopamine DB00476 Duloxetine DB01363 Ephedra DB01175 Escitalopram DB01463 Fencamfamine DB00458 Imipramine DB08824 Ioflupane I-123 DB01255 Lisdexamfetamine DB00408 Loxapine DB00579 Mazindol DB01577 Methamphetamine DB09543 Methyl salicylate DB00422 Methylphenidate DB06148 Mianserin DB00370 Mirtazapine DB01442 MMDA DB00745 Modafinil DB01149 Nefazodone DB04821 Nomifensine DB00454 Pethidine DB00830 Phenmetrazine DB00191 Phentermine DB00721 Procaine DB00852 Pseudoephedrine DB01104 Sertraline DB01105 Sibutramine DB00726 Trimipramine DB00285 Venlafaxine
GuidetoPHARMACOLOGYⁱ	927

Protein family/group databases

TCDBⁱ	2.A.22.1.3 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.1.3 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetⁱ	Q01959
PhosphoSitePlusⁱ	Q01959

Polymorphism and mutation databases

BioMutaⁱ	SLC6A3
DMDMⁱ	266667

Proteomic databases

PaxDbⁱ	Q01959
PeptideAtlasⁱ	Q01959
PRIDEⁱ	Q01959
ProteomicsDBⁱ	58021

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000270349; ENSP00000270349; ENSG00000142319 ENST00000621716; ENSP00000479597; ENSG00000276996
GeneIDⁱ	6531
KEGGⁱ	hsa:6531
UCSCⁱ	uc003jck.4 human

Organism-specific databases

CTDⁱ	6531
DisGeNETⁱ	6531
EuPathDBⁱ	HostDB:ENSG00000142319.17
GeneCardsⁱ	SLC6A3
HGNCⁱ	HGNC:11049 SLC6A3
HPAⁱ	CAB016249 CAB078172 HPA012763 HPA013602
MalaCardsⁱ	SLC6A3
MIMⁱ	126455 gene 613135 phenotype
neXtProtⁱ	NX_Q01959
OpenTargetsⁱ	ENSG00000142319
Orphanetⁱ	238455 Infantile dystonia-parkinsonism
PharmGKBⁱ	PA311
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q01959
KOⁱ	K05036
OMAⁱ	GMATFIF
OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q01959
TreeFamⁱ	TF343812

Enzyme and pathway databases

Reactomeⁱ	R-HSA-379401 Dopamine clearance from the synaptic cleft R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619081 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
SABIO-RKⁱ	Q01959

Miscellaneous databases

ChiTaRSⁱ	SLC6A3 human
GeneWikiⁱ	Dopamine_transporter
GenomeRNAiⁱ	6531
PMAP-CutDBⁱ	Q01959
Protein Ontology More...PROⁱ	PR:Q01959
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142319 Expressed in 60 organ(s), highest expression level in substantia nigra
CleanExⁱ	HS_SLC6A3
Genevisibleⁱ	Q01959 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002436 Na/ntran_symport_dopamine IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR01202 DOPTRANSPORT PR00176 NANEUSMPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC6A3_HUMAN
Accessionⁱ	Q01959Primary (citable) accession number: Q01959 Secondary accession number(s): A2RUN4, Q14996
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	September 12, 2018
	This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q01959 (SC6A3_HUMAN)

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Sodium-dependent dopamine transporter

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ