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Protein

Sodium-dependent dopamine transporter

Gene

SLC6A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.3 Publications

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi75Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi77Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi78Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi82Sodium 2By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei105Contributes to high-affinity binding to cocaineBy similarity1
Metal bindingi321Sodium 2By similarity1
Metal bindingi353Sodium 2By similarity1
Metal bindingi418Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi421Sodium 1By similarity1
Metal bindingi422Sodium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-379401 Dopamine clearance from the synaptic cleft
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619081 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
R-HSA-5660724 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q01959

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.22.1.3 the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent dopamine transporter
Short name:
DA transporter
Short name:
DAT
Alternative name(s):
Solute carrier family 6 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC6A3
Synonyms:DAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142319.17

Human Gene Nomenclature Database

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HGNCi
HGNC:11049 SLC6A3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
126455 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q01959

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 89Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini161 – 237ExtracellularSequence analysisAdd BLAST77
Transmembranei238 – 256Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei265 – 282Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei318 – 335Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei347 – 368Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei401 – 420Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei447 – 465Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei481 – 501Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei522 – 541Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei560 – 578Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini579 – 620CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinsonism-dystonia infantile (PKDYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.
See also OMIM:613135
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063771368L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar.1
Natural variantiVAR_063772395P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dystonia, Neurodegeneration, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
6531

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC6A3

MalaCards human disease database

More...
MalaCardsi
SLC6A3
MIMi613135 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000142319

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
238455 Infantile dystonia-parkinsonism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA311

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL238

Drug and drug target database

More...
DrugBanki
DB01472 4-Methoxyamphetamine
DB04947 Altropane
DB00543 Amoxapine
DB00182 Amphetamine
DB06413 Armodafinil
DB00289 Atomoxetine
DB00245 Benzatropine
DB00865 Benzphetamine
DB01156 Bupropion
DB01161 Chloroprocaine
DB01114 Chlorphenamine
DB00215 Citalopram
DB00907 Cocaine
DB06701 Dexmethylphenidate
DB01576 Dextroamphetamine
DB00937 Diethylpropion
DB01146 Diphenylpyraline
DB00988 Dopamine
DB00476 Duloxetine
DB01363 Ephedra
DB01175 Escitalopram
DB01463 Fencamfamine
DB00458 Imipramine
DB08824 Ioflupane I-123
DB01255 Lisdexamfetamine
DB00408 Loxapine
DB00579 Mazindol
DB01577 Methamphetamine
DB09543 Methyl salicylate
DB00422 Methylphenidate
DB06148 Mianserin
DB00370 Mirtazapine
DB01442 MMDA
DB00745 Modafinil
DB01149 Nefazodone
DB04821 Nomifensine
DB00454 Pethidine
DB00830 Phenmetrazine
DB00191 Phentermine
DB00721 Procaine
DB00852 Pseudoephedrine
DB01104 Sertraline
DB01105 Sibutramine
DB00726 Trimipramine
DB00285 Venlafaxine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
927

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC6A3

Domain mapping of disease mutations (DMDM)

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DMDMi
266667

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002147511 – 620Sodium-dependent dopamine transporterAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi180 ↔ 189By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi306Interchain1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q01959

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q01959

PeptideAtlas

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PeptideAtlasi
Q01959

PRoteomics IDEntifications database

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PRIDEi
Q01959

ProteomicsDB human proteome resource

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ProteomicsDBi
58021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q01959

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q01959

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q01959

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in substantia nigra.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142319 Expressed in 60 organ(s), highest expression level in substantia nigra

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC6A3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q01959 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016249
CAB078172
HPA012763
HPA013602

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; disulfide-linked (Ref. 14). Interacts with PRKCABP and TGFB1I1 (PubMed:11343649, PubMed:12177201). Interacts (via N-terminus) with SYNGR3 (via N-terminus). Interacts with SLC18A2. Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112422, 14 interactors

Database of interacting proteins

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DIPi
DIP-41827N

Protein interaction database and analysis system

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IntActi
Q01959, 8 interactors

Molecular INTeraction database

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MINTi
Q01959

STRING: functional protein association networks

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STRINGi
9606.ENSP00000270349

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q01959

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q01959

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01959

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni561 – 590Interaction with TGFB1I11 PublicationAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3659 Eukaryota
COG0733 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161224

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116406

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG071421

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01959

KEGG Orthology (KO)

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KOi
K05036

Identification of Orthologs from Complete Genome Data

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OMAi
PLTFAKM

Database of Orthologous Groups

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OrthoDBi
250396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q01959

TreeFam database of animal gene trees

More...
TreeFami
TF343812

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000175 Na/ntran_symport
IPR002436 Na/ntran_symport_dopamine
IPR037272 SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209 SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01202 DOPTRANSPORT
PR00176 NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP
60 70 80 90 100
RQSPVEAQDR ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV
110 120 130 140 150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPILKG VGFTVILISL
160 170 180 190 200
YVGFFYNVII AWALHYLFSS FTTELPWIHC NNSWNSPNCS DAHPGDSSGD
210 220 230 240 250
SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL TACLVLVIVL
260 270 280 290 300
LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV
310 320 330 340 350
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT
360 370 380 390 400
SINSLTSFSS GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT
410 420 430 440 450
LPLSSAWAVV FFIMLLTLGI DSAMGGMESV ITGLIDEFQL LHRHRELFTL
460 470 480 490 500
FIVLATFLLS LFCVTNGGIY VFTLLDHFAA GTSILFGVLI EAIGVAWFYG
510 520 530 540 550
VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI VTFRPPHYGA
560 570 580 590 600
YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD
610 620
RELVDRGEVR QFTLRHWLKV
Length:620
Mass (Da):68,495
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD95009B6BA93108
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35K → M in AAB23443 (PubMed:1406597).Curated1
Sequence conflicti354S → C in AAB23443 (PubMed:1406597).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036158121G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760871529Ensembl.1
Natural variantiVAR_014180237R → Q1 PublicationCorresponds to variant dbSNP:rs6345Ensembl.1
Natural variantiVAR_063771368L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar.1
Natural variantiVAR_063772395P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar.1
Natural variantiVAR_064580471V → I1 PublicationCorresponds to variant dbSNP:rs75916702Ensembl.1
Natural variantiVAR_036159544R → S in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M95167 mRNA Translation: AAC41720.1
S46955 mRNA Translation: AAA11754.1
S44626 mRNA Translation: AAB23443.1
L24178 mRNA Translation: AAA19560.1
D88570 Genomic DNA Translation: BAA22511.1
AF119117 Genomic DNA Translation: AAC50179.2
AF321321
, AF306558, AF321320, AF306559, AF306560, AF306561, AF306562, AF306563, AF306564 Genomic DNA Translation: AAG33844.1
EF174603 mRNA Translation: ABO77644.1
AY623110 Genomic DNA Translation: AAT38106.1
CH471102 Genomic DNA Translation: EAX08159.1
BC132977 mRNA Translation: AAI32978.1
BC133003 mRNA Translation: AAI33004.1
M96670 mRNA Translation: AAA35770.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3863.1

Protein sequence database of the Protein Information Resource

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PIRi
A48980
I57937
I84455

NCBI Reference Sequences

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RefSeqi
NP_001035.1, NM_001044.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.406

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000270349; ENSP00000270349; ENSG00000142319
ENST00000621716; ENSP00000479597; ENSG00000276996

Database of genes from NCBI RefSeq genomes

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GeneIDi
6531

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6531

UCSC genome browser

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UCSCi
uc003jck.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Dopamine transporter entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95167 mRNA Translation: AAC41720.1
S46955 mRNA Translation: AAA11754.1
S44626 mRNA Translation: AAB23443.1
L24178 mRNA Translation: AAA19560.1
D88570 Genomic DNA Translation: BAA22511.1
AF119117 Genomic DNA Translation: AAC50179.2
AF321321
, AF306558, AF321320, AF306559, AF306560, AF306561, AF306562, AF306563, AF306564 Genomic DNA Translation: AAG33844.1
EF174603 mRNA Translation: ABO77644.1
AY623110 Genomic DNA Translation: AAT38106.1
CH471102 Genomic DNA Translation: EAX08159.1
BC132977 mRNA Translation: AAI32978.1
BC133003 mRNA Translation: AAI33004.1
M96670 mRNA Translation: AAA35770.1
CCDSiCCDS3863.1
PIRiA48980
I57937
I84455
RefSeqiNP_001035.1, NM_001044.4
UniGeneiHs.406

3D structure databases

ProteinModelPortaliQ01959
SMRiQ01959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112422, 14 interactors
DIPiDIP-41827N
IntActiQ01959, 8 interactors
MINTiQ01959
STRINGi9606.ENSP00000270349

Chemistry databases

BindingDBiQ01959
ChEMBLiCHEMBL238
DrugBankiDB01472 4-Methoxyamphetamine
DB04947 Altropane
DB00543 Amoxapine
DB00182 Amphetamine
DB06413 Armodafinil
DB00289 Atomoxetine
DB00245 Benzatropine
DB00865 Benzphetamine
DB01156 Bupropion
DB01161 Chloroprocaine
DB01114 Chlorphenamine
DB00215 Citalopram
DB00907 Cocaine
DB06701 Dexmethylphenidate
DB01576 Dextroamphetamine
DB00937 Diethylpropion
DB01146 Diphenylpyraline
DB00988 Dopamine
DB00476 Duloxetine
DB01363 Ephedra
DB01175 Escitalopram
DB01463 Fencamfamine
DB00458 Imipramine
DB08824 Ioflupane I-123
DB01255 Lisdexamfetamine
DB00408 Loxapine
DB00579 Mazindol
DB01577 Methamphetamine
DB09543 Methyl salicylate
DB00422 Methylphenidate
DB06148 Mianserin
DB00370 Mirtazapine
DB01442 MMDA
DB00745 Modafinil
DB01149 Nefazodone
DB04821 Nomifensine
DB00454 Pethidine
DB00830 Phenmetrazine
DB00191 Phentermine
DB00721 Procaine
DB00852 Pseudoephedrine
DB01104 Sertraline
DB01105 Sibutramine
DB00726 Trimipramine
DB00285 Venlafaxine
GuidetoPHARMACOLOGYi927

Protein family/group databases

TCDBi2.A.22.1.3 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiQ01959
PhosphoSitePlusiQ01959

Polymorphism and mutation databases

BioMutaiSLC6A3
DMDMi266667

Proteomic databases

jPOSTiQ01959
PaxDbiQ01959
PeptideAtlasiQ01959
PRIDEiQ01959
ProteomicsDBi58021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270349; ENSP00000270349; ENSG00000142319
ENST00000621716; ENSP00000479597; ENSG00000276996
GeneIDi6531
KEGGihsa:6531
UCSCiuc003jck.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6531
DisGeNETi6531
EuPathDBiHostDB:ENSG00000142319.17

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC6A3
GeneReviewsiSLC6A3
HGNCiHGNC:11049 SLC6A3
HPAiCAB016249
CAB078172
HPA012763
HPA013602
MalaCardsiSLC6A3
MIMi126455 gene
613135 phenotype
neXtProtiNX_Q01959
OpenTargetsiENSG00000142319
Orphaneti238455 Infantile dystonia-parkinsonism
PharmGKBiPA311

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00940000161224
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ01959
KOiK05036
OMAiPLTFAKM
OrthoDBi250396at2759
PhylomeDBiQ01959
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-HSA-379401 Dopamine clearance from the synaptic cleft
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619081 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
R-HSA-5660724 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
SABIO-RKiQ01959

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC6A3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Dopamine_transporter

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6531
PMAP-CutDBiQ01959

Protein Ontology

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PROi
PR:Q01959

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142319 Expressed in 60 organ(s), highest expression level in substantia nigra
CleanExiHS_SLC6A3
GenevisibleiQ01959 HS

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002436 Na/ntran_symport_dopamine
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01202 DOPTRANSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC6A3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01959
Secondary accession number(s): A2RUN4, Q14996
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 16, 2019
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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