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UniProtKB - Q01959 (SC6A3_HUMAN)

Entry version 207 (02 Dec 2020)
Sequence version 1 (01 Apr 1993)
Previous versions | rss
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Protein

Sodium-dependent dopamine transporter

Gene

SLC6A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).By similarity3 Publications

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi75Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi77Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi78Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi82Sodium 2By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei105Contributes to high-affinity binding to cocaineBy similarity1
Metal bindingi321Sodium 2By similarity1
Metal bindingi353Sodium 2By similarity1
Metal bindingi418Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi421Sodium 1By similarity1
Metal bindingi422Sodium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q01959

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-379401, Dopamine clearance from the synaptic cleft
R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619081, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
R-HSA-5660724, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q01959

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01959

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.22.1.3, the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-dependent dopamine transporter
Short name:
DA transporter
Short name:
DAT
Alternative name(s):
Solute carrier family 6 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC6A3
Synonyms:DAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000142319.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:11049, SLC6A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		126455, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01959

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 89Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini161 – 237ExtracellularSequence analysisAdd BLAST77
Transmembranei238 – 256Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei265 – 282Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei318 – 335Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei347 – 368Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei401 – 420Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei447 – 465Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei481 – 501Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei522 – 541Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei560 – 578Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini579 – 620CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinsonism-dystonia infantile (PKDYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063771368L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar.1
Natural variantiVAR_063772395P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dystonia, Neurodegeneration, Parkinsonism

Organism-specific databases

DisGeNET

More...DisGeNETi		6531

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		SLC6A3

MalaCards human disease database

More...MalaCardsi		SLC6A3
MIMi613135, phenotype

Open Targets

More...OpenTargetsi		ENSG00000142319

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		238455, Infantile dystonia-parkinsonism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA311

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01959, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL238

Drug and drug target database

More...DrugBanki		DB01472, 4-Methoxyamphetamine
DB04947, Altropane
DB00543, Amoxapine
DB00182, Amphetamine
DB01238, Aripiprazole
DB06413, Armodafinil
DB00245, Benzatropine
DB00865, Benzphetamine
DB01156, Bupropion
DB01161, Chloroprocaine
DB01114, Chlorpheniramine
DB00907, Cocaine
DB12305, Dasotraline
DB06700, Desvenlafaxine
DB06701, Dexmethylphenidate
DB01576, Dextroamphetamine
DB00937, Diethylpropion
DB01146, Diphenylpyraline
DB00988, Dopamine
DB00476, Duloxetine
DB01363, Ephedra sinica root
DB01175, Escitalopram
DB09194, Etoperidone
DB01463, Fencamfamin
DB00458, Imipramine
DB08824, Ioflupane I-123
DB00408, Loxapine
DB00579, Mazindol
DB00454, Meperidine
DB01577, Metamfetamine
DB00422, Methylphenidate
DB06148, Mianserin
DB01454, Midomafetamine
DB01442, MMDA
DB00745, Modafinil
DB01149, Nefazodone
DB04821, Nomifensine
DB00830, Phenmetrazine
DB00191, Phentermine
DB00721, Procaine
DB00852, Pseudoephedrine
DB01104, Sertraline
DB01105, Sibutramine
DB14754, Solriamfetol
DB06156, Tesofensine
DB00726, Trimipramine
DB06333, Trodusquemine
DB03701, Vanoxerine
DB00285, Venlafaxine

DrugCentral

More...DrugCentrali		Q01959

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		927

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC6A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		266667

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002147511 – 620Sodium-dependent dopamine transporterAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi180 ↔ 189By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi306Interchain1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01959

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01959

PeptideAtlas

More...PeptideAtlasi		Q01959

PRoteomics IDEntifications database

More...PRIDEi		Q01959

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58021

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q01959, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01959

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01959

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q01959

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in substantia nigra.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142319, Expressed in substantia nigra and 72 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01959, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142319, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; disulfide-linked (Ref. 14).

Interacts with PRKCABP and TGFB1I1 (PubMed:11343649, PubMed:12177201).

Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity).

Interacts with SLC18A2 (By similarity).

Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (PubMed:15505207).

Interacts with alpha-synuclein/SNCA (PubMed:26442590).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112422, 15 interactors

Database of interacting proteins

More...DIPi		DIP-41827N

Protein interaction database and analysis system

More...IntActi		Q01959, 9 interactors

Molecular INTeraction database

More...MINTi		Q01959

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000270349

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q01959

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q01959, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01959

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni561 – 590Interaction with TGFB1I11 PublicationAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3659, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161224

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006855_9_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01959

Identification of Orthologs from Complete Genome Data

More...OMAi		IFPEWAN

Database of Orthologous Groups

More...OrthoDBi		250396at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01959

TreeFam database of animal gene trees

More...TreeFami		TF343812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000175, Na/ntran_symport
IPR002436, Na/ntran_symport_dopamine
IPR037272, SNS_sf

The PANTHER Classification System

More...PANTHERi		PTHR11616, PTHR11616, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00209, SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01202, DOPTRANSPORT
PR00176, NANEUSMPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161070, SSF161070, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP 
        60         70         80         90        100
RQSPVEAQDR ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV 
       110        120        130        140        150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPILKG VGFTVILISL 
       160        170        180        190        200
YVGFFYNVII AWALHYLFSS FTTELPWIHC NNSWNSPNCS DAHPGDSSGD 
       210        220        230        240        250
SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL TACLVLVIVL 
       260        270        280        290        300
LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV 
       310        320        330        340        350
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT 
       360        370        380        390        400
SINSLTSFSS GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT 
       410        420        430        440        450
LPLSSAWAVV FFIMLLTLGI DSAMGGMESV ITGLIDEFQL LHRHRELFTL 
       460        470        480        490        500
FIVLATFLLS LFCVTNGGIY VFTLLDHFAA GTSILFGVLI EAIGVAWFYG 
       510        520        530        540        550
VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI VTFRPPHYGA 
       560        570        580        590        600
YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 
       610        620
RELVDRGEVR QFTLRHWLKV
Length:620
Mass (Da):68,495
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD95009B6BA93108
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35K → M in AAB23443 (PubMed:1406597).Curated1
Sequence conflicti354S → C in AAB23443 (PubMed:1406597).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036158121G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760871529Ensembl.1
Natural variantiVAR_014180237R → Q1 PublicationCorresponds to variant dbSNP:rs6345EnsemblClinVar.1
Natural variantiVAR_063771368L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar.1
Natural variantiVAR_063772395P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar.1
Natural variantiVAR_064580471V → I1 PublicationCorresponds to variant dbSNP:rs75916702Ensembl.1
Natural variantiVAR_036159544R → S in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M95167 mRNA Translation: AAC41720.1
S46955 mRNA Translation: AAA11754.1
S44626 mRNA Translation: AAB23443.1
L24178 mRNA Translation: AAA19560.1
D88570 Genomic DNA Translation: BAA22511.1
AF119117 Genomic DNA Translation: AAC50179.2
AF321321 AF306564 Genomic DNA Translation: AAG33844.1
EF174603 mRNA Translation: ABO77644.1
AY623110 Genomic DNA Translation: AAT38106.1
CH471102 Genomic DNA Translation: EAX08159.1
BC132977 mRNA Translation: AAI32978.1
BC133003 mRNA Translation: AAI33004.1
M96670 mRNA Translation: AAA35770.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3863.1

Protein sequence database of the Protein Information Resource

More...PIRi		A48980
I57937
I84455

NCBI Reference Sequences

More...RefSeqi		NP_001035.1, NM_001044.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000270349; ENSP00000270349; ENSG00000142319
ENST00000621716; ENSP00000479597; ENSG00000276996

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6531

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6531

UCSC genome browser

More...UCSCi		uc003jck.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Dopamine transporter entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95167 mRNA Translation: AAC41720.1
S46955 mRNA Translation: AAA11754.1
S44626 mRNA Translation: AAB23443.1
L24178 mRNA Translation: AAA19560.1
D88570 Genomic DNA Translation: BAA22511.1
AF119117 Genomic DNA Translation: AAC50179.2
AF321321 AF306564 Genomic DNA Translation: AAG33844.1
EF174603 mRNA Translation: ABO77644.1
AY623110 Genomic DNA Translation: AAT38106.1
CH471102 Genomic DNA Translation: EAX08159.1
BC132977 mRNA Translation: AAI32978.1
BC133003 mRNA Translation: AAI33004.1
M96670 mRNA Translation: AAA35770.1
CCDSiCCDS3863.1
PIRiA48980
I57937
I84455
RefSeqiNP_001035.1, NM_001044.4

3D structure databases

SMRiQ01959
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112422, 15 interactors
DIPiDIP-41827N
IntActiQ01959, 9 interactors
MINTiQ01959
STRINGi9606.ENSP00000270349

Chemistry databases

BindingDBiQ01959
ChEMBLiCHEMBL238
DrugBankiDB01472, 4-Methoxyamphetamine
DB04947, Altropane
DB00543, Amoxapine
DB00182, Amphetamine
DB01238, Aripiprazole
DB06413, Armodafinil
DB00245, Benzatropine
DB00865, Benzphetamine
DB01156, Bupropion
DB01161, Chloroprocaine
DB01114, Chlorpheniramine
DB00907, Cocaine
DB12305, Dasotraline
DB06700, Desvenlafaxine
DB06701, Dexmethylphenidate
DB01576, Dextroamphetamine
DB00937, Diethylpropion
DB01146, Diphenylpyraline
DB00988, Dopamine
DB00476, Duloxetine
DB01363, Ephedra sinica root
DB01175, Escitalopram
DB09194, Etoperidone
DB01463, Fencamfamin
DB00458, Imipramine
DB08824, Ioflupane I-123
DB00408, Loxapine
DB00579, Mazindol
DB00454, Meperidine
DB01577, Metamfetamine
DB00422, Methylphenidate
DB06148, Mianserin
DB01454, Midomafetamine
DB01442, MMDA
DB00745, Modafinil
DB01149, Nefazodone
DB04821, Nomifensine
DB00830, Phenmetrazine
DB00191, Phentermine
DB00721, Procaine
DB00852, Pseudoephedrine
DB01104, Sertraline
DB01105, Sibutramine
DB14754, Solriamfetol
DB06156, Tesofensine
DB00726, Trimipramine
DB06333, Trodusquemine
DB03701, Vanoxerine
DB00285, Venlafaxine
DrugCentraliQ01959
GuidetoPHARMACOLOGYi927

Protein family/group databases

TCDBi2.A.22.1.3, the neurotransmitter:sodium symporter (nss) family

PTM databases

GlyGeniQ01959, 3 sites
iPTMnetiQ01959
PhosphoSitePlusiQ01959
SwissPalmiQ01959

Polymorphism and mutation databases

BioMutaiSLC6A3
DMDMi266667

Proteomic databases

MassIVEiQ01959
PaxDbiQ01959
PeptideAtlasiQ01959
PRIDEiQ01959
ProteomicsDBi58021

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2799, 436 antibodies

Genome annotation databases

EnsembliENST00000270349; ENSP00000270349; ENSG00000142319
ENST00000621716; ENSP00000479597; ENSG00000276996
GeneIDi6531
KEGGihsa:6531
UCSCiuc003jck.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6531
DisGeNETi6531
EuPathDBiHostDB:ENSG00000142319.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC6A3
GeneReviewsiSLC6A3
HGNCiHGNC:11049, SLC6A3
HPAiENSG00000142319, Tissue enriched (brain)
MalaCardsiSLC6A3
MIMi126455, gene
613135, phenotype
neXtProtiNX_Q01959
OpenTargetsiENSG00000142319
Orphaneti238455, Infantile dystonia-parkinsonism
PharmGKBiPA311

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3659, Eukaryota
GeneTreeiENSGT00940000161224
HOGENOMiCLU_006855_9_0_1
InParanoidiQ01959
OMAiIFPEWAN
OrthoDBi250396at2759
PhylomeDBiQ01959
TreeFamiTF343812

Enzyme and pathway databases

PathwayCommonsiQ01959
ReactomeiR-HSA-379401, Dopamine clearance from the synaptic cleft
R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619081, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
R-HSA-5660724, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
SABIO-RKiQ01959
SIGNORiQ01959

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6531, 3 hits in 843 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Dopamine_transporter

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6531
PharosiQ01959, Tclin

Protein Ontology

More...PROi		PR:Q01959
RNActiQ01959, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142319, Expressed in substantia nigra and 72 other tissues
GenevisibleiQ01959, HS

Family and domain databases

InterProiView protein in InterPro
IPR000175, Na/ntran_symport
IPR002436, Na/ntran_symport_dopamine
IPR037272, SNS_sf
PANTHERiPTHR11616, PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209, SNF, 1 hit
PRINTSiPR01202, DOPTRANSPORT
PR00176, NANEUSMPORT
SUPFAMiSSF161070, SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC6A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01959
Secondary accession number(s): A2RUN4, Q14996
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 2, 2020
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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