UniProtKB - Q01959 (SC6A3_HUMAN)
Protein
Sodium-dependent dopamine transporter
Gene
SLC6A3
Organism
Homo sapiens (Human)
Status
Functioni
Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).By similarity3 Publications
Miscellaneous
This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 75 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 77 | Sodium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 78 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 82 | Sodium 2By similarity | 1 | |
Sitei | 105 | Contributes to high-affinity binding to cocaineBy similarity | 1 | |
Metal bindingi | 321 | Sodium 2By similarity | 1 | |
Metal bindingi | 353 | Sodium 2By similarity | 1 | |
Metal bindingi | 418 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 421 | Sodium 1By similarity | 1 | |
Metal bindingi | 422 | Sodium 1By similarity | 1 |
GO - Molecular functioni
- dopamine:sodium symporter activity Source: UniProtKB
- dopamine binding Source: Ensembl
- drug binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- monoamine transmembrane transporter activity Source: MGI
- neurotransmitter transmembrane transporter activity Source: ARUK-UCL
- norepinephrine:sodium symporter activity Source: GO_Central
- protease binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
- signaling receptor binding Source: Ensembl
GO - Biological processi
- adenohypophysis development Source: Ensembl
- aging Source: Ensembl
- dopamine biosynthetic process Source: Ensembl
- dopamine catabolic process Source: Ensembl
- dopamine transport Source: UniProtKB
- dopamine uptake Source: ParkinsonsUK-UCL
- dopamine uptake involved in synaptic transmission Source: GO_Central
- hyaloid vascular plexus regression Source: UniProtKB
- lactation Source: Ensembl
- locomotory behavior Source: Ensembl
- monoamine transport Source: MGI
- neurotransmitter biosynthetic process Source: Reactome
- neurotransmitter transport Source: ARUK-UCL
- norepinephrine transport Source: GO_Central
- positive regulation of multicellular organism growth Source: Ensembl
- prepulse inhibition Source: Ensembl
- regulation of dopamine metabolic process Source: Ensembl
- response to cAMP Source: Ensembl
- response to cocaine Source: Ensembl
- response to drug Source: Ensembl
- response to ethanol Source: Ensembl
- response to iron ion Source: Ensembl
- response to nicotine Source: Ensembl
- sensory perception of smell Source: Ensembl
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Neurotransmitter transport, Symport, Transport |
Ligand | Metal-binding, Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q01959 |
Reactomei | R-HSA-379401, Dopamine clearance from the synaptic cleft R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters R-HSA-5619081, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) |
SABIO-RKi | Q01959 |
SIGNORi | Q01959 |
Protein family/group databases
TCDBi | 2.A.22.1.3, the neurotransmitter:sodium symporter (nss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-dependent dopamine transporterShort name: DA transporter Short name: DAT Alternative name(s): Solute carrier family 6 member 3 |
Gene namesi | Name:SLC6A3 Synonyms:DAT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000142319.17 |
HGNCi | HGNC:11049, SLC6A3 |
MIMi | 126455, gene |
neXtProti | NX_Q01959 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein 1 Publication
Plasma Membrane
- flotillin complex Source: UniProtKB
- integral component of plasma membrane Source: InterPro
- neuronal cell body membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- presynaptic membrane Source: GO_Central
Other locations
- axon Source: UniProtKB
- cell surface Source: UniProtKB
- cytoplasm Source: ProtInc
- integral component of membrane Source: ProtInc
- membrane raft Source: ParkinsonsUK-UCL
- neuron projection Source: ParkinsonsUK-UCL
- neuronal cell body Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 68 | CytoplasmicSequence analysisAdd BLAST | 68 | |
Transmembranei | 69 – 89 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 140 – 160 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 237 | ExtracellularSequence analysisAdd BLAST | 77 | |
Transmembranei | 238 – 256 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Transmembranei | 265 – 282 | Helical; Name=5Sequence analysisAdd BLAST | 18 | |
Transmembranei | 318 – 335 | Helical; Name=6Sequence analysisAdd BLAST | 18 | |
Transmembranei | 347 – 368 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Transmembranei | 401 – 420 | Helical; Name=8Sequence analysisAdd BLAST | 20 | |
Transmembranei | 447 – 465 | Helical; Name=9Sequence analysisAdd BLAST | 19 | |
Transmembranei | 481 – 501 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Transmembranei | 522 – 541 | Helical; Name=11Sequence analysisAdd BLAST | 20 | |
Transmembranei | 560 – 578 | Helical; Name=12Sequence analysisAdd BLAST | 19 | |
Topological domaini | 579 – 620 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Parkinsonism-dystonia infantile (PKDYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063771 | 368 | L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar. | 1 | |
Natural variantiVAR_063772 | 395 | P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Dystonia, Neurodegeneration, ParkinsonismOrganism-specific databases
DisGeNETi | 6531 |
GeneReviewsi | SLC6A3 |
MalaCardsi | SLC6A3 |
MIMi | 613135, phenotype |
OpenTargetsi | ENSG00000142319 |
Orphaneti | 238455, Infantile dystonia-parkinsonism |
PharmGKBi | PA311 |
Miscellaneous databases
Pharosi | Q01959, Tclin |
Chemistry databases
ChEMBLi | CHEMBL238 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB04947, Altropane DB00543, Amoxapine DB00182, Amphetamine DB01238, Aripiprazole DB06413, Armodafinil DB00245, Benzatropine DB00865, Benzphetamine DB01156, Bupropion DB01161, Chloroprocaine DB01114, Chlorpheniramine DB00907, Cocaine DB12305, Dasotraline DB06700, Desvenlafaxine DB06701, Dexmethylphenidate DB01576, Dextroamphetamine DB00937, Diethylpropion DB01146, Diphenylpyraline DB00988, Dopamine DB00476, Duloxetine DB01363, Ephedra sinica root DB01175, Escitalopram DB09194, Etoperidone DB01463, Fencamfamin DB00458, Imipramine DB08824, Ioflupane I-123 DB00408, Loxapine DB00579, Mazindol DB00454, Meperidine DB01577, Metamfetamine DB00422, Methylphenidate DB06148, Mianserin DB01454, Midomafetamine DB01442, MMDA DB00745, Modafinil DB01149, Nefazodone DB04821, Nomifensine DB00830, Phenmetrazine DB00191, Phentermine DB00721, Procaine DB00852, Pseudoephedrine DB01104, Sertraline DB01105, Sibutramine DB14754, Solriamfetol DB06156, Tesofensine DB00726, Trimipramine DB06333, Trodusquemine DB03701, Vanoxerine DB00285, Venlafaxine |
DrugCentrali | Q01959 |
GuidetoPHARMACOLOGYi | 927 |
Polymorphism and mutation databases
BioMutai | SLC6A3 |
DMDMi | 266667 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214751 | 1 – 620 | Sodium-dependent dopamine transporterAdd BLAST | 620 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 180 ↔ 189 | By similarity | ||
Glycosylationi | 181 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 306 | Interchain1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q01959 |
PaxDbi | Q01959 |
PeptideAtlasi | Q01959 |
PRIDEi | Q01959 |
ProteomicsDBi | 58021 |
PTM databases
GlyGeni | Q01959, 3 sites |
iPTMneti | Q01959 |
PhosphoSitePlusi | Q01959 |
SwissPalmi | Q01959 |
Expressioni
Tissue specificityi
Highly expressed in substantia nigra.1 Publication
Gene expression databases
Bgeei | ENSG00000142319, Expressed in substantia nigra and 72 other tissues |
Genevisiblei | Q01959, HS |
Organism-specific databases
HPAi | ENSG00000142319, Tissue enriched (brain) |
Interactioni
Subunit structurei
Homooligomer; disulfide-linked (Ref. 14).
Interacts with PRKCABP and TGFB1I1 (PubMed:11343649, PubMed:12177201).
Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity).
Interacts with SLC18A2 (By similarity).
Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (PubMed:15505207).
Interacts with alpha-synuclein/SNCA (PubMed:26442590).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ01959
GO - Molecular functioni
- protease binding Source: Ensembl
- protein N-terminus binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112422, 15 interactors |
DIPi | DIP-41827N |
IntActi | Q01959, 9 interactors |
MINTi | Q01959 |
STRINGi | 9606.ENSP00000270349 |
Chemistry databases
BindingDBi | Q01959 |
Miscellaneous databases
RNActi | Q01959, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 561 – 590 | Interaction with TGFB1I11 PublicationAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000161224 |
HOGENOMi | CLU_006855_9_0_1 |
InParanoidi | Q01959 |
OMAi | IFPEWAN |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q01959 |
TreeFami | TF343812 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002436, Na/ntran_symport_dopamine IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR01202, DOPTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q01959-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP
60 70 80 90 100
RQSPVEAQDR ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV
110 120 130 140 150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPILKG VGFTVILISL
160 170 180 190 200
YVGFFYNVII AWALHYLFSS FTTELPWIHC NNSWNSPNCS DAHPGDSSGD
210 220 230 240 250
SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL TACLVLVIVL
260 270 280 290 300
LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV
310 320 330 340 350
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT
360 370 380 390 400
SINSLTSFSS GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT
410 420 430 440 450
LPLSSAWAVV FFIMLLTLGI DSAMGGMESV ITGLIDEFQL LHRHRELFTL
460 470 480 490 500
FIVLATFLLS LFCVTNGGIY VFTLLDHFAA GTSILFGVLI EAIGVAWFYG
510 520 530 540 550
VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI VTFRPPHYGA
560 570 580 590 600
YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD
610 620
RELVDRGEVR QFTLRHWLKV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 | K → M in AAB23443 (PubMed:1406597).Curated | 1 | |
Sequence conflicti | 354 | S → C in AAB23443 (PubMed:1406597).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036158 | 121 | G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs760871529Ensembl. | 1 | |
Natural variantiVAR_014180 | 237 | R → Q1 PublicationCorresponds to variant dbSNP:rs6345EnsemblClinVar. | 1 | |
Natural variantiVAR_063771 | 368 | L → Q in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607068EnsemblClinVar. | 1 | |
Natural variantiVAR_063772 | 395 | P → L in PKDYS; loss of function. 1 PublicationCorresponds to variant dbSNP:rs267607069EnsemblClinVar. | 1 | |
Natural variantiVAR_064580 | 471 | V → I1 PublicationCorresponds to variant dbSNP:rs75916702Ensembl. | 1 | |
Natural variantiVAR_036159 | 544 | R → S in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95167 mRNA Translation: AAC41720.1 S46955 mRNA Translation: AAA11754.1 S44626 mRNA Translation: AAB23443.1 L24178 mRNA Translation: AAA19560.1 D88570 Genomic DNA Translation: BAA22511.1 AF119117 Genomic DNA Translation: AAC50179.2 AF321321 , AF306558, AF321320, AF306559, AF306560, AF306561, AF306562, AF306563, AF306564 Genomic DNA Translation: AAG33844.1 EF174603 mRNA Translation: ABO77644.1 AY623110 Genomic DNA Translation: AAT38106.1 CH471102 Genomic DNA Translation: EAX08159.1 BC132977 mRNA Translation: AAI32978.1 BC133003 mRNA Translation: AAI33004.1 M96670 mRNA Translation: AAA35770.1 |
CCDSi | CCDS3863.1 |
PIRi | A48980 I57937 I84455 |
RefSeqi | NP_001035.1, NM_001044.4 |
Genome annotation databases
Ensembli | ENST00000270349; ENSP00000270349; ENSG00000142319 ENST00000621716; ENSP00000479597; ENSG00000276996 |
GeneIDi | 6531 |
KEGGi | hsa:6531 |
UCSCi | uc003jck.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Dopamine transporter entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95167 mRNA Translation: AAC41720.1 S46955 mRNA Translation: AAA11754.1 S44626 mRNA Translation: AAB23443.1 L24178 mRNA Translation: AAA19560.1 D88570 Genomic DNA Translation: BAA22511.1 AF119117 Genomic DNA Translation: AAC50179.2 AF321321 , AF306558, AF321320, AF306559, AF306560, AF306561, AF306562, AF306563, AF306564 Genomic DNA Translation: AAG33844.1 EF174603 mRNA Translation: ABO77644.1 AY623110 Genomic DNA Translation: AAT38106.1 CH471102 Genomic DNA Translation: EAX08159.1 BC132977 mRNA Translation: AAI32978.1 BC133003 mRNA Translation: AAI33004.1 M96670 mRNA Translation: AAA35770.1 |
CCDSi | CCDS3863.1 |
PIRi | A48980 I57937 I84455 |
RefSeqi | NP_001035.1, NM_001044.4 |
3D structure databases
SMRi | Q01959 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112422, 15 interactors |
DIPi | DIP-41827N |
IntActi | Q01959, 9 interactors |
MINTi | Q01959 |
STRINGi | 9606.ENSP00000270349 |
Chemistry databases
BindingDBi | Q01959 |
ChEMBLi | CHEMBL238 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB04947, Altropane DB00543, Amoxapine DB00182, Amphetamine DB01238, Aripiprazole DB06413, Armodafinil DB00245, Benzatropine DB00865, Benzphetamine DB01156, Bupropion DB01161, Chloroprocaine DB01114, Chlorpheniramine DB00907, Cocaine DB12305, Dasotraline DB06700, Desvenlafaxine DB06701, Dexmethylphenidate DB01576, Dextroamphetamine DB00937, Diethylpropion DB01146, Diphenylpyraline DB00988, Dopamine DB00476, Duloxetine DB01363, Ephedra sinica root DB01175, Escitalopram DB09194, Etoperidone DB01463, Fencamfamin DB00458, Imipramine DB08824, Ioflupane I-123 DB00408, Loxapine DB00579, Mazindol DB00454, Meperidine DB01577, Metamfetamine DB00422, Methylphenidate DB06148, Mianserin DB01454, Midomafetamine DB01442, MMDA DB00745, Modafinil DB01149, Nefazodone DB04821, Nomifensine DB00830, Phenmetrazine DB00191, Phentermine DB00721, Procaine DB00852, Pseudoephedrine DB01104, Sertraline DB01105, Sibutramine DB14754, Solriamfetol DB06156, Tesofensine DB00726, Trimipramine DB06333, Trodusquemine DB03701, Vanoxerine DB00285, Venlafaxine |
DrugCentrali | Q01959 |
GuidetoPHARMACOLOGYi | 927 |
Protein family/group databases
TCDBi | 2.A.22.1.3, the neurotransmitter:sodium symporter (nss) family |
PTM databases
GlyGeni | Q01959, 3 sites |
iPTMneti | Q01959 |
PhosphoSitePlusi | Q01959 |
SwissPalmi | Q01959 |
Polymorphism and mutation databases
BioMutai | SLC6A3 |
DMDMi | 266667 |
Proteomic databases
MassIVEi | Q01959 |
PaxDbi | Q01959 |
PeptideAtlasi | Q01959 |
PRIDEi | Q01959 |
ProteomicsDBi | 58021 |
Protocols and materials databases
Antibodypediai | 2799, 436 antibodies |
Genome annotation databases
Ensembli | ENST00000270349; ENSP00000270349; ENSG00000142319 ENST00000621716; ENSP00000479597; ENSG00000276996 |
GeneIDi | 6531 |
KEGGi | hsa:6531 |
UCSCi | uc003jck.4, human |
Organism-specific databases
CTDi | 6531 |
DisGeNETi | 6531 |
EuPathDBi | HostDB:ENSG00000142319.17 |
GeneCardsi | SLC6A3 |
GeneReviewsi | SLC6A3 |
HGNCi | HGNC:11049, SLC6A3 |
HPAi | ENSG00000142319, Tissue enriched (brain) |
MalaCardsi | SLC6A3 |
MIMi | 126455, gene 613135, phenotype |
neXtProti | NX_Q01959 |
OpenTargetsi | ENSG00000142319 |
Orphaneti | 238455, Infantile dystonia-parkinsonism |
PharmGKBi | PA311 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000161224 |
HOGENOMi | CLU_006855_9_0_1 |
InParanoidi | Q01959 |
OMAi | IFPEWAN |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q01959 |
TreeFami | TF343812 |
Enzyme and pathway databases
PathwayCommonsi | Q01959 |
Reactomei | R-HSA-379401, Dopamine clearance from the synaptic cleft R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters R-HSA-5619081, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724, Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) |
SABIO-RKi | Q01959 |
SIGNORi | Q01959 |
Miscellaneous databases
BioGRID-ORCSi | 6531, 3 hits in 843 CRISPR screens |
GeneWikii | Dopamine_transporter |
GenomeRNAii | 6531 |
Pharosi | Q01959, Tclin |
PROi | PR:Q01959 |
RNActi | Q01959, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142319, Expressed in substantia nigra and 72 other tissues |
Genevisiblei | Q01959, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002436, Na/ntran_symport_dopamine IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR01202, DOPTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SC6A3_HUMAN | |
Accessioni | Q01959Primary (citable) accession number: Q01959 Secondary accession number(s): A2RUN4, Q14996 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations